Rheb promotes cancer cell survival through p27Kip1-dependent activation of autophagy.

abstract：:Astrocyte elevated gene-1 (AEG-1) plays a critical role in the development, progression, and metastasis of a variety of cancers, including non-small-cell lung cancer (NSCLC). The objective of the current study is to unravel the upstream signaling of AEG-1. A cohort of 28 NSCLC tissues and 30 normal tissues were collec...

journal_title：Molecular carcinogenesis

authors： Li YH,Xu CL,He CJ,Pu HH,Liu JL,Wang Y

更新日期：2020-02-01 00:00:00

abstract：:Increased epidermal growth factor receptor (EGFR) expression in triple-negative breast cancer (TNBC) is recognized as a promising therapeutic target, specifically through the use of selective EGFR inhibitors combined with chemotherapies. TNBC is characterized by genetic instability that leads to increased sensitivity ...

journal_title：Molecular carcinogenesis

authors： El Guerrab A,Bamdad M,Bignon YJ,Penault-Llorca F,Aubel C

更新日期：2017-05-01 00:00:00

abstract：:DPC4/SMAD4 is a candidate tumor suppressor gene with a strikingly high frequency of gene alterations in pancreatic cancer that suggests a discrete role for DPC4 in these tumors. DPC4 tumor-suppressive function has been implicated to mediate the transforming growth factor-beta (TGFbeta)-suppressive pathway; however, in...

journal_title：Molecular carcinogenesis

authors： Dai JL,Schutte M,Bansal RK,Wilentz RE,Sugar AY,Kern SE

更新日期：1999-09-01 00:00:00

abstract：:Adipose tissue dysregulation, a hallmark of obesity, contributes to a chronic state of low-grade inflammation and is associated with increased risk and progression of several breast cancer subtypes, including claudin-low breast tumors. Unfortunately, mechanistic targets for breaking the links between obesity-associate...

journal_title：Molecular carcinogenesis

authors： Rossi EL,Khatib SA,Doerstling SS,Bowers LW,Pruski M,Ford NA,Glickman RD,Niu M,Yang P,Cui Z,DiGiovanni J,Hursting SD

更新日期：2018-03-01 00:00:00

abstract：:C>T substitutions at dipyrimidine sites dominate the melanoma genome. We recently analyzed the exomes of spontaneous and neonatal UVR-induced murine melanomas, noting a dramatic change in the genomic footprint at C>T substitutions in the latter. Here we re-analyzed published exome-wide footprints in human melanomas st...

journal_title：Molecular carcinogenesis

authors： Mukhopadhyay P,Roberts JA,Walker GJ

更新日期：2017-06-01 00:00:00

abstract：:Lasp2, as well as Lasp1, is a member of the LIM-protein subfamily of the nebulin group characterized by the combined presence of LIM and SH3 domains. Lasp1 and Lasp2 are highly conserved in their LIM, nebulin-like, and SH3 domains but differ significantly at their linker regions. Lasp1 had been described as an oncogen...

journal_title：Molecular carcinogenesis

authors： Zhang X,Cai L,Zhou H,Liu Y,Fan C,Wang L,Li A,Miao Y,Li Q,Qiu X,Wang E

更新日期：2017-12-01 00:00:00

abstract：:Plakoglobin (Pg) and beta-catenin are homologous proteins that function in cell-cell adhesion and signaling. The cadherin-associated form of these proteins mediates adhesion, whereas the cytosolic/nuclear form has a signaling role. Despite their interactions with common cellular partners, beta-catenin has a well-docum...

journal_title：Molecular carcinogenesis

authors： Li L,Chapman K,Hu X,Wong A,Pasdar M

更新日期：2007-10-01 00:00:00

abstract：:Mutational activation of RAS proteins occurs in nearly 30% of all human tumors. To date direct pharmacological inhibition of RAS oncoproteins has not been possible. As a consequence, current strategies are focusing on the development of inhibitors that target those kinases acting downstream of RAS proteins, including ...

journal_title：Molecular carcinogenesis

authors： Urosevic J,Sum EY,Moneo V,Drosten M,Dhawahir A,Becerra M,Carnero A,Barbacid M

更新日期：2009-11-01 00:00:00

abstract：:Chromosomal double-strand breaks (DSBs) occurring in mammalian cells can initiate genomic instability, and their misrepairs result in chromosomal deletion, amplification, and translocation, common findings in human tumors. The tumor-suppressor protein p53 is involved in maintaining genomic stability. In this study, we...

journal_title：Molecular carcinogenesis

authors： Honma M,Momose M,Tanabe H,Sakamoto H,Yu Y,Little JB,Sofuni T,Hayashi M

更新日期：2000-08-01 00:00:00

abstract：:The tyrosinase promoter has been used to target expression of the mutated human T24 Ha-ras oncogene in pigment-producing cells of transgenic mice. Two independent founder mice carrying the transgene survived and showed the same distinct phenotype of mutated coat color, deeply pigmented skin with multiple nevi, and twi...

