Pre-existing Fas ligand (FasL) in cancer cells elicits tumor-specific protective immunity, but delayed induction of FasL expression after inoculation facilitates tumor formation.

abstract：:Because oxidative processes can participate in tumor promotion, it is likely that the cellular antioxidant defense also plays a role. We have compared the levels of the three major antioxidant enzymes, Cu,Zn-superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx), in promotable mouse epidermal JB6 cells ...

journal_title：Molecular carcinogenesis

authors： Crawford DR,Amstad PA,Foo DD,Cerutti PA

更新日期：1989-01-01 00:00:00

abstract：:Liver tumors of certain strains of mice frequently contain mutations at codon 61 of the c-Ha-ras gene. In our study, we investigated the significance of these mutations in the carcinogenic process. Male C3H/He mice received a single injection of diethylnitrosamine (DEN) on day 15 after birth, and groups of animals wer...

journal_title：Molecular carcinogenesis

authors： Bauer-Hofmann R,Klimek F,Buchmann A,Müller O,Bannasch P,Schwarz M

更新日期：1992-01-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) is a cellular energy sensor that is conserved in eukaryotes. Although AMPK is traditionally thought to play a major role in the regulation of cellular lipid and protein metabolism, recent discoveries reveal that AMPK inhibits mammalian target of rapamycin (mTOR) signaling and connec...

journal_title：Molecular carcinogenesis

authors： Tong X,Smith KA,Pelling JC

更新日期：2012-03-01 00:00:00

abstract：:Transgenic mice were developed to study the role of c-src in epithelial tumorigenesis through targeted expression of a constitutively active form of murine c-src (src(529)). Src(529) was targeted to the interfollicular epidermis with the human keratin 1 (HK1) promoter. The skin phenotype of these mice was characterize...

journal_title：Molecular carcinogenesis

authors： Matsumoto T,Jiang J,Kiguchi K,Carbajal S,Rho O,Gimenez-Conti I,Beltrán L,DiGiovanni J

更新日期：2002-03-01 00:00:00

abstract：:RAD51D, a paralog of the mammalian RAD51 gene, contributes towards maintaining genomic integrity by homologous recombination DNA repair and telomere maintenance. A RAD51D variant, E233G, was initially identified as a potential susceptibility allele in high-risk, site-specific, familial breast cancer. We describe in th...

journal_title：Molecular carcinogenesis

authors： Nadkarni A,Rajesh P,Ruch RJ,Pittman DL

更新日期：2009-07-01 00:00:00

abstract：:The aims of the present study are to investigate sub-cellular location, differential expression in different cancer stages and functional role of FAM134B in colon cancer development. FAM134B expression was studied and quantified at protein and mRNA levels in cell lines using immunocytochemistry, Western blot and real-...

journal_title：Molecular carcinogenesis

authors： Islam F,Gopalan V,Wahab R,Smith RA,Qiao B,Lam AK

更新日期：2017-01-01 00:00:00

abstract：:Although carcinoma of the uterine endometrium is the most frequently diagnosed malignancy of the female reproductive tract, the molecular genetic features of this tumor have yet to be described in significant detail. Since mutations of the p53 tumor suppressor gene are the single most common genetic alteration found i...

journal_title：Molecular carcinogenesis

authors： Risinger JI,Dent GA,Ignar-Trowbridge D,McLachlan JA,Tsao MS,Senterman M,Boyd J

更新日期：1992-01-01 00:00:00

abstract：:The majority of human neoplasms have aberrations in the retinoblastoma pathway due to hyperactivation of cyclin-dependent kinases (CDK). Based on this observation, novel small molecules, such as flavopiridol and UCN-01, are being developed and are currently being tested in the clinic. Efforts to develop CDK modulators...

journal_title：Molecular carcinogenesis

authors： Lahusen T,De Siervi A,Kunick C,Senderowicz AM

更新日期：2003-04-01 00:00:00

abstract：:The aim of this study is to evaluate the role of adipose tissue resident stromal cells on tumor cell invasion. Our data show that a subpopulation of adipose tissue derived stromal cells expressing Nestin, NG2, α-smooth muscle actin and PDGFR-α migrate toward the cancer cells. Microarray analysis revealed the upregulat...

journal_title：Molecular carcinogenesis

authors： Welte G,Alt E,Devarajan E,Krishnappa S,Jotzu C,Song YH

更新日期：2012-11-01 00:00:00

abstract：:Promoter hypermethylation is gaining strength as one of the main mechanisms through which tumor suppressor genes are silenced during tumor progression. Three tumor suppressor genes are frequently found methylated in their promoter, in concordance with absence of expression, RASSF1A, SLIT2, and WIF1. In addition, a pre...

journal_title：Molecular carcinogenesis

authors： Alvarez C,Tapia T,Cornejo V,Fernandez W,Muñoz A,Camus M,Alvarez M,Devoto L,Carvallo P

更新日期：2013-06-01 00:00:00

abstract：:Gliomas are common, aggressive central nervous system tumors with poor overall survival rates. Despite improvements in neurosurgery, chemotherapy, and radiotherapy, the outcomes of patients with malignant gliomas remain poor. Therefore, increased knowledge of the molecular mechanisms that regulate glioma progression i...

