Abstract:
:Exposure to aflatoxin B(1) (AFB(1)) is one of the risk factors for developing hepatoma. In rats, activation of the ras gene is a prevalent event in AFB(1)-induced hepatocarcinogenesis. It is not clear whether a similar event occurs in humans. By analysis of codon 249 of the p53 gene, six of 36 human hepatoma samples were found to show a G-->T transversion, suggesting that AFB(1) may be a risk factor for hepatocarcinogenesis. However, analysis at codons 12, 13, and 61 in the ras family genes revealed a A-->T transversion at codon 61 of the N-ras gene in a single tumor. Apparently, ras activation is rare in human hepatoma, and the mutation detected might not be induced by AFB(1). This suggests that activation of the ras gene may not be a major event in AFB(1)-related human hepatocarcinogenesis.
journal_name
Mol Carcinogjournal_title
Molecular carcinogenesisauthors
Chao HK,Tsai TF,Lin CS,Su TSdoi
10.1002/(sici)1098-2744(199910)26:2<69::aid-mc1>3.subject
Has Abstractpub_date
1999-10-01 00:00:00pages
69-73issue
2eissn
0899-1987issn
1098-2744pii
10.1002/(SICI)1098-2744(199910)26:2<69::AID-MC1>3.journal_volume
26pub_type
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