Osteopontin induces multiple changes in gene expression that reflect the six "hallmarks of cancer" in a model of breast cancer progression.

abstract：:Ezrin is known to regulate cellular survival, adhesion, migration, and invasion and has been identified as one of the key components of tumor progression and metastasis. The authors investigated ezrin expression in human hepatocellular carcinoma (HCC) and sought to determine its relation with clinicopathologic paramet...

journal_title：Molecular carcinogenesis

authors： Kang YK,Hong SW,Lee H,Kim WH

更新日期：2010-09-01 00:00:00

abstract：:The Ron receptor tyrosine kinase is overexpressed in approximately half of all human colon cancers. Increased Ron expression positively correlates with tumor progression, and reduction of Ron levels in human colon adenocarcinoma cells reverses their tumorigenic properties. Nearly all colon tumors demonstrate loss of t...

journal_title：Molecular carcinogenesis

authors： Meyer SE,Waltz SE,Goss KH

更新日期：2009-11-01 00:00:00

abstract：:2-Methoxyestradiol (2-ME), an endogenous metabolite of 17beta-estradiol, is present in human blood and urine. Here we show for the first time that 2-ME significantly inhibited the growth of normal prostate epithelial cells and androgen-dependent LNCaP and androgen-independent DU145 prostate cancer cells. This growth i...

journal_title：Molecular carcinogenesis

authors： Kumar AP,Garcia GE,Slaga TJ

更新日期：2001-07-01 00:00:00

abstract：:Ultraviolet (UV) light-induced activation of activator protein-1 (AP-1), resulting at least in part from oxidative stress, promotes skin carcinogenesis. It has not yet been determined whether elevating cellular phase II enzymes and glutathione (GSH) levels inhibits the AP-1 activation. We have, therefore, examined the...

journal_title：Molecular carcinogenesis

authors： Zhu M,Zhang Y,Cooper S,Sikorski E,Rohwer J,Bowden GT

更新日期：2004-11-01 00:00:00

abstract：:In epithelial ovarian cancer, tumor grade is an independent prognosticator whose molecular determinants remain unknown. We investigated patterns of gene expression in well- and poorly differentiated serous papillary ovarian and peritoneal carcinomas with cDNA microarrays. A 6500-feature cDNA microarray was used for co...

journal_title：Molecular carcinogenesis

authors： Jazaeri AA,Lu K,Schmandt R,Harris CP,Rao PH,Sotiriou C,Chandramouli GV,Gershenson DM,Liu ET

更新日期：2003-02-01 00:00:00

abstract：:The DNA repair gene Ku70 plays a key role in the DNA double strand break (DSB) repair system. Defects in DSB repair capacity can lead to genomic instability. We hypothesized that the Ku70 C-1310G polymorphism (rs2267437) was associated with risk of renal cell carcinoma (RCC). We genotyped the Ku70 C-1310G polymorphism...

journal_title：Molecular carcinogenesis

authors： Wang W,Pan X,Huo X,Yan F,Wang M,Wang D,Gao Y,Cao Q,Luo D,Qin C,Yin C,Zhang Z

更新日期：2012-10-01 00:00:00

abstract：:Nuclear factor kappa B (NFkappaB) is a central participant in the metastasis and chemoresistance of colorectal cancer (CRC). However, it is not fully understood to what extent NFkappaB contributes to induction of the metastasis-associated matrix metalloprotease-9 (MMP-9) gene and sensitivity to the commonly used chemo...

journal_title：Molecular carcinogenesis

authors： Fukuyama R,Ng KP,Cicek M,Kelleher C,Niculaita R,Casey G,Sizemore N

更新日期：2007-05-01 00:00:00

abstract：:Aberrant microRNA (miRNA) expression is involved in tumorigenesis of several cancers, including non-small cell lung cancer (NSCLC). Furthermore, expression of some miRNAs has been shown to be under epigenetic regulation. However, less is known regarding the role of miRNA methylation in NSCLC development or clinical ou...

