Silencing of tumor suppressor genes RASSF1A, SLIT2, and WIF1 by promoter hypermethylation in hereditary breast cancer.

abstract：:Serially transplantable rat mammary tumor (RMT) cells are not dependent on exogenous epidermal growth factor (EGF) and insulin-like growth factor-I for continuous growth in serum-free medium. Previously, we found that conditioned medium obtained from these cells contained EGF-like mitogenic activity and stimulated tyr...

journal_title：Molecular carcinogenesis

authors： Ethier SP,Langton BC,Dilts CA

更新日期：1996-02-01 00:00:00

abstract：:The molecular pathogenesis of papillary thyroid carcinoma (PTC) is largely attributed to chromosomal rearrangements and point mutations in genes within the MAPK pathway (i.e., BRAF and RAS). Despite KRAS being the 6th most frequently mutated gene for all cancers, the reported frequency in thyroid cancer is only 2%. Th...

journal_title：Molecular carcinogenesis

authors： Myers MB,McKim KL,Parsons BL

更新日期：2014-02-01 00:00:00

abstract：:The mutational specificity of the cyclic nitrosamine N-nitrosopyrrolidine (NPYR) was determined through the DNA sequence characterization of 33 lacl-d mutations of Escherichia coli. Base substitution was the predominant class of mutation induced (91%). The majority of these (64%) occurred at GC base pairs, in accordan...

journal_title：Molecular carcinogenesis

authors： Zielenska M,Ahmed A,Glickman BW

更新日期：1990-01-01 00:00:00

abstract：:To study the possible involvement of DNA damage in cell transformation induced by estrogens, we examined whether DNA adduct formation is elicited in cultured Syrian hamster embryo (SHE) cells treated with estrogens and their derivatives by means of the 32P-postlabeling assay. Morphological transformation of the cells ...

journal_title：Molecular carcinogenesis

authors： Hayashi N,Hasegawa K,Komine A,Tanaka Y,McLachian JA,Barrett JC,Tsutsui T

更新日期：1996-07-01 00:00:00

abstract：:N-nitrosomethylbenzylamine (NMBA)-induced rat esophageal tumorigenesis is an important model for squamous cell carcinoma of the human esophagus. In this model, previous studies have shown that the GGA-->GAA Ha-ras codon 12 mutation is present in the majority of papillomas. No other Ha-ras mutation has been identified....

journal_title：Molecular carcinogenesis

authors： Liston BW,Gupta A,Nines R,Carlton PS,Kresty LA,Harris GK,Stoner GD

更新日期：2001-09-01 00:00:00

abstract：:Mutations in the Ki-ras oncogene and the p53 tumor suppressor gene are known to occur at high frequencies in human colon cancers. We measured the frequency of mutations in these two genes in colon adenocarcinomas obtained from a widely used experimental model of human colon carcinogenesis: F344 rats treated with the c...

journal_title：Molecular carcinogenesis

authors： Erdman SH,Wu HD,Hixson LJ,Ahnen DJ,Gerner EW

更新日期：1997-06-01 00:00:00

abstract：:Obesity and its associated metabolic syndrome (MetS) are recognized risk factors for breast cancer. The molecular basis for this association remains largely unknown. Adipokines, in particular leptin and adiponectin, are thought to form part of the mechanism linking obesity with cancer through their altered expression/...

journal_title：Molecular carcinogenesis

authors： Carroll PA,Healy L,Lysaght J,Boyle T,Reynolds JV,Kennedy MJ,Pidgeon G,Connolly EM

更新日期：2011-08-01 00:00:00

abstract：:Breast cancer-associated mutations affecting the highly-conserved C-terminal BRCT domains of the tumor suppressor gene breast cancer susceptibility gene 1 (BRCA1) fully disrupt the ability of BRCA1 to interact with acetyl coenzyme A carboxylase alpha (ACCA), the rate-limiting enzyme catalyzing de novo fatty acid bioge...

journal_title：Molecular carcinogenesis

authors： Brunet J,Vazquez-Martin A,Colomer R,Graña-Suarez B,Martin-Castillo B,Menendez JA

更新日期：2008-02-01 00:00:00

abstract：:2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MelQx) are carcinogens found in cooked meats that form DNA adducts upon metabolic activation. Purified DNA from Chinese hamster ovary (CHO) cells was reacted in vitro with the active metabolites N-acetoxy-IQ or N-acetoxy-Me...

journal_title：Molecular carcinogenesis

authors： Nouso K,Bohr VA,Schut HA,Snyderwine EG

更新日期：1993-01-01 00:00:00

abstract：:Tamoxifen (TAM) is widely used in the treatment and prevention of breast cancer. There is clear evidence that cytochrome P450 (CYP) 3A enzymes play an important role in TAM metabolism, resulting in metabolites that lead to formation of TAM-DNA adducts. We have investigated the effect of CYP3A2 antisense (AVI-4472) exp...

journal_title：Molecular carcinogenesis

authors： Mahadevan B,Arora V,Schild LJ,Keshava C,Cate ML,Iversen PL,Poirier MC,Weston A,Pereira C,Baird WM

