miR-577 inhibits glioblastoma tumor growth via the Wnt signaling pathway.


:microRNAs (miRNAs) are commonly altered in glioblastoma. Publicly available algorithms suggest the Wnt pathway is a potential target of miR-577 and the Wnt pathway is commonly altered in glioblastoma. Glioblastoma has not been previously evaluated for miR-577 expression. Glioblastoma tumors and cell lines were evaluated for their expression of miR-577. Cell lines were transfected with miR-577, miR-577-mutant, or control mimics to evaluate the effect of miR-577 expression on cell proliferation in vitro and in an animal model. Wnt pathway markers were also evaluated for their association with miR-577 expression. miR-577 expression was decreased in 33 of 40 (82.5%) glioblastoma tumors and 5 of 6 glioblastoma cell lines. miR-577 expression correlated negatively with cell growth and cell viability. miR-577 down-regulation was associated with increased expression of the Wnt signaling pathway genes lipoprotein receptor-related protein (LRP) 6 (LRP6) and β-catenin. Western blot analysis confirmed decreased expression of the Wnt signaling pathway genes Axin2, c-myc, and cyclin D1 in miR-577 transfected cells. miR-577 expression is down-regulated in glioblastoma. miR-577 directly targets Wnt signaling pathway components LRP6 and β-catenin. miR-577 suppresses glioblastoma multiforme (GBM) growth by regulating the Wnt signaling pathway.


Mol Carcinog


Molecular carcinogenesis


Zhang W,Shen C,Li C,Yang G,Liu H,Chen X,Zhu D,Zou H,Zhen Y,Zhang D,Zhao S




Has Abstract


2016-05-01 00:00:00












  • Aberrant overexpression of FOXM1 transcription factor plays a critical role in lung carcinogenesis induced by low doses of arsenic.

    abstract::Environmental or occupational exposure to low doses of arsenic induces a series of health problems including cancer. The molecular events in arsenic-induced carcinogenicity remain to be defined. In the NuLi-1 immortalized human lung epithelial cell line with p53 and pRb deficiency, exposure to low doses of arsenic tri...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Liu Y,Hock JM,Van Beneden RJ,Li X

    更新日期:2014-05-01 00:00:00

  • Further assessment of exome-wide UVR footprints in melanoma and their possible relevance.

    abstract::C>T substitutions at dipyrimidine sites dominate the melanoma genome. We recently analyzed the exomes of spontaneous and neonatal UVR-induced murine melanomas, noting a dramatic change in the genomic footprint at C>T substitutions in the latter. Here we re-analyzed published exome-wide footprints in human melanomas st...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Mukhopadhyay P,Roberts JA,Walker GJ

    更新日期:2017-06-01 00:00:00

  • Expression and localization of matrix-degrading metalloproteinases during colorectal tumorigenesis.

    abstract::The metalloproteinase matrilysin is widely expressed in the epithelial tumor cells of malignant colorectal adenocarcinomas. Approximately 50% of benign adenomas also express low levels of matrilysin that is focally localized. The expression of stromelysin-1, stromelysin-3, and gelatinase A was observed in the stromal ...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Newell KJ,Witty JP,Rodgers WH,Matrisian LM

    更新日期:1994-08-01 00:00:00

  • Overexpression of SHCBP1 promotes migration and invasion in gliomas by activating the NF-κB signaling pathway.

    abstract::Gliomas are common, aggressive central nervous system tumors with poor overall survival rates. Despite improvements in neurosurgery, chemotherapy, and radiotherapy, the outcomes of patients with malignant gliomas remain poor. Therefore, increased knowledge of the molecular mechanisms that regulate glioma progression i...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Zhou Y,Tan Z,Chen K,Wu W,Zhu J,Wu G,Cao L,Zhang X,Zeng X,Li J,Zhang W

    更新日期:2018-09-01 00:00:00

  • Involvement of protein kinase C α and δ activities on the induction of the retinoic acid system in mammary cancer cells.