journal_title：Molecular carcinogenesis

authors： Tan W,Gu J,Huang M,Wu X,Hildebrandt MA

更新日期：2015-06-01 00:00:00

abstract：:The mutational specificity of the cyclic nitrosamine N-nitrosopyrrolidine (NPYR) was determined through the DNA sequence characterization of 33 lacl-d mutations of Escherichia coli. Base substitution was the predominant class of mutation induced (91%). The majority of these (64%) occurred at GC base pairs, in accordan...

journal_title：Molecular carcinogenesis

authors： Zielenska M,Ahmed A,Glickman BW

更新日期：1990-01-01 00:00:00

abstract：:Development of chemoresistance in androgen-refractory prostate cancer cells is partly due to constitutive activation of Rel/NF-kappaB transcription factors that regulate several cell survival and anti-apoptotic genes. In this study we examined whether betulinic acid (BetA), a pentacyclic triterpene from the bark of wh...

journal_title：Molecular carcinogenesis

authors： Rabi T,Shukla S,Gupta S

更新日期：2008-12-01 00:00:00

abstract：:Cancer cells mainly rely on glycolysis for energetic needs, and mitochondrial ATP production is almost inactive. However, cancer cells require the integrity of mitochondrial functions for their survival, such as the maintenance of the internal membrane potential gradient (DeltaPsim). It thus may be predicted that Delt...

journal_title：Molecular carcinogenesis

authors： Loiseau D,Morvan D,Chevrollier A,Demidem A,Douay O,Reynier P,Stepien G

更新日期：2009-08-01 00:00:00

abstract：:Hypoxia is a critical event in solid tumor development, invasion, and metastasis. Cellular adaptation to hypoxic microenvironment is essential for tumor progression and is largely mediated by hypoxia-inducible factor-1α (HIF-1α) through coordinated regulation of hypoxia-responsive genes. In this study, we found that m...

journal_title：Molecular carcinogenesis

authors： Zhu S,Zhou Y,Wang L,Zhang J,Wu H,Xiong J,Zhang J,Tian Y,Wang C,Wu H

更新日期：2011-10-01 00:00:00

abstract：:The restriction of energy intake has a profound inhibitory effect on carcinogenesis, yet the mechanism or mechanisms that account for this effect are unknown. In this experiment, the hypothesis tested was that energy restriction upregulates the expression of p27/kip1, a gene product associated with cell-cycle growth a...

journal_title：Molecular carcinogenesis

authors： Zhu Z,Jiang W,Thompson HJ

更新日期：1999-04-01 00:00:00

abstract：:Chromosomal double-strand breaks (DSBs) occurring in mammalian cells can initiate genomic instability, and their misrepairs result in chromosomal deletion, amplification, and translocation, common findings in human tumors. The tumor-suppressor protein p53 is involved in maintaining genomic stability. In this study, we...

journal_title：Molecular carcinogenesis

authors： Honma M,Momose M,Tanabe H,Sakamoto H,Yu Y,Little JB,Sofuni T,Hayashi M

更新日期：2000-08-01 00:00:00

abstract：:Identification of long noncoding RNA (lncRNA) expression quantitative trait loci (lncR-eQTL) that associated with lung cancer can provide insights into regulatory mechanisms of lncRNA, and help reveal the role of lncRNA in lung cancer. A two-stage case-control design was implemented in this study. We first selected th...

journal_title：Molecular carcinogenesis

authors： Sun Q,Wang Y,Fan J,Li Z,Zhang J,Wang L,Fan X,Ji M,Zhu M,Dai J,Ma H,Jin G,Hu Z,Shen H

更新日期：2019-07-01 00:00:00

abstract：:We investigated the in vitro effects of pyrogallol on cell growth, cell cycle regulation, and apoptosis in HeLa cells. Pyrogallol inhibited the growth of HeLa cells with an IC(50) of approximately 45 microM. Pyrogallol induced arrest during all phases of the cell cycle and also very efficiently resulted in apoptosis i...

