Expression and localization of the matrix metalloproteinase pump-1 (MMP-7) in human gastric and colon carcinomas.

abstract：:Ultraviolet (UV) light-induced activation of activator protein-1 (AP-1), resulting at least in part from oxidative stress, promotes skin carcinogenesis. It has not yet been determined whether elevating cellular phase II enzymes and glutathione (GSH) levels inhibits the AP-1 activation. We have, therefore, examined the...

journal_title：Molecular carcinogenesis

authors： Zhu M,Zhang Y,Cooper S,Sikorski E,Rohwer J,Bowden GT

更新日期：2004-11-01 00:00:00

abstract：:DPC4/SMAD4 is a candidate tumor suppressor gene with a strikingly high frequency of gene alterations in pancreatic cancer that suggests a discrete role for DPC4 in these tumors. DPC4 tumor-suppressive function has been implicated to mediate the transforming growth factor-beta (TGFbeta)-suppressive pathway; however, in...

journal_title：Molecular carcinogenesis

authors： Dai JL,Schutte M,Bansal RK,Wilentz RE,Sugar AY,Kern SE

更新日期：1999-09-01 00:00:00

abstract：:ZD1839 ("Iressa") is an orally active, selective epidermal growth factor (EGF) receptor-tyrosine kinase inhibitor. We evaluated the antitumor activity of ZD1839 in combination with HSP90 antagonist, 17-AAG in malignant human glioma cell lines. ZD1839 independently produced a dose-dependent inhibition of cellular proli...

journal_title：Molecular carcinogenesis

authors： Premkumar DR,Arnold B,Pollack IF

更新日期：2006-05-01 00:00:00

abstract：:MAP1S (originally named C19ORF5) is a widely distributed homolog of neuronal-specific MAP1A and MAP1B, and bridges autophagic components with microtubules and mitochondria to affect autophagosomal biogenesis and degradation. Mitochondrion-associated protein LRPPRC functions as an inhibitor for autophagy initiation to ...

journal_title：Molecular carcinogenesis

authors： Jiang X,Zhong W,Huang H,He H,Jiang F,Chen Y,Yue F,Zou J,Li X,He Y,You P,Yang W,Lai Y,Wang F,Liu L

更新日期：2015-10-01 00:00:00

abstract：:The restriction of energy intake has a profound inhibitory effect on carcinogenesis, yet the mechanism or mechanisms that account for this effect are unknown. In this experiment, the hypothesis tested was that energy restriction upregulates the expression of p27/kip1, a gene product associated with cell-cycle growth a...

journal_title：Molecular carcinogenesis

authors： Zhu Z,Jiang W,Thompson HJ

更新日期：1999-04-01 00:00:00

abstract：:Krüppel-like factor 4 (KLF4) is a zinc-finger-containing transcription factor with tumor suppressor activity in various cancer types. Cells that sustain double strand breaks (DSBs) in their DNA due to high levels of reactive oxygen species (ROS) can develop genomic instability, which can result in cancer formation. On...

journal_title：Molecular carcinogenesis

authors： Liu C,La Rosa S,Hagos EG

更新日期：2015-09-01 00:00:00

abstract：:Lasp2, as well as Lasp1, is a member of the LIM-protein subfamily of the nebulin group characterized by the combined presence of LIM and SH3 domains. Lasp1 and Lasp2 are highly conserved in their LIM, nebulin-like, and SH3 domains but differ significantly at their linker regions. Lasp1 had been described as an oncogen...

journal_title：Molecular carcinogenesis

authors： Zhang X,Cai L,Zhou H,Liu Y,Fan C,Wang L,Li A,Miao Y,Li Q,Qiu X,Wang E

更新日期：2017-12-01 00:00:00

abstract：:The role of estrogen and the estrogen receptor (ER) in the induction and promotion of tumors was investigated by using transgenic MT-mER mice, which overexpress the ER. It was hypothesized that because of this abnormal expression of the ER, the reproductive-tract tissues of the MT-mER mice may be more susceptible to t...

