Abstract:
:Phloretin (Ph), which can be obtained from apples, apple juice, and cider, is a known inhibitor of the type II glucose transporter (GLUT2). In this study, real-time PCR analysis of laser-capture microdissected (LCM) human hepatoma cells showed elevated expression (>5-fold) of GLUT2 mRNA in comparison with nonmalignant hepatocytes. In vitro and in vivo studies were performed to assess Ph antitumor activity when combined with paclitaxel (PTX) for treatment of human liver cancer cells. Inhibition of GLUT2 by Ph potentiated the anticancer effects of PTX, resensitizing human liver cancer cells to drugs. These results demonstrate that 50-150 microM Ph significantly potentiates DNA laddering induced in Hep G2 cells by 10 nM PTX. Activity assays showed that caspases 3, 8, and 9 are involved in this apoptosis. The antitumor therapeutic efficacy of Ph (10 mg/kg body weight) was determined in cells of the SCID mouse model that were treated in parallel with PTX (1 mg/kg body weight). The Hep G2-xenografted tumor volume was reduced more than fivefold in the Ph + PTX-treated mice compared to the PTX-treated group. These results suggest that Ph may be useful for cancer chemotherapy and chemoprevention.
journal_name
Mol Carcinogjournal_title
Molecular carcinogenesisauthors
Yang KC,Tsai CY,Wang YJ,Wei PL,Lee CH,Chen JH,Wu CH,Ho YSdoi
10.1002/mc.20480subject
Has Abstractpub_date
2009-05-01 00:00:00pages
420-31issue
5eissn
0899-1987issn
1098-2744journal_volume
48pub_type
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
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更新日期:1996-12-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
doi:10.1002/mc.20055
更新日期:2004-12-01 00:00:00
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更新日期:2008-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-10-01 00:00:00
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doi:10.1002/mc.22051
更新日期:2014-02-01 00:00:00
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journal_title:Molecular carcinogenesis
pub_type: 杂志文章
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更新日期:2013-09-01 00:00:00
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journal_title:Molecular carcinogenesis
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更新日期:1997-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1999-04-01 00:00:00
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更新日期:2016-09-01 00:00:00