Atypical role of sprouty in p21 dependent inhibition of cell proliferation in colorectal cancer.

abstract：:We examined whether betulin, a naturally abundant compound, has anticancer functions in human cancer cells. The results showed that betulin significantly inhibited cell viability in cervix carcinoma HeLa cells, hepatoma HepG2 cells, lung adenocarcinoma A549 cells, and breast cancer MCF-7 cells with IC(50) values rangi...

journal_title：Molecular carcinogenesis

authors： Li Y,He K,Huang Y,Zheng D,Gao C,Cui L,Jin YH

更新日期：2010-07-01 00:00:00

abstract：:2-Deoxyglucose (2-DG), which has been shown to inhibit mammary carcinogenesis, was used as a metabolic probe to investigate effects of limiting energy availability (reduced cellular ATP) on patterns of proteins' phosphorylation that play a role in the development of cancer. Experiments were conducted using a human bre...

journal_title：Molecular carcinogenesis

authors： Jiang W,Zhu Z,Thompson HJ

更新日期：2008-08-01 00:00:00

abstract：:Hypoxia is a critical event in solid tumor development, invasion, and metastasis. Cellular adaptation to hypoxic microenvironment is essential for tumor progression and is largely mediated by hypoxia-inducible factor-1α (HIF-1α) through coordinated regulation of hypoxia-responsive genes. In this study, we found that m...

journal_title：Molecular carcinogenesis

authors： Zhu S,Zhou Y,Wang L,Zhang J,Wu H,Xiong J,Zhang J,Tian Y,Wang C,Wu H

更新日期：2011-10-01 00:00:00

abstract：:Mice with conditional gene deletions have been extremely valuable in allowing investigators to study the genes of interest in a tissue-specific manner. The Cre-loxP recombination system provides a powerful tool to produce targeted rearrangements of particular genes. The keratin 5-Cre recombinase (K5Cre) transgenic mou...

journal_title：Molecular carcinogenesis

authors： Chan EL,Peace BE,Toney K,Kader SA,Pathrose P,Collins MH,Waltz SE

更新日期：2007-01-01 00:00:00

abstract：:High levels of the cell growth inhibitor transforming growth factor-beta1 (TGF-beta1) are often found in a variety of human cancers. However, the physiological significance of this overexpression depends on the availability of the biologically active form of TGF-beta1 within the extracellular matrix of the tumor micro...

journal_title：Molecular carcinogenesis

authors： Guda K,Claffey KP,Dong M,Nambiar PR,Rosenberg DW

更新日期：2003-05-01 00:00:00

abstract：:Phloretin (Ph), which can be obtained from apples, apple juice, and cider, is a known inhibitor of the type II glucose transporter (GLUT2). In this study, real-time PCR analysis of laser-capture microdissected (LCM) human hepatoma cells showed elevated expression (>5-fold) of GLUT2 mRNA in comparison with nonmalignant...

journal_title：Molecular carcinogenesis

authors： Yang KC,Tsai CY,Wang YJ,Wei PL,Lee CH,Chen JH,Wu CH,Ho YS

更新日期：2009-05-01 00:00:00

abstract：UNLABELLED:Colon carcinogenesis is long known to be associated with ulcerative colitis (UC), a chronic gastrointestinal disorder. Various pre-clinical and clinical studies have shown that melatonin (MEL) has beneficial effects in cancer. However, elucidation of the detailed molecular mechanisms involved in MEL-mediated...

journal_title：Molecular carcinogenesis

authors： Trivedi PP,Jena GB,Tikoo KB,Kumar V

更新日期：2016-03-01 00:00:00

abstract：:Genomic DNA sequences with the ability to assume non-B form secondary structures have been recently shown to be particularly susceptible to genetic instability, an early contributing factor in human disease and cancer development. Transcription appears to play a central role in formation of these structures and in pro...

journal_title：Molecular carcinogenesis

authors： Tornaletti S

更新日期：2009-04-01 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), a compound found in cooked meat, is a mammary gland carcinogen in female Sprague-Dawley rats. PhIP-induced rat mammary gland carcinomas were examined for mutations in several genes (exons) known to regulate cell growth and apoptosis, including p53 (4-8), p21(Waf1...

journal_title：Molecular carcinogenesis

authors： Yu M,Ryu DY,Snyderwine EG

更新日期：2000-02-01 00:00:00

abstract：:Gene amplification contributes to carcinogenesis by enhancing proto-oncogene activity and causing chromosomal instability. The ease of detecting amplified tumor-virus sequences has encouraged use of this system as a surrogate for studying the molecular events involved in endogenous gene amplification. We report here a...

journal_title：Molecular carcinogenesis

authors： Rossman TG,Wolosin D

更新日期：1992-01-01 00:00:00

abstract：:Paclitaxel is the last choice for the treatment of advanced melanoma as a second-line chemotherapeutic agent, but there are still many cases of intrinsic resistance to paclitaxel in melanoma and the reasons that cause paclitaxel resistance remain unclear. Here, we identified that high expression of SRY-box transcripti...