更新日期：2006-02-01 00:00:00

abstract：:In tumor cells that have lost responsiveness to the growth inhibitory effects of transforming growth factor beta (TGFbeta), increased TGFbeta production by the tumor cells often contributes to cancer progression, primarily through paracrine mechanisms. Here we investigated the major components of the activator protein...

journal_title：Molecular carcinogenesis

authors： Liu G,Ding W,Liu X,Mulder KM

更新日期：2006-08-01 00:00:00

abstract：:Ultraviolet (UV) light-induced activation of activator protein-1 (AP-1), resulting at least in part from oxidative stress, promotes skin carcinogenesis. It has not yet been determined whether elevating cellular phase II enzymes and glutathione (GSH) levels inhibits the AP-1 activation. We have, therefore, examined the...

journal_title：Molecular carcinogenesis

authors： Zhu M,Zhang Y,Cooper S,Sikorski E,Rohwer J,Bowden GT

更新日期：2004-11-01 00:00:00

abstract：:Elevation of the steady-state mRNA levels of glucose transporter and c-myc are among the earliest changes in gene expression observed after Ha-rasT24 stimulation of Rat-1 fibroblasts to enter the cell cycle. Since the expression of these genes may be the result of either increased cell proliferation or a specific resp...

journal_title：Molecular carcinogenesis

authors： Godwin AK,Lieberman MW

更新日期：1991-01-01 00:00:00

abstract：:BCL2L10 is an apoptosis-related member of the BCL-2 protein family. The role of BCL2L10 in the pathogenesis of hepatocellular carcinoma (HCC) is poorly understood. This study was aimed to investigate the function and underlying mechanisms of BCL2L10 in HCC. BCL2L10 expression in human HCC and corresponding adjacent no...

journal_title：Molecular carcinogenesis

authors： Bai Y,Wang J,Han J,Xie XL,Ji CG,Yin J,Chen L,Wang CK,Jiang XY,Qi W,Jiang HQ

更新日期：2017-03-01 00:00:00

abstract：:Ras/Raf/MEKs/ERKs and PI3 K/Akt/mTOR signaling pathways have key roles in cancer development and growth processes, as well as in cancer malignance and chemoresistance. In this study, we screened the therapeutic potential of magnolin using 15 human cancer cell lines and combined magnolin sensitivity with the CCLE mutao...

journal_title：Molecular carcinogenesis

authors： Song JH,Lee CJ,An HJ,Yoo SM,Kang HC,Lee JY,Kim KD,Kim DJ,Lee HS,Cho YY

更新日期：2019-01-01 00:00:00

abstract：:Apc mutations cause intestinal tumorigenesis through Tcf4 activation. However, direct techniques for studying Tcf4 activation in vivo are limited. Here, we describe the development of a Tcf4-GFP reporter mouse model for directly studying Tcf4 activation. We first developed a GFP reporter construct (Tcf4-GFP) and trans...

journal_title：Molecular carcinogenesis

authors： Boman B,Kopelovich L,Siracusa LD,Zhang T,Henderson K,Cofer Z,Buchberg AM,Fields JZ,Otevrel T

更新日期：2009-09-01 00:00:00

abstract：:The presence of RD(INK4/ARF) (RD) enhancer in the INK4-ARF locus provides a novel mechanism to simultaneously increase the transcription of p15(INK4b) (p15), p14ARF (p14), and p16(INK4a) (p16). While such upregulation can be repressed through interactions between RD and oncoproteins CDC6 and BMI1, little is known abou...

journal_title：Molecular carcinogenesis

authors： Poi MJ,Knobloch TJ,Sears MT,Warner BM,Uhrig LK,Weghorst CM,Li J

更新日期：2015-07-01 00:00:00

abstract：:Telomerase activity is suppressed in normal human somatic tissues but is activated in cancer cells and immortal cell lines. The reverse transcriptase (RT) subunit human telomerase reverse transcriptase (hTERT) is the key regulator of telomerase activity. The hTERT promoter contains E-box elements and may allow upstrea...

journal_title：Molecular carcinogenesis

authors： Chang JT,Yang HT,Wang TC,Cheng AJ

更新日期：2005-11-01 00:00:00

abstract：:Microsatellite instability (MI) and loss of heterozygosity (LOH) were examined in mammary tumors induced in Sprague-Dawley x F344 F1 female rats by 2-amino-l-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Examination of 62 microsatellite loci revealed MI in nine of 15 (60%) PhIP-induced mammary tumors, and five of thes...

journal_title：Molecular carcinogenesis

authors： Toyota M,Ushijima T,Weisburger JH,Hosoya Y,Canzian F,Rivenson A,Imai K,Sugimura T,Nagao M

更新日期：1996-03-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) is a growth modulator that inhibits the proliferation of many epithelial cells through interaction with its receptors, the type I and type II receptors (TGF-beta RI and RII) by activating their serine/threonine kinase activities. Loss of growth inhibition by TGF-beta is thoug...

