MAPK pathways regulation by DUSP1 in the development of osteosarcoma: Potential markers and therapeutic targets.

abstract：:The genetic or functional inactivation of the p53 pathway plays an important role with regards to disease progression from the chronic phase (CP) to blast phase (BP) and imatinib treatment response in chronic myeloid leukemia (CML). Two functional single nucleotide polymorphisms (SNPs), p53 R72P and MDM2 SNP309, are a...

journal_title：Molecular carcinogenesis

authors： Liu YC,Hsiao HH,Yang WC,Liu TC,Chang CS,Yang MY,Lin PM,Hsu JF,Lee CP,Lin SF

更新日期：2014-12-01 00:00:00

abstract：:Because oxidative processes can participate in tumor promotion, it is likely that the cellular antioxidant defense also plays a role. We have compared the levels of the three major antioxidant enzymes, Cu,Zn-superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx), in promotable mouse epidermal JB6 cells ...

journal_title：Molecular carcinogenesis

authors： Crawford DR,Amstad PA,Foo DD,Cerutti PA

更新日期：1989-01-01 00:00:00

abstract：:N(6)-isopentenyladenosine (i6A) inhibits the tumor cell growth by inducing cell apoptosis in various cancer cell lines. However, little is known regarding the mechanisms by which the drug induces cell apoptosis. In this study, we further explored the molecular mechanisms of i6A as an anticancer agent on a human breast...

journal_title：Molecular carcinogenesis

authors： Laezza C,Malfitano AM,Di Matola T,Ricchi P,Bifulco M

更新日期：2010-10-01 00:00:00

abstract：:Barrett's metaplasia consists of columnar epithelium that replaces the normal esophageal mucosa in patients with chronic gastroesophageal reflux. Because intestinal-type Barrett's metaplasia is the major risk factor for adenocarcinoma development, understanding the mechanisms that predispose the esophageal mucosa to m...

journal_title：Molecular carcinogenesis

authors： Compton KR,Orringer MB,Beer DG

更新日期：1999-02-01 00:00:00

abstract：:An in vitro model system for xenogenization has been developed in which an immunogenic, nonmalignant phenotype was selected from a highly malignant T-cell line (S49). We showed by single-strand conformation polymorphism and DNA sequence analysis that specific point mutations in the p53 tumor suppressor gene correlated...

journal_title：Molecular carcinogenesis

authors： Bergel M,Bhatia K,Siwarski D,Gutierrez M,Hochman J,Huppi K

更新日期：1993-01-01 00:00:00

abstract：:The majority of human neoplasms have aberrations in the retinoblastoma pathway due to hyperactivation of cyclin-dependent kinases (CDK). Based on this observation, novel small molecules, such as flavopiridol and UCN-01, are being developed and are currently being tested in the clinic. Efforts to develop CDK modulators...

journal_title：Molecular carcinogenesis

authors： Lahusen T,De Siervi A,Kunick C,Senderowicz AM

更新日期：2003-04-01 00:00:00

abstract：:As the prognostic significance of the three most frequently amplified oncogenes in breast cancer (c-myc, int-2/FGF3, and c-erbB-2/neu) is still unclear, and as the amplification of these genes appears to be mutually exclusive, we investigated the prognostic significance of oncogene amplification per se by multivariate...

journal_title：Molecular carcinogenesis

authors： Champème MH,Bièche I,Hacène K,Lidereau R

更新日期：1994-12-01 00:00:00

abstract：:The levels of the antioxidant enzyme manganese superoxide dismutase (Mn-SOD) are frequently decreased in tumor cells and increased in normal cells upon treatment with ionizing radiation. We studied Mn-SOD at different stages during the neoplastic conversion of radiation-initiated Syrian hamster embryo HDR-3 cells. Mn-...

journal_title：Molecular carcinogenesis

authors： Otero G,Avila MA,Emfietzoglou D,Clerch LB,Massaro D,Notario V

更新日期：1996-12-01 00:00:00

abstract：:The human p53 gene, a putative tumor suppressor gene, has a polymorphism in amino acid residue 72. We recently developed a method of detecting codon 72 polymorphism in this gene by digestion of polymerase chain reaction-amplified DNA using an allele-specific restriction endonuclease. This polymorphism allows the ident...

journal_title：Molecular carcinogenesis

authors： Oka K,Ishikawa J,Bruner JM,Takahashi R,Saya H

更新日期：1991-01-01 00:00:00

abstract：:Transforming growth factor beta (TGFbeta) signaling has both tumor suppression and promotion roles. Smads are transcription factors that primarily mediate intracellular signaling for the TGFbeta superfamily. Loss of Smad2 and Smad4, but not Smad3 is common in human cancers. Given the complex nature of TGFbeta signalin...

journal_title：Molecular carcinogenesis

authors： Bornstein S,Hoot K,Han GW,Lu SL,Wang XJ

更新日期：2007-08-01 00:00:00

abstract：:Polymorphisms of the base excision repair gene APE1 may be associated with an increased risk for developing prostate cancer. In other cancer types, altered APE1 protein expression is a candidate prognostic marker. Using immunohistochemistry, we thus analyzed APE1 expression in 9763 prostate cancers in a tissue microar...

