CLIC4, skin homeostasis and cutaneous cancer: surprising connections.

abstract：:The most common NF1 feature is the benign neurofibroma, which consists predominantly of Schwann cells. Dermal neurofibromas usually arise during puberty and increase in number throughout adulthood. Plexiform neurofibromas, associated with larger nerves, are often congenital and can be life threatening. Malignant perip...

journal_title：Molecular carcinogenesis

authors： Fishbein L,Zhang X,Fisher LB,Li H,Campbell-Thompson M,Yachnis A,Rubenstein A,Muir D,Wallace MR

更新日期：2007-07-01 00:00:00

abstract：:The ubiquitin-proteasome pathway is fundamental to synchronized continuation of many cellular processes, for example, cell-cycle progression, stress response, and cell differentiation. Recent studies have shown that the ubiquitin-proteasome pathway functions in the regulation of nucleotide excision repair (NER) in yea...

journal_title：Molecular carcinogenesis

authors： Wang QE,Wani MA,Chen J,Zhu Q,Wani G,El-Mahdy MA,Wani AA

更新日期：2005-01-01 00:00:00

abstract：:N-acetyltransferase 1 (NAT1) is a phase II metabolic enzyme responsible for the biotransformation of aromatic and heterocyclic amine carcinogens such as 4-aminobiphenyl (ABP). NAT1 catalyzes N-acetylation of arylamines as well as the O-acetylation of N-hydroxylated arylamines. O-acetylation leads to the formation of e...

journal_title：Molecular carcinogenesis

authors： Millner LM,Doll MA,Cai J,States JC,Hein DW

更新日期：2012-08-01 00:00:00

abstract：:Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide. The colonic mucosa constitutes a critical barrier and a major site of immune regulation. The immune system plays important roles in cancer development and treatment, and immune activation caused by chronic infection or inflammation is well-k...

journal_title：Molecular carcinogenesis

authors： Ruan H,Leibowitz BJ,Zhang L,Yu J

更新日期：2020-07-01 00:00:00

abstract：:Krüppel-like factor 4 (KLF4) is a zinc-finger-containing transcription factor with tumor suppressor activity in various cancer types. Cells that sustain double strand breaks (DSBs) in their DNA due to high levels of reactive oxygen species (ROS) can develop genomic instability, which can result in cancer formation. On...

journal_title：Molecular carcinogenesis

authors： Liu C,La Rosa S,Hagos EG

更新日期：2015-09-01 00:00:00

abstract：:In this report we characterized the transcriptional regulation of the rat mdr1b gene by xenobiotics. The expression of this gene was increased in primary rat hepatocytes and in the H4-II-E hepatoma cell line by exposure to carcinogens such as aflatoxin B1, N-acetoxy-2-acetylaminofluorene, and methyl methanesulfonate. ...

journal_title：Molecular carcinogenesis

authors： Silverman JA,Hill BA

更新日期：1995-05-01 00:00:00

abstract：:In human lung cancers, alterations of both a dominant oncogene (ras) and a tumor suppressor gene (p53) have been identified. Polymerase chain reaction (PCR) analysis of mRNA was used to amplify the c-Ki-ras-2 and p53 genes from Syrian golden hamsters. The PCR products were confirmed by predicted-size analysis, probing...

journal_title：Molecular carcinogenesis

authors： Oreffo VI,Lin HW,Gumerlock PH,Kraegel SA,Witschi H

更新日期：1992-01-01 00:00:00

abstract：:The effects of rat-specific hepatocarcinogen 3'-methyl-4-dimethylaminoazobenzene (3'-MeDAB), mouse-specific hepatocarcinogen ortho-aminoazotoluene (OAT), non-species-specific hepatocarcinogen diethylnitrosamine (DENA), and non-carcinogenic 4'-methyl-4-dimethylaminoazobenzene (4'-MeDAB) on glucocorticoid induction of t...

journal_title：Molecular carcinogenesis

authors： Merkulova TI,Kropachev KY,Timofeeva OA,Vasiliev GV,Levashova ZB,Ilnitskaya SI,Kobzev VF,Pakharukova MY,Bryzgalov LO,Kaledin VI

更新日期：2005-12-01 00:00:00

abstract：:Prostate cancer (PCa) patients' mortality is mainly attributed to complications caused by metastasis of the tumor cells to organs critical for survival, such as bone. We hypothesized that PCa cell-bone interactions would promote paracrine signaling. A panel of PCa cell lines were cocultured with hydroxyapatite ([HA]; ...

journal_title：Molecular carcinogenesis

authors： Henderson VM,Hawsawi O,Burton LJ,Campbell T,Trice K,Dougan J,Howard SM,Odero-Marah VA

更新日期：2019-08-01 00:00:00

abstract：:Rat neoplasms induced by methylating carcinogens frequently contain ras genes activated by a single point mutation. Rat prostatic tumors induced by a combination of a single injection of N-methyl-N-nitrosourea (MNU) and long-term treatment with testosterone were examined for the presence of such activating point mutat...