journal_title：Molecular carcinogenesis

authors： Kim SW,Han YW,Lee ST,Jeong HJ,Kim SH,Kim IH,Lee SO,Kim DG,Kim SH,Kim SZ,Park WH

更新日期：2008-02-01 00:00:00

abstract：:Human colorectal cancer (CRC) cells are resistant to the anti-proliferative effect of transforming growth factor-β (TGF-β), suggesting that disruption of TGF-β signaling plays an important role in colorectal carcinogenesis. Ecotropic virus integration site-1 (Evi-1) oncoprotein represses TGF-β signaling by interacting...

journal_title：Molecular carcinogenesis

authors： Deng X,Cao Y,Liu Y,Li F,Sambandam K,Rajaraman S,Perkins AS,Fields AP,Hellmich MR,Townsend CM Jr,Thompson EA,Ko TC

更新日期：2013-04-01 00:00:00

abstract：:The influence of the tumor promoter 2-acetylaminofluorene (2-AAF) on cell proliferation and on the epidermal growth factor receptor (EGFR) system was assessed in normal and nodular rat livers. DNA replication in vivo was inhibited below the detection level after 8d of dietary 2-AAF treatment of previously unexposed ra...

journal_title：Molecular carcinogenesis

authors： Strömblad S,Eriksson LC,Andersson G

更新日期：1994-06-01 00:00:00

abstract：:Both EGFR and HER2 are important mediators of tumorigenesis and tumor progression. Despite their best-characterized roles as plasma membrane-bound receptors, both receptors undergo nuclear translocation though the impact of this process remains unclear. In this study, we provide evidence showing that EGFR upregulates ...

journal_title：Molecular carcinogenesis

authors： Han W,Carpenter RL,Cao X,Lo HW

更新日期：2013-12-01 00:00:00

abstract：:Osteosarcoma (OS) is the most frequent primary bone tumor that affect children and adolescents. This tumor is highly aggressive with high risk of metastasis and the implementation of new drugs has not been successful. The search for biomarkers or new therapeutic targets is urgently needed and can help in advances of O...

journal_title：Molecular carcinogenesis

authors： Lopes LJS,Tesser-Gamba F,Petrilli AS,de Seixas Alves MT,Garcia-Filho RJ,Toledo SRC

更新日期：2017-06-01 00:00:00

abstract：:Paclitaxel is the last choice for the treatment of advanced melanoma as a second-line chemotherapeutic agent, but there are still many cases of intrinsic resistance to paclitaxel in melanoma and the reasons that cause paclitaxel resistance remain unclear. Here, we identified that high expression of SRY-box transcripti...

journal_title：Molecular carcinogenesis

authors： Si X,Gao Z,Xu F,Zheng Y

更新日期：2020-03-01 00:00:00

abstract：:Transformation of cloned rat embryo fibroblast (CREF) cells with the wild-type 5 adenovirus (wtAd5) transforming genes E1A and E1B (which extend from 0 to 11.2 map units) results in morphologically transformed cells that exhibit an increased saturation density in monolayer culture and display an anchorage-independent ...

journal_title：Molecular carcinogenesis

authors： Boylan JF,Shih TY,Fisher PB,Zimmer SG

更新日期：1992-01-01 00:00:00

abstract：:The vaccinia virus cDNA expression system was used to produce human cytochrome P450 IA2 in a hepatoma cell line that is devoid of significant basal levels of P450. The expressed enzyme yielded a reduced carbon monoxide-bound difference spectrum with a lambda max of 449 nm. Catalytic activities and mutagen activation a...

