Oncogene amplification per se: an independent prognostic factor in human breast cancer.


:As the prognostic significance of the three most frequently amplified oncogenes in breast cancer (c-myc, int-2/FGF3, and c-erbB-2/neu) is still unclear, and as the amplification of these genes appears to be mutually exclusive, we investigated the prognostic significance of oncogene amplification per se by multivariate analysis in a group of 112 primary human breast cancer cases. Amplification of at least one gene (c-myc, int-2/FGF3, or c-erbB-2/neu), progesterone receptor status, and pathological tumor size were the only independent variables predictive of metastasis-free survival. Moreover, we constructed prognostic profiles by computing risks associated with the three parameters predictive of poor survival and discriminated high-, moderate-, and low-risk categories.


Mol Carcinog


Molecular carcinogenesis


Champème MH,Bièche I,Hacène K,Lidereau R




Has Abstract


1994-12-01 00:00:00












  • Association of genetic variants of human telomerase with colorectal polyps and colorectal cancer risk.

    abstract::Human telomerase reverse transcriptase (TERT) gene encodes the catalytic subunit of telomerase and is located on chromosome 5p15, a genomic region which was found to be associated with multiple cancer types. But no associations with colorectal cancer (CRC) have been reported until recently. Therefore, the purpose of t...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Hofer P,Baierl A,Bernhart K,Leeb G,Mach K,Micksche M,Gsur A

    更新日期:2012-10-01 00:00:00

  • Inhibition of osteoclast differentiation and bone resorption by cathepsin K antisense oligonucleotides.

    abstract::We confirmed the expression of cathepsin K, the most abundant and specific cysteine protease found in osteoclasts, at the mRNA level in most of our cases of breast cancer, and even at the protein level in bone metastatic lesions. Therefore, we investigated the functions of cathepsin K in osteoclasts with special atten...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Ishikawa T,Kamiyama M,Tani-Ishii N,Suzuki H,Ichikawa Y,Hamaguchi Y,Momiyama N,Shimada H

    更新日期:2001-10-01 00:00:00

  • Involvement of protein kinase C α and δ activities on the induction of the retinoic acid system in mammary cancer cells.

    abstract::It has been established that retinoids exert some of their effects on cell differentiation and malignant phenotype reversion through the interaction with different members of the protein kinase C (PKC) family. Till nowadays the nature and extension of this interaction is not well understood. Due to the cytostatic and ...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Berardi DE,Bessone MI,Motter A,Bal de Kier Joffé ED,Urtreger AJ,Todaro LB

    更新日期:2015-10-01 00:00:00

  • bcl-2 delay of alkylating agent-induced apoptotic death in a murine hemopoietic stem cell line.

    abstract::Many cytotoxic agents kill cells by invoking a specific death pathway termed physiological cell death, or apoptosis. Treatment of a murine hemopoietic stem cell line, FDCP-mix, with methylmethanesulfonate (MMS) or N'-methyl-N'-nitrosourea (MNU) leads to death by apoptosis. Retroviral gene transfer was used to overexpr...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Fairbairn LJ,Cowling GJ,Dexter TM,Rafferty JA,Margison GP,Reipert B

    更新日期:1994-09-01 00:00:00

  • Formation of an active form of the interleukin-2/15 receptor beta-chain by insertion of the intracisternal A particle in a radiation-induced mouse thymic lymphoma and its role in tumorigenesis.

    abstract::Although many reports suggest that aberrant regulation of cytokine signaling pathways via the interleukin-2 receptor (IL-2R) induces tumorigenic transformation, constitutively active IL-2R in tumors has not been reported. We searched for genomic alteration of the IL-2/15R beta-subunit gene (IL-2/15R beta) in cytokine-...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Ukai H,Ishii-Oba H,Ukai-Tadenuma M,Ogiu T,Tsuji H

    更新日期:2003-06-01 00:00:00

  • Withaferin A suppresses the up-regulation of acetyl-coA carboxylase 1 and skin tumor formation in a skin carcinogenesis mouse model.

    abstract::Withaferin A (WA), a natural product derived from Withania somnifera, has been used in traditional oriental medicines to treat neurological disorders. Recent studies have demonstrated that this compound may have a potential for cancer treatment and a clinical trial has been launched to test WA in treating melanoma. He...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Li W,Zhang C,Du H,Huang V,Sun B,Harris JP,Richardson Q,Shen X,Jin R,Li G,Kevil CG,Gu X,Shi R,Zhao Y