journal_title：Molecular carcinogenesis

authors： Couse JF,Davis VL,Hanson RB,Jefferson WN,McLachlan JA,Bullock BC,Newbold RR,Korach KS

更新日期：1997-08-01 00:00:00

abstract：:Transforming growth factor beta (TGFbeta) signaling has both tumor suppression and promotion roles. Smads are transcription factors that primarily mediate intracellular signaling for the TGFbeta superfamily. Loss of Smad2 and Smad4, but not Smad3 is common in human cancers. Given the complex nature of TGFbeta signalin...

journal_title：Molecular carcinogenesis

authors： Bornstein S,Hoot K,Han GW,Lu SL,Wang XJ

更新日期：2007-08-01 00:00:00

abstract：:Urothelial cell carcinoma of the bladder (UCCB) is the most common form of bladder cancer and it is estimated that ~15,000 people in the United States succumbed to this disease in 2013. Bladder cancer treatment options are limited and research to understand the molecular mechanisms of this disease is needed to design ...

journal_title：Molecular carcinogenesis

authors： Lombard AP,Mooso BA,Libertini SJ,Lim RM,Nakagawa RM,Vidallo KD,Costanzo NC,Ghosh PM,Mudryj M

更新日期：2016-05-01 00:00:00

abstract：:Rapid advances in multimodality therapy have not significantly improved the overall 5-yr survival of oral cancer patients in the past two decades, thereby underscoring the need for molecular therapeutics. The development of new treatment strategies for more effective management of oral cancer requires identification o...

journal_title：Molecular carcinogenesis

authors： Arora S,Matta A,Shukla NK,Deo SV,Ralhan R

更新日期：2005-02-01 00:00:00

abstract：:Although fibroblast growth factor (FGF) signals are strongly associated with malignancy, limited information is available regarding the role of the FGF9 signal in colorectal cancer (CRC). In this study, we investigated the frequency of FGF9 amplification in CRC clinical specimens and the association between the FGF9 g...

journal_title：Molecular carcinogenesis

authors： Mizukami T,Togashi Y,Naruki S,Banno E,Terashima M,de Velasco MA,Sakai K,Yoneshige A,Hayashi H,Fujita Y,Tomida S,Nakajima TE,Fujino T,Boku N,Ito A,Nakagawa K,Nishio K

更新日期：2017-01-01 00:00:00

abstract：:To explore the mechanisms through which hypoxic tumor microenvironment (TME) modulates the transition of tumor-associated macrophages (TAMs). The migration ability of RAW264.7 macrophages was determined by transwell assay. Flow cytometric, western blot and immunofluorescence analyses of CD206 further validated the M2 ...

journal_title：Molecular carcinogenesis

authors： Chen XJ,Wu S,Yan RM,Fan LS,Yu L,Zhang YM,Wei WF,Zhou CF,Wu XG,Zhong M,Yu YH,Liang L,Wang W

更新日期：2019-03-01 00:00:00

abstract：:We investigated the in vitro effects of pyrogallol on cell growth, cell cycle regulation, and apoptosis in HeLa cells. Pyrogallol inhibited the growth of HeLa cells with an IC(50) of approximately 45 microM. Pyrogallol induced arrest during all phases of the cell cycle and also very efficiently resulted in apoptosis i...

journal_title：Molecular carcinogenesis

authors： Kim SW,Han YW,Lee ST,Jeong HJ,Kim SH,Kim IH,Lee SO,Kim DG,Kim SH,Kim SZ,Park WH

更新日期：2008-02-01 00:00:00

abstract：:Integrin alpha6beta4 is altered in many neoplastic cells, but no data exist to show this happens in esophageal neoplasms. To examine the expression of this integrin in rat esophageal tumorigenesis induced by N-nitrosomethylbenzylamine (NMBA), (alpha6 and beta4 expression was evaluated in normal esophageal epithelium, ...

