Microarray meta-analysis defines global angiogenesis-related gene expression signatures in human carcinomas.

abstract：:Astrocyte elevated gene-1 (AEG-1) plays a critical role in the development, progression, and metastasis of a variety of cancers, including non-small-cell lung cancer (NSCLC). The objective of the current study is to unravel the upstream signaling of AEG-1. A cohort of 28 NSCLC tissues and 30 normal tissues were collec...

journal_title：Molecular carcinogenesis

authors： Li YH,Xu CL,He CJ,Pu HH,Liu JL,Wang Y

更新日期：2020-02-01 00:00:00

abstract：:2-Methoxyestradiol (2-ME), an endogenous metabolite of 17beta-estradiol, is present in human blood and urine. Here we show for the first time that 2-ME significantly inhibited the growth of normal prostate epithelial cells and androgen-dependent LNCaP and androgen-independent DU145 prostate cancer cells. This growth i...

journal_title：Molecular carcinogenesis

authors： Kumar AP,Garcia GE,Slaga TJ

更新日期：2001-07-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) is a growth modulator that inhibits the proliferation of many epithelial cells through interaction with its receptors, the type I and type II receptors (TGF-beta RI and RII) by activating their serine/threonine kinase activities. Loss of growth inhibition by TGF-beta is thoug...

journal_title：Molecular carcinogenesis

authors： Jakowlew SB,Moody TW,You L,Mariano JM

更新日期：1998-05-01 00:00:00

abstract：:We found that caffeine significantly inhibited epidermal growth factor (EGF)- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cell transformation in the JB6 mouse epidermal cell line. The tumor promoter-induced cell transformation was also blocked by treatment with an adenosine A1 receptor antagonist, 8-phenylt...

journal_title：Molecular carcinogenesis

authors： Nomura M,Ichimatsu D,Moritani S,Koyama I,Dong Z,Yokogawa K,Miyamoto K

更新日期：2005-09-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) is a cellular energy sensor that is conserved in eukaryotes. Although AMPK is traditionally thought to play a major role in the regulation of cellular lipid and protein metabolism, recent discoveries reveal that AMPK inhibits mammalian target of rapamycin (mTOR) signaling and connec...

journal_title：Molecular carcinogenesis

authors： Tong X,Smith KA,Pelling JC

更新日期：2012-03-01 00:00:00

abstract：:The protein EPHB4 plays a vital role in various tumor types. However, few studies into the function of circ-EPHB4 (hsa_circ_0001730) in tumors have been conducted. This study aimed to investigate the functions of circ-EPHB4 and the underlying mechanism of circ-EPHB4 in regulating hepatocellular carcinoma (HCC). The ex...

journal_title：Molecular carcinogenesis

authors： Tan Y,Du B,Zhan Y,Wang K,Wang X,Chen B,Wei X,Xiao J

更新日期：2019-06-01 00:00:00

abstract：:Xiphophorus fish have been the subject of intensive genetic research for more than 60 yr, primarily because of the availability of a number of interspecific hybrids that are malignant melanoma models with apparently simple oncogene and tumor suppressor gene determinants. The gene map of Xiphophorus is one of the most ...

journal_title：Molecular carcinogenesis

authors： Morizot DC,McEntire BB,Della Coletta L,Kazianis S,Schartl M,Nairn RS

更新日期：1998-07-01 00:00:00

abstract：:Thymidylate synthase (TYMS) is involved in the folate metabolism and provision of nucleotides needed for DNA synthesis and repair. Thus, functional genetic variants in TYMS may alter cancer risk. In the study, we evaluated associations of three germline variants (rs2790 A > G, rs16430 6 bp > 0 bp, and rs1059394 C > T)...

journal_title：Molecular carcinogenesis

authors： Guan X,Liu H,Ju J,Li Y,Li P,Wang LE,Brewster AM,Buchholz TA,Arun BK,Wei Q,Liu Z

更新日期：2015-04-01 00:00:00

abstract：:We previously reported that two dietary regimens, calorie restriction (CR) and a high olive oil-containing diet supplemented with a freeze-dried fruit and vegetable extract (OFV), reduced the development of intestinal adenomas in Apc(Min) mice by 57% and 33%, respectively, compared to control mice fed a defined diet a...

journal_title：Molecular carcinogenesis

authors： Mai V,Colbert LH,Perkins SN,Schatzkin A,Hursting SD

更新日期：2007-01-01 00:00:00

abstract：:We evaluated whether high-fat diet (HFD), in the absence of increased calorie intake, increases colon cancer growth and metastasis. Four-week-old male BALB/c mice were fed on an HFD (60 kcal% fat) or control diet (10 kcal% fat) for 16 wk, after which CT26 colon cancer cells were subcutaneously injected into the right ...

journal_title：Molecular carcinogenesis

authors： Park H,Kim M,Kwon GT,Lim DY,Yu R,Sung MK,Lee KW,Daily JW 3rd,Park JH

更新日期：2012-11-01 00:00:00

abstract：:Human telomerase reverse transcriptase (TERT) gene encodes the catalytic subunit of telomerase and is located on chromosome 5p15, a genomic region which was found to be associated with multiple cancer types. But no associations with colorectal cancer (CRC) have been reported until recently. Therefore, the purpose of t...

