Identification of RB and p53 mutations in mouse lymphoma cell lines.

abstract：:Glucocorticoid hormones are strong inhibitors of normal keratinocyte proliferation, but established mouse skin papillomas and carcinomas become resistant to these hormones. The biological effect of glucocorticoids is mediated through a highly specific glucocorticoid receptor (GR). To study the possible mechanisms of g...

journal_title：Molecular carcinogenesis

authors： Spiegelman VS,Budunova IV,Carbajal S,Slaga TJ

更新日期：1997-09-01 00:00:00

abstract：:Most human colorectal cancers arise through the accumulation of a series of genetic alterations such as point mutations within the Ki-ras and p53 genes, but the chemical carcinogens that may be implicated in these events are still unidentified. In a previous study, we showed that DNA from human colorectal tissue conta...

journal_title：Molecular carcinogenesis

authors： Jackson PE,Hall CN,Badawi AF,O'Connor PJ,Cooper DP,Povey AC

更新日期：1996-05-01 00:00:00

abstract：:Carcinogenesis is a multistep sequential process of clonal expansion of initiated cells associated with the accumulation of multiple cancer-specific heritable phenotypes. The acquisition of these heritable cancer-specific alterations may be triggered by mutational and/or non-mutational changes in the genome that affec...

journal_title：Molecular carcinogenesis

authors： Koturbash I,Melnyk S,James SJ,Beland FA,Pogribny IP

更新日期：2013-04-01 00:00:00

abstract：:Chloride intracellular channel 4 (CLIC4) is a putative chloride channel for intracellular organelles. CLIC4 has biological activities in addition to or because of its channel activity. In keratinocytes, CLIC4 resides in the mitochondria and cytoplasm, and CLIC4 gene expression is regulated by p53, TNF-alpha, and c-Myc...

journal_title：Molecular carcinogenesis

authors： Suh KS,Malik M,Shukla A,Yuspa SH

更新日期：2007-08-01 00:00:00

abstract：:Formation of G4 DNA may occur in the course of replication and transcription, and contribute to genomic instability. We have quantitated abundance of G4 motifs and potential for G4 DNA formation of the nontemplate strand of 5' exons and introns of transcripts of human genes. We find that, for all human genes, G4 motif...

journal_title：Molecular carcinogenesis

authors： Eddy J,Maizels N

更新日期：2009-04-01 00:00:00

abstract：:Expression of the tumor suppressor deleted in liver cancer-1 (DLC-1) is lost in non-small cell lung (NSCLC) and other human carcinomas, and ectopic DLC-1 expression dramatically reduces proliferation and tumorigenicity. DLC-1 is a multi-domain protein that includes a Rho GTPase activating protein (RhoGAP) domain which...

journal_title：Molecular carcinogenesis

authors： Healy KD,Hodgson L,Kim TY,Shutes A,Maddileti S,Juliano RL,Hahn KM,Harden TK,Bang YJ,Der CJ

更新日期：2008-05-01 00:00:00

abstract：:Environmental health science research, with its focus on fundamental science and disease prevention, is important for the development of rational and cost-effective public health and regulatory policies related to environmental protection. Environmentally related diseases are preventable, yet they impose a major burde...

journal_title：Molecular carcinogenesis

authors： Olden K,Klein JL

更新日期：1995-09-01 00:00:00

abstract：:The endocannabinoid arachidonoyl ethanolamide (AEA) is a potent inducer of tumor cell apoptosis however its mechanism of cytotoxicity is unclear. A previous report from our laboratory showed that AEA induced cell death in a cyclooxygenase-2 (COX-2)-dependent manner and in this report our data indicate that AEA-induced...

journal_title：Molecular carcinogenesis

authors： Kuc C,Jenkins A,Van Dross RT

更新日期：2012-02-01 00:00:00

abstract：:The interplay between cancer cells and the normal surrounding tissue is believed to influence the biological behavior of the tumor. However, the presence of multiple cell types within the prelevated tumor specimen may attenuate changes that occur specifically in the malignant cells within their microenvironment. To st...

journal_title：Molecular carcinogenesis

authors： Verlinden I,Janssens J,Raus J,Michiels L

更新日期：2004-12-01 00:00:00

abstract：:The WW domain-containing oxidoreductase (WWOX) gene is an identified tumor suppressor gene, of which several single nucleotide polymorphisms have been reported to contribute to cancer susceptibility. We hypothesized that genetic variations in WWOX are associated with lung cancer risk. In two independent case-control s...

journal_title：Molecular carcinogenesis

authors： Huang D,Qiu F,Yang L,Li Y,Cheng M,Wang H,Ma G,Wang Y,Hu M,Ji W,Zhou Y,Lu J