journal_title：Molecular carcinogenesis

authors： Khare L,Sabourin CL,DeYoung BR,Wagner BA,Stoner GD

更新日期：1998-03-01 00:00:00

abstract：:Ajoene is a natural allylsulfur compound found in crushed garlic that arrests growth and induces apoptosis in cancer cells. To gain mechanistic insights into the cytotoxicity of ajoene in cancer cells, two fluorescently labelled ajoene analogs with dansyl- (DP) and fluorescein- (FOX) tags were synthesized. The tagged ...

journal_title：Molecular carcinogenesis

authors： Kaschula CH,Hunter R,Cotton J,Tuveri R,Ngarande E,Dzobo K,Schäfer G,Siyo V,Lang D,Kusza DA,Davies B,Katz AA,Parker MI

更新日期：2016-08-01 00:00:00

abstract：:Quercetin, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), and okadaic acid are found in various foods and have been shown to have mutagenic or promoter-like activity. The effects of these three compounds on the transmission of the inactive X chromosome were examined in MST-C6 murine tumor cells, which were de...

journal_title：Molecular carcinogenesis

authors： Kuwabara K,Odani S,Takahashi Y,Arakawa M,Takagi N,Nagao M,Kominami R

更新日期：1995-12-01 00:00:00

abstract：:Recent studies have implicated a role for midkine (MK) in cancer progression. This is based upon its structural homology with pleiotrophin, an angiogenic growth factor, and its ability to enhance fibrinolytic activity of bovine endothelial cells. To investigate whether MK plays a role in breast cancer, we examined MK ...

journal_title：Molecular carcinogenesis

authors： Chen Y,McKenzie KE,Aldaz CM,Sukumar S

更新日期：1996-11-01 00:00:00

abstract：:Overexpression of Fas ligand (FasL) in cancer cells elicits potential antitumor effects via recruitment of neutrophils. Conversely, FasL-expressing tumors may counterattack tumor-infiltrating lymphocytes by delivering apoptotic death signals via Fas/FasL interactions, which may lead to tumor escape. In order to distin...

journal_title：Molecular carcinogenesis

authors： Chiu HY,Sun GH,Chen SY,Wang HH,Ho MY,Chu CY,Wu WL,Jhou RS,Tsai YL,Huang RT,Sun KH,Tang SJ

更新日期：2013-09-01 00:00:00

abstract：:Increasing evidence from recent research suggests a connection between cancer and a deranged equilibrium of histone acetylation, which is maintained by two competing enzymatic activities, histone acetyltransferases (HATs) and histone deacetylases (HDACs). It is our hypothesis that a significant proportion of leukemias...

journal_title：Molecular carcinogenesis

authors： Mahlknecht U,Ottmann OG,Hoelzer D

更新日期：2000-04-01 00:00:00

abstract：:Phloretin (Ph), which can be obtained from apples, apple juice, and cider, is a known inhibitor of the type II glucose transporter (GLUT2). In this study, real-time PCR analysis of laser-capture microdissected (LCM) human hepatoma cells showed elevated expression (>5-fold) of GLUT2 mRNA in comparison with nonmalignant...

journal_title：Molecular carcinogenesis

authors： Yang KC,Tsai CY,Wang YJ,Wei PL,Lee CH,Chen JH,Wu CH,Ho YS

更新日期：2009-05-01 00:00:00

abstract：:In this report we characterized the transcriptional regulation of the rat mdr1b gene by xenobiotics. The expression of this gene was increased in primary rat hepatocytes and in the H4-II-E hepatoma cell line by exposure to carcinogens such as aflatoxin B1, N-acetoxy-2-acetylaminofluorene, and methyl methanesulfonate. ...

journal_title：Molecular carcinogenesis

authors： Silverman JA,Hill BA

更新日期：1995-05-01 00:00:00

abstract：:Recent evidence suggests that the A allele of the ornithine decarboxylase (ODC) gene is a genetic risk factor for prostate cancer. ODC is a target gene of the highly polymorphic androgen receptor (AR) gene, short alleles of which have been associated in some studies with increased prostate cancer risk. We determined O...