    更新日期:2016-11-01 00:00:00

  • Effects of polyunsaturated fatty acids on prostaglandin synthesis and cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines in human adenocarcinoma colon cells.

    abstract::Dietary heterocyclic aromatic amines (HCA) and polyunsaturated fatty acids (PUFA) are both believed to play a role in colon carcinogenesis, and are both substrate for the enzyme cyclooxygenase (COX). In HCA-7 cells, highly expressing isoform COX-2, we investigated the effects of PUFA on prostaglandin synthesis and DNA...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Moonen HJ,Dommels YE,van Zwam M,van Herwijnen MH,Kleinjans JC,Alink GM,de Kok TM

    更新日期:2004-07-01 00:00:00

  • In vitro studies of steroid hormones in neurofibromatosis 1 tumors and Schwann cells.

    abstract::The most common NF1 feature is the benign neurofibroma, which consists predominantly of Schwann cells. Dermal neurofibromas usually arise during puberty and increase in number throughout adulthood. Plexiform neurofibromas, associated with larger nerves, are often congenital and can be life threatening. Malignant perip...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Fishbein L,Zhang X,Fisher LB,Li H,Campbell-Thompson M,Yachnis A,Rubenstein A,Muir D,Wallace MR

    更新日期:2007-07-01 00:00:00

  • Mango polyphenolics reduce inflammation in intestinal colitis-involvement of the miR-126/PI3K/AKT/mTOR axis in vitro and in vivo.

    abstract::This study sought to elucidate the mechanisms underlying the anti-inflammatory effect of mango (Mangifera Indica L.) polyphenolics containing gallic acid and gallotanins, and the role of the miR-126/PI3K/AKT/mTOR signaling axis in vitro and in vivo. Polyphenolics extracted from mango (var. Keitt) were investigated in ...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Kim H,Banerjee N,Barnes RC,Pfent CM,Talcott ST,Dashwood RH,Mertens-Talcott SU

    更新日期:2017-01-01 00:00:00

  • Overexpression of Evi-1 oncoprotein represses TGF-β signaling in colorectal cancer.

    abstract::Human colorectal cancer (CRC) cells are resistant to the anti-proliferative effect of transforming growth factor-β (TGF-β), suggesting that disruption of TGF-β signaling plays an important role in colorectal carcinogenesis. Ecotropic virus integration site-1 (Evi-1) oncoprotein represses TGF-β signaling by interacting...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Deng X,Cao Y,Liu Y,Li F,Sambandam K,Rajaraman S,Perkins AS,Fields AP,Hellmich MR,Townsend CM Jr,Thompson EA,Ko TC

    更新日期:2013-04-01 00:00:00

  • Quantitation of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline DNA adducts in specific sequences using alkali or uvrABC excinuclease.

    abstract::2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MelQx) are carcinogens found in cooked meats that form DNA adducts upon metabolic activation. Purified DNA from Chinese hamster ovary (CHO) cells was reacted in vitro with the active metabolites N-acetoxy-IQ or N-acetoxy-Me...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Nouso K,Bohr VA,Schut HA,Snyderwine EG

    更新日期:1993-01-01 00:00:00

  • Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling.

    abstract::Prostate cancer (PCA) is the second most malignancy in American men. Advanced stage PCA cells possess unlimited replication potential as well as resistance to apoptosis. Therefore, targeting survival mechanisms and activating apoptotic machinery in PCA cells using nontoxic phytochemicals is suggested as an attractive ...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Deep G,Gangar SC,Oberlies NH,Kroll DJ,Agarwal R

    更新日期:2010-10-01 00:00:00

  • Oxidative DNA damage causes premature senescence in mouse embryonic fibroblasts deficient for Krüppel-like factor 4.

    abstract::Krüppel-like factor 4 (KLF4) is a zinc-finger-containing transcription factor with tumor suppressor activity in various cancer types. Cells that sustain double strand breaks (DSBs) in their DNA due to high levels of reactive oxygen species (ROS) can develop genomic instability, which can result in cancer formation. On...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Liu C,La Rosa S,Hagos EG

    更新日期:2015-09-01 00:00:00

  • Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential.

    abstract::The majority of human neoplasms have aberrations in the retinoblastoma pathway due to hyperactivation of cyclin-dependent kinases (CDK). Based on this observation, novel small molecules, such as flavopiridol and UCN-01, are being developed and are currently being tested in the clinic. Efforts to develop CDK modulators...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Lahusen T,De Siervi A,Kunick C,Senderowicz AM

