The garlic compound ajoene targets protein folding in the endoplasmic reticulum of cancer cells.

abstract：:Prostate cancer (PCa) patients' mortality is mainly attributed to complications caused by metastasis of the tumor cells to organs critical for survival, such as bone. We hypothesized that PCa cell-bone interactions would promote paracrine signaling. A panel of PCa cell lines were cocultured with hydroxyapatite ([HA]; ...

journal_title：Molecular carcinogenesis

authors： Henderson VM,Hawsawi O,Burton LJ,Campbell T,Trice K,Dougan J,Howard SM,Odero-Marah VA

更新日期：2019-08-01 00:00:00

abstract：:The number of validated biomarkers of tobacco smoke exposure is limited, and none exist for tobacco-related cancer. Additional biomarkers for smoke, effects on cellular systems in vivo are needed to improve early detection of lung cancer, and to assist the Food and Drug Administration in regulating exposures to tobacc...

journal_title：Molecular carcinogenesis

authors： Weng DY,Chen J,Taslim C,Hsu PC,Marian C,David SP,Loffredo CA,Shields PG

更新日期：2016-10-01 00:00:00

abstract：:Differentiation antagonizing non-protein coding RNA (DANCR) is a newly identified oncogenic long noncoding RNA found in various cancers. However, the functional role of DANCR in tumor angiogenesis and the underlying mechanisms are still unclear. The expression of DANCR was determined in ovarian malignant tissues and c...

journal_title：Molecular carcinogenesis

authors： Lin X,Yang F,Qi X,Li Q,Wang D,Yi T,Yin R,Zhao X,Zhong X,Bian C

更新日期：2019-12-01 00:00:00

abstract：:In this study, we found that rat nasal coumarin-7-hydroxylase (COH) activity was two orders of magnitude higher than rat hepatic COH activity and could be induced by adding coumarin to the rats' drinking water. In western blot analysis, an anti-cytochrome P450 (Cyp) 2a-5 (mouse liver COH) antibody recognized a sharp b...

journal_title：Molecular carcinogenesis

authors： Béréziat JC,Raffalli F,Schmezer P,Frei E,Geneste O,Lang MA

更新日期：1995-10-01 00:00:00

abstract：:Rat neoplasms induced by methylating carcinogens frequently contain ras genes activated by a single point mutation. Rat prostatic tumors induced by a combination of a single injection of N-methyl-N-nitrosourea (MNU) and long-term treatment with testosterone were examined for the presence of such activating point mutat...

journal_title：Molecular carcinogenesis

authors： Sukumar S,Armstrong B,Bruyntjes JP,Leav I,Bosland MC

更新日期：1991-01-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) is a cellular energy sensor that is conserved in eukaryotes. Although AMPK is traditionally thought to play a major role in the regulation of cellular lipid and protein metabolism, recent discoveries reveal that AMPK inhibits mammalian target of rapamycin (mTOR) signaling and connec...

journal_title：Molecular carcinogenesis

authors： Tong X,Smith KA,Pelling JC

更新日期：2012-03-01 00:00:00

abstract：:Elevation of the steady-state mRNA levels of glucose transporter and c-myc are among the earliest changes in gene expression observed after Ha-rasT24 stimulation of Rat-1 fibroblasts to enter the cell cycle. Since the expression of these genes may be the result of either increased cell proliferation or a specific resp...

journal_title：Molecular carcinogenesis

authors： Godwin AK,Lieberman MW

更新日期：1991-01-01 00:00:00

abstract：:Polyamine metabolism is a highly coordinated process that is essential for normal development and neoplastic growth in mammals. Although polyamine metabolism is a validated pathway for prevention of carcinogenesis, the mechanisms by which polyamines elicit their tumorigenic effects are poorly understood. In this study...

journal_title：Molecular carcinogenesis

authors： Paz EA,LaFleur B,Gerner EW

更新日期：2014-02-01 00:00:00

abstract：:Chloride intracellular channel 4 (CLIC4) is a putative chloride channel for intracellular organelles. CLIC4 has biological activities in addition to or because of its channel activity. In keratinocytes, CLIC4 resides in the mitochondria and cytoplasm, and CLIC4 gene expression is regulated by p53, TNF-alpha, and c-Myc...

journal_title：Molecular carcinogenesis

authors： Suh KS,Malik M,Shukla A,Yuspa SH

更新日期：2007-08-01 00:00:00

abstract：:Apigenin (4',5,7-trihydroxyflavone), a flavone subclass of flavonoid widely distributed in many herbs, fruits, and vegetables is a substantial component of the human diet and has been shown to possess a variety of biological activities including tumor growth inhibition and chemoprevention. Recent studies in several bi...

journal_title：Molecular carcinogenesis

authors： Jeyabal PV,Syed MB,Venkataraman M,Sambandham JK,Sakthisekaran D

更新日期：2005-09-01 00:00:00

abstract：:We previously reported that the Wnt pathway is preferentially activated in basal-like breast cancer. However, the mechanisms by which the Wnt pathway regulates down-stream targets in basal-like breast cancer, and the biological significance of this regulation, are poorly understood. In this study, we found that c-Myc ...

