Abstract:
:Dishevelled-3 (Dvl-3) and p120-catenin (p120ctn) have abnormal expression in non-small cell lung cancer (NSCLC), which is associated with poor prognosis. Dvl-3 upregulates p120ctn transcription in NSCLC cells, but the mechanism is unknown. Here we transiently transfected Dvl-3 cDNA to NSCLC cells. Dvl-3 transfection is sufficient for induction of p38 signaling. In turn, Dvl-3 induces p38-mediated activation of the p65 so as to facilitate its nuclear translocation. Treatment with SB203580 (p38 inhibitor) or BAY 11-7082 (IκB-α phosphorylation inhibitor) suppresses Dvl-3 induced activation of p65. The results further show that active p65 interacts with PAX2 promoter to increase the expression of PAX2 and then PAX2 binds to p120ctn promoter so as to upregulate p120ctn gene transcription. Moreover, Dvl-3 transfection enhanced the binding of active p65 to Sp1 so as to decrease the binding of Sp1 to p120ctn promoter. The above-mentioned effects are linked to biological behavior of non-small cell lung cancer cells. These findings confirm that p38 and PAX2 are important for the Dvl-3 induced upregulation of p120ctn. Dvl-3 activates a p38 → p65 → PAX2 → p120ctn pathway to affect biological behavior of NSCLC cells.
journal_name
Mol Carcinogjournal_title
Molecular carcinogenesisauthors
Zhao H,Zhao Y,Jiang G,Zhang X,Zhang Y,Dong Q,Luan L,Papavassiliou P,Wang E,Wang Edoi
10.1002/mc.22196subject
Has Abstractpub_date
2015-06-01 00:00:00pages
E112-21eissn
0899-1987issn
1098-2744journal_volume
54 Suppl 1pub_type
杂志文章abstract::Black currant fruits containing high amounts of anthocyanins are known to possess potent antioxidant and anti-inflammatory properties. We have previously reported that anthocyanin-rich black currant skin extract (BCSE) inhibits diethylnitrosamine (DENA)-initiated hepatocarcinogenesis in rats although the underlying me...
journal_title:Molecular carcinogenesis
pub_type: 杂志文章
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更新日期:2013-04-01 00:00:00
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journal_title:Molecular carcinogenesis
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
doi:10.1002/mc.2940050307
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
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更新日期:2016-03-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
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更新日期:2019-07-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/mc.20188
更新日期:2006-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/mc.22423
更新日期:2016-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/mc.2940010404
更新日期:1989-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/mc.20236
更新日期:2007-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/mc.10064
更新日期:2002-08-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
doi:10.1002/mc.22379
更新日期:2016-09-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
doi:10.1002/mc.22484
更新日期:2017-01-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章,meta分析
doi:10.1002/mc.20874
更新日期:2013-01-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
doi:10.1002/(sici)1098-2744(199807)22:3<150::aid-mc2>3
更新日期:1998-07-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
doi:10.1002/mc.23255
更新日期:2020-11-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
doi:10.1002/mc.2940110109
更新日期:1994-09-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
doi:10.1002/mc.22157
更新日期:2015-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-04-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
doi:10.1002/mc.2940030508
更新日期:1990-01-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
doi:10.1002/mc.2940020403
更新日期:1989-01-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
doi:10.1002/(sici)1098-2744(199812)23:4<217::aid-mc4>3
更新日期:1998-12-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
doi:10.1002/(sici)1098-2744(199707)19:2<137::aid-mc8>3
更新日期:1997-06-01 00:00:00
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journal_title:Molecular carcinogenesis
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更新日期:1992-01-01 00:00:00
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更新日期:1991-01-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
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更新日期:2016-10-01 00:00:00