Accumulation of aberrant Y chromosomes in gamma-ray-induced thymic lymphomas lacking p53.

abstract：:Exposure to aflatoxin B(1) (AFB(1)) is one of the risk factors for developing hepatoma. In rats, activation of the ras gene is a prevalent event in AFB(1)-induced hepatocarcinogenesis. It is not clear whether a similar event occurs in humans. By analysis of codon 249 of the p53 gene, six of 36 human hepatoma samples w...

journal_title：Molecular carcinogenesis

authors： Chao HK,Tsai TF,Lin CS,Su TS

更新日期：1999-10-01 00:00:00

abstract：:Mutations in the Ki-ras oncogene and the p53 tumor suppressor gene are known to occur at high frequencies in human colon cancers. We measured the frequency of mutations in these two genes in colon adenocarcinomas obtained from a widely used experimental model of human colon carcinogenesis: F344 rats treated with the c...

journal_title：Molecular carcinogenesis

authors： Erdman SH,Wu HD,Hixson LJ,Ahnen DJ,Gerner EW

更新日期：1997-06-01 00:00:00

abstract：:The cellular senescence program is controlled by multiple genetic pathways, one of which involves the regulation of telomerase and telomere shortening. The introduction of a normal human chromosome 3 into the human renal cell carcinoma cell line RCC23 caused repression of telomerase activity, progressive shortening of...

journal_title：Molecular carcinogenesis

authors： Horikawa I,Oshimura M,Barrett JC

更新日期：1998-06-01 00:00:00

abstract：:Formation of G4 DNA may occur in the course of replication and transcription, and contribute to genomic instability. We have quantitated abundance of G4 motifs and potential for G4 DNA formation of the nontemplate strand of 5' exons and introns of transcripts of human genes. We find that, for all human genes, G4 motif...

journal_title：Molecular carcinogenesis

authors： Eddy J,Maizels N

更新日期：2009-04-01 00:00:00

abstract：:The effects of the flavonoid compound, kaempferol, which is an inhibitor of cancer cell proliferation and an inducer of cell apoptosis have been shown in various cancers, including lung, pancreatic, and ovarian, but its effect has never been studied in bladder cancer. Here, we investigated the effects of kaempferol on...

journal_title：Molecular carcinogenesis

authors： Dang Q,Song W,Xu D,Ma Y,Li F,Zeng J,Zhu G,Wang X,Chang LS,He D,Li L

更新日期：2015-09-01 00:00:00

abstract：:Transforming growth factor beta (TGFbeta) signaling has both tumor suppression and promotion roles. Smads are transcription factors that primarily mediate intracellular signaling for the TGFbeta superfamily. Loss of Smad2 and Smad4, but not Smad3 is common in human cancers. Given the complex nature of TGFbeta signalin...

journal_title：Molecular carcinogenesis

authors： Bornstein S,Hoot K,Han GW,Lu SL,Wang XJ

更新日期：2007-08-01 00:00:00

abstract：:microRNAs (miRNAs) are commonly altered in glioblastoma. Publicly available algorithms suggest the Wnt pathway is a potential target of miR-577 and the Wnt pathway is commonly altered in glioblastoma. Glioblastoma has not been previously evaluated for miR-577 expression. Glioblastoma tumors and cell lines were evaluat...

journal_title：Molecular carcinogenesis

authors： Zhang W,Shen C,Li C,Yang G,Liu H,Chen X,Zhu D,Zou H,Zhen Y,Zhang D,Zhao S

更新日期：2016-05-01 00:00:00

abstract：:Both ultraviolet irradiation and oxidation of DNA produce a variety of pyrimidine base damages. A human endonuclease recognizes such altered bases on these DNA substrates. This human endonuclease incises ultraviolet-irradiated DNA exclusively at sites of photochemically modified cytosines. The precise sites of incisio...