journal_title：Molecular carcinogenesis

authors： Zhou Y,Tan Z,Chen K,Wu W,Zhu J,Wu G,Cao L,Zhang X,Zeng X,Li J,Zhang W

更新日期：2018-09-01 00:00:00

abstract：:Expression of the tumor suppressor deleted in liver cancer-1 (DLC-1) is lost in non-small cell lung (NSCLC) and other human carcinomas, and ectopic DLC-1 expression dramatically reduces proliferation and tumorigenicity. DLC-1 is a multi-domain protein that includes a Rho GTPase activating protein (RhoGAP) domain which...

journal_title：Molecular carcinogenesis

authors： Healy KD,Hodgson L,Kim TY,Shutes A,Maddileti S,Juliano RL,Hahn KM,Harden TK,Bang YJ,Der CJ

更新日期：2008-05-01 00:00:00

abstract：:Osteosarcoma (OS) is the most frequent primary bone tumor that affect children and adolescents. This tumor is highly aggressive with high risk of metastasis and the implementation of new drugs has not been successful. The search for biomarkers or new therapeutic targets is urgently needed and can help in advances of O...

journal_title：Molecular carcinogenesis

authors： Lopes LJS,Tesser-Gamba F,Petrilli AS,de Seixas Alves MT,Garcia-Filho RJ,Toledo SRC

更新日期：2017-06-01 00:00:00

abstract：:The pi-class glutathione S-transferase (GSTP1) actively protect cells from carcinogens and electrophilic compounds. Loss of GSTP1 expression via promoter hypermethylation is the most common epigenetic alteration observed in human prostate cancer. Silencing of GSTP1 can increase generation of reactive oxygen species (R...

journal_title：Molecular carcinogenesis

authors： Kanwal R,Pandey M,Bhaskaran N,Maclennan GT,Fu P,Ponsky LE,Gupta S

更新日期：2014-01-01 00:00:00

abstract：:Reports on the association of TP53 polymorphisms with oral cancer are not only limited but also not specific to site and/or gender. Hence, we examined the effect of TP53 polymorphisms (EX4 215G>C, IVS3+40-41ins16 and IVS6+62G>A) on buccal mucosa cancer (BMC) and tongue cancer (TC) risk, survival of patients in relatio...

journal_title：Molecular carcinogenesis

authors： Nagam SL,Katta S,Prasad VV

更新日期：2017-03-01 00:00:00

abstract：:We have reported that connexin (Cx) 32 gene, a member of gap junction protein family, acts as a tumor suppressor gene in human renal cell carcinoma (RCC). Of solid tumors, RCC is one of the most chemoresistant cancers, and there is no effective cancer chemotherapy against RCC at present. In this study, we examined if ...

journal_title：Molecular carcinogenesis

authors： Sato H,Senba H,Virgona N,Fukumoto K,Ishida T,Hagiwara H,Negishi E,Ueno K,Yamasaki H,Yano T

更新日期：2007-03-01 00:00:00

abstract：:The cellular response to cisplatin involves activation of multiple signal transduction pathways, including the mitogen-activated protein (MAP) kinase pathways. In this study, we compared the cisplatin-induced activation of two MAP kinases, c-jun N-terminal kinase 1 (JNK1) and extracellular signal-regulated protein kin...

journal_title：Molecular carcinogenesis

authors： Cui W,Yazlovitskaya EM,Mayo MS,Pelling JC,Persons DL

更新日期：2000-12-01 00:00:00

abstract：:There is an unmet need to develop new agents or strategies against therapy resistant pancreatic cancer (PanCA). Recent studies from our laboratory showed that STAT3 negatively regulates NF-κB and that inhibition of this crosstalk using Nexrutine® (Nx) reduces transcriptional activity of COX-2. Inhibition of these mole...

journal_title：Molecular carcinogenesis

authors： Gong J,Muñoz AR,Pingali S,Payton-Stewart F,Chan DE,Freeman JW,Ghosh R,Kumar AP

更新日期：2017-02-01 00:00:00

abstract：:Loss or decrease of wild type BRCA1 function, by either mutation or reduced expression, has a role in hereditary and sporadic human breast and ovarian cancers. We report here that the PI3K/AKT pathway is constitutively active in BRCA1-defective human breast cancer cells. Levels of phospho-AKT are sustained even after ...

journal_title：Molecular carcinogenesis

authors： Yi YW,Kang HJ,Kim HJ,Hwang JS,Wang A,Bae I

更新日期：2013-09-01 00:00:00

abstract：:Increased epidermal growth factor receptor (EGFR) expression in triple-negative breast cancer (TNBC) is recognized as a promising therapeutic target, specifically through the use of selective EGFR inhibitors combined with chemotherapies. TNBC is characterized by genetic instability that leads to increased sensitivity ...

journal_title：Molecular carcinogenesis

authors： El Guerrab A,Bamdad M,Bignon YJ,Penault-Llorca F,Aubel C

更新日期：2017-05-01 00:00:00

abstract：:Triptolide is an active component from a Chinese herb, Tripterygium wilfordii which has been applied for treating immune-related diseases over centuries. Recently, it was reported that a variety of cancer cell lines could be sensitized to DNA-damage based chemotherapy drugs in combination with Triptolide treatment. In...

