Oncogene amplification per se: an independent prognostic factor in human breast cancer.

Abstract:

:As the prognostic significance of the three most frequently amplified oncogenes in breast cancer (c-myc, int-2/FGF3, and c-erbB-2/neu) is still unclear, and as the amplification of these genes appears to be mutually exclusive, we investigated the prognostic significance of oncogene amplification per se by multivariate analysis in a group of 112 primary human breast cancer cases. Amplification of at least one gene (c-myc, int-2/FGF3, or c-erbB-2/neu), progesterone receptor status, and pathological tumor size were the only independent variables predictive of metastasis-free survival. Moreover, we constructed prognostic profiles by computing risks associated with the three parameters predictive of poor survival and discriminated high-, moderate-, and low-risk categories.

journal_name

Mol Carcinog

journal_title

Molecular carcinogenesis

authors

Champème MH,Bièche I,Hacène K,Lidereau R

doi

10.1002/mc.2940110403

subject

Has Abstract

pub_date

1994-12-01 00:00:00

pages

189-91

issue

4

eissn

0899-1987

issn

1098-2744

journal_volume

11

pub_type

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