Cotransfection of plasmids with ras and myc oncogenes to diploid cells derived from rodent fetuses: alteration of neoplastic transformation frequency depending on the gestation period.

abstract：:In humans, bone marrow (BM) failure syndromes, both constitutional and acquired, predispose to myeloid malignancies. We have modeled acquired immune aplastic anemia, the paradigmatic disease of these syndromes, in the mouse by infusing lymph node cells from specific pathogen-free (SPF) CD45.1 congenic C57BL/6 (B6) don...

journal_title：Molecular carcinogenesis

authors： Li J,Dubois W,Thovarai V,Wu Z,Feng X,Peat T,Zhang S,Sen SK,Trinchieri G,Chen J,Mock BA,Young NS

更新日期：2020-02-01 00:00:00

abstract：:Promoter hypermethylation is gaining strength as one of the main mechanisms through which tumor suppressor genes are silenced during tumor progression. Three tumor suppressor genes are frequently found methylated in their promoter, in concordance with absence of expression, RASSF1A, SLIT2, and WIF1. In addition, a pre...

journal_title：Molecular carcinogenesis

authors： Alvarez C,Tapia T,Cornejo V,Fernandez W,Muñoz A,Camus M,Alvarez M,Devoto L,Carvallo P

更新日期：2013-06-01 00:00:00

abstract：:The temporal order of replication of several genes was studied in 10T1/2 cells synchronized by release from confluence-induced arrest of proliferation followed by treatment with 2 micrograms/mL aphidicolin for 24 h. DNA subjected to bromodeoxyuridine substitution for 1- or 2-h intervals spanning the S phase was separa...

journal_title：Molecular carcinogenesis

authors： Doggett NA,Cordeiro-Stone M,Chae CB,Kaufman DG

更新日期：1988-01-01 00:00:00

abstract：:Nuclear factor kappa B (NFkappaB) is a central participant in the metastasis and chemoresistance of colorectal cancer (CRC). However, it is not fully understood to what extent NFkappaB contributes to induction of the metastasis-associated matrix metalloprotease-9 (MMP-9) gene and sensitivity to the commonly used chemo...

journal_title：Molecular carcinogenesis

authors： Fukuyama R,Ng KP,Cicek M,Kelleher C,Niculaita R,Casey G,Sizemore N

更新日期：2007-05-01 00:00:00

abstract：:LW-213 is a derivative of Wogonin and the anticancer activities of Wogonin have been reported. To study whether LW-213 inhibits cancer cells and explore a possible mechanism, we investigate the compound in several cancer cell lines. We found LW-213 arrests G2/M cycle in breast cancer cells by suppression of Akt/Gsk3β/...

journal_title：Molecular carcinogenesis

authors： Zhao L,Miao HC,Li WJ,Sun Y,Huang SL,Li ZY,Guo QL

更新日期：2016-05-01 00:00:00

abstract：:In human lung cancers, alterations of both a dominant oncogene (ras) and a tumor suppressor gene (p53) have been identified. Polymerase chain reaction (PCR) analysis of mRNA was used to amplify the c-Ki-ras-2 and p53 genes from Syrian golden hamsters. The PCR products were confirmed by predicted-size analysis, probing...

journal_title：Molecular carcinogenesis

authors： Oreffo VI,Lin HW,Gumerlock PH,Kraegel SA,Witschi H

更新日期：1992-01-01 00:00:00

abstract：:Bone metastases are common complications of breast cancer. Integrins are the major adhesive molecules in mammalian cells. Here we found that osteoblast conditioned medium (OBCM) increased the migration and cell surface expression of beta1 or beta3 integrin in human breast cancer cells (MDA-MB-231 cells). beta1 or beta...

journal_title：Molecular carcinogenesis

authors： Wei YY,Chen YJ,Hsiao YC,Huang YC,Lai TH,Tang CH

更新日期：2008-07-01 00:00:00

abstract：:Neuroblastoma, the most common extracranial solid tumor in children, arises from precursors of the sympathetic nervous system. Neuroblastoma cell lines are responsive to the differentiation agent retinoic acid, which induces its effects by altering transcription rates of specific target genes. We identified autotaxin ...

journal_title：Molecular carcinogenesis

authors： Dufner-Beattie J,Lemons RS,Thorburn A

更新日期：2001-04-01 00:00:00

abstract：:Palliative treatment options for human cholangiocarcinoma (CCC) are quite limited and new therapeutic strategies are of utmost need. c-MET has been shown to be deregulated in many cancers, but the role of c-MET in the carcinogenesis of CCC remains unclear. The main purpose of this study is to evaluate the expression a...

journal_title：Molecular carcinogenesis

authors： Barat S,Bozko P,Chen X,Scholta T,Hanert F,Götze J,Malek NP,Wilkens L,Plentz RR

更新日期：2016-12-01 00:00:00

abstract：:The E5 open reading frame (ORF) from bovine papillomavirus type 1 (BPV 1) as well as the E5 ORFs from human papillomaviruses (HPV) type 6 and type 16 have been reported to transform immortalized rodent cells. In an analysis of murine and human tumors for the presence of putative papillomavirus-related sequences, we cl...

