Abstract:
:The mutational specificity of the cyclic nitrosamine N-nitrosopyrrolidine (NPYR) was determined through the DNA sequence characterization of 33 lacl-d mutations of Escherichia coli. Base substitution was the predominant class of mutation induced (91%). The majority of these (64%) occurred at GC base pairs, in accordance with the predicted significance of NPYR-derived guanine adducts. In addition, this nitrosamine efficiently produced other kinds of base substitution events as 11 of the 33 mutations occurred at AT base pairs. Deletion, frameshift, and duplication events were also recovered. The complexity of the NPYR mutational spectrum appears to be consistent with the suggestion that this compound acts through both direct and indirect mutational pathways.
journal_name
Mol Carcinogjournal_title
Molecular carcinogenesisauthors
Zielenska M,Ahmed A,Glickman BWdoi
10.1002/mc.2940030304subject
Has Abstractpub_date
1990-01-01 00:00:00pages
122-5issue
3eissn
0899-1987issn
1098-2744journal_volume
3pub_type
杂志文章abstract::Telomerase activity is suppressed in normal human somatic tissues but is activated in cancer cells and immortal cell lines. The reverse transcriptase (RT) subunit human telomerase reverse transcriptase (hTERT) is the key regulator of telomerase activity. The hTERT promoter contains E-box elements and may allow upstrea...
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journal_title:Molecular carcinogenesis
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
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更新日期:2010-10-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2015-04-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
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更新日期:1989-01-01 00:00:00
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journal_title:Molecular carcinogenesis
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pub_type: 杂志文章
doi:10.1002/mc.22051
更新日期:2014-02-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
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更新日期:2001-08-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章,随机对照试验
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更新日期:2017-08-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1002/mc.20617
更新日期:2010-04-01 00:00:00
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journal_title:Molecular carcinogenesis
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doi:10.1002/mc.22379
更新日期:2016-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/mc.20120
更新日期:2005-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/mc.22217
更新日期:2015-11-01 00:00:00
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更新日期:2010-03-01 00:00:00
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journal_title:Molecular carcinogenesis
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-06-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
doi:10.1002/mc.22972
更新日期:2019-05-01 00:00:00
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pub_type: 杂志文章,评审
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