In vitro growth suppression and morphological change in a human renal cell carcinoma cell line by the introduction of normal chromosome 3 via microcell fusion.

abstract：:The knowledge about the role of calcium-regulated pathways in cancer cell growth and differentiation could be useful for the development of new therapeutic approaches to diminish its mortality. The ATP2A genes encode for SERCA pumps, which modulate cytosolic Ca2+ concentration, regulating various cellular processes in...

journal_title：Molecular carcinogenesis

authors： Meneses-Morales I,Izquierdo-Torres E,Flores-Peredo L,Rodríguez G,Hernández-Oliveras A,Zarain-Herzberg Á

更新日期：2019-06-01 00:00:00

abstract：:The P53 gene is a tumor suppressor gene and can prevent mutation and tumor induction though apoptosis and DNA repair when it is activated by genotoxic stress. miR-34a expression is regulated by the P53 gene and might be required for cell response to DNA damage. TK6 cells are human lymphoblast cells with normal P53 fun...

journal_title：Molecular carcinogenesis

authors： Chen X,Yan J,Chen T

更新日期：2012-08-01 00:00:00

abstract：:Microsatellite instability (MI) and loss of heterozygosity (LOH) were examined in mammary tumors induced in Sprague-Dawley x F344 F1 female rats by 2-amino-l-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Examination of 62 microsatellite loci revealed MI in nine of 15 (60%) PhIP-induced mammary tumors, and five of thes...

journal_title：Molecular carcinogenesis

authors： Toyota M,Ushijima T,Weisburger JH,Hosoya Y,Canzian F,Rivenson A,Imai K,Sugimura T,Nagao M

更新日期：1996-03-01 00:00:00

abstract：:To analyze the mechanism of neoplastic transformation of rodent diploid cells by ras and myc oncogenes, human EJ c-Ha-ras and mouse c-myc second and third exons promoted by SV40 promoter were connected to pSV2neo and pSV2gpt, respectively. Mouse and rat primary fetal cells cotransfected with both genes formed transfor...

journal_title：Molecular carcinogenesis

authors： Yagi T,Sasayama S,Sasai H,Kakunaga T

更新日期：1989-01-01 00:00:00

abstract：:PCPH is a gene involved in the regulation of eukaryotic cell proliferation and stress response. Recently, analyses of human and animal solid tumors and cell lines suggested that PCPH protein deregulation may participate in neoplastic progression. To test this possibility, we first examined PCPH expression in several l...

journal_title：Molecular carcinogenesis

authors： Blánquez MJ,Regadera J,Mariño J,Newman RE,Notario V

更新日期：2002-12-01 00:00:00

abstract：:Ezrin is known to regulate cellular survival, adhesion, migration, and invasion and has been identified as one of the key components of tumor progression and metastasis. The authors investigated ezrin expression in human hepatocellular carcinoma (HCC) and sought to determine its relation with clinicopathologic paramet...

journal_title：Molecular carcinogenesis

authors： Kang YK,Hong SW,Lee H,Kim WH

更新日期：2010-09-01 00:00:00

abstract：:Centchroman (CC), a female oral contraceptive, has been shown to possess breast anti-cancer activities. Recently, we have shown CC-mediated antimetastatic effect through reversal of epithelial-to-mesenchymal transition (EMT) in breast cancer. The loss of tumor suppressor genes (TSGs) has been shown to promote EMT in b...

journal_title：Molecular carcinogenesis

authors： Khan S,Shukla S,Sinha S,Meeran SM

更新日期：2016-11-01 00:00:00

abstract：:We evaluated whether high-fat diet (HFD), in the absence of increased calorie intake, increases colon cancer growth and metastasis. Four-week-old male BALB/c mice were fed on an HFD (60 kcal% fat) or control diet (10 kcal% fat) for 16 wk, after which CT26 colon cancer cells were subcutaneously injected into the right ...

journal_title：Molecular carcinogenesis

authors： Park H,Kim M,Kwon GT,Lim DY,Yu R,Sung MK,Lee KW,Daily JW 3rd,Park JH

更新日期：2012-11-01 00:00:00

abstract：:Experimentally induced models of breast carcinogenesis in the rat are widely used for studying the biology of breast cancer and for developing and evaluating cancer prevention and control strategies. However, very little is known about gene expression changes that are associated with experimentally induced mammary car...

journal_title：Molecular carcinogenesis

authors： Lu J,Pei H,Kaeck M,Thompson HJ

更新日期：1997-10-01 00:00:00

abstract：:Gliomas are common, aggressive central nervous system tumors with poor overall survival rates. Despite improvements in neurosurgery, chemotherapy, and radiotherapy, the outcomes of patients with malignant gliomas remain poor. Therefore, increased knowledge of the molecular mechanisms that regulate glioma progression i...

journal_title：Molecular carcinogenesis

authors： Zhou Y,Tan Z,Chen K,Wu W,Zhu J,Wu G,Cao L,Zhang X,Zeng X,Li J,Zhang W

更新日期：2018-09-01 00:00:00

abstract：:Carcinogenesis is a multistep sequential process of clonal expansion of initiated cells associated with the accumulation of multiple cancer-specific heritable phenotypes. The acquisition of these heritable cancer-specific alterations may be triggered by mutational and/or non-mutational changes in the genome that affec...