    更新日期:2003-04-01 00:00:00

  • Mutations of the p53 tumor suppressor gene and the ras gene family in intrahepatic cholangiocellular carcinomas in Japan and Thailand.

    abstract::The incidence and pattern of mutations of the ras oncogenes and the p53 tumor suppressor gene have been shown to differ among different cancer types and even among the same cancer types with different etiological backgrounds. For example, in a previous study we showed that not only the etiology but also the incidence ...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Kiba T,Tsuda H,Pairojkul C,Inoue S,Sugimura T,Hirohashi S

    更新日期:1993-01-01 00:00:00

  • The role of ERK2 in colorectal carcinogenesis is partly regulated by TRAPPC4.

    abstract::The extracellular signal-regulated kinase (ERK), mitogen-activated protein kinase (MAPK) pathway is an important cell proliferation pathway. We previously reported that the transport protein particle complex 4 (TRAPPC4), ERK2 interaction may activate ERK1/2, modulate pERK2 nuclear localization and regulate proliferati...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Weng YR,Kong X,Yu YN,Wang YC,Hong J,Zhao SL,Fang JY

    更新日期:2014-02-01 00:00:00

  • Epigenetic regulation of the human ATP2A3 gene promoter in gastric and colon cancer cell lines.

    abstract::The knowledge about the role of calcium-regulated pathways in cancer cell growth and differentiation could be useful for the development of new therapeutic approaches to diminish its mortality. The ATP2A genes encode for SERCA pumps, which modulate cytosolic Ca2+ concentration, regulating various cellular processes in...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Meneses-Morales I,Izquierdo-Torres E,Flores-Peredo L,Rodríguez G,Hernández-Oliveras A,Zarain-Herzberg Á

    更新日期:2019-06-01 00:00:00

  • Beetroot red (betanin) inhibits vinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis through apoptosis.

    abstract::Betanin, also called beetroot red, has been extensively used as a food colorant. In this study, the chemopreventive activity of betanin by oral consumption was investigated in two mouse lung tumor models. Vinyl carbamate (VC) and benzo(a)pyrene (B(a)P) were used to induce lung tumors, and female A/J mice were treated ...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Zhang Q,Pan J,Wang Y,Lubet R,You M

    更新日期:2013-09-01 00:00:00

  • Expression of peptidylarginine deiminase type 4 (PAD4) in various tumors.

    abstract::Peptidylarginine deiminase type 4 (PAD4/PADI4) posttranslationally converts peptidylarginine to citrulline, in a process known as citrullination. Evidence suggests that PAD4 plays an essential role in pathogenesis of rheumatoid arthritis (RA). RA synovium has many features in common with tumor tissues, including abnor...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Chang X,Han J

    更新日期:2006-03-01 00:00:00

  • The Ron receptor tyrosine kinase is not required for adenoma formation in Apc(Min/+) mice.

    abstract::The Ron receptor tyrosine kinase is overexpressed in approximately half of all human colon cancers. Increased Ron expression positively correlates with tumor progression, and reduction of Ron levels in human colon adenocarcinoma cells reverses their tumorigenic properties. Nearly all colon tumors demonstrate loss of t...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Meyer SE,Waltz SE,Goss KH

    更新日期:2009-11-01 00:00:00

  • Identification of chromatin-accessible domains in non-alcoholic steatohepatitis-derived hepatocellular carcinoma.

    abstract::Non-alcoholic steatohepatitis (NASH) is becoming one of the major causes of hepatocellular carcinoma (HCC) in the United States and Western countries; however, the molecular mechanisms associated with NASH-related liver carcinogenesis are not well understood. In the present study, we investigated cancer-associated chr...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Dechassa ML,Tryndyak V,de Conti A,Xiao W,Beland FA,Pogribny IP

    更新日期:2018-08-01 00:00:00

  • A Tcf4-GFP reporter mouse model for monitoring effects of Apc mutations during intestinal tumorigenesis.

    abstract::Apc mutations cause intestinal tumorigenesis through Tcf4 activation. However, direct techniques for studying Tcf4 activation in vivo are limited. Here, we describe the development of a Tcf4-GFP reporter mouse model for directly studying Tcf4 activation. We first developed a GFP reporter construct (Tcf4-GFP) and trans...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Boman B,Kopelovich L,Siracusa LD,Zhang T,Henderson K,Cofer Z,Buchberg AM,Fields JZ,Otevrel T