journal_title：Molecular carcinogenesis

authors： Kahn T,Friesl H,Copeland NG,Gilbert DJ,Jenkins NA,Gissmann L,Kramer J,zur Hausen H

更新日期：1992-01-01 00:00:00

abstract：:Withaferin A (WA), a bioactive constituent of Ayurvedic medicine plant Withania somnifera, is a potent apoptosis inducer in cancer cells but the mechanism of cell death induction is not fully characterized. The present study was undertaken to determine the role of mitogen-activated protein kinases (MAPK), including c-...

journal_title：Molecular carcinogenesis

authors： Hahm ER,Lee J,Singh SV

更新日期：2014-11-01 00:00:00

abstract：:Parafibromin, encoded by the gene HRPT2, is a tumor suppressor protein associated with the RNA polymerase II-associated complex, Paf1 complex. HRPT2 mutations were first identified in patients with the multiple endocrine neoplasia syndrome, hyperparathyroidism-jaw tumor (HPT-JT) syndrome, and have also been found in s...

journal_title：Molecular carcinogenesis

authors： Farber LJ,Kort EJ,Wang P,Chen J,Teh BT

更新日期：2010-03-01 00:00:00

abstract：:Atypical adenomatous hyperplasia (AAH) of the prostate is characterized by lobular proliferation of closely packed small acini. It is hypothesized that AAH is a precursor lesion for low-grade prostate cancer arising from the transition zone. Telomere dysfunction is common during malignant transformation of epithelia. ...

journal_title：Molecular carcinogenesis

authors： Cheng L,Montironi R,Davidson DD,Wang M,Lopez-Beltran A,Zhang S

更新日期：2019-07-01 00:00:00

abstract：:Human colorectal cancer (CRC) cells are resistant to the anti-proliferative effect of transforming growth factor-β (TGF-β), suggesting that disruption of TGF-β signaling plays an important role in colorectal carcinogenesis. Ecotropic virus integration site-1 (Evi-1) oncoprotein represses TGF-β signaling by interacting...

journal_title：Molecular carcinogenesis

authors： Deng X,Cao Y,Liu Y,Li F,Sambandam K,Rajaraman S,Perkins AS,Fields AP,Hellmich MR,Townsend CM Jr,Thompson EA,Ko TC

更新日期：2013-04-01 00:00:00

abstract：:We previously reported that the Wnt pathway is preferentially activated in basal-like breast cancer. However, the mechanisms by which the Wnt pathway regulates down-stream targets in basal-like breast cancer, and the biological significance of this regulation, are poorly understood. In this study, we found that c-Myc ...

journal_title：Molecular carcinogenesis

authors： Xu J,Chen Y,Huo D,Khramtsov A,Khramtsova G,Zhang C,Goss KH,Olopade OI

更新日期：2016-05-01 00:00:00

abstract：:Growth factor receptors of the tyrosine kinase family regulate proliferation of a variety of cell types. In some human cancers, the epidermal growth factor receptor (EGFR) and its ligands often are overexpressed, leading to both constitutive and autocrine activation. Intracellular signaling via this receptor takes pla...

journal_title：Molecular carcinogenesis

authors： Crowe DL,Tsang KJ

更新日期：2001-12-01 00:00:00

abstract：:N-acetyltransferase 1 (NAT1) is a phase II metabolic enzyme responsible for the biotransformation of aromatic and heterocyclic amine carcinogens such as 4-aminobiphenyl (ABP). NAT1 catalyzes N-acetylation of arylamines as well as the O-acetylation of N-hydroxylated arylamines. O-acetylation leads to the formation of e...

journal_title：Molecular carcinogenesis

authors： Millner LM,Doll MA,Cai J,States JC,Hein DW

更新日期：2012-08-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is one of the isoforms of cyclooxygenase, a rate-limiting enzyme in the arachidonic acid cascade. COX-2 protein expression is highly induced by numerous factors and it has been reportedly overexpressed in various human malignancies. Although anti-tumorigenic effects of COX-2 inhibitors have be...

journal_title：Molecular carcinogenesis

authors： Kim J,Shim M

更新日期：2016-12-01 00:00:00

abstract：:Gastrointestinal stromal tumor (GIST) is a common mesenchymal tumor in the gastrointestinal tract. Prostate cancer associated transcript 6 (PCAT6) is a long noncoding RNA (lncRNA) and plays a pivotal role in tumor formation. Present study was designed to explore the function of PCAT6 in GIST. Ki67 staining, colony for...

journal_title：Molecular carcinogenesis

authors： Bai F,Zhang N,Fang W,He X,Zheng Y,Gu D

更新日期：2020-06-01 00:00:00

abstract：:The pi-class glutathione S-transferase (GSTP1) actively protect cells from carcinogens and electrophilic compounds. Loss of GSTP1 expression via promoter hypermethylation is the most common epigenetic alteration observed in human prostate cancer. Silencing of GSTP1 can increase generation of reactive oxygen species (R...