journal_title：Molecular carcinogenesis

authors： Hofer P,Baierl A,Bernhart K,Leeb G,Mach K,Micksche M,Gsur A

更新日期：2012-10-01 00:00:00

abstract：:The expression profile of adenoma induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice was compared with that of normal lung tissue by suppression subtractive hybridization (SSH). The mRNAs of surfactant-associated protein A (SP-A) and lysozyme showed characteristically higher transcription in t...

journal_title：Molecular carcinogenesis

authors： Okubo C,Morishita Y,Minami Y,Ishiyama T,Kano J,Iijima T,Noguchi M

更新日期：2005-02-01 00:00:00

abstract：:There is an unmet need to develop new agents or strategies against therapy resistant pancreatic cancer (PanCA). Recent studies from our laboratory showed that STAT3 negatively regulates NF-κB and that inhibition of this crosstalk using Nexrutine® (Nx) reduces transcriptional activity of COX-2. Inhibition of these mole...

journal_title：Molecular carcinogenesis

authors： Gong J,Muñoz AR,Pingali S,Payton-Stewart F,Chan DE,Freeman JW,Ghosh R,Kumar AP

更新日期：2017-02-01 00:00:00

abstract：:Transformation of cloned rat embryo fibroblast (CREF) cells with the wild-type 5 adenovirus (wtAd5) transforming genes E1A and E1B (which extend from 0 to 11.2 map units) results in morphologically transformed cells that exhibit an increased saturation density in monolayer culture and display an anchorage-independent ...

journal_title：Molecular carcinogenesis

authors： Boylan JF,Shih TY,Fisher PB,Zimmer SG

更新日期：1992-01-01 00:00:00

abstract：:The expression of members of the family of matrix-degrading metalloproteinases (MMPs) is believed to contribute to the complex process of invasion and metastasis. In this study, specific cDNA probes for three members of the stromelysin subfamily of MMPs--stromelysin (MMP-3), stromelysin-2 (MMP-10), and pump-1 (MMP-7)-...

journal_title：Molecular carcinogenesis

authors： McDonnell S,Navre M,Coffey RJ Jr,Matrisian LM

更新日期：1991-01-01 00:00:00

abstract：:Growth factor receptors of the tyrosine kinase family regulate proliferation of a variety of cell types. In some human cancers, the epidermal growth factor receptor (EGFR) and its ligands often are overexpressed, leading to both constitutive and autocrine activation. Intracellular signaling via this receptor takes pla...

journal_title：Molecular carcinogenesis

authors： Crowe DL,Tsang KJ

更新日期：2001-12-01 00:00:00

abstract：:The cellular senescence program is controlled by multiple genetic pathways, one of which involves the regulation of telomerase and telomere shortening. The introduction of a normal human chromosome 3 into the human renal cell carcinoma cell line RCC23 caused repression of telomerase activity, progressive shortening of...

journal_title：Molecular carcinogenesis

authors： Horikawa I,Oshimura M,Barrett JC

更新日期：1998-06-01 00:00:00

abstract：:The E5 open reading frame (ORF) from bovine papillomavirus type 1 (BPV 1) as well as the E5 ORFs from human papillomaviruses (HPV) type 6 and type 16 have been reported to transform immortalized rodent cells. In an analysis of murine and human tumors for the presence of putative papillomavirus-related sequences, we cl...

journal_title：Molecular carcinogenesis

authors： Kahn T,Friesl H,Copeland NG,Gilbert DJ,Jenkins NA,Gissmann L,Kramer J,zur Hausen H

更新日期：1992-01-01 00:00:00

abstract：:Paclitaxel is the last choice for the treatment of advanced melanoma as a second-line chemotherapeutic agent, but there are still many cases of intrinsic resistance to paclitaxel in melanoma and the reasons that cause paclitaxel resistance remain unclear. Here, we identified that high expression of SRY-box transcripti...

journal_title：Molecular carcinogenesis

authors： Si X,Gao Z,Xu F,Zheng Y

更新日期：2020-03-01 00:00:00

abstract：:Polymorphisms of the base excision repair gene APE1 may be associated with an increased risk for developing prostate cancer. In other cancer types, altered APE1 protein expression is a candidate prognostic marker. Using immunohistochemistry, we thus analyzed APE1 expression in 9763 prostate cancers in a tissue microar...

journal_title：Molecular carcinogenesis

authors： Juhnke M,Heumann A,Chirico V,Höflmayer D,Menz A,Hinsch A,Hube-Magg C,Kluth M,Lang DS,Möller-Koop C,Sauter G,Simon R,Beyer B,Pompe R,Thederan I,Schlomm T,Luebke AM

更新日期：2017-09-01 00:00:00

abstract：:This study examines the relationship between p53 immunostaining and direct sequencing of polymerase chain reaction (PCR) products in 61 gliomas. Glioma tissues obtained from patients at surgery were analyzed immunohistochemically with the monoclonal antibody PAb1801 to detect p53 protein abnormalities. Amplified p53 c...