journal_title：Molecular carcinogenesis

authors： Xu J,Chen Y,Huo D,Khramtsov A,Khramtsova G,Zhang C,Goss KH,Olopade OI

更新日期：2016-05-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is frequently over-expressed in human cancers and is associated with tumorigenesis, and increased tumor proliferation and progression. Also found in breast tumors with high levels is B-Myb, a transcription factor whose expression is activated b...

journal_title：Molecular carcinogenesis

authors： Hanada N,Lo HW,Day CP,Pan Y,Nakajima Y,Hung MC

更新日期：2006-01-01 00:00:00

abstract：:The WW domain-containing oxidoreductase (WWOX) gene is an identified tumor suppressor gene, of which several single nucleotide polymorphisms have been reported to contribute to cancer susceptibility. We hypothesized that genetic variations in WWOX are associated with lung cancer risk. In two independent case-control s...

journal_title：Molecular carcinogenesis

authors： Huang D,Qiu F,Yang L,Li Y,Cheng M,Wang H,Ma G,Wang Y,Hu M,Ji W,Zhou Y,Lu J

更新日期：2013-11-01 00:00:00

abstract：:The interaction of urokinase-type plasminogen activator (uPA) with its cell-surface receptor (uPAR) is implicated in diverse biological processes such as cell migration, tissue remodeling, and tumor cell invasion. Recent studies indicated that uPAR can act as an extracellular matrix receptor during cell adhesion. Rece...

journal_title：Molecular carcinogenesis

authors： Chintala SK,Mohanam S,Go Y,Venkaiah B,Sawaya R,Gokaslan ZL,Rao JS

更新日期：1997-12-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a neoplasia representing the fifth most common malignancy worldwide and the third cause of death from cancer. Diets with high content in fruits and vegetables are widely recommended for their health-promoting properties, among them, the protection against diabetes, cancer, and cardiov...

journal_title：Molecular carcinogenesis

authors： Fernández-Bedmar Z,Anter J,Alonso-Moraga A,Martín de Las Mulas J,Millán-Ruiz Y,Guil-Luna S

更新日期：2017-06-01 00:00:00

abstract：:In rats, gamma-glutamyl transpeptidase (gamma GT) exists as a single-copy gene, and three distinct species of RNA (types I, II, and III) that differ in their 5' untranslated regions have been identified. To compare steady-state levels of these gamma GT RNAs in rat tissues, hepatic carcinomas, and cultured cells, we us...

journal_title：Molecular carcinogenesis

authors： Habib GM,Rajagopalan S,Godwin AK,Lebovitz RM,Lieberman MW

更新日期：1992-01-01 00:00:00

abstract：:Exposure to aflatoxin B(1) (AFB(1)) is one of the risk factors for developing hepatoma. In rats, activation of the ras gene is a prevalent event in AFB(1)-induced hepatocarcinogenesis. It is not clear whether a similar event occurs in humans. By analysis of codon 249 of the p53 gene, six of 36 human hepatoma samples w...

journal_title：Molecular carcinogenesis

authors： Chao HK,Tsai TF,Lin CS,Su TS

更新日期：1999-10-01 00:00:00

abstract：:Experimentally induced models of breast carcinogenesis in the rat are widely used for studying the biology of breast cancer and for developing and evaluating cancer prevention and control strategies. However, very little is known about gene expression changes that are associated with experimentally induced mammary car...

journal_title：Molecular carcinogenesis

authors： Lu J,Pei H,Kaeck M,Thompson HJ

更新日期：1997-10-01 00:00:00

abstract：:Gastrointestinal stromal tumor (GIST) is a common mesenchymal tumor in the gastrointestinal tract. Prostate cancer associated transcript 6 (PCAT6) is a long noncoding RNA (lncRNA) and plays a pivotal role in tumor formation. Present study was designed to explore the function of PCAT6 in GIST. Ki67 staining, colony for...

journal_title：Molecular carcinogenesis

authors： Bai F,Zhang N,Fang W,He X,Zheng Y,Gu D

更新日期：2020-06-01 00:00:00

abstract：:Both ultraviolet irradiation and oxidation of DNA produce a variety of pyrimidine base damages. A human endonuclease recognizes such altered bases on these DNA substrates. This human endonuclease incises ultraviolet-irradiated DNA exclusively at sites of photochemically modified cytosines. The precise sites of incisio...

journal_title：Molecular carcinogenesis

authors： Gallagher PE,Weiss RB,Brent TP,Duker NJ

更新日期：1989-01-01 00:00:00

abstract：:Thymidylate synthase (TYMS) is involved in the folate metabolism and provision of nucleotides needed for DNA synthesis and repair. Thus, functional genetic variants in TYMS may alter cancer risk. In the study, we evaluated associations of three germline variants (rs2790 A > G, rs16430 6 bp > 0 bp, and rs1059394 C > T)...