journal_title：Molecular carcinogenesis

authors： Kanwal R,Pandey M,Bhaskaran N,Maclennan GT,Fu P,Ponsky LE,Gupta S

更新日期：2014-01-01 00:00:00

abstract：:Recent studies of the individual functionalities of long non-coding RNAs (lncRNAs) in the development and progression of cancer have suggested that HOX transcript antisense RNA (HOTAIR) is capable of reprogramming chromatin organization and promoting cancer cell metastasis. In order to ascertain the expression pattern...

journal_title：Molecular carcinogenesis

authors： Chen FJ,Sun M,Li SQ,Wu QQ,Ji L,Liu ZL,Zhou GZ,Cao G,Jin L,Xie HW,Wang CM,Lv J,De W,Wu M,Cao XF

更新日期：2013-11-01 00:00:00

abstract：:Rat neoplasms induced by methylating carcinogens frequently contain ras genes activated by a single point mutation. Rat prostatic tumors induced by a combination of a single injection of N-methyl-N-nitrosourea (MNU) and long-term treatment with testosterone were examined for the presence of such activating point mutat...

journal_title：Molecular carcinogenesis

authors： Sukumar S,Armstrong B,Bruyntjes JP,Leav I,Bosland MC

更新日期：1991-01-01 00:00:00

abstract：:Telomerase expression is the hallmark of tumor cells, and activation of this ribonucleoprotein complex may be a rate-limiting or critical step in cellular immortalization and oncogenesis. Fungal immunomodulatory protein, FIP-gts, has been isolated from Ganoderma tsugae. In the present study, we expressed and purified ...

journal_title：Molecular carcinogenesis

authors： Liao CH,Hsiao YM,Hsu CP,Lin MY,Wang JC,Huang YL,Ko JL

更新日期：2006-04-01 00:00:00

abstract：:The Ki-ras proto-oncogene is activated by specific point mutations and is the transforming gene often identified in rodent and human lung tumors. An in vitro model to aid in the study of the consequences of Ki-ras activation and expression in mouse lung is needed. Accordingly, we have examined cell lines derived from ...

journal_title：Molecular carcinogenesis

authors： Pan YH,Nuzum EO,Hanson LA,Beer DG

更新日期：1990-01-01 00:00:00

abstract：:2-Deoxyglucose (2-DG), which has been shown to inhibit mammary carcinogenesis, was used as a metabolic probe to investigate effects of limiting energy availability (reduced cellular ATP) on patterns of proteins' phosphorylation that play a role in the development of cancer. Experiments were conducted using a human bre...

journal_title：Molecular carcinogenesis

authors： Jiang W,Zhu Z,Thompson HJ

更新日期：2008-08-01 00:00:00

abstract：:We have reported that connexin (Cx) 32 gene, a member of gap junction protein family, acts as a tumor suppressor gene in human renal cell carcinoma (RCC). Of solid tumors, RCC is one of the most chemoresistant cancers, and there is no effective cancer chemotherapy against RCC at present. In this study, we examined if ...

journal_title：Molecular carcinogenesis

authors： Sato H,Senba H,Virgona N,Fukumoto K,Ishida T,Hagiwara H,Negishi E,Ueno K,Yamasaki H,Yano T

更新日期：2007-03-01 00:00:00

abstract：:The expression profile of adenoma induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice was compared with that of normal lung tissue by suppression subtractive hybridization (SSH). The mRNAs of surfactant-associated protein A (SP-A) and lysozyme showed characteristically higher transcription in t...

journal_title：Molecular carcinogenesis

authors： Okubo C,Morishita Y,Minami Y,Ishiyama T,Kano J,Iijima T,Noguchi M

更新日期：2005-02-01 00:00:00

abstract：:Both ultraviolet irradiation and oxidation of DNA produce a variety of pyrimidine base damages. A human endonuclease recognizes such altered bases on these DNA substrates. This human endonuclease incises ultraviolet-irradiated DNA exclusively at sites of photochemically modified cytosines. The precise sites of incisio...

journal_title：Molecular carcinogenesis

authors： Gallagher PE,Weiss RB,Brent TP,Duker NJ

更新日期：1989-01-01 00:00:00

abstract：:Expression analysis of 7129 transcripts was carried out in five human prostate cancer cell lines derived from orthotopic xenografts after one to five passages in nude mice and primary cultures of human normal prostate epithelial (NPE) cells. These experiments identified a consensus class of 214 genes (43 up- and 171 d...

journal_title：Molecular carcinogenesis

authors： Glinsky GV,Krones-Herzig A,Glinskii AB,Gebauer G

更新日期：2003-08-01 00:00:00

abstract：:Environmental health science research, with its focus on fundamental science and disease prevention, is important for the development of rational and cost-effective public health and regulatory policies related to environmental protection. Environmentally related diseases are preventable, yet they impose a major burde...

journal_title：Molecular carcinogenesis

authors： Olden K,Klein JL

更新日期：1995-09-01 00:00:00