journal_title：Molecular carcinogenesis

authors： Deng Y,Li F,He P,Yang Y,Yang J,Zhang Y,Liu J,Tong Y,Li Q,Mei X,Shu Z,Zhao Q

更新日期：2018-06-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common malignant tumors worldwide. As tumor metastasis is the leading cause of death in patients with CRC, it is important to elucidate the molecular mechanisms that drive CRC metastasis. Studies have shown a close relationship between Iroquois homeobox (IRX) family genes and...

journal_title：Molecular carcinogenesis

authors： Zhu Q,Wu Y,Yang M,Wang Z,Zhang H,Jiang X,Chen M,Jin T,Wang T

更新日期：2019-11-01 00:00:00

abstract：:Extrachromosomal replication of viral DNA sequences has been observed in transformed as well as in normal cells following "stress"-inducing treatments. To explore the effect of growth conditions on the ability to support such replication, we analyzed SEWA sarcoma cells that grew subcutaneously or as ascites tumors in ...

journal_title：Molecular carcinogenesis

authors： Robinson R,Ronai Z

更新日期：1990-01-01 00:00:00

abstract：:Sprouty (SPRY) appears to act as a tumor suppressor in cancer, whereas we reported that SPRY2 functions as a putative oncogene in colorectal cancer (CRC) [Oncogene, 2010, 29: 5241-5253]. In general, various studies established inhibition of cell proliferation by SPRY in cancer. The mechanisms by which SPRY regulates c...

journal_title：Molecular carcinogenesis

authors： Zhang Q,Shim K,Wright K,Jurkevich A,Khare S

更新日期：2016-09-01 00:00:00

abstract：:The knowledge about the role of calcium-regulated pathways in cancer cell growth and differentiation could be useful for the development of new therapeutic approaches to diminish its mortality. The ATP2A genes encode for SERCA pumps, which modulate cytosolic Ca2+ concentration, regulating various cellular processes in...

journal_title：Molecular carcinogenesis

authors： Meneses-Morales I,Izquierdo-Torres E,Flores-Peredo L,Rodríguez G,Hernández-Oliveras A,Zarain-Herzberg Á

更新日期：2019-06-01 00:00:00

abstract：:Hepatitis B virus (HBV) X protein (HBx) and cyclooxygenase-2 (COX-2) are all playing roles in hepatocellular carcinoma (HCC), but the reversing effects of COX-2 inhibitors on the neoplastic features caused by HBx protein is still unclear. To further evaluate the therapeutic potential of celecoxib on HBx mediated trans...

journal_title：Molecular carcinogenesis

authors： Xie H,Gao L,Chai N,Song J,Wang J,Song Z,Chen C,Pan Y,Zhao L,Sun S,Wu K,Feitelson MA,Liu J,Fan D

更新日期：2009-01-01 00:00:00

abstract：:Increasing evidence from recent research suggests a connection between cancer and a deranged equilibrium of histone acetylation, which is maintained by two competing enzymatic activities, histone acetyltransferases (HATs) and histone deacetylases (HDACs). It is our hypothesis that a significant proportion of leukemias...

journal_title：Molecular carcinogenesis

authors： Mahlknecht U,Ottmann OG,Hoelzer D

更新日期：2000-04-01 00:00:00

abstract：:Malignant rhabdoid tumors (MRTs) are poorly differentiated pediatric cancers that arise in various anatomical locations and have a very poor outcome. The large majority of these malignancies are caused by loss of function of the SNF5/INI1 component of the SWI/SNF chromatin remodeling complex. However, the mechanism of...

journal_title：Molecular carcinogenesis

authors： DelBove J,Kuwahara Y,Mora-Blanco EL,Godfrey V,Funkhouser WK,Fletcher CD,Van Dyke T,Roberts CW,Weissman BE

更新日期：2009-12-01 00:00:00

abstract：:Angiogenesis is a prerequisite for progression of cancers. The number of genes linked to angiogenesis suggests the existence of complex gene-networks, which remain to be elucidated. To identify angiogenesis genes deregulated in carcinomas, we performed a meta-profiling analysis of published gene expression microarray ...

journal_title：Molecular carcinogenesis

authors： Anders M,Fehlker M,Wang Q,Wissmann C,Pilarsky C,Kemmner W,Höcker M

更新日期：2013-01-01 00:00:00

abstract：:Oxidative stress is known to play a key role in estrogen-induced breast cancer. This study assessed the chemopreventive activity of the naturally occurring γ-tocopherol-rich mixture of tocopherols (γ-TmT) in early stages of estrogen-induced mammary hyperplasia in ACI rats. ACI rats provide an established model of rode...

journal_title：Molecular carcinogenesis

authors： Das Gupta S,So JY,Wall B,Wahler J,Smolarek AK,Sae-Tan S,Soewono KY,Yu H,Lee MJ,Thomas PE,Yang CS,Suh N

更新日期：2015-09-01 00:00:00