journal_title：Molecular carcinogenesis

authors： Jakowlew SB,Moody TW,You L,Mariano JM

更新日期：1998-05-01 00:00:00

abstract：:2-Deoxyglucose (2-DG), which has been shown to inhibit mammary carcinogenesis, was used as a metabolic probe to investigate effects of limiting energy availability (reduced cellular ATP) on patterns of proteins' phosphorylation that play a role in the development of cancer. Experiments were conducted using a human bre...

journal_title：Molecular carcinogenesis

authors： Jiang W,Zhu Z,Thompson HJ

更新日期：2008-08-01 00:00:00

abstract：:The molecular changes associated with the aging process include the reduced activity of transcription factors (such as AP-1) and an impaired response to stress, which has been well documented in the case of the heat-shock (HS) response. Using human diploid fibroblasts of early and late passages as an in vitro model fo...

journal_title：Molecular carcinogenesis

authors： Adler V,Dolan LR,Kim J,Pincus M,Barrett JC,Ronai Z

更新日期：1996-09-01 00:00:00

abstract：:Single nucleotide polymorphisms (SNPs) of matrix metalloproteinase3 (MMP3) promoter in the development and progression of gastric cancer of whole stomach has never been investigated in any population. We conducted a hospital-based case-control study to explore the MMP3 SNPs and their haplotypes with the risk of gastri...

journal_title：Molecular carcinogenesis

authors： Dey S,Stalin S,Gupta A,Saha D,Kesh K,Swarnakar S

更新日期：2012-10-01 00:00:00

abstract：:Black currant fruits containing high amounts of anthocyanins are known to possess potent antioxidant and anti-inflammatory properties. We have previously reported that anthocyanin-rich black currant skin extract (BCSE) inhibits diethylnitrosamine (DENA)-initiated hepatocarcinogenesis in rats although the underlying me...

journal_title：Molecular carcinogenesis

authors： Bishayee A,Thoppil RJ,Mandal A,Darvesh AS,Ohanyan V,Meszaros JG,Háznagy-Radnai E,Hohmann J,Bhatia D

更新日期：2013-04-01 00:00:00

abstract：:Adipose tissue dysregulation, a hallmark of obesity, contributes to a chronic state of low-grade inflammation and is associated with increased risk and progression of several breast cancer subtypes, including claudin-low breast tumors. Unfortunately, mechanistic targets for breaking the links between obesity-associate...

journal_title：Molecular carcinogenesis

authors： Rossi EL,Khatib SA,Doerstling SS,Bowers LW,Pruski M,Ford NA,Glickman RD,Niu M,Yang P,Cui Z,DiGiovanni J,Hursting SD

更新日期：2018-03-01 00:00:00

abstract：:We transformed JB6P+ cells with prolonged intermittent low-dose UVB radiation or prolonged exposure to low-dose H(2)O(2) or CdCl(2). Stable transformation was confirmed by an anchorage-independence assay. The JB6P+ transformants formed more colonies (approximately six folds) in soft agar as compared to their JB6P+ par...

journal_title：Molecular carcinogenesis

authors： Yang S,Misner B,Chiu R,Meyskens FL Jr

更新日期：2008-07-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is an embryonic program that is reactivated in cancer and regulates the invasion and metastasis of tumor cells. Zinc finger E-box binding homeobox 2 (ZEB2) induces EMT by upregulating matrix metalloproteinases (MMP), yet MMP genes lack ZEB2 binding motif in their promoters. Rece...

journal_title：Molecular carcinogenesis

authors： Yalim-Camci I,Balcik-Ercin P,Cetin M,Odabas G,Tokay N,Sayan AE,Yagci T

更新日期：2019-06-01 00:00:00

abstract：:Chromosomal double-strand breaks (DSBs) occurring in mammalian cells can initiate genomic instability, and their misrepairs result in chromosomal deletion, amplification, and translocation, common findings in human tumors. The tumor-suppressor protein p53 is involved in maintaining genomic stability. In this study, we...

journal_title：Molecular carcinogenesis

authors： Honma M,Momose M,Tanabe H,Sakamoto H,Yu Y,Little JB,Sofuni T,Hayashi M

更新日期：2000-08-01 00:00:00

abstract：:Loss or decrease of wild type BRCA1 function, by either mutation or reduced expression, has a role in hereditary and sporadic human breast and ovarian cancers. We report here that the PI3K/AKT pathway is constitutively active in BRCA1-defective human breast cancer cells. Levels of phospho-AKT are sustained even after ...

journal_title：Molecular carcinogenesis

authors： Yi YW,Kang HJ,Kim HJ,Hwang JS,Wang A,Bae I

更新日期：2013-09-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) plays an important role in the development and progression of lung cancer. A previous report noted that an increased number of polymorphic CA repeats in the first intron of the EGFR gene results in decreased transcriptional activity. To estimate the association of the length of ...

journal_title：Molecular carcinogenesis

authors： Zhang W,Weissfeld JL,Romkes M,Land SR,Grandis JR,Siegfried JM

更新日期：2007-05-01 00:00:00