journal_title：Molecular carcinogenesis

authors： Sukumar S,Armstrong B,Bruyntjes JP,Leav I,Bosland MC

更新日期：1991-01-01 00:00:00

abstract：:The molecular changes associated with the aging process include the reduced activity of transcription factors (such as AP-1) and an impaired response to stress, which has been well documented in the case of the heat-shock (HS) response. Using human diploid fibroblasts of early and late passages as an in vitro model fo...

journal_title：Molecular carcinogenesis

authors： Adler V,Dolan LR,Kim J,Pincus M,Barrett JC,Ronai Z

更新日期：1996-09-01 00:00:00

abstract：:Although there are extensive studies on the genetics of bladder cancer, several questions remain unanswered. One of the pathways which are altered in bladder cancer is the mTOR signaling pathway. In the present study, we analyzed the expression of Rheb gene and genetic alterations in the LKB1 gene which are the key co...

journal_title：Molecular carcinogenesis

authors： Tigli H,Seven D,Tunc M,Sanli O,Basaran S,Ulutin T,Buyru N

更新日期：2013-08-01 00:00:00

abstract：:Lasp2, as well as Lasp1, is a member of the LIM-protein subfamily of the nebulin group characterized by the combined presence of LIM and SH3 domains. Lasp1 and Lasp2 are highly conserved in their LIM, nebulin-like, and SH3 domains but differ significantly at their linker regions. Lasp1 had been described as an oncogen...

journal_title：Molecular carcinogenesis

authors： Zhang X,Cai L,Zhou H,Liu Y,Fan C,Wang L,Li A,Miao Y,Li Q,Qiu X,Wang E

更新日期：2017-12-01 00:00:00

abstract：:The number of validated biomarkers of tobacco smoke exposure is limited, and none exist for tobacco-related cancer. Additional biomarkers for smoke, effects on cellular systems in vivo are needed to improve early detection of lung cancer, and to assist the Food and Drug Administration in regulating exposures to tobacc...

journal_title：Molecular carcinogenesis

authors： Weng DY,Chen J,Taslim C,Hsu PC,Marian C,David SP,Loffredo CA,Shields PG

更新日期：2016-10-01 00:00:00

abstract：:RhoBTB2 was isolated recently as a tumor suppressor gene from human chromosome 8p21.3. Although RhoBTB2 was found to be frequently lost in breast cancer lines, expression status of RhoBTB2 in sporadic breast cancer tissues and its clinical and prognostic value, however, remain unclear. Tissue samples from breast cance...

journal_title：Molecular carcinogenesis

authors： Mao H,Qu X,Yang Y,Zuo W,Bi Y,Zhou C,Yin H,Deng B,Sun J,Zhang L

更新日期：2010-03-01 00:00:00

abstract：:Bone cells are a prime target for the biological function of the fos/jun (activating protein-1 (AP-1)) transcription factor complex. Deregulated expression of c-fos or v-fos in bone cells induces tumorigenicity and the formation of non-metastatic osteosarcomas. In contrast, fos oncogenes transform fibroblasts to an in...

journal_title：Molecular carcinogenesis

authors： Rupp B,Lorenz U,Schmidt J,Werenskiold AK

更新日期：1998-10-01 00:00:00

abstract：:Cr(VI) causes severe kidney damage. The patient's renal function could gradually recover by spontaneous kidney regeneration. The molecular effect of Cr(VI) on recovery of kidney cells, however, has not been clearly elucidated. Here we show that Cr(VI) induces expression of mesenchymal and stem cell markers, cell marke...

journal_title：Molecular carcinogenesis

authors： Li WJ,Yang CL,Chow KC,Kuo TW

更新日期：2016-02-01 00:00:00

abstract：:Because oxidative processes can participate in tumor promotion, it is likely that the cellular antioxidant defense also plays a role. We have compared the levels of the three major antioxidant enzymes, Cu,Zn-superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx), in promotable mouse epidermal JB6 cells ...

journal_title：Molecular carcinogenesis

authors： Crawford DR,Amstad PA,Foo DD,Cerutti PA

更新日期：1989-01-01 00:00:00

abstract：:Potassium chromate induced the formation of DNA-protein complexes in cultured Chinese hamster ovary cells. The DNA-protein complexes were isolated by ultracentrifugal sedimentation in the presence of 2% sodium dodecyl sulfate (SDS) and 5 M urea. Two-dimensional SDS-polyacrylamide gel electrophoresis analysis of the ch...

journal_title：Molecular carcinogenesis

authors： Miller CA 3rd,Costa M

更新日期：1988-01-01 00:00:00

abstract：:The prevalence of obesity, an established risk and progression factor for postmenopausal breast cancer, remains high in US women. Activation of Akt/mammalian target of rapamycin (mTOR) signaling plays a key role in the obesity-breast cancer link. However, the impact of weight normalization in obese postmenopausal wome...

journal_title：Molecular carcinogenesis

authors： De Angel RE,Conti CJ,Wheatley KE,Brenner AJ,Otto G,Degraffenried LA,Hursting SD