    abstract::It has been established that retinoids exert some of their effects on cell differentiation and malignant phenotype reversion through the interaction with different members of the protein kinase C (PKC) family. Till nowadays the nature and extension of this interaction is not well understood. Due to the cytostatic and ...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Berardi DE,Bessone MI,Motter A,Bal de Kier Joffé ED,Urtreger AJ,Todaro LB

    更新日期:2015-10-01 00:00:00

  • Immunogenic cell death in colon cancer prevention and therapy.

    abstract::Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide. The colonic mucosa constitutes a critical barrier and a major site of immune regulation. The immune system plays important roles in cancer development and treatment, and immune activation caused by chronic infection or inflammation is well-k...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章,评审


    authors: Ruan H,Leibowitz BJ,Zhang L,Yu J

    更新日期:2020-07-01 00:00:00

  • Increased expression of stromelysin-3 in basal cell carcinomas.

    abstract::We examined the expression of two groups of matrix metalloproteinases (MMPs), stromelysin and interstitial collagenase, in human skin cancer by northern blot analysis and in situ hybridization. Stromelysin-3 (ST-3) mRNA was overexpressed more than tenfold in 17 of 19 (89%) specimens of basal cell carcinoma (BCC) but i...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


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    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


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  • Evidence for possible non-canonical pathway(s) driven early-onset colorectal cancer in India.

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    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


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  • An in vitro system to characterize prostate cancer progression identified signaling required for self-renewal.

    abstract::Mutations in RB and PTEN are linked to castration resistance and poor prognosis in prostate cancer. Identification of genes that are regulated by these tumor suppressors in a context that recapitulates cancer progression may be beneficial for discovering novel therapeutic targets. Although various genetically engineer...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


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  • Frequency of Ki-ras mutations and DNA alkylation in colorectal tissue from individuals living in Manchester.

    abstract::Most human colorectal cancers arise through the accumulation of a series of genetic alterations such as point mutations within the Ki-ras and p53 genes, but the chemical carcinogens that may be implicated in these events are still unidentified. In a previous study, we showed that DNA from human colorectal tissue conta...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


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  • Induction of the mesenchymal to epithelial transition by demethylation- activated microRNA-200c is involved in the anti-migration/invasion effects of arsenic trioxide on human breast cancer cells.

    abstract::Breast cancer is a major health problem worldwide. Current standard practices for treatment of breast cancer are less than satisfactory because of high rates of metastasis. Arsenic trioxide (As(2)O(3)), which induces demethylation of DNA and causes apoptosis, has been used as an anti-tumor agent. Little is known, howe...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Si L,Jiang F,Li Y,Ye X,Mu J,Wang X,Ning S,Hu C,Li Z

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  • Polyamines are oncometabolites that regulate the LIN28/let-7 pathway in colorectal cancer cells.

    abstract::Polyamine metabolism is a highly coordinated process that is essential for normal development and neoplastic growth in mammals. Although polyamine metabolism is a validated pathway for prevention of carcinogenesis, the mechanisms by which polyamines elicit their tumorigenic effects are poorly understood. In this study...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Paz EA,LaFleur B,Gerner EW

    更新日期:2014-02-01 00:00:00

  • Prognostic implications of ezrin expression in human hepatocellular carcinoma.

    abstract::Ezrin is known to regulate cellular survival, adhesion, migration, and invasion and has been identified as one of the key components of tumor progression and metastasis. The authors investigated ezrin expression in human hepatocellular carcinoma (HCC) and sought to determine its relation with clinicopathologic paramet...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Kang YK,Hong SW,Lee H,Kim WH

    更新日期:2010-09-01 00:00:00

  • Oxidative DNA damage causes premature senescence in mouse embryonic fibroblasts deficient for Krüppel-like factor 4.

    abstract::Krüppel-like factor 4 (KLF4) is a zinc-finger-containing transcription factor with tumor suppressor activity in various cancer types. Cells that sustain double strand breaks (DSBs) in their DNA due to high levels of reactive oxygen species (ROS) can develop genomic instability, which can result in cancer formation. On...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Liu C,La Rosa S,Hagos EG

    更新日期:2015-09-01 00:00:00

  • Dipyridamole intervention of breast cell carcinogenesis.