journal_title：Molecular carcinogenesis

authors： Juhnke M,Heumann A,Chirico V,Höflmayer D,Menz A,Hinsch A,Hube-Magg C,Kluth M,Lang DS,Möller-Koop C,Sauter G,Simon R,Beyer B,Pompe R,Thederan I,Schlomm T,Luebke AM

更新日期：2017-09-01 00:00:00

abstract：:Patulin (PAT), a present day major contaminant of commercial apple and apple products is reported to be carcinogenic, embryotoxic, and immunotoxic. While oral and inhalation are considered to be the most prevalent routes of exposure to this toxin, exposure through skin is now being extensively investigated. Our previo...

journal_title：Molecular carcinogenesis

authors： Alam S,Pal A,Kumar R,Dwivedi PD,Das M,Ansari KM

更新日期：2014-12-01 00:00:00

abstract：:Sel-1-like (SEL1L) is a putative tumor suppressor gene that is significantly downregulated in human pancreatic ductal adenocarcinoma (PDA). The mechanism of the downregulation is unclear. Here, we investigated whether aberrantly upregulated microRNAs (miRNAs) repressed the expression of SEL1L. From reported miRNA micr...

journal_title：Molecular carcinogenesis

authors： Liu Q,Chen J,Wang J,Amos C,Killary AM,Sen S,Wei C,Frazier ML

更新日期：2014-09-01 00:00:00

abstract：:Growth factor receptors of the tyrosine kinase family regulate proliferation of a variety of cell types. In some human cancers, the epidermal growth factor receptor (EGFR) and its ligands often are overexpressed, leading to both constitutive and autocrine activation. Intracellular signaling via this receptor takes pla...

journal_title：Molecular carcinogenesis

authors： Crowe DL,Tsang KJ

更新日期：2001-12-01 00:00:00

abstract：:Gastrointestinal stromal tumor (GIST) is a common mesenchymal tumor in the gastrointestinal tract. Prostate cancer associated transcript 6 (PCAT6) is a long noncoding RNA (lncRNA) and plays a pivotal role in tumor formation. Present study was designed to explore the function of PCAT6 in GIST. Ki67 staining, colony for...

journal_title：Molecular carcinogenesis

authors： Bai F,Zhang N,Fang W,He X,Zheng Y,Gu D

更新日期：2020-06-01 00:00:00

abstract：:An allelotype analysis of lung tumors in mouse hybrids was conducted to identify common regions of allelic loss. By using 50 informative genetic markers, the autosomes of 36 (A/J x C3H/HeJ) F1 adenocarcinomas were examined. Additional adenocarcinomas from as many as 72 (C3H/HeJ x A/J) F1 and 15 (BALB/cJ x DBA/2J) F1 h...

journal_title：Molecular carcinogenesis

authors： Herzog CR,Chen B,Wang Y,Schut HA,You M

更新日期：1996-06-01 00:00:00

abstract：:Protein kinases play important roles in tumor development and progression. A variety of members of the signal transduction enzymes serve as targets for therapeutic intervention in cancer. The dysregulation of Axl receptor and its ligand growth arrest-specific 6 (Gas6) is implicated in the pathogenesis of several cance...

journal_title：Molecular carcinogenesis

authors： He L,Zhang J,Jiang L,Jin C,Zhao Y,Yang G,Jia L

更新日期：2010-10-01 00:00:00

abstract：:Bcl-x(L) is one of several antiapoptotic proteins regulated by signal transducer and activator of transcription 3 (Stat3). We have recently shown that Stat3 is required for chemically induced and ultraviolet B (UVB)-induced skin carcinogenesis. In this study, the functional role of Bcl-x(L) in skin carcinogenesis was ...

journal_title：Molecular carcinogenesis

authors： Kim DJ,Kataoka K,Sano S,Connolly K,Kiguchi K,DiGiovanni J

更新日期：2009-10-01 00:00:00

abstract：:Tumor-associated stromal cells are dynamic characters that endorse the carcinogenic process in a multitude of ways. The tumor microenvironment plays a crucial role throughout the tumor progression, which includes initiation, growth, invasion, and metastasis. The tumor microenvironment consists of cellular and non-cell...

journal_title：Molecular carcinogenesis

authors： Spaw M,Anant S,Thomas SM

更新日期：2017-04-01 00:00:00

abstract：:To study the possible involvement of DNA damage in cell transformation induced by estrogens, we examined whether DNA adduct formation is elicited in cultured Syrian hamster embryo (SHE) cells treated with estrogens and their derivatives by means of the 32P-postlabeling assay. Morphological transformation of the cells ...

journal_title：Molecular carcinogenesis

authors： Hayashi N,Hasegawa K,Komine A,Tanaka Y,McLachian JA,Barrett JC,Tsutsui T

