Requirement of wild-type p53 protein for maintenance of chromosomal integrity.

abstract：:Transforming growth factor beta (TGFbeta) signaling has both tumor suppression and promotion roles. Smads are transcription factors that primarily mediate intracellular signaling for the TGFbeta superfamily. Loss of Smad2 and Smad4, but not Smad3 is common in human cancers. Given the complex nature of TGFbeta signalin...

journal_title：Molecular carcinogenesis

authors： Bornstein S,Hoot K,Han GW,Lu SL,Wang XJ

更新日期：2007-08-01 00:00:00

abstract：:Reports on the association of TP53 polymorphisms with oral cancer are not only limited but also not specific to site and/or gender. Hence, we examined the effect of TP53 polymorphisms (EX4 215G>C, IVS3+40-41ins16 and IVS6+62G>A) on buccal mucosa cancer (BMC) and tongue cancer (TC) risk, survival of patients in relatio...

journal_title：Molecular carcinogenesis

authors： Nagam SL,Katta S,Prasad VV

更新日期：2017-03-01 00:00:00

abstract：:Plakoglobin (Pg) and beta-catenin are homologous proteins that function in cell-cell adhesion and signaling. The cadherin-associated form of these proteins mediates adhesion, whereas the cytosolic/nuclear form has a signaling role. Despite their interactions with common cellular partners, beta-catenin has a well-docum...

journal_title：Molecular carcinogenesis

authors： Li L,Chapman K,Hu X,Wong A,Pasdar M

更新日期：2007-10-01 00:00:00

abstract：:Adipose tissue dysregulation, a hallmark of obesity, contributes to a chronic state of low-grade inflammation and is associated with increased risk and progression of several breast cancer subtypes, including claudin-low breast tumors. Unfortunately, mechanistic targets for breaking the links between obesity-associate...

journal_title：Molecular carcinogenesis

authors： Rossi EL,Khatib SA,Doerstling SS,Bowers LW,Pruski M,Ford NA,Glickman RD,Niu M,Yang P,Cui Z,DiGiovanni J,Hursting SD

更新日期：2018-03-01 00:00:00

abstract：:Breast cancer is a major health problem worldwide. Current standard practices for treatment of breast cancer are less than satisfactory because of high rates of metastasis. Arsenic trioxide (As(2)O(3)), which induces demethylation of DNA and causes apoptosis, has been used as an anti-tumor agent. Little is known, howe...

journal_title：Molecular carcinogenesis

authors： Si L,Jiang F,Li Y,Ye X,Mu J,Wang X,Ning S,Hu C,Li Z

更新日期：2015-09-01 00:00:00

abstract：:Dietary prevention is a cost-efficient strategy to reduce the risk of human cancers. More than 85% breast cancers are sporadic and attributable to long-term exposure to environmental carcinogens through a multistep and multiyear disease process. We used our chronically induced cellular carcinogenesis model as a target...

journal_title：Molecular carcinogenesis

authors： Choudhary S,Sood S,Wang HC

更新日期：2014-03-01 00:00:00

abstract：:Promoter hypermethylation is gaining strength as one of the main mechanisms through which tumor suppressor genes are silenced during tumor progression. Three tumor suppressor genes are frequently found methylated in their promoter, in concordance with absence of expression, RASSF1A, SLIT2, and WIF1. In addition, a pre...

journal_title：Molecular carcinogenesis

authors： Alvarez C,Tapia T,Cornejo V,Fernandez W,Muñoz A,Camus M,Alvarez M,Devoto L,Carvallo P

更新日期：2013-06-01 00:00:00

abstract：:The growth hormone receptor (GHR) and growth hormone-binding protein (GH-BP) expression were characterized in liver nodules and hepatomas from male Wistar rats. The mRNA levels of GHR and GH-BP, studied by northern blot analysis and solution hybridization, were 35-50% (in nodules) and 2-6% (in hepatomas) of the level ...

journal_title：Molecular carcinogenesis

authors： Levinovitz A,Husman B,Eriksson LC,Norstedt G,Andersson G

更新日期：1990-01-01 00:00:00

abstract：:The identification of cancer-associated long non-coding RNAs (lncRNAs) and the investigation of their molecular and biological functions are vital for understanding the molecular biology and progression of cancer. The lncRNA-LET, a newly identified lncRNA, was demonstrated to be down-regulated in hepatocellular cancer...

journal_title：Molecular carcinogenesis

authors： Ma MZ,Kong X,Weng MZ,Zhang MD,Qin YY,Gong W,Zhang WJ,Quan ZW

更新日期：2015-11-01 00:00:00

abstract：:Heat shock protein 60 (HSP60) overexpresses in various types of cancer, but its expression levels and functions in hepatocellular carcinoma (HCC) are still in dispute. We aim to clarify this issue and examine whether HSP60 could be a therapeutic target for HCC. We found drastically enhanced cell apoptosis and suppress...