journal_title：Molecular carcinogenesis

authors： Si X,Gao Z,Xu F,Zheng Y

更新日期：2020-03-01 00:00:00

abstract：:Some of the progeny of isolated mouse embryo fibroblasts acquire the ability to grow indefinitely during cultivation, presumably through some mutational events. The relevance of p53 mutations and loss of heterozygosity to the mechanism of such immortal growth capability remains controversial. Since four bases in intro...

journal_title：Molecular carcinogenesis

authors： Tokumitsu M,Kadohama T,Ogawa K

更新日期：1994-05-01 00:00:00

abstract：:In this paper, patterns of allelic imbalances (Als) in chemically induced rat mammary, colon, and bladder tumors from (Wistar Furth x Fischer 344)F1 rats are described and compared. Male F1 rats were administered azoxymethane (AOM), and colon tumors were collected at 58 wk after treatment. Female F1 rats were given ei...

journal_title：Molecular carcinogenesis

authors： Haag JD,Brasic GM,Shepel LA,Newton MA,Grubbs CJ,Lubet RA,Kelloff GJ,Gould MN

更新日期：1999-01-01 00:00:00

abstract：:2-Methoxyestradiol (2-ME), an endogenous metabolite of 17beta-estradiol, is present in human blood and urine. Here we show for the first time that 2-ME significantly inhibited the growth of normal prostate epithelial cells and androgen-dependent LNCaP and androgen-independent DU145 prostate cancer cells. This growth i...

journal_title：Molecular carcinogenesis

authors： Kumar AP,Garcia GE,Slaga TJ

更新日期：2001-07-01 00:00:00

abstract：:Glucocorticoid hormones are strong inhibitors of normal keratinocyte proliferation, but established mouse skin papillomas and carcinomas become resistant to these hormones. The biological effect of glucocorticoids is mediated through a highly specific glucocorticoid receptor (GR). To study the possible mechanisms of g...

journal_title：Molecular carcinogenesis

authors： Spiegelman VS,Budunova IV,Carbajal S,Slaga TJ

更新日期：1997-09-01 00:00:00

abstract：:Human DEAD-box RNA helicase gene DDX6 was cloned from B-cell lymphoma cell line RC-K8. Previously, we reported that DDX6 acts as oncogene in several cancers such as colorectal cancer and hepatocellular carcinoma. However, the detailed mechanism of DDX6 action in carcinogenesis is largely unknown. In this study, we exa...

journal_title：Molecular carcinogenesis

authors： Taniguchi K,Iwatsuki A,Sugito N,Shinohara H,Kuranaga Y,Oshikawa Y,Tajirika T,Futamura M,Yoshida K,Uchiyama K,Akao Y

更新日期：2018-05-01 00:00:00

abstract：:In this study, we found that rat nasal coumarin-7-hydroxylase (COH) activity was two orders of magnitude higher than rat hepatic COH activity and could be induced by adding coumarin to the rats' drinking water. In western blot analysis, an anti-cytochrome P450 (Cyp) 2a-5 (mouse liver COH) antibody recognized a sharp b...

journal_title：Molecular carcinogenesis

authors： Béréziat JC,Raffalli F,Schmezer P,Frei E,Geneste O,Lang MA

更新日期：1995-10-01 00:00:00

abstract：:The pi-class glutathione S-transferase (GSTP1) actively protect cells from carcinogens and electrophilic compounds. Loss of GSTP1 expression via promoter hypermethylation is the most common epigenetic alteration observed in human prostate cancer. Silencing of GSTP1 can increase generation of reactive oxygen species (R...

journal_title：Molecular carcinogenesis

authors： Kanwal R,Pandey M,Bhaskaran N,Maclennan GT,Fu P,Ponsky LE,Gupta S

更新日期：2014-01-01 00:00:00

abstract：:The tyrosinase promoter has been used to target expression of the mutated human T24 Ha-ras oncogene in pigment-producing cells of transgenic mice. Two independent founder mice carrying the transgene survived and showed the same distinct phenotype of mutated coat color, deeply pigmented skin with multiple nevi, and twi...

journal_title：Molecular carcinogenesis

authors： Powell MB,Hyman P,Bell OD,Balmain A,Brown K,Alberts D,Bowden GT

更新日期：1995-02-01 00:00:00

abstract：:Although fibroblast growth factor (FGF) signals are strongly associated with malignancy, limited information is available regarding the role of the FGF9 signal in colorectal cancer (CRC). In this study, we investigated the frequency of FGF9 amplification in CRC clinical specimens and the association between the FGF9 g...

journal_title：Molecular carcinogenesis

authors： Mizukami T,Togashi Y,Naruki S,Banno E,Terashima M,de Velasco MA,Sakai K,Yoneshige A,Hayashi H,Fujita Y,Tomida S,Nakajima TE,Fujino T,Boku N,Ito A,Nakagawa K,Nishio K