更新日期：1996-07-01 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) exerts an important role in the late steps of carcinogenesis by cooperating with Ras to induce cell motility and tumor invasion. The transcription complex AP-1 has been implicated in the regulation of genes involved in motility and invasion, by mechanisms not yet delineated. ...

journal_title：Molecular carcinogenesis

authors： Güller MC,André J,Legrand A,Setterblad N,Mauviel A,Verrecchia F,Daniel F,Bernuau D

更新日期：2009-06-01 00:00:00

abstract：:N-nitrosomethylbenzylamine (NMBA)-induced rat esophageal tumorigenesis is an important model for squamous cell carcinoma of the human esophagus. In this model, previous studies have shown that the GGA-->GAA Ha-ras codon 12 mutation is present in the majority of papillomas. No other Ha-ras mutation has been identified....

journal_title：Molecular carcinogenesis

authors： Liston BW,Gupta A,Nines R,Carlton PS,Kresty LA,Harris GK,Stoner GD

更新日期：2001-09-01 00:00:00

abstract：:Increasing evidence from recent research suggests a connection between cancer and a deranged equilibrium of histone acetylation, which is maintained by two competing enzymatic activities, histone acetyltransferases (HATs) and histone deacetylases (HDACs). It is our hypothesis that a significant proportion of leukemias...

journal_title：Molecular carcinogenesis

authors： Mahlknecht U,Ottmann OG,Hoelzer D

更新日期：2000-04-01 00:00:00

abstract：:In this study, we found that rat nasal coumarin-7-hydroxylase (COH) activity was two orders of magnitude higher than rat hepatic COH activity and could be induced by adding coumarin to the rats' drinking water. In western blot analysis, an anti-cytochrome P450 (Cyp) 2a-5 (mouse liver COH) antibody recognized a sharp b...

journal_title：Molecular carcinogenesis

authors： Béréziat JC,Raffalli F,Schmezer P,Frei E,Geneste O,Lang MA

更新日期：1995-10-01 00:00:00

abstract：:Male F(1) hybrids between MSM mice carrying a deficient p53 allele and BALB/c mice were irradiated with gamma-rays, and 80 thymic lymphomas were obtained, 46 of which developed in mice carrying the deficient p53 allele. Because the Y chromosome contributes little to cellular function, the stability of the Y chromosome...

journal_title：Molecular carcinogenesis

authors： Chou D,Matsuki J,Saitou Y,Kosugi SI,Shinbo T,Gejyo F,Niwa O,Kominami R

更新日期：1999-11-01 00:00:00

abstract：:In the present study, we evaluated the effect of deleting Twist1 on keratinocyte proliferation and on skin tumor development using the two-stage chemical carcinogenesis model. BK5.Cre × Twist1(flox/flox) mice, which have a keratinocyte-specific Twist1 knockout (Twist1 KO), developed significantly reduced numbers of pa...

journal_title：Molecular carcinogenesis

authors： Srivastava J,Rho O,Youssef RM,DiGiovanni J

更新日期：2016-05-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest cancers in the world. All-trans retinoic acid (ATRA) is the major physiologically active form of vitamin A, regulating expression of many genes. Disturbances of vitamin A metabolism are prevalent in some cancer cells. The main aim of this work was...

journal_title：Molecular carcinogenesis

authors： Bleul T,Rühl R,Bulashevska S,Karakhanova S,Werner J,Bazhin AV

更新日期：2015-09-01 00:00:00

abstract：:Aberrant epigenetic silencing of the tissue inhibitor of matrix metalloproteinase-3 (TIMP-3) gene that negatively regulates matrix metalloproteinases (MMPs) activity has been implicated in the pathogenesis and metastasis of breast cancer. In the present study, we demonstrate that green tea polyphenols (GTP) and its ma...

journal_title：Molecular carcinogenesis

authors： Deb G,Thakur VS,Limaye AM,Gupta S

更新日期：2015-06-01 00:00:00

abstract：:Carcinogenesis is a multistep sequential process of clonal expansion of initiated cells associated with the accumulation of multiple cancer-specific heritable phenotypes. The acquisition of these heritable cancer-specific alterations may be triggered by mutational and/or non-mutational changes in the genome that affec...

journal_title：Molecular carcinogenesis

authors： Koturbash I,Melnyk S,James SJ,Beland FA,Pogribny IP

更新日期：2013-04-01 00:00:00

abstract：:Dishevelled-3 (Dvl-3) and p120-catenin (p120ctn) have abnormal expression in non-small cell lung cancer (NSCLC), which is associated with poor prognosis. Dvl-3 upregulates p120ctn transcription in NSCLC cells, but the mechanism is unknown. Here we transiently transfected Dvl-3 cDNA to NSCLC cells. Dvl-3 transfection i...

journal_title：Molecular carcinogenesis

authors： Zhao H,Zhao Y,Jiang G,Zhang X,Zhang Y,Dong Q,Luan L,Papavassiliou P,Wang E,Wang E

更新日期：2015-06-01 00:00:00