journal_title：Molecular carcinogenesis

authors： Huang YH,Lin KH,Yu JS,Wu TJ,Lee WC,Chao CC,Pan TL,Yeh CT

更新日期：2018-09-01 00:00:00

abstract：:Merkel cell carcinoma (MCC) is a rare neuroendocrine carcinoma of the skin, for which the exact mechanisms of carcinogenesis remain unknown. Therapeutic options for this highly aggressive malignancy have historically been limited in both their initial response and response durability. Recent improvements in our unders...

journal_title：Molecular carcinogenesis

authors： Cohen L,Tsai KY

更新日期：2019-09-01 00:00:00

abstract：:2-Methoxyestradiol (2-ME), an endogenous metabolite of 17beta-estradiol, is present in human blood and urine. Here we show for the first time that 2-ME significantly inhibited the growth of normal prostate epithelial cells and androgen-dependent LNCaP and androgen-independent DU145 prostate cancer cells. This growth i...

journal_title：Molecular carcinogenesis

authors： Kumar AP,Garcia GE,Slaga TJ

更新日期：2001-07-01 00:00:00

abstract：:The metalloproteinase matrilysin is widely expressed in the epithelial tumor cells of malignant colorectal adenocarcinomas. Approximately 50% of benign adenomas also express low levels of matrilysin that is focally localized. The expression of stromelysin-1, stromelysin-3, and gelatinase A was observed in the stromal ...

journal_title：Molecular carcinogenesis

authors： Newell KJ,Witty JP,Rodgers WH,Matrisian LM

更新日期：1994-08-01 00:00:00

abstract：:Prostate cancer (PCA) is the second most malignancy in American men. Advanced stage PCA cells possess unlimited replication potential as well as resistance to apoptosis. Therefore, targeting survival mechanisms and activating apoptotic machinery in PCA cells using nontoxic phytochemicals is suggested as an attractive ...

journal_title：Molecular carcinogenesis

authors： Deep G,Gangar SC,Oberlies NH,Kroll DJ,Agarwal R

更新日期：2010-10-01 00:00:00

abstract：:Overexpression of Fas ligand (FasL) in cancer cells elicits potential antitumor effects via recruitment of neutrophils. Conversely, FasL-expressing tumors may counterattack tumor-infiltrating lymphocytes by delivering apoptotic death signals via Fas/FasL interactions, which may lead to tumor escape. In order to distin...

journal_title：Molecular carcinogenesis

authors： Chiu HY,Sun GH,Chen SY,Wang HH,Ho MY,Chu CY,Wu WL,Jhou RS,Tsai YL,Huang RT,Sun KH,Tang SJ

更新日期：2013-09-01 00:00:00

abstract：:N(6)-isopentenyladenosine (i6A) inhibits the tumor cell growth by inducing cell apoptosis in various cancer cell lines. However, little is known regarding the mechanisms by which the drug induces cell apoptosis. In this study, we further explored the molecular mechanisms of i6A as an anticancer agent on a human breast...

journal_title：Molecular carcinogenesis

authors： Laezza C,Malfitano AM,Di Matola T,Ricchi P,Bifulco M

更新日期：2010-10-01 00:00:00

abstract：:High rate of chronic hepatitis B virus (HBV) infection and p16 promoter methylation were found in the majority of hepatocellular carcinoma (HCC). To investigate the potential linkage between high rate of p16 methylation and HBV infection, p16 methylation was detected with methylation-specific polymerase chain reaction...

journal_title：Molecular carcinogenesis

authors： Jicai Z,Zongtao Y,Jun L,Haiping L,Jianmin W,Lihua H

更新日期：2006-07-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) is a growth modulator that inhibits the proliferation of many epithelial cells through interaction with its receptors, the type I and type II receptors (TGF-beta RI and RII) by activating their serine/threonine kinase activities. Loss of growth inhibition by TGF-beta is thoug...

journal_title：Molecular carcinogenesis

authors： Jakowlew SB,Moody TW,You L,Mariano JM

更新日期：1998-05-01 00:00:00

abstract：:Withaferin A (WA), a natural product derived from Withania somnifera, has been used in traditional oriental medicines to treat neurological disorders. Recent studies have demonstrated that this compound may have a potential for cancer treatment and a clinical trial has been launched to test WA in treating melanoma. He...

journal_title：Molecular carcinogenesis

authors： Li W,Zhang C,Du H,Huang V,Sun B,Harris JP,Richardson Q,Shen X,Jin R,Li G,Kevil CG,Gu X,Shi R,Zhao Y

更新日期：2016-11-01 00:00:00

abstract：:The role of estrogen and the estrogen receptor (ER) in the induction and promotion of tumors was investigated by using transgenic MT-mER mice, which overexpress the ER. It was hypothesized that because of this abnormal expression of the ER, the reproductive-tract tissues of the MT-mER mice may be more susceptible to t...

journal_title：Molecular carcinogenesis

authors： Couse JF,Davis VL,Hanson RB,Jefferson WN,McLachlan JA,Bullock BC,Newbold RR,Korach KS

更新日期：1997-08-01 00:00:00

abstract：:Genotoxicity tests indicate methanol (MeOH) is not mutagenic, but a rodent study has suggested carcinogenic potential, which could result from free radical-initiated oxidative DNA damage. To investigate this possibility we treated male CD-1 mice, New Zealand white rabbits, and cynomolgus monkeys with MeOH (2.0 g/kg ip...