    abstract::Dietary prevention is a cost-efficient strategy to reduce the risk of human cancers. More than 85% breast cancers are sporadic and attributable to long-term exposure to environmental carcinogens through a multistep and multiyear disease process. We used our chronically induced cellular carcinogenesis model as a target...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Choudhary S,Sood S,Wang HC

    更新日期:2014-03-01 00:00:00

  • Targeting c-MET by LY2801653 for treatment of cholangiocarcinoma.

    abstract::Palliative treatment options for human cholangiocarcinoma (CCC) are quite limited and new therapeutic strategies are of utmost need. c-MET has been shown to be deregulated in many cancers, but the role of c-MET in the carcinogenesis of CCC remains unclear. The main purpose of this study is to evaluate the expression a...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Barat S,Bozko P,Chen X,Scholta T,Hanert F,Götze J,Malek NP,Wilkens L,Plentz RR

    更新日期:2016-12-01 00:00:00

  • Upregulation of the long non-coding RNA HOTAIR promotes esophageal squamous cell carcinoma metastasis and poor prognosis.

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    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Chen FJ,Sun M,Li SQ,Wu QQ,Ji L,Liu ZL,Zhou GZ,Cao G,Jin L,Xie HW,Wang CM,Lv J,De W,Wu M,Cao XF

    更新日期:2013-11-01 00:00:00

  • Regulation of keratinocyte growth factor expression in human endometrium: implications for hormonal carcinogenesis.

    abstract::Estrogen is thought to be an important etiologic agent in endometrial and breast cancers. However, the mechanism or mechanisms by which estrogen acts as a hormonal carcinogen are not well understood. We hypothesize that in response to chronic exposure to estrogens, human endometrial stromal fibroblasts (ESF) produce f...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Li Y,Rinehart CA

    更新日期:1998-12-01 00:00:00

  • Mutational specificity of 2-amino-3-methylimidazo-[4,5-f]quinoline in the hprt locus of CHO-K1 cells.

    abstract::2-Amino-3-methylimidazo[4,5-f]quinoline (IQ), a food carcinogen formed in cooked meats, can induce gene mutation at the hprt locus of CHO-K1 cells in the presence of hepatic S9 mix. To elucidate the molecular nature of IQ-induced mutation, we characterized the entire coding region of the hypoxanthine phosphoribosyl-tr...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Lee H,Shih MK

    更新日期:1995-06-01 00:00:00

  • Persistent alterations of gene expression profiling of human peripheral blood mononuclear cells from smokers.

    abstract::The number of validated biomarkers of tobacco smoke exposure is limited, and none exist for tobacco-related cancer. Additional biomarkers for smoke, effects on cellular systems in vivo are needed to improve early detection of lung cancer, and to assist the Food and Drug Administration in regulating exposures to tobacc...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Weng DY,Chen J,Taslim C,Hsu PC,Marian C,David SP,Loffredo CA,Shields PG

    更新日期:2016-10-01 00:00:00

  • Co-regulation of B-Myb expression by E2F1 and EGF receptor.

    abstract::Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is frequently over-expressed in human cancers and is associated with tumorigenesis, and increased tumor proliferation and progression. Also found in breast tumors with high levels is B-Myb, a transcription factor whose expression is activated b...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Hanada N,Lo HW,Day CP,Pan Y,Nakajima Y,Hung MC

    更新日期:2006-01-01 00:00:00

  • Species-specific effects of the hepatocarcinogens 3'-methyl-4-dimethyl-aminoazobenzene and ortho-aminoazotoluene in mouse and rat liver.

    abstract::The effects of rat-specific hepatocarcinogen 3'-methyl-4-dimethylaminoazobenzene (3'-MeDAB), mouse-specific hepatocarcinogen ortho-aminoazotoluene (OAT), non-species-specific hepatocarcinogen diethylnitrosamine (DENA), and non-carcinogenic 4'-methyl-4-dimethylaminoazobenzene (4'-MeDAB) on glucocorticoid induction of t...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Merkulova TI,Kropachev KY,Timofeeva OA,Vasiliev GV,Levashova ZB,Ilnitskaya SI,Kobzev VF,Pakharukova MY,Bryzgalov LO,Kaledin VI