journal_title：Molecular carcinogenesis

authors： Powell MB,Hyman P,Bell OD,Balmain A,Brown K,Alberts D,Bowden GT

更新日期：1995-02-01 00:00:00

abstract：:Ras-mediated transformation is associated with upregulation of cyclooxygenase-2 (COX-2), which in turn promotes prostaglandin E2 (PGE2) synthesis and secretion. Although recent studies have identified molecular mechanisms by which Ras mediates upregulation of COX-2, conflicting observations have been made. Furthermore...

journal_title：Molecular carcinogenesis

authors： Repasky GA,Zhou Y,Morita S,Der CJ

更新日期：2007-12-01 00:00:00

abstract：:Loss of heterozygosity (LOH) on the long arm of chromosome 13 is common in human breast tumors, pointing to the existence of several suppressor genes in this region. LOH at 13q14 has been implicated in alterations of retinoblastoma gene (RB1) expression. However, attempts to identify a link between the absence of reti...

journal_title：Molecular carcinogenesis

authors： Bièche I,Lidereau R

更新日期：2000-11-01 00:00:00

abstract：:Transgenic mice were developed to study the role of c-src in epithelial tumorigenesis through targeted expression of a constitutively active form of murine c-src (src(529)). Src(529) was targeted to the interfollicular epidermis with the human keratin 1 (HK1) promoter. The skin phenotype of these mice was characterize...

journal_title：Molecular carcinogenesis

authors： Matsumoto T,Jiang J,Kiguchi K,Carbajal S,Rho O,Gimenez-Conti I,Beltrán L,DiGiovanni J

更新日期：2002-03-01 00:00:00

abstract：:Mutations induced by activated benzo[a]pyrene ((+)-anti-B[a]PDE) in Escherichia coli are being investigated, by using both random and adduct-site-specific mutagenesis approaches. A working hypothesis was proposed that the major adduct of (+)-anti-B[a]PDE (formed at N2-Gua) is able to induce different base-substitution...

journal_title：Molecular carcinogenesis

authors： Loechler EL

更新日期：1995-08-01 00:00:00

abstract：:The ubiquitin-proteasome pathway is fundamental to synchronized continuation of many cellular processes, for example, cell-cycle progression, stress response, and cell differentiation. Recent studies have shown that the ubiquitin-proteasome pathway functions in the regulation of nucleotide excision repair (NER) in yea...

journal_title：Molecular carcinogenesis

authors： Wang QE,Wani MA,Chen J,Zhu Q,Wani G,El-Mahdy MA,Wani AA

更新日期：2005-01-01 00:00:00

abstract：:The interaction of urokinase-type plasminogen activator (uPA) with its cell-surface receptor (uPAR) is implicated in diverse biological processes such as cell migration, tissue remodeling, and tumor cell invasion. Recent studies indicated that uPAR can act as an extracellular matrix receptor during cell adhesion. Rece...

journal_title：Molecular carcinogenesis

authors： Chintala SK,Mohanam S,Go Y,Venkaiah B,Sawaya R,Gokaslan ZL,Rao JS

更新日期：1997-12-01 00:00:00

abstract：:Xiphophorus fish have been the subject of intensive genetic research for more than 60 yr, primarily because of the availability of a number of interspecific hybrids that are malignant melanoma models with apparently simple oncogene and tumor suppressor gene determinants. The gene map of Xiphophorus is one of the most ...

journal_title：Molecular carcinogenesis

authors： Morizot DC,McEntire BB,Della Coletta L,Kazianis S,Schartl M,Nairn RS

更新日期：1998-07-01 00:00:00

abstract：:To investigate the importance of oncogenes and tumor suppressor genes in bladder carcinogenesis, we determined the status of the expression of the MDM-2 and p53 genes and genetic alterations in the p53 gene in five bladder carcinoma cell lines and one kidney urothelial carcinoma cell line. Overexpression of MDM-2 mRNA...

journal_title：Molecular carcinogenesis

authors： Cheng YT,Li YL,Wu JD,Long SB,Tzai TS,Tzeng CC,Lai MD

更新日期：1995-07-01 00:00:00

abstract：:Dietary heterocyclic aromatic amines (HCA) and polyunsaturated fatty acids (PUFA) are both believed to play a role in colon carcinogenesis, and are both substrate for the enzyme cyclooxygenase (COX). In HCA-7 cells, highly expressing isoform COX-2, we investigated the effects of PUFA on prostaglandin synthesis and DNA...

journal_title：Molecular carcinogenesis

authors： Moonen HJ,Dommels YE,van Zwam M,van Herwijnen MH,Kleinjans JC,Alink GM,de Kok TM

更新日期：2004-07-01 00:00:00

abstract：:N(6)-isopentenyladenosine (i6A) inhibits the tumor cell growth by inducing cell apoptosis in various cancer cell lines. However, little is known regarding the mechanisms by which the drug induces cell apoptosis. In this study, we further explored the molecular mechanisms of i6A as an anticancer agent on a human breast...