更新日期：2013-11-01 00:00:00

abstract：:To investigate the importance of oncogenes and tumor suppressor genes in bladder carcinogenesis, we determined the status of the expression of the MDM-2 and p53 genes and genetic alterations in the p53 gene in five bladder carcinoma cell lines and one kidney urothelial carcinoma cell line. Overexpression of MDM-2 mRNA...

journal_title：Molecular carcinogenesis

authors： Cheng YT,Li YL,Wu JD,Long SB,Tzai TS,Tzeng CC,Lai MD

更新日期：1995-07-01 00:00:00

abstract：:Telomerase expression is the hallmark of tumor cells, and activation of this ribonucleoprotein complex may be a rate-limiting or critical step in cellular immortalization and oncogenesis. Fungal immunomodulatory protein, FIP-gts, has been isolated from Ganoderma tsugae. In the present study, we expressed and purified ...

journal_title：Molecular carcinogenesis

authors： Liao CH,Hsiao YM,Hsu CP,Lin MY,Wang JC,Huang YL,Ko JL

更新日期：2006-04-01 00:00:00

abstract：:Apigenin (4',5,7-trihydroxyflavone), a flavone subclass of flavonoid widely distributed in many herbs, fruits, and vegetables is a substantial component of the human diet and has been shown to possess a variety of biological activities including tumor growth inhibition and chemoprevention. Recent studies in several bi...

journal_title：Molecular carcinogenesis

authors： Jeyabal PV,Syed MB,Venkataraman M,Sambandham JK,Sakthisekaran D

更新日期：2005-09-01 00:00:00

abstract：:As the prognostic significance of the three most frequently amplified oncogenes in breast cancer (c-myc, int-2/FGF3, and c-erbB-2/neu) is still unclear, and as the amplification of these genes appears to be mutually exclusive, we investigated the prognostic significance of oncogene amplification per se by multivariate...

journal_title：Molecular carcinogenesis

authors： Champème MH,Bièche I,Hacène K,Lidereau R

更新日期：1994-12-01 00:00:00

abstract：:Using relatively primitive tools in the 1920s, Otto Warburg demonstrated that tumor cells show an increased dependence on glycolysis to meet their energy needs, regardless of whether they were well-oxygenated or not. High rates of glucose uptake, fueling glycolysis, are now used clinically to identify cancer cells. Ho...

journal_title：Molecular carcinogenesis

authors： Nakajima EC,Van Houten B

更新日期：2013-05-01 00:00:00

abstract：:The temporal order of replication of several genes was studied in 10T1/2 cells synchronized by release from confluence-induced arrest of proliferation followed by treatment with 2 micrograms/mL aphidicolin for 24 h. DNA subjected to bromodeoxyuridine substitution for 1- or 2-h intervals spanning the S phase was separa...

journal_title：Molecular carcinogenesis

authors： Doggett NA,Cordeiro-Stone M,Chae CB,Kaufman DG

更新日期：1988-01-01 00:00:00

abstract：:Genomic DNA sequences with the ability to assume non-B form secondary structures have been recently shown to be particularly susceptible to genetic instability, an early contributing factor in human disease and cancer development. Transcription appears to play a central role in formation of these structures and in pro...

journal_title：Molecular carcinogenesis

authors： Tornaletti S

更新日期：2009-04-01 00:00:00

abstract：:Bone cells are a prime target for the biological function of the fos/jun (activating protein-1 (AP-1)) transcription factor complex. Deregulated expression of c-fos or v-fos in bone cells induces tumorigenicity and the formation of non-metastatic osteosarcomas. In contrast, fos oncogenes transform fibroblasts to an in...

journal_title：Molecular carcinogenesis

authors： Rupp B,Lorenz U,Schmidt J,Werenskiold AK

更新日期：1998-10-01 00:00:00

abstract：:In human lung cancers, alterations of both a dominant oncogene (ras) and a tumor suppressor gene (p53) have been identified. Polymerase chain reaction (PCR) analysis of mRNA was used to amplify the c-Ki-ras-2 and p53 genes from Syrian golden hamsters. The PCR products were confirmed by predicted-size analysis, probing...

journal_title：Molecular carcinogenesis

authors： Oreffo VI,Lin HW,Gumerlock PH,Kraegel SA,Witschi H

更新日期：1992-01-01 00:00:00

abstract：:The extracellular signal-regulated kinase (ERK), mitogen-activated protein kinase (MAPK) pathway is an important cell proliferation pathway. We previously reported that the transport protein particle complex 4 (TRAPPC4), ERK2 interaction may activate ERK1/2, modulate pERK2 nuclear localization and regulate proliferati...

journal_title：Molecular carcinogenesis

authors： Weng YR,Kong X,Yu YN,Wang YC,Hong J,Zhao SL,Fang JY

更新日期：2014-02-01 00:00:00

abstract：:FAM134B is an autophagy regulator of endoplasmic reticulum and acts as a cancer suppressor in colon cancer. However, the molecular signaling pathways by which FAM134B interacts within colon carcinogenesis is still unknown. Herein, this study aims to determine the interacting partners of FAM134B for the first time in c...