journal_title：Molecular carcinogenesis

authors： McCallum GP,Siu M,Ondovcik SL,Sweeting JN,Wells PG

更新日期：2011-03-01 00:00:00

abstract：:Dishevelled-3 (Dvl-3) and p120-catenin (p120ctn) have abnormal expression in non-small cell lung cancer (NSCLC), which is associated with poor prognosis. Dvl-3 upregulates p120ctn transcription in NSCLC cells, but the mechanism is unknown. Here we transiently transfected Dvl-3 cDNA to NSCLC cells. Dvl-3 transfection i...

journal_title：Molecular carcinogenesis

authors： Zhao H,Zhao Y,Jiang G,Zhang X,Zhang Y,Dong Q,Luan L,Papavassiliou P,Wang E,Wang E

更新日期：2015-06-01 00:00:00

abstract：:Nonmelanoma skin cancers (NMSCs) consist of a variety of tumor types including basal cell carcinoma, squamous cell carcinoma, a variety of hair follicle tumors, and sebaceous gland tumors. Genetic alterations that alter the fate of multipotent stem cells are believed to influence NMSC phenotype. We previously generate...

journal_title：Molecular carcinogenesis

authors： Honeycutt KA,Waikel RL,Koster MI,Wang XJ,Roop DR

更新日期：2010-04-01 00:00:00

abstract：:Protein kinases play important roles in tumor development and progression. A variety of members of the signal transduction enzymes serve as targets for therapeutic intervention in cancer. The dysregulation of Axl receptor and its ligand growth arrest-specific 6 (Gas6) is implicated in the pathogenesis of several cance...

journal_title：Molecular carcinogenesis

authors： He L,Zhang J,Jiang L,Jin C,Zhao Y,Yang G,Jia L

更新日期：2010-10-01 00:00:00

abstract：:Microsatellite instability (MI) and loss of heterozygosity (LOH) were examined in mammary tumors induced in Sprague-Dawley x F344 F1 female rats by 2-amino-l-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Examination of 62 microsatellite loci revealed MI in nine of 15 (60%) PhIP-induced mammary tumors, and five of thes...

journal_title：Molecular carcinogenesis

authors： Toyota M,Ushijima T,Weisburger JH,Hosoya Y,Canzian F,Rivenson A,Imai K,Sugimura T,Nagao M

更新日期：1996-03-01 00:00:00

abstract：:Bcl-x(L) is one of several antiapoptotic proteins regulated by signal transducer and activator of transcription 3 (Stat3). We have recently shown that Stat3 is required for chemically induced and ultraviolet B (UVB)-induced skin carcinogenesis. In this study, the functional role of Bcl-x(L) in skin carcinogenesis was ...

journal_title：Molecular carcinogenesis

authors： Kim DJ,Kataoka K,Sano S,Connolly K,Kiguchi K,DiGiovanni J

更新日期：2009-10-01 00:00:00

abstract：:Liver tumors of certain strains of mice frequently contain mutations at codon 61 of the c-Ha-ras gene. In our study, we investigated the significance of these mutations in the carcinogenic process. Male C3H/He mice received a single injection of diethylnitrosamine (DEN) on day 15 after birth, and groups of animals wer...

journal_title：Molecular carcinogenesis

authors： Bauer-Hofmann R,Klimek F,Buchmann A,Müller O,Bannasch P,Schwarz M

更新日期：1992-01-01 00:00:00

abstract：:In the present study, we evaluated the effect of deleting Twist1 on keratinocyte proliferation and on skin tumor development using the two-stage chemical carcinogenesis model. BK5.Cre × Twist1(flox/flox) mice, which have a keratinocyte-specific Twist1 knockout (Twist1 KO), developed significantly reduced numbers of pa...

journal_title：Molecular carcinogenesis

authors： Srivastava J,Rho O,Youssef RM,DiGiovanni J

更新日期：2016-05-01 00:00:00

abstract：:To study the possible involvement of DNA damage in cell transformation induced by estrogens, we examined whether DNA adduct formation is elicited in cultured Syrian hamster embryo (SHE) cells treated with estrogens and their derivatives by means of the 32P-postlabeling assay. Morphological transformation of the cells ...

journal_title：Molecular carcinogenesis

authors： Hayashi N,Hasegawa K,Komine A,Tanaka Y,McLachian JA,Barrett JC,Tsutsui T

更新日期：1996-07-01 00:00:00

abstract：:Ultraviolet (UV) light-induced activation of activator protein-1 (AP-1), resulting at least in part from oxidative stress, promotes skin carcinogenesis. It has not yet been determined whether elevating cellular phase II enzymes and glutathione (GSH) levels inhibits the AP-1 activation. We have, therefore, examined the...

journal_title：Molecular carcinogenesis

authors： Zhu M,Zhang Y,Cooper S,Sikorski E,Rohwer J,Bowden GT

更新日期：2004-11-01 00:00:00