    更新日期:2005-12-01 00:00:00

  • Correlation of increased levels of Ha-ras T24 protein with extent of loss of gap junction function in rat liver epithelial cells.

    abstract::Although it is known that cells transformed by ras and other oncogenes show reduced gap junction function, to date there has been no investigation of the quantitative relationship between intracellular levels of ras oncoprotein and loss of cell-cell communication. Using the rat liver epithelial cell line MTR6, which c...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: de Feijter AW,Trosko JE,Krizman DB,Lebovitz RM,Lieberman MW

    更新日期:1992-01-01 00:00:00

  • The infant mouse as a in vivo model for the detection and study of DNA damage-induced changes in the liver.

    abstract::The present work describes the use of the infant (4-wk-old) mouse as an animal model for the study of DNA damage-induced G(1) checkpoint response, changes in p53 protein levels, and multiple gene expression changes after DNA damage has been induced in the liver. Hepatocytes in the infant B6C3F1 mouse had a proliferati...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Reynolds R,Witherspoon S,Fox T

    更新日期:2004-05-01 00:00:00

  • Ras-mediated intestinal epithelial cell transformation requires cyclooxygenase-2-induced prostaglandin E2 signaling.

    abstract::Ras-mediated transformation is associated with upregulation of cyclooxygenase-2 (COX-2), which in turn promotes prostaglandin E2 (PGE2) synthesis and secretion. Although recent studies have identified molecular mechanisms by which Ras mediates upregulation of COX-2, conflicting observations have been made. Furthermore...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Repasky GA,Zhou Y,Morita S,Der CJ

    更新日期:2007-12-01 00:00:00

  • BCL2L10 inhibits growth and metastasis of hepatocellular carcinoma both in vitro and in vivo.

    abstract::BCL2L10 is an apoptosis-related member of the BCL-2 protein family. The role of BCL2L10 in the pathogenesis of hepatocellular carcinoma (HCC) is poorly understood. This study was aimed to investigate the function and underlying mechanisms of BCL2L10 in HCC. BCL2L10 expression in human HCC and corresponding adjacent no...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Bai Y,Wang J,Han J,Xie XL,Ji CG,Yin J,Chen L,Wang CK,Jiang XY,Qi W,Jiang HQ

    更新日期:2017-03-01 00:00:00

  • Molecular evidence supporting the precursor nature of atypical adenomatous hyperplasia of the prostate.

    abstract::Atypical adenomatous hyperplasia (AAH) of the prostate is characterized by lobular proliferation of closely packed small acini. It is hypothesized that AAH is a precursor lesion for low-grade prostate cancer arising from the transition zone. Telomere dysfunction is common during malignant transformation of epithelia. ...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Cheng L,Montironi R,Davidson DD,Wang M,Lopez-Beltran A,Zhang S

    更新日期:2019-07-01 00:00:00

  • Alterations in the expression of alpha6beta4 integrin and p21/WAF1/Cip1 in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis.

    abstract::Integrin alpha6beta4 is altered in many neoplastic cells, but no data exist to show this happens in esophageal neoplasms. To examine the expression of this integrin in rat esophageal tumorigenesis induced by N-nitrosomethylbenzylamine (NMBA), (alpha6 and beta4 expression was evaluated in normal esophageal epithelium, ...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Khare L,Sabourin CL,DeYoung BR,Wagner BA,Stoner GD

    更新日期:1998-03-01 00:00:00

  • Role of IKK and oscillatory NFkappaB kinetics in MMP-9 gene expression and chemoresistance to 5-fluorouracil in RKO colorectal cancer cells.

    abstract::Nuclear factor kappa B (NFkappaB) is a central participant in the metastasis and chemoresistance of colorectal cancer (CRC). However, it is not fully understood to what extent NFkappaB contributes to induction of the metastasis-associated matrix metalloprotease-9 (MMP-9) gene and sensitivity to the commonly used chemo...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章


    authors: Fukuyama R,Ng KP,Cicek M,Kelleher C,Niculaita R,Casey G,Sizemore N

    更新日期:2007-05-01 00:00:00