    更新日期:2009-09-01 00:00:00

  • Hyperpigmentation and melanocytic hyperplasia in transgenic mice expressing the human T24 Ha-ras gene regulated by a mouse tyrosinase promoter.

    abstract::The tyrosinase promoter has been used to target expression of the mutated human T24 Ha-ras oncogene in pigment-producing cells of transgenic mice. Two independent founder mice carrying the transgene survived and showed the same distinct phenotype of mutated coat color, deeply pigmented skin with multiple nevi, and twi...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Powell MB,Hyman P,Bell OD,Balmain A,Brown K,Alberts D,Bowden GT

    更新日期:1995-02-01 00:00:00

  • The polymorphisms and haplotypes of WWOX gene are associated with the risk of lung cancer in southern and eastern Chinese populations.

    abstract::The WW domain-containing oxidoreductase (WWOX) gene is an identified tumor suppressor gene, of which several single nucleotide polymorphisms have been reported to contribute to cancer susceptibility. We hypothesized that genetic variations in WWOX are associated with lung cancer risk. In two independent case-control s...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Huang D,Qiu F,Yang L,Li Y,Cheng M,Wang H,Ma G,Wang Y,Hu M,Ji W,Zhou Y,Lu J

    更新日期:2013-11-01 00:00:00

  • Constitutive and phorbol-myristate-acetate regulated antioxidant defense of mouse epidermal JB6 cells.

    abstract::Because oxidative processes can participate in tumor promotion, it is likely that the cellular antioxidant defense also plays a role. We have compared the levels of the three major antioxidant enzymes, Cu,Zn-superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx), in promotable mouse epidermal JB6 cells ...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Crawford DR,Amstad PA,Foo DD,Cerutti PA

    更新日期:1989-01-01 00:00:00

  • The role of transforming growth factor-beta in immune suppression and chronic inflammation of squamous cell carcinomas.

    abstract::Despite a decline in the incidence of squamous cell carcinomas (SCCs) over the past 20 years, their survival rate has remained nearly the same, indicating that treatment options have not improved relative to other cancer types. Immunotherapies have a high potential for a sustained effect in SCC patients, but their res...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章,评审


    authors: Strait AA,Wang XJ

    更新日期:2020-07-01 00:00:00

  • Prognostic implications of ezrin expression in human hepatocellular carcinoma.

    abstract::Ezrin is known to regulate cellular survival, adhesion, migration, and invasion and has been identified as one of the key components of tumor progression and metastasis. The authors investigated ezrin expression in human hepatocellular carcinoma (HCC) and sought to determine its relation with clinicopathologic paramet...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Kang YK,Hong SW,Lee H,Kim WH

    更新日期:2010-09-01 00:00:00

  • Rheb promotes cancer cell survival through p27Kip1-dependent activation of autophagy.

    abstract::We previously found that the small GTPase Rheb regulates the cell-cycle inhibitor p27KIP1 (p27) in colon cancer cells by a mTORC1-independent mechanism. However, the biological function of the Rheb/p27 axis in cancer cells remains unknown. Here, we show that siRNA-mediated depletion of Rheb decreases survival of human...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Campos T,Ziehe J,Palma M,Escobar D,Tapia JC,Pincheira R,Castro AF

    更新日期:2016-02-01 00:00:00

  • Apple polyphenol phloretin potentiates the anticancer actions of paclitaxel through induction of apoptosis in human hep G2 cells.

    abstract::Phloretin (Ph), which can be obtained from apples, apple juice, and cider, is a known inhibitor of the type II glucose transporter (GLUT2). In this study, real-time PCR analysis of laser-capture microdissected (LCM) human hepatoma cells showed elevated expression (>5-fold) of GLUT2 mRNA in comparison with nonmalignant...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Yang KC,Tsai CY,Wang YJ,Wei PL,Lee CH,Chen JH,Wu CH,Ho YS

    更新日期:2009-05-01 00:00:00

  • Uridine-cytidine kinase 2 upregulation predicts poor prognosis of hepatocellular carcinoma and is associated with cancer aggressiveness.

    abstract::Patients with advanced hepatocellular carcinoma (HCC) continue to have a dismal prognosis. Potential biomarkers to determine prognosis and select targeted therapies are urgently needed for patients with HCC. This study aimed to elucidate the role of UCK2 in HCC prognosis and tumor progression. We performed a screen of...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Huang S,Li J,Tam NL,Sun C,Hou Y,Hughes B,Wang Z,Zhou Q,He X,Wu L

    更新日期:2019-04-01 00:00:00