journal_title：Molecular carcinogenesis

authors： Koturbash I,Melnyk S,James SJ,Beland FA,Pogribny IP

更新日期：2013-04-01 00:00:00

abstract：:Inflammation plays a major role in colon carcinogenesis. Endogenously produced specialized proresolving lipid mediators (SPMs) play a central role in inflammation and tissue homeostasis, and have been implicated in carcinogenesis. We studied the associations of plasma levels of two SPMs [lipoxin A4 (LXA4 ) and resolvi...

journal_title：Molecular carcinogenesis

authors： Fedirko V,McKeown-Eyssen G,Serhan CN,Barry EL,Sandler RS,Figueiredo JC,Ahnen DJ,Bresalier RS,Robertson DJ,Anderson CW,Baron JA

更新日期：2017-08-01 00:00:00

abstract：:Preventive measures against oral carcinogenesis are urgently warranted to lower the high morbidity and mortality associated with this malignancy worldwide. Here, we investigated the chemopreventive efficacy of grape seed extract (GSE) and resveratrol (Res) in 4-nitroquinoline-1-oxide (4NQO)-induced tongue tumorigenesi...

journal_title：Molecular carcinogenesis

authors： Shrotriya S,Tyagi A,Deep G,Orlicky DJ,Wisell J,Wang XJ,Sclafani RA,Agarwal R,Agarwal C

更新日期：2015-04-01 00:00:00

abstract：:The physical gut barrier, comprised of a thick mucus layer and the epithelium, plays an important role in defense against microbes and foreign antigens. Calcium and vitamin D may be involved in maintaining the integrity of the intestinal mucosal barrier, the dysfunction of which may lead to endotoxemia and inflammatio...

journal_title：Molecular carcinogenesis

authors： Mandle HB,Jahan FA,Bostick RM,Baron JA,Barry EL,Yacoub R,Merrill J,Rutherford RE,Seabrook ME,Fedirko V

更新日期：2019-07-01 00:00:00

abstract：:Formation of G4 DNA may occur in the course of replication and transcription, and contribute to genomic instability. We have quantitated abundance of G4 motifs and potential for G4 DNA formation of the nontemplate strand of 5' exons and introns of transcripts of human genes. We find that, for all human genes, G4 motif...

journal_title：Molecular carcinogenesis

authors： Eddy J,Maizels N

更新日期：2009-04-01 00:00:00

abstract：:Benzo[alpha]pyrene-7,8-diol-9,10-epoxide (B[a]PDE), the major metabolite of benzo[a]pyrene (B[a]P), shows an ultimate complete carcinogen in various animals and is a causative agent for human cancers. However, its effects on the activation of signal pathways and the expression of genes involved in its carcinogenic eff...

journal_title：Molecular carcinogenesis

authors： Ouyang W,Ma Q,Li J,Zhang D,Ding J,Huang Y,Xing MM,Huang C

更新日期：2007-01-01 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) exerts an important role in the late steps of carcinogenesis by cooperating with Ras to induce cell motility and tumor invasion. The transcription complex AP-1 has been implicated in the regulation of genes involved in motility and invasion, by mechanisms not yet delineated. ...

journal_title：Molecular carcinogenesis

authors： Güller MC,André J,Legrand A,Setterblad N,Mauviel A,Verrecchia F,Daniel F,Bernuau D

更新日期：2009-06-01 00:00:00

abstract：:The Ki-ras proto-oncogene is activated by specific point mutations and is the transforming gene often identified in rodent and human lung tumors. An in vitro model to aid in the study of the consequences of Ki-ras activation and expression in mouse lung is needed. Accordingly, we have examined cell lines derived from ...

journal_title：Molecular carcinogenesis

authors： Pan YH,Nuzum EO,Hanson LA,Beer DG

更新日期：1990-01-01 00:00:00

abstract：:We examined the expression of two groups of matrix metalloproteinases (MMPs), stromelysin and interstitial collagenase, in human skin cancer by northern blot analysis and in situ hybridization. Stromelysin-3 (ST-3) mRNA was overexpressed more than tenfold in 17 of 19 (89%) specimens of basal cell carcinoma (BCC) but i...

journal_title：Molecular carcinogenesis

authors： Majmudar G,Nelson BR,Jensen TC,Voorhees JJ,Johnson TM

更新日期：1994-01-01 00:00:00

abstract：:Bone metastases are common complications of breast cancer. Integrins are the major adhesive molecules in mammalian cells. Here we found that osteoblast conditioned medium (OBCM) increased the migration and cell surface expression of beta1 or beta3 integrin in human breast cancer cells (MDA-MB-231 cells). beta1 or beta...

journal_title：Molecular carcinogenesis

authors： Wei YY,Chen YJ,Hsiao YC,Huang YC,Lai TH,Tang CH

更新日期：2008-07-01 00:00:00

abstract：:Tumor progression is a multistep process, which enables cells to evolve from benign to malignant tumors. This progression has been suggested to depend on six essential characteristics identified as the "hallmarks of cancer," which include: self-sufficiency in growth signals, insensitivity to growth-inhibitory signals,...

