Abstract:
:Genomic DNA sequences with the ability to assume non-B form secondary structures have been recently shown to be particularly susceptible to genetic instability, an early contributing factor in human disease and cancer development. Transcription appears to play a central role in formation of these structures and in promoting instability at these sites. The subpathway of nucleotide excision DNA repair, transcription-coupled DNA repair (TCR), removes transcription-arresting damage from the transcribed strands of expressed genes, but little is known about how non-canonical DNA structures are processed when encountered by the transcription machinery. If such structures arrest transcription, they may elicit "gratuitous" TCR in which the resulting reiterative and futile repair replication might generate a significant level of mutagenesis in a frequently transcribed gene because of faulty processing in the area of transcription arrest. Here we will describe our current understanding of how TCR may be elicited at non-B DNA structures and summarize recent literature describing the behavior of RNA polymerases when encountering non-canonical DNA structures, with particular emphasis on quadruplex DNA.
journal_name
Mol Carcinogjournal_title
Molecular carcinogenesisauthors
Tornaletti Sdoi
10.1002/mc.20513subject
Has Abstractpub_date
2009-04-01 00:00:00pages
326-35issue
4eissn
0899-1987issn
1098-2744journal_volume
48pub_type
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journal_title:Molecular carcinogenesis
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
doi:
更新日期:1999-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/mc.22444
更新日期:2016-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-02-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
doi:10.1002/mc.20233
更新日期:2007-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/mc.10011
更新日期:2001-12-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
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更新日期:1994-12-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章,评审
doi:10.1002/mc.22583
更新日期:2017-04-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2012-10-01 00:00:00
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更新日期:2015-12-01 00:00:00
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更新日期:2012-03-01 00:00:00
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更新日期:2015-09-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
doi:10.1002/mc.20115
更新日期:2005-09-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
doi:10.1002/mc.2940120102
更新日期:1995-01-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
doi:10.1002/1098-2744(200007)28:3<139::aid-mc2>3.0.co;
更新日期:2000-07-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
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更新日期:2017-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-02-01 00:00:00