更新日期：2017-01-01 00:00:00

abstract：:Increased epidermal growth factor receptor (EGFR) expression in triple-negative breast cancer (TNBC) is recognized as a promising therapeutic target, specifically through the use of selective EGFR inhibitors combined with chemotherapies. TNBC is characterized by genetic instability that leads to increased sensitivity ...

journal_title：Molecular carcinogenesis

authors： El Guerrab A,Bamdad M,Bignon YJ,Penault-Llorca F,Aubel C

更新日期：2017-05-01 00:00:00

abstract：:Three okadaic acid class tumor promoters, okadaic acid, dinophysistoxin-1, and calyculin A, have potent tumor-promoting activity in two-stage carcinogenesis experiments on mouse skin. DNA isolated from tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) and each of these tumor promoters revealed the same mutation ...

journal_title：Molecular carcinogenesis

authors： Fujiki H,Suganuma M,Yoshizawa S,Kanazawa H,Sugimura T,Manam S,Kahn SM,Jiang W,Hoshina S,Weinstein IB

更新日期：1989-01-01 00:00:00

abstract：:Increasing evidence from various clinical and experimental studies has demonstrated that the inflammatory microenvironment facilitates tumor metastasis. Clinically, it will be a promising choice to suppress tumor metastasis by targeting inflammatory microenvironment. Our previous studies have demonstrated that wogonin...

journal_title：Molecular carcinogenesis

authors： Zhao Y,Yao J,Wu XP,Zhao L,Zhou YX,Zhang Y,You QD,Guo QL,Lu N

更新日期：2015-06-01 00:00:00

abstract：:Quercetin, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), and okadaic acid are found in various foods and have been shown to have mutagenic or promoter-like activity. The effects of these three compounds on the transmission of the inactive X chromosome were examined in MST-C6 murine tumor cells, which were de...

journal_title：Molecular carcinogenesis

authors： Kuwabara K,Odani S,Takahashi Y,Arakawa M,Takagi N,Nagao M,Kominami R

更新日期：1995-12-01 00:00:00

abstract：:Recent studies have implicated a role for midkine (MK) in cancer progression. This is based upon its structural homology with pleiotrophin, an angiogenic growth factor, and its ability to enhance fibrinolytic activity of bovine endothelial cells. To investigate whether MK plays a role in breast cancer, we examined MK ...

journal_title：Molecular carcinogenesis

authors： Chen Y,McKenzie KE,Aldaz CM,Sukumar S

更新日期：1996-11-01 00:00:00

abstract：:The majority of human neoplasms have aberrations in the retinoblastoma pathway due to hyperactivation of cyclin-dependent kinases (CDK). Based on this observation, novel small molecules, such as flavopiridol and UCN-01, are being developed and are currently being tested in the clinic. Efforts to develop CDK modulators...

journal_title：Molecular carcinogenesis

authors： Lahusen T,De Siervi A,Kunick C,Senderowicz AM

更新日期：2003-04-01 00:00:00

abstract：:Hexavalent chromium [Cr(VI)] is a well-known environment carcinogen. The exposure of Cr(VI) through contaminated soil, air particles, and drinking water is a strong concern for the public health worldwide. While many studies have been done, it remains unclear which intracellular molecules transduce Cr(VI)-mediated car...

journal_title：Molecular carcinogenesis

authors： Ganapathy S,Li P,Lafontant J,Xiong R,Yu T,Zhang G,Chen C

更新日期：2017-07-01 00:00:00

abstract：:Withaferin A (WA), a natural product derived from Withania somnifera, has been used in traditional oriental medicines to treat neurological disorders. Recent studies have demonstrated that this compound may have a potential for cancer treatment and a clinical trial has been launched to test WA in treating melanoma. He...

journal_title：Molecular carcinogenesis

authors： Li W,Zhang C,Du H,Huang V,Sun B,Harris JP,Richardson Q,Shen X,Jin R,Li G,Kevil CG,Gu X,Shi R,Zhao Y

更新日期：2016-11-01 00:00:00

abstract：:Several studies have shown that E-cadherin expression is lost during malignant transformation. We hypothesized that CpG methylation in the promoter region may inactivate the expression of the E-cadherin gene in human bladder cancer. Normal and bladder cancer samples from 51 patients were compared in terms of E-cadheri...

journal_title：Molecular carcinogenesis

authors： Ribeiro-Filho LA,Franks J,Sasaki M,Shiina H,Li LC,Nojima D,Arap S,Carroll P,Enokida H,Nakagawa M,Yonezawa S,Dahiya R

更新日期：2002-08-01 00:00:00

abstract：:Tobacco smoking represents an important known cause of ductal pancreatic adenocarcinoma. Recent data from pooled analyses in consortia involving multiple case-control and cohort studies suggest that heavy (but not moderate or light) alcohol consumption also may increase pancreatic cancer risk. Animal and human evidenc...

journal_title：Molecular carcinogenesis

authors： Duell EJ

更新日期：2012-01-01 00:00:00