journal_title：Molecular carcinogenesis

authors： Cook AC,Tuck AB,McCarthy S,Turner JG,Irby RB,Bloom GC,Yeatman TJ,Chambers AF

更新日期：2005-08-01 00:00:00

abstract：:Glioblastoma (GBM) is the most aggressive and highly invasive type of astrocytic tumors. Despite advances in diagnosis and therapy, the prognosis and survival time remain poor. Identifying key mediators of tumor cell proliferation, migration, and invasion is crucial to the development of new and more effective therapi...

journal_title：Molecular carcinogenesis

authors： Liu X,Gao Q,Zhao N,Zhang X,Cui W,Sun J,Fu J,Hao J

更新日期：2018-04-01 00:00:00

abstract：:Studies with murine models suggest that maternal exposure to aromatic hydrocarbon receptor (AhR) agonists may impair mammary gland differentiation and increase the susceptibility to mammary carcinogenesis in offspring. However, the molecular mechanisms responsible for these perturbations remain largely unknown. Previo...

journal_title：Molecular carcinogenesis

authors： Papoutsis AJ,Selmin OI,Borg JL,Romagnolo DF

更新日期：2015-04-01 00:00:00

abstract：:Krüppel-like factor 4 (KLF4) is a zinc-finger-containing transcription factor with tumor suppressor activity in various cancer types. Cells that sustain double strand breaks (DSBs) in their DNA due to high levels of reactive oxygen species (ROS) can develop genomic instability, which can result in cancer formation. On...

journal_title：Molecular carcinogenesis

authors： Liu C,La Rosa S,Hagos EG

更新日期：2015-09-01 00:00:00

abstract：:Mutations in RB and PTEN are linked to castration resistance and poor prognosis in prostate cancer. Identification of genes that are regulated by these tumor suppressors in a context that recapitulates cancer progression may be beneficial for discovering novel therapeutic targets. Although various genetically engineer...

journal_title：Molecular carcinogenesis

authors： Salah M,Nishimoto Y,Kohno S,Kondoh A,Kitajima S,Muranaka H,Nishiuchi T,Ibrahim A,Yoshida A,Takahashi C

更新日期：2016-12-01 00:00:00

abstract：:In our previous study, we showed that miR-125a directly targeted a WT1 oncogene, which was overexpressed in leukemia and various kinds of solid tumors including lung, breast, gastric, and colon cancers, and brain tumors and was deeply involved in leukemogenesis and tumorigenesis and that miR-125a knockout mice overexp...

journal_title：Molecular carcinogenesis

authors： Hojo N,Tatsumi N,Moriguchi N,Matsumura A,Morimoto S,Nakata J,Fujiki F,Nishida S,Nakajima H,Tsuboi A,Oka Y,Hosen N,Hayashi S,Sugiyama H,Oji Y

更新日期：2016-12-01 00:00:00

abstract：:ZD1839 ("Iressa") is an orally active, selective epidermal growth factor (EGF) receptor-tyrosine kinase inhibitor. We evaluated the antitumor activity of ZD1839 in combination with HSP90 antagonist, 17-AAG in malignant human glioma cell lines. ZD1839 independently produced a dose-dependent inhibition of cellular proli...

journal_title：Molecular carcinogenesis

authors： Premkumar DR,Arnold B,Pollack IF

更新日期：2006-05-01 00:00:00

abstract：:The tumor suppressor p27, which is a member of the Cip/Kip family of Cyclin-dependent kinase inhibitory proteins (CKIs), controls anti-proliferative events. The post-translational addition of O-GlcNAc to p27 occurs in HEK293T and HCC (hepatocellular carcinoma) cell lines, and we identified Ser2, Ser106, Ser110, Thr157...

journal_title：Molecular carcinogenesis

authors： Qiu H,Liu F,Tao T,Zhang D,Liu X,Zhu G,Xu Z,Ni R,Shen A

更新日期：2017-01-01 00:00:00

abstract：:The levels of the antioxidant enzyme manganese superoxide dismutase (Mn-SOD) are frequently decreased in tumor cells and increased in normal cells upon treatment with ionizing radiation. We studied Mn-SOD at different stages during the neoplastic conversion of radiation-initiated Syrian hamster embryo HDR-3 cells. Mn-...

journal_title：Molecular carcinogenesis

authors： Otero G,Avila MA,Emfietzoglou D,Clerch LB,Massaro D,Notario V

更新日期：1996-12-01 00:00:00

abstract：:Breast cancer is a major health problem worldwide. Current standard practices for treatment of breast cancer are less than satisfactory because of high rates of metastasis. Arsenic trioxide (As(2)O(3)), which induces demethylation of DNA and causes apoptosis, has been used as an anti-tumor agent. Little is known, howe...

journal_title：Molecular carcinogenesis

authors： Si L,Jiang F,Li Y,Ye X,Mu J,Wang X,Ning S,Hu C,Li Z

更新日期：2015-09-01 00:00:00