Abstract:
:Polymorphisms of the base excision repair gene APE1 may be associated with an increased risk for developing prostate cancer. In other cancer types, altered APE1 protein expression is a candidate prognostic marker. Using immunohistochemistry, we thus analyzed APE1 expression in 9763 prostate cancers in a tissue microarray (TMA) with attached clinical and molecular data. The comparison with normal prostate tissue revealed an upregulation of APE1 in cancer samples. APE1 immunostaining was considered weak in 20.2%, moderate in 36.7%, and strong in 33.4% of cancers. Strong APE1 expression was markedly more frequent in prostate cancers harboring the TMPRSS2:ERG fusion (52.9%) than in ERG-negative cancers (19.1%, P < 0.0001). Significant associations with Gleason grade, tumor stage, tumor grade, and early biochemical recurrence (P < 0.0001 each) were largely limited to ERG-negative tumors. Multivariable analysis revealed that the prognostic value of APE1 upregulation in ERG-negative prostate cancers was independent from established histopathological and clinical parameters. In conclusion, the results of our study demonstrate that APE1 overexpression is an independent prognostic marker, but exclusively in ERG-negative prostate cancers.
journal_name
Mol Carcinogjournal_title
Molecular carcinogenesisauthors
Juhnke M,Heumann A,Chirico V,Höflmayer D,Menz A,Hinsch A,Hube-Magg C,Kluth M,Lang DS,Möller-Koop C,Sauter G,Simon R,Beyer B,Pompe R,Thederan I,Schlomm T,Luebke AMdoi
10.1002/mc.22670subject
Has Abstractpub_date
2017-09-01 00:00:00pages
2135-2145issue
9eissn
0899-1987issn
1098-2744journal_volume
56pub_type
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journal_title:Molecular carcinogenesis
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更新日期:2005-09-01 00:00:00
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pub_type: 杂志文章
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journal_title:Molecular carcinogenesis
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doi:
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更新日期:2008-08-01 00:00:00
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更新日期:2014-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-03-01 00:00:00
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更新日期:2003-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
doi:
更新日期:1999-11-01 00:00:00
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更新日期:2008-05-01 00:00:00
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更新日期:2017-03-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章,评审
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更新日期:2013-08-01 00:00:00
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更新日期:2013-06-01 00:00:00
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