更新日期：2013-06-01 00:00:00

abstract：:The human p53 gene, a putative tumor suppressor gene, has a polymorphism in amino acid residue 72. We recently developed a method of detecting codon 72 polymorphism in this gene by digestion of polymerase chain reaction-amplified DNA using an allele-specific restriction endonuclease. This polymorphism allows the ident...

journal_title：Molecular carcinogenesis

authors： Oka K,Ishikawa J,Bruner JM,Takahashi R,Saya H

更新日期：1991-01-01 00:00:00

abstract：:We confirmed the expression of cathepsin K, the most abundant and specific cysteine protease found in osteoclasts, at the mRNA level in most of our cases of breast cancer, and even at the protein level in bone metastatic lesions. Therefore, we investigated the functions of cathepsin K in osteoclasts with special atten...

journal_title：Molecular carcinogenesis

authors： Ishikawa T,Kamiyama M,Tani-Ishii N,Suzuki H,Ichikawa Y,Hamaguchi Y,Momiyama N,Shimada H

更新日期：2001-10-01 00:00:00

abstract：:Diet-derived butyrate, a histone deacetylase inhibitor (HDI), decreases proliferation and increases apoptosis in colorectal cancer (CRC) cells via epigenetic changes in gene expression. Other HDIs such as suberoylanilide hydroxamic acid (SAHA) and trichostatin A (TSA) have similar effects. This study examined the role...

journal_title：Molecular carcinogenesis

authors： Humphreys KJ,Cobiac L,Le Leu RK,Van der Hoek MB,Michael MZ

更新日期：2013-06-01 00:00:00

abstract：:The role of telomerase as an essential requirement for the neoplastic conversion of human cells has been controversial. In the model of conversion of normal human cells to cancer cells by the combination of simian virus 40 (SV40) early region genes and oncogenic Ras (H-Ras(G12V)), telomerase (hTERT) was originally des...

journal_title：Molecular carcinogenesis

authors： Liang S,Kahlenberg MS,Rousseau DL Jr,Hornsby PJ

更新日期：2008-06-01 00:00:00

abstract：:The aim of this study is to evaluate the role of adipose tissue resident stromal cells on tumor cell invasion. Our data show that a subpopulation of adipose tissue derived stromal cells expressing Nestin, NG2, α-smooth muscle actin and PDGFR-α migrate toward the cancer cells. Microarray analysis revealed the upregulat...

journal_title：Molecular carcinogenesis

authors： Welte G,Alt E,Devarajan E,Krishnappa S,Jotzu C,Song YH

更新日期：2012-11-01 00:00:00

abstract：:High rate of chronic hepatitis B virus (HBV) infection and p16 promoter methylation were found in the majority of hepatocellular carcinoma (HCC). To investigate the potential linkage between high rate of p16 methylation and HBV infection, p16 methylation was detected with methylation-specific polymerase chain reaction...

journal_title：Molecular carcinogenesis

authors： Jicai Z,Zongtao Y,Jun L,Haiping L,Jianmin W,Lihua H

更新日期：2006-07-01 00:00:00

abstract：:Astrocyte elevated gene-1 (AEG-1) plays a critical role in the development, progression, and metastasis of a variety of cancers, including non-small-cell lung cancer (NSCLC). The objective of the current study is to unravel the upstream signaling of AEG-1. A cohort of 28 NSCLC tissues and 30 normal tissues were collec...

journal_title：Molecular carcinogenesis

authors： Li YH,Xu CL,He CJ,Pu HH,Liu JL,Wang Y

更新日期：2020-02-01 00:00:00

abstract：:The interplay between cancer cells and the normal surrounding tissue is believed to influence the biological behavior of the tumor. However, the presence of multiple cell types within the prelevated tumor specimen may attenuate changes that occur specifically in the malignant cells within their microenvironment. To st...

journal_title：Molecular carcinogenesis

authors： Verlinden I,Janssens J,Raus J,Michiels L

更新日期：2004-12-01 00:00:00

abstract：:Osteosarcoma (OS) is the most frequent primary bone tumor that affect children and adolescents. This tumor is highly aggressive with high risk of metastasis and the implementation of new drugs has not been successful. The search for biomarkers or new therapeutic targets is urgently needed and can help in advances of O...

journal_title：Molecular carcinogenesis

authors： Lopes LJS,Tesser-Gamba F,Petrilli AS,de Seixas Alves MT,Garcia-Filho RJ,Toledo SRC

更新日期：2017-06-01 00:00:00

abstract：:Telomerase expression is the hallmark of tumor cells, and activation of this ribonucleoprotein complex may be a rate-limiting or critical step in cellular immortalization and oncogenesis. Fungal immunomodulatory protein, FIP-gts, has been isolated from Ganoderma tsugae. In the present study, we expressed and purified ...

journal_title：Molecular carcinogenesis

authors： Liao CH,Hsiao YM,Hsu CP,Lin MY,Wang JC,Huang YL,Ko JL

更新日期：2006-04-01 00:00:00