journal_title：Molecular carcinogenesis

authors： Guan X,Liu H,Ju J,Li Y,Li P,Wang LE,Brewster AM,Buchholz TA,Arun BK,Wei Q,Liu Z

更新日期：2015-04-01 00:00:00

abstract：:Genomic DNA sequences with the ability to assume non-B form secondary structures have been recently shown to be particularly susceptible to genetic instability, an early contributing factor in human disease and cancer development. Transcription appears to play a central role in formation of these structures and in pro...

journal_title：Molecular carcinogenesis

authors： Tornaletti S

更新日期：2009-04-01 00:00:00

abstract：:Preventive measures against oral carcinogenesis are urgently warranted to lower the high morbidity and mortality associated with this malignancy worldwide. Here, we investigated the chemopreventive efficacy of grape seed extract (GSE) and resveratrol (Res) in 4-nitroquinoline-1-oxide (4NQO)-induced tongue tumorigenesi...

journal_title：Molecular carcinogenesis

authors： Shrotriya S,Tyagi A,Deep G,Orlicky DJ,Wisell J,Wang XJ,Sclafani RA,Agarwal R,Agarwal C

更新日期：2015-04-01 00:00:00

abstract：:The molecular changes associated with the aging process include the reduced activity of transcription factors (such as AP-1) and an impaired response to stress, which has been well documented in the case of the heat-shock (HS) response. Using human diploid fibroblasts of early and late passages as an in vitro model fo...

journal_title：Molecular carcinogenesis

authors： Adler V,Dolan LR,Kim J,Pincus M,Barrett JC,Ronai Z

更新日期：1996-09-01 00:00:00

abstract：:Expression of the tumor suppressor deleted in liver cancer-1 (DLC-1) is lost in non-small cell lung (NSCLC) and other human carcinomas, and ectopic DLC-1 expression dramatically reduces proliferation and tumorigenicity. DLC-1 is a multi-domain protein that includes a Rho GTPase activating protein (RhoGAP) domain which...

journal_title：Molecular carcinogenesis

authors： Healy KD,Hodgson L,Kim TY,Shutes A,Maddileti S,Juliano RL,Hahn KM,Harden TK,Bang YJ,Der CJ

更新日期：2008-05-01 00:00:00

abstract：:2-Methoxyestradiol (2-ME), an endogenous metabolite of 17beta-estradiol, is present in human blood and urine. Here we show for the first time that 2-ME significantly inhibited the growth of normal prostate epithelial cells and androgen-dependent LNCaP and androgen-independent DU145 prostate cancer cells. This growth i...

journal_title：Molecular carcinogenesis

authors： Kumar AP,Garcia GE,Slaga TJ

更新日期：2001-07-01 00:00:00

abstract：:To perform a comprehensive genomic analysis of colorectal cancer (CRC) tumor to detect genetic variants and identify novel resistant mutations associated with cetuximab-resistance in CRC patients. A retrospective study was performed using whole exome sequencing (WES) to identify common genetic factors from 22 cetuxima...

journal_title：Molecular carcinogenesis

authors： Jing C,Wang T,Ma R,Cao H,Wang Z,Liu S,Chen D,Zhang J,Wu Y,Zhang Y,Wu J,Feng J

更新日期：2020-05-01 00:00:00

abstract：:Angiogenesis plays an important role in growth, progression, and metastasis of tumors. The most important regulator of angiogenesis is vascular endothelial growth factor (VEGF). VEGF expression has been associated with advance stage and poor survival of several cancers. In the present study we evaluated the associatio...

journal_title：Molecular carcinogenesis

authors： Dassoulas K,Gazouli M,Rizos S,Theodoropoulos G,Christoni Z,Nikiteas N,Karakitsos P

更新日期：2009-06-01 00:00:00

abstract：:Dishevelled-3 (Dvl-3) and p120-catenin (p120ctn) have abnormal expression in non-small cell lung cancer (NSCLC), which is associated with poor prognosis. Dvl-3 upregulates p120ctn transcription in NSCLC cells, but the mechanism is unknown. Here we transiently transfected Dvl-3 cDNA to NSCLC cells. Dvl-3 transfection i...

journal_title：Molecular carcinogenesis

authors： Zhao H,Zhao Y,Jiang G,Zhang X,Zhang Y,Dong Q,Luan L,Papavassiliou P,Wang E,Wang E

更新日期：2015-06-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is a common malignant tumor with poor prognosis. And different individuals respond to the same drug differently. Increasing evidence has confirmed that metabolism reprogramming was involved in the drug sensitivity of tumor cells. However, the potential molecular mechanism of 5...

journal_title：Molecular carcinogenesis

authors： Cui Y,Yang D,Wang W,Zhang L,Liu H,Ma S,Guo W,Yao M,Zhang K,Li W,Zhang Y,Guan F

更新日期：2020-08-01 00:00:00