journal_title：Molecular carcinogenesis

authors： Gallagher PE,Weiss RB,Brent TP,Duker NJ

更新日期：1989-01-01 00:00:00

abstract：:Merkel cell carcinoma (MCC) is a rare neuroendocrine carcinoma of the skin, for which the exact mechanisms of carcinogenesis remain unknown. Therapeutic options for this highly aggressive malignancy have historically been limited in both their initial response and response durability. Recent improvements in our unders...

journal_title：Molecular carcinogenesis

authors： Cohen L,Tsai KY

更新日期：2019-09-01 00:00:00

abstract：:The tumor suppressor p27, which is a member of the Cip/Kip family of Cyclin-dependent kinase inhibitory proteins (CKIs), controls anti-proliferative events. The post-translational addition of O-GlcNAc to p27 occurs in HEK293T and HCC (hepatocellular carcinoma) cell lines, and we identified Ser2, Ser106, Ser110, Thr157...

journal_title：Molecular carcinogenesis

authors： Qiu H,Liu F,Tao T,Zhang D,Liu X,Zhu G,Xu Z,Ni R,Shen A

更新日期：2017-01-01 00:00:00

abstract：:Metformin, an oral biguanide for the treatment of type II diabetes, has been shown to have anticancer effects in ovarian cancer. Energy starvation induced by metformin causes endoplasmic reticulum stress-mediated unfolded protein response (UPR) and autophagy. UPR and autophagy act as a survival or death mechanism in c...

journal_title：Molecular carcinogenesis

authors： Moon HS,Kim B,Gwak H,Suh DH,Song YS

更新日期：2016-04-01 00:00:00

abstract：:Triptolide is an active component from a Chinese herb, Tripterygium wilfordii which has been applied for treating immune-related diseases over centuries. Recently, it was reported that a variety of cancer cell lines could be sensitized to DNA-damage based chemotherapy drugs in combination with Triptolide treatment. In...

journal_title：Molecular carcinogenesis

authors： Deng Y,Li F,He P,Yang Y,Yang J,Zhang Y,Liu J,Tong Y,Li Q,Mei X,Shu Z,Zhao Q

更新日期：2018-06-01 00:00:00

abstract：:Increasing evidence from various clinical and experimental studies has demonstrated that the inflammatory microenvironment facilitates tumor metastasis. Clinically, it will be a promising choice to suppress tumor metastasis by targeting inflammatory microenvironment. Our previous studies have demonstrated that wogonin...

journal_title：Molecular carcinogenesis

authors： Zhao Y,Yao J,Wu XP,Zhao L,Zhou YX,Zhang Y,You QD,Guo QL,Lu N

更新日期：2015-06-01 00:00:00

abstract：:Signaling networks play important roles in cancer progression. For example, overexpression of the epidermal growth factor receptor (EGFR) is a poor prognostic indicator in multiple tumor types. Recent studies have postulated that the EGFR functions as a central conduit for signaling by different classes of cell surfac...

journal_title：Molecular carcinogenesis

authors： Boerner JL,Biscardi JS,Silva CM,Parsons SJ

更新日期：2005-12-01 00:00:00

abstract：:Intratumoral hypoxia promotes the distant metastasis of cancer subclones. The clinical expression level of hypoxia-inducible factor-1α (HIF-1α) reflects the prognosis of a variety of cancers, especially breast cancer. Histone deacetylase (HDAC) inhibitors can target HIF-1α protein due to von Hippel-Lindau (VHL) protei...

journal_title：Molecular carcinogenesis

authors： Wei Z,Shan Y,Tao L,Liu Y,Zhu Z,Liu Z,Wu Y,Chen W,Wang A,Lu Y

更新日期：2017-10-01 00:00:00

abstract：:As the prognostic significance of the three most frequently amplified oncogenes in breast cancer (c-myc, int-2/FGF3, and c-erbB-2/neu) is still unclear, and as the amplification of these genes appears to be mutually exclusive, we investigated the prognostic significance of oncogene amplification per se by multivariate...