journal_title：Molecular carcinogenesis

authors： Kyritsis AP,Xu R,Bondy ML,Levin VA,Bruner JM

更新日期：1996-01-01 00:00:00

abstract：:Serially transplantable rat mammary tumor (RMT) cells are not dependent on exogenous epidermal growth factor (EGF) and insulin-like growth factor-I for continuous growth in serum-free medium. Previously, we found that conditioned medium obtained from these cells contained EGF-like mitogenic activity and stimulated tyr...

journal_title：Molecular carcinogenesis

authors： Ethier SP,Langton BC,Dilts CA

更新日期：1996-02-01 00:00:00

abstract：:Flavonoids are the most investigated phytochemicals due to their pharmacological and therapeutic activities. Their ability to chelate with metal ions has resulted in the emergence of a new category of molecules with a broader spectrum of pharmacological activities. In this study, the ruthenium quercetin complex has be...

journal_title：Molecular carcinogenesis

authors： Roy S,Das R,Ghosh B,Chakraborty T

更新日期：2018-06-01 00:00:00

abstract：:Withaferin A (WA), a natural product derived from Withania somnifera, has been used in traditional oriental medicines to treat neurological disorders. Recent studies have demonstrated that this compound may have a potential for cancer treatment and a clinical trial has been launched to test WA in treating melanoma. He...

journal_title：Molecular carcinogenesis

authors： Li W,Zhang C,Du H,Huang V,Sun B,Harris JP,Richardson Q,Shen X,Jin R,Li G,Kevil CG,Gu X,Shi R,Zhao Y

更新日期：2016-11-01 00:00:00

abstract：:Alterations of the Rassf1a gene were investigated in pancreatic duct adenocarcinomas (PDAs) induced by N-nitrosobis(2-oxopropyl)amine (BOP) in hamsters. Female Syrian golden hamsters received 70 mg/kg BOP, followed by repeated exposures to an augmentation pressure regimen consisting of a choline-deficient diet combine...

journal_title：Molecular carcinogenesis

authors： Shimizu K,Itsuzaki Y,Fujii H,Honoki K,Tsujiuchi T

更新日期：2008-02-01 00:00:00

abstract：:Hepatitis B virus (HBV) X protein (HBx) and cyclooxygenase-2 (COX-2) are all playing roles in hepatocellular carcinoma (HCC), but the reversing effects of COX-2 inhibitors on the neoplastic features caused by HBx protein is still unclear. To further evaluate the therapeutic potential of celecoxib on HBx mediated trans...

journal_title：Molecular carcinogenesis

authors： Xie H,Gao L,Chai N,Song J,Wang J,Song Z,Chen C,Pan Y,Zhao L,Sun S,Wu K,Feitelson MA,Liu J,Fan D

更新日期：2009-01-01 00:00:00

abstract：:Parafibromin, encoded by the gene HRPT2, is a tumor suppressor protein associated with the RNA polymerase II-associated complex, Paf1 complex. HRPT2 mutations were first identified in patients with the multiple endocrine neoplasia syndrome, hyperparathyroidism-jaw tumor (HPT-JT) syndrome, and have also been found in s...

journal_title：Molecular carcinogenesis

authors： Farber LJ,Kort EJ,Wang P,Chen J,Teh BT

更新日期：2010-03-01 00:00:00

abstract：:DIXDC1 (Dishevelled-Axin domain containing 1) is a DIX (Dishevelled-Axin) domain-possessing protein that promotes colon cancer cell proliferation and increases the invasion and migration ability of non-small-cell lung cancer via the PI3K pathway. As a positive regulator of the Wnt/β-catenin pathway, the biological rol...

journal_title：Molecular carcinogenesis

authors： Tan C,Qiao F,Wei P,Chi Y,Wang W,Ni S,Wang Q,Chen T,Sheng W,Du X,Wang L

更新日期：2016-04-01 00:00:00

abstract：:In the present study, we evaluated the effect of deleting Twist1 on keratinocyte proliferation and on skin tumor development using the two-stage chemical carcinogenesis model. BK5.Cre × Twist1(flox/flox) mice, which have a keratinocyte-specific Twist1 knockout (Twist1 KO), developed significantly reduced numbers of pa...

journal_title：Molecular carcinogenesis

authors： Srivastava J,Rho O,Youssef RM,DiGiovanni J

更新日期：2016-05-01 00:00:00

abstract：:Malignant rhabdoid tumors (MRTs) are poorly differentiated pediatric cancers that arise in various anatomical locations and have a very poor outcome. The large majority of these malignancies are caused by loss of function of the SNF5/INI1 component of the SWI/SNF chromatin remodeling complex. However, the mechanism of...

journal_title：Molecular carcinogenesis

authors： DelBove J,Kuwahara Y,Mora-Blanco EL,Godfrey V,Funkhouser WK,Fletcher CD,Van Dyke T,Roberts CW,Weissman BE

更新日期：2009-12-01 00:00:00