journal_title：Molecular carcinogenesis

authors： Islam F,Chaousis S,Wahab R,Gopalan V,Lam AK

更新日期：2018-11-01 00:00:00

abstract：:Human colorectal cancer (CRC) cells are resistant to the anti-proliferative effect of transforming growth factor-β (TGF-β), suggesting that disruption of TGF-β signaling plays an important role in colorectal carcinogenesis. Ecotropic virus integration site-1 (Evi-1) oncoprotein represses TGF-β signaling by interacting...

journal_title：Molecular carcinogenesis

authors： Deng X,Cao Y,Liu Y,Li F,Sambandam K,Rajaraman S,Perkins AS,Fields AP,Hellmich MR,Townsend CM Jr,Thompson EA,Ko TC

更新日期：2013-04-01 00:00:00

abstract：:Signaling networks play important roles in cancer progression. For example, overexpression of the epidermal growth factor receptor (EGFR) is a poor prognostic indicator in multiple tumor types. Recent studies have postulated that the EGFR functions as a central conduit for signaling by different classes of cell surfac...

journal_title：Molecular carcinogenesis

authors： Boerner JL,Biscardi JS,Silva CM,Parsons SJ

更新日期：2005-12-01 00:00:00

abstract：:Glioblastoma (GBM) is the most aggressive and highly invasive type of astrocytic tumors. Despite advances in diagnosis and therapy, the prognosis and survival time remain poor. Identifying key mediators of tumor cell proliferation, migration, and invasion is crucial to the development of new and more effective therapi...

journal_title：Molecular carcinogenesis

authors： Liu X,Gao Q,Zhao N,Zhang X,Cui W,Sun J,Fu J,Hao J

更新日期：2018-04-01 00:00:00

abstract：:Black currant fruits containing high amounts of anthocyanins are known to possess potent antioxidant and anti-inflammatory properties. We have previously reported that anthocyanin-rich black currant skin extract (BCSE) inhibits diethylnitrosamine (DENA)-initiated hepatocarcinogenesis in rats although the underlying me...

journal_title：Molecular carcinogenesis

authors： Bishayee A,Thoppil RJ,Mandal A,Darvesh AS,Ohanyan V,Meszaros JG,Háznagy-Radnai E,Hohmann J,Bhatia D

更新日期：2013-04-01 00:00:00

abstract：:The cellular response to cisplatin involves activation of multiple signal transduction pathways, including the mitogen-activated protein (MAP) kinase pathways. In this study, we compared the cisplatin-induced activation of two MAP kinases, c-jun N-terminal kinase 1 (JNK1) and extracellular signal-regulated protein kin...

journal_title：Molecular carcinogenesis

authors： Cui W,Yazlovitskaya EM,Mayo MS,Pelling JC,Persons DL

更新日期：2000-12-01 00:00:00

abstract：:2-Deoxyglucose (2-DG), which has been shown to inhibit mammary carcinogenesis, was used as a metabolic probe to investigate effects of limiting energy availability (reduced cellular ATP) on patterns of proteins' phosphorylation that play a role in the development of cancer. Experiments were conducted using a human bre...

journal_title：Molecular carcinogenesis

authors： Jiang W,Zhu Z,Thompson HJ

更新日期：2008-08-01 00:00:00

abstract：:Because oxidative processes can participate in tumor promotion, it is likely that the cellular antioxidant defense also plays a role. We have compared the levels of the three major antioxidant enzymes, Cu,Zn-superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx), in promotable mouse epidermal JB6 cells ...

journal_title：Molecular carcinogenesis

authors： Crawford DR,Amstad PA,Foo DD,Cerutti PA

更新日期：1989-01-01 00:00:00

abstract：:DIXDC1 (Dishevelled-Axin domain containing 1) is a DIX (Dishevelled-Axin) domain-possessing protein that promotes colon cancer cell proliferation and increases the invasion and migration ability of non-small-cell lung cancer via the PI3K pathway. As a positive regulator of the Wnt/β-catenin pathway, the biological rol...

journal_title：Molecular carcinogenesis

authors： Tan C,Qiao F,Wei P,Chi Y,Wang W,Ni S,Wang Q,Chen T,Sheng W,Du X,Wang L

更新日期：2016-04-01 00:00:00

abstract：:N-acetyltransferase 1 (NAT1) is a phase II metabolic enzyme responsible for the biotransformation of aromatic and heterocyclic amine carcinogens such as 4-aminobiphenyl (ABP). NAT1 catalyzes N-acetylation of arylamines as well as the O-acetylation of N-hydroxylated arylamines. O-acetylation leads to the formation of e...

journal_title：Molecular carcinogenesis

authors： Millner LM,Doll MA,Cai J,States JC,Hein DW

更新日期：2012-08-01 00:00:00