Activation and up-regulation of translation initiation factor 4B contribute to arsenic-induced transformation.

Abstract:

:Arsenic is a known human carcinogen. However, the mechanism of how arsenic induces cell transformation remains unclear. In this study, we demonstrated that long-term exposure to sodium arsenite at low-dose (2 µM) increases cell proliferation and neoplastic transformation in a mouse epidermal cell model, JB6 promotion-susceptible cells. The phosphorylation of AKT and its downstream targets, 70-kDa ribosomal protein S6 kinase (p70S6K) and translation initiation factor 4B (eIF4B), are increased in the arsenite treated cells, indicating that long-term arsenite treatment activates AKT-p70S6K signaling pathway. In addition, long-term exposure to arsenite up-regulates eIF4B expression and increases the rate of translation. Knockdown of eIF4B expression resulted in inhibition of arsenic-induced cell proliferation, transformation, and translation. Moreover, the expression of c-Myc which is up-regulated by long-term arsenite treatment is inhibited by eIF4B knockdown. Taken together, these results indicate that activation and up-regulation of eIF4B contributes to arsenic-induced transformation in JB6 cells.

journal_name

Mol Carcinog

journal_title

Molecular carcinogenesis

authors

Zhang Y,Wang Q,Guo X,Miller R,Guo Y,Yang HS

doi

10.1002/mc.20733

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

528-38

issue

7

eissn

0899-1987

issn

1098-2744

journal_volume

50

pub_type

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