journal_title：Molecular carcinogenesis

authors： Aoyama T,Gonzalez FJ,Gelboin HV

更新日期：1989-01-01 00:00:00

abstract：:Withaferin A (WA), a natural product derived from Withania somnifera, has been used in traditional oriental medicines to treat neurological disorders. Recent studies have demonstrated that this compound may have a potential for cancer treatment and a clinical trial has been launched to test WA in treating melanoma. He...

journal_title：Molecular carcinogenesis

authors： Li W,Zhang C,Du H,Huang V,Sun B,Harris JP,Richardson Q,Shen X,Jin R,Li G,Kevil CG,Gu X,Shi R,Zhao Y

更新日期：2016-11-01 00:00:00

abstract：:The abnormal expression of adipocyte enhancer binding protein 1 (AEBP1) has been implicated in the carcinogenesis and progression of various types of human tumors. However, the role of AEBP1 in colon adenocarcinoma (COAD) remains largely unelucidated. In this study, we explored the clinical significance and biological...

journal_title：Molecular carcinogenesis

authors： Xing Y,Zhang Z,Chi F,Zhou Y,Ren S,Zhao Z,Zhu Y,Piao D

更新日期：2019-10-01 00:00:00

abstract：:DPC4/SMAD4 is a candidate tumor suppressor gene with a strikingly high frequency of gene alterations in pancreatic cancer that suggests a discrete role for DPC4 in these tumors. DPC4 tumor-suppressive function has been implicated to mediate the transforming growth factor-beta (TGFbeta)-suppressive pathway; however, in...

journal_title：Molecular carcinogenesis

authors： Dai JL,Schutte M,Bansal RK,Wilentz RE,Sugar AY,Kern SE

更新日期：1999-09-01 00:00:00

abstract：:The genetic or functional inactivation of the p53 pathway plays an important role with regards to disease progression from the chronic phase (CP) to blast phase (BP) and imatinib treatment response in chronic myeloid leukemia (CML). Two functional single nucleotide polymorphisms (SNPs), p53 R72P and MDM2 SNP309, are a...

journal_title：Molecular carcinogenesis

authors： Liu YC,Hsiao HH,Yang WC,Liu TC,Chang CS,Yang MY,Lin PM,Hsu JF,Lee CP,Lin SF

更新日期：2014-12-01 00:00:00

abstract：:Hepatitis B virus (HBV) X protein (HBx) and cyclooxygenase-2 (COX-2) are all playing roles in hepatocellular carcinoma (HCC), but the reversing effects of COX-2 inhibitors on the neoplastic features caused by HBx protein is still unclear. To further evaluate the therapeutic potential of celecoxib on HBx mediated trans...

journal_title：Molecular carcinogenesis

authors： Xie H,Gao L,Chai N,Song J,Wang J,Song Z,Chen C,Pan Y,Zhao L,Sun S,Wu K,Feitelson MA,Liu J,Fan D

更新日期：2009-01-01 00:00:00

abstract：:DIXDC1 (Dishevelled-Axin domain containing 1) is a DIX (Dishevelled-Axin) domain-possessing protein that promotes colon cancer cell proliferation and increases the invasion and migration ability of non-small-cell lung cancer via the PI3K pathway. As a positive regulator of the Wnt/β-catenin pathway, the biological rol...

journal_title：Molecular carcinogenesis

authors： Tan C,Qiao F,Wei P,Chi Y,Wang W,Ni S,Wang Q,Chen T,Sheng W,Du X,Wang L

更新日期：2016-04-01 00:00:00

abstract：:Nonmelanoma skin cancers (NMSCs) consist of a variety of tumor types including basal cell carcinoma, squamous cell carcinoma, a variety of hair follicle tumors, and sebaceous gland tumors. Genetic alterations that alter the fate of multipotent stem cells are believed to influence NMSC phenotype. We previously generate...

journal_title：Molecular carcinogenesis

authors： Honeycutt KA,Waikel RL,Koster MI,Wang XJ,Roop DR

更新日期：2010-04-01 00:00:00