journal_title：Molecular carcinogenesis

authors： Champème MH,Bièche I,Hacène K,Lidereau R

更新日期：1994-12-01 00:00:00

abstract：:It is well known that the TP53 gene considerably influences on DNA repair processes. Polymorphisms in the TP53 gene, particularly the well-known Arg72Pro in codon 72 of exon 4 (Ex4+119 G>C; rs1042522), can modify the functionality of the p53 protein and activation of DNA repair. Actually, polymorphic variants Arg and ...

journal_title：Molecular carcinogenesis

authors： Litviakov NV,Denisov EV,Takhauov RM,Karpov AB,Skobel'skaja EV,Vasil'eva EO,Goncharik OO,Ageeva AM,Mamonova NV,Mezheritskiy SA,Sevost'janova NV,Koshel AP

更新日期：2010-06-01 00:00:00

abstract：:Polymorphisms in metabolic and DNA repair genes may alter protein function, consequently affecting patients' response to chemo/radiotherapy. We retrospectively assessed whether polymorphisms of glutathione-S-transferase genes GSTM1 (deletion), GSTT1 (deletion), GSTP1 (Ile105Val, rs1695), and DNA repair genes hOGG1 (Se...

journal_title：Molecular carcinogenesis

authors： Mahimkar MB,Samant TA,Kannan S,Tulsulkar J,Pai PS,Anantharaman D

更新日期：2012-10-01 00:00:00

abstract：:Although many reports suggest that aberrant regulation of cytokine signaling pathways via the interleukin-2 receptor (IL-2R) induces tumorigenic transformation, constitutively active IL-2R in tumors has not been reported. We searched for genomic alteration of the IL-2/15R beta-subunit gene (IL-2/15R beta) in cytokine-...

journal_title：Molecular carcinogenesis

authors： Ukai H,Ishii-Oba H,Ukai-Tadenuma M,Ogiu T,Tsuji H

更新日期：2003-06-01 00:00:00

abstract：:Atypical adenomatous hyperplasia (AAH) of the prostate is characterized by lobular proliferation of closely packed small acini. It is hypothesized that AAH is a precursor lesion for low-grade prostate cancer arising from the transition zone. Telomere dysfunction is common during malignant transformation of epithelia. ...

journal_title：Molecular carcinogenesis

authors： Cheng L,Montironi R,Davidson DD,Wang M,Lopez-Beltran A,Zhang S

更新日期：2019-07-01 00:00:00

abstract：:Multidrug resistance (MDR) is one of the most important factors leading to chemotherapeutic failure in patients with breast cancer. The invasive/metastatic ability of MDR cells is strengthened compared with their parental cells. However, the mechanisms underlying MDR have not been fully elucidated. We found that CD44 ...

journal_title：Molecular carcinogenesis

authors： Cheng Y,Tao L,Xu J,Li Q,Yu J,Jin Y,Chen Q,Xu Z,Zou Q,Liu X

更新日期：2014-09-01 00:00:00

abstract：:DNA hypermethylation is associated with decreased expression of tumor suppressor genes. We previously observed decreased Fhit expression and Fhit promoter region hypermethylation in rodent tumors induced by various carcinogens, and noted that the 5' regulatory regions in the promoter, exon 1, and intron 1 were differe...

journal_title：Molecular carcinogenesis

authors： Guler G,Iliopoulos D,Han SY,Fong LY,Lubet RA,Grubbs CJ,Huebner K

更新日期：2005-07-01 00:00:00

abstract：:We have reported that connexin (Cx) 32 gene, a member of gap junction protein family, acts as a tumor suppressor gene in human renal cell carcinoma (RCC). Of solid tumors, RCC is one of the most chemoresistant cancers, and there is no effective cancer chemotherapy against RCC at present. In this study, we examined if ...

journal_title：Molecular carcinogenesis

authors： Sato H,Senba H,Virgona N,Fukumoto K,Ishida T,Hagiwara H,Negishi E,Ueno K,Yamasaki H,Yano T