journal_title：Molecular carcinogenesis

authors： O'Brien TG,Guo Y,Visvanathan K,Sciulli J,McLaine M,Helzlsouer KJ,Watkins-Bruner D

更新日期：2004-10-01 00:00:00

abstract：:Promoter hypermethylation is gaining strength as one of the main mechanisms through which tumor suppressor genes are silenced during tumor progression. Three tumor suppressor genes are frequently found methylated in their promoter, in concordance with absence of expression, RASSF1A, SLIT2, and WIF1. In addition, a pre...

journal_title：Molecular carcinogenesis

authors： Alvarez C,Tapia T,Cornejo V,Fernandez W,Muñoz A,Camus M,Alvarez M,Devoto L,Carvallo P

更新日期：2013-06-01 00:00:00

abstract：:Alterations in the p16(INK4a) gene have been implicated in the pathogenesis of different human cancers and animal tumors. We postulated that alterations in the p16(INK4a) gene may also be involved in mouse colon tumorigenesis induced by the chemical carcinogen azoxymethane (AOM). In the present study, p16(INK4a) delet...

journal_title：Molecular carcinogenesis

authors： Wang QS,Papanikolaou A,Nambiar PR,Rosenberg DW

更新日期：2000-07-01 00:00:00

abstract：:The atomic bombing of Hiroshima and Nagasaki and the nuclear accident at Chernobyl raised the question of prenatal sensitivity to ionizing radiation-induced cancer. In this study, mice were exposed to single doses of gamma-radiation (0.2-2.0 Gy) at different embryonic stages. The tumor incidence increased with dose fr...

journal_title：Molecular carcinogenesis

authors： Lumniczky K,Antal S,Unger E,Wunderlich L,Hidvégi EJ,Sáfrány G

更新日期：1998-02-01 00:00:00

abstract：:Although many reports suggest that aberrant regulation of cytokine signaling pathways via the interleukin-2 receptor (IL-2R) induces tumorigenic transformation, constitutively active IL-2R in tumors has not been reported. We searched for genomic alteration of the IL-2/15R beta-subunit gene (IL-2/15R beta) in cytokine-...

journal_title：Molecular carcinogenesis

authors： Ukai H,Ishii-Oba H,Ukai-Tadenuma M,Ogiu T,Tsuji H

更新日期：2003-06-01 00:00:00

abstract：:In human lung cancers, alterations of both a dominant oncogene (ras) and a tumor suppressor gene (p53) have been identified. Polymerase chain reaction (PCR) analysis of mRNA was used to amplify the c-Ki-ras-2 and p53 genes from Syrian golden hamsters. The PCR products were confirmed by predicted-size analysis, probing...

journal_title：Molecular carcinogenesis

authors： Oreffo VI,Lin HW,Gumerlock PH,Kraegel SA,Witschi H

更新日期：1992-01-01 00:00:00

abstract：:Breast cancer-associated mutations affecting the highly-conserved C-terminal BRCT domains of the tumor suppressor gene breast cancer susceptibility gene 1 (BRCA1) fully disrupt the ability of BRCA1 to interact with acetyl coenzyme A carboxylase alpha (ACCA), the rate-limiting enzyme catalyzing de novo fatty acid bioge...

journal_title：Molecular carcinogenesis

authors： Brunet J,Vazquez-Martin A,Colomer R,Graña-Suarez B,Martin-Castillo B,Menendez JA

更新日期：2008-02-01 00:00:00

abstract：:Transformation of cloned rat embryo fibroblast (CREF) cells with the wild-type 5 adenovirus (wtAd5) transforming genes E1A and E1B (which extend from 0 to 11.2 map units) results in morphologically transformed cells that exhibit an increased saturation density in monolayer culture and display an anchorage-independent ...

journal_title：Molecular carcinogenesis

authors： Boylan JF,Shih TY,Fisher PB,Zimmer SG

更新日期：1992-01-01 00:00:00