Abstract:
:Many cytotoxic agents kill cells by invoking a specific death pathway termed physiological cell death, or apoptosis. Treatment of a murine hemopoietic stem cell line, FDCP-mix, with methylmethanesulfonate (MMS) or N'-methyl-N'-nitrosourea (MNU) leads to death by apoptosis. Retroviral gene transfer was used to overexpress the bcl-2 oncogene in FDCP-mix cells, and this was associated with a delay in apoptosis in these cells after treatment with MNU and MMS and decreased sensitivity of colony formation to the cytotoxic effects of MMS. These data suggest an explanation for the refractory nature of bcl-2-expressing follicular lymphoma to cytotoxic chemotherapy and furthermore suggest that DNA-damaging antitumor therapy may contribute to the progression of disease.
journal_name
Mol Carcinogjournal_title
Molecular carcinogenesisauthors
Fairbairn LJ,Cowling GJ,Dexter TM,Rafferty JA,Margison GP,Reipert Bdoi
10.1002/mc.2940110109subject
Has Abstractpub_date
1994-09-01 00:00:00pages
49-55issue
1eissn
0899-1987issn
1098-2744journal_volume
11pub_type
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journal_title:Molecular carcinogenesis
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journal_title:Molecular carcinogenesis
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journal_title:Molecular carcinogenesis
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更新日期:2013-04-01 00:00:00
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journal_title:Molecular carcinogenesis
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journal_title:Molecular carcinogenesis
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
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journal_title:Molecular carcinogenesis
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更新日期:2003-08-01 00:00:00
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journal_title:Molecular carcinogenesis
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journal_title:Molecular carcinogenesis
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journal_title:Molecular carcinogenesis
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更新日期:2015-09-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
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更新日期:2005-07-01 00:00:00
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更新日期:2015-09-01 00:00:00
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更新日期:2020-07-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
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更新日期:2013-04-01 00:00:00
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journal_title:Molecular carcinogenesis
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00