更新日期：2007-03-01 00:00:00

abstract：:To explore the mechanisms through which hypoxic tumor microenvironment (TME) modulates the transition of tumor-associated macrophages (TAMs). The migration ability of RAW264.7 macrophages was determined by transwell assay. Flow cytometric, western blot and immunofluorescence analyses of CD206 further validated the M2 ...

journal_title：Molecular carcinogenesis

authors： Chen XJ,Wu S,Yan RM,Fan LS,Yu L,Zhang YM,Wei WF,Zhou CF,Wu XG,Zhong M,Yu YH,Liang L,Wang W

更新日期：2019-03-01 00:00:00

abstract：:FAM134B is an autophagy regulator of endoplasmic reticulum and acts as a cancer suppressor in colon cancer. However, the molecular signaling pathways by which FAM134B interacts within colon carcinogenesis is still unknown. Herein, this study aims to determine the interacting partners of FAM134B for the first time in c...

journal_title：Molecular carcinogenesis

authors： Islam F,Chaousis S,Wahab R,Gopalan V,Lam AK

更新日期：2018-11-01 00:00:00

abstract：:The growth hormone receptor (GHR) and growth hormone-binding protein (GH-BP) expression were characterized in liver nodules and hepatomas from male Wistar rats. The mRNA levels of GHR and GH-BP, studied by northern blot analysis and solution hybridization, were 35-50% (in nodules) and 2-6% (in hepatomas) of the level ...

journal_title：Molecular carcinogenesis

authors： Levinovitz A,Husman B,Eriksson LC,Norstedt G,Andersson G

更新日期：1990-01-01 00:00:00

abstract：:N-acetyltransferase 1 (NAT1) is a phase II metabolic enzyme responsible for the biotransformation of aromatic and heterocyclic amine carcinogens such as 4-aminobiphenyl (ABP). NAT1 catalyzes N-acetylation of arylamines as well as the O-acetylation of N-hydroxylated arylamines. O-acetylation leads to the formation of e...

journal_title：Molecular carcinogenesis

authors： Millner LM,Doll MA,Cai J,States JC,Hein DW

更新日期：2012-08-01 00:00:00

abstract：:Bcl-x(L) is one of several antiapoptotic proteins regulated by signal transducer and activator of transcription 3 (Stat3). We have recently shown that Stat3 is required for chemically induced and ultraviolet B (UVB)-induced skin carcinogenesis. In this study, the functional role of Bcl-x(L) in skin carcinogenesis was ...

journal_title：Molecular carcinogenesis

authors： Kim DJ,Kataoka K,Sano S,Connolly K,Kiguchi K,DiGiovanni J

更新日期：2009-10-01 00:00:00

abstract：:Mutations in RB and PTEN are linked to castration resistance and poor prognosis in prostate cancer. Identification of genes that are regulated by these tumor suppressors in a context that recapitulates cancer progression may be beneficial for discovering novel therapeutic targets. Although various genetically engineer...

journal_title：Molecular carcinogenesis

authors： Salah M,Nishimoto Y,Kohno S,Kondoh A,Kitajima S,Muranaka H,Nishiuchi T,Ibrahim A,Yoshida A,Takahashi C

更新日期：2016-12-01 00:00:00

abstract：:Although fibroblast growth factor (FGF) signals are strongly associated with malignancy, limited information is available regarding the role of the FGF9 signal in colorectal cancer (CRC). In this study, we investigated the frequency of FGF9 amplification in CRC clinical specimens and the association between the FGF9 g...

journal_title：Molecular carcinogenesis

authors： Mizukami T,Togashi Y,Naruki S,Banno E,Terashima M,de Velasco MA,Sakai K,Yoneshige A,Hayashi H,Fujita Y,Tomida S,Nakajima TE,Fujino T,Boku N,Ito A,Nakagawa K,Nishio K

更新日期：2017-01-01 00:00:00