journal_title：Molecular carcinogenesis

authors： Laezza C,Malfitano AM,Di Matola T,Ricchi P,Bifulco M

更新日期：2010-10-01 00:00:00

abstract：:The incidence and pattern of mutations of the ras oncogenes and the p53 tumor suppressor gene have been shown to differ among different cancer types and even among the same cancer types with different etiological backgrounds. For example, in a previous study we showed that not only the etiology but also the incidence ...

journal_title：Molecular carcinogenesis

authors： Kiba T,Tsuda H,Pairojkul C,Inoue S,Sugimura T,Hirohashi S

更新日期：1993-01-01 00:00:00

abstract：:In this report, we describe in detail the evolving procedures to optimize humanized mouse cohort generation, including optimal conditioning, choice of lineage for engraftment, threshold for successful engraftment, HNSCC tumor implantation, and immune and stroma cell analyses. We developed a dual infusion protocol of h...

journal_title：Molecular carcinogenesis

authors： Morton JJ,Keysar SB,Perrenoud L,Chimed TS,Reisinger J,Jackson B,Le PN,Nieto C,Gomez K,Miller B,Gao D,Somerset H,Wang XJ,Jimeno A

更新日期：2018-11-01 00:00:00

abstract：:Osteosarcoma is the primary human malignant tumor affecting bone. This cancer most frequently arises in children and adolescents, with a second peak in those over the age of 50. Currently, surgery followed by radiotherapy and chemotherapy are the main treatments, but long-term positive effects are very poor. Aurora B ...

journal_title：Molecular carcinogenesis

authors： Zhao Z,Jin G,Yao K,Liu K,Liu F,Chen H,Wang K,Gorja DR,Reddy K,Bode AM,Guo Z,Dong Z

更新日期：2019-06-01 00:00:00

abstract：:DIXDC1 (Dishevelled-Axin domain containing 1) is a DIX (Dishevelled-Axin) domain-possessing protein that promotes colon cancer cell proliferation and increases the invasion and migration ability of non-small-cell lung cancer via the PI3K pathway. As a positive regulator of the Wnt/β-catenin pathway, the biological rol...

journal_title：Molecular carcinogenesis

authors： Tan C,Qiao F,Wei P,Chi Y,Wang W,Ni S,Wang Q,Chen T,Sheng W,Du X,Wang L

更新日期：2016-04-01 00:00:00

abstract：:An allelotype analysis of lung tumors in mouse hybrids was conducted to identify common regions of allelic loss. By using 50 informative genetic markers, the autosomes of 36 (A/J x C3H/HeJ) F1 adenocarcinomas were examined. Additional adenocarcinomas from as many as 72 (C3H/HeJ x A/J) F1 and 15 (BALB/cJ x DBA/2J) F1 h...

journal_title：Molecular carcinogenesis

authors： Herzog CR,Chen B,Wang Y,Schut HA,You M

更新日期：1996-06-01 00:00:00

abstract：:Alterations in the transforming growth factor-beta (TGF-beta) pathway are implicated in the pathogenesis of colorectal cancer. We hypothesize that alterations in the TGF-beta pathway contribute to differential sensitivity of mice to the colon carcinogen azoxymethane (AOM). A/J (sensitive) and AKR/J (resistant) mice we...

journal_title：Molecular carcinogenesis

authors： Guda K,Giardina C,Nambiar P,Cui H,Rosenberg DW

更新日期：2001-08-01 00:00:00

abstract：:Fusion between HeLa cells and normal human fibroblasts results in the suppression of tumorigenicity. Under prolonged culture conditions, rare tumorigenic segregants arise and have been shown to reexpress a cell surface antigen, p75, which is also present in the HeLa parent but not in the fibroblast parent or in the no...

journal_title：Molecular carcinogenesis

authors： Gross MM,Janiaud P,Stanbridge EJ

更新日期：1993-01-01 00:00:00

abstract：:Telomerase expression is the hallmark of tumor cells, and activation of this ribonucleoprotein complex may be a rate-limiting or critical step in cellular immortalization and oncogenesis. Fungal immunomodulatory protein, FIP-gts, has been isolated from Ganoderma tsugae. In the present study, we expressed and purified ...

journal_title：Molecular carcinogenesis

authors： Liao CH,Hsiao YM,Hsu CP,Lin MY,Wang JC,Huang YL,Ko JL

更新日期：2006-04-01 00:00:00

abstract：:The cellular senescence program is controlled by multiple genetic pathways, one of which involves the regulation of telomerase and telomere shortening. The introduction of a normal human chromosome 3 into the human renal cell carcinoma cell line RCC23 caused repression of telomerase activity, progressive shortening of...

journal_title：Molecular carcinogenesis

authors： Horikawa I,Oshimura M,Barrett JC

更新日期：1998-06-01 00:00:00

abstract：:Base excision repair (BER) is critical for the maintenance of genome stability because it repairs at least 20,000 endogenously generated DNA lesions/cell/d. Several enzymes within the BER pathway exhibit sequence context dependency during the excision and DNA synthesis steps of repair. New evidence is emerging that ge...

journal_title：Molecular carcinogenesis

authors： Donigan KA,Sweasy JB

更新日期：2009-04-01 00:00:00