DIXDC1 activates the Wnt signaling pathway and promotes gastric cancer cell invasion and metastasis.

abstract：:Most human colorectal cancers arise through the accumulation of a series of genetic alterations such as point mutations within the Ki-ras and p53 genes, but the chemical carcinogens that may be implicated in these events are still unidentified. In a previous study, we showed that DNA from human colorectal tissue conta...

journal_title：Molecular carcinogenesis

authors： Jackson PE,Hall CN,Badawi AF,O'Connor PJ,Cooper DP,Povey AC

更新日期：1996-05-01 00:00:00

abstract：:Heat shock protein 60 (HSP60) overexpresses in various types of cancer, but its expression levels and functions in hepatocellular carcinoma (HCC) are still in dispute. We aim to clarify this issue and examine whether HSP60 could be a therapeutic target for HCC. We found drastically enhanced cell apoptosis and suppress...

journal_title：Molecular carcinogenesis

authors： Huang YH,Lin KH,Yu JS,Wu TJ,Lee WC,Chao CC,Pan TL,Yeh CT

更新日期：2018-09-01 00:00:00

abstract：:The mouse benign keratinocyte cell line 308 was previously shown to have less AP-1 DNA binding and transactivation ability than its malignant variant 10Gy5. Because elevated AP-1 activity in 10Gy5 appears to be critical for its malignant phenotype, we were interested in examining the molecular mechanisms that regulate...

journal_title：Molecular carcinogenesis

authors： Joseloff E,Bowden GT

更新日期：1997-01-01 00:00:00

abstract：:The expression profile of adenoma induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice was compared with that of normal lung tissue by suppression subtractive hybridization (SSH). The mRNAs of surfactant-associated protein A (SP-A) and lysozyme showed characteristically higher transcription in t...

journal_title：Molecular carcinogenesis

authors： Okubo C,Morishita Y,Minami Y,Ishiyama T,Kano J,Iijima T,Noguchi M

更新日期：2005-02-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a member of the tumor necrosis factor family, induces apoptosis in a variety of cancer cells. However, gastric cancer (GC) cells are insensitive to TRAIL usually. In the previous study, we showed that Periplocin could induce apoptosis in GC cells via the...

journal_title：Molecular carcinogenesis

authors： Zhao LM,Li L,Huang Y,Han LJ,Li D,Huo BJ,Dai SL,Xu LY,Zhan Q,Shan BE

更新日期：2019-06-01 00:00:00

abstract：:The physical gut barrier, comprised of a thick mucus layer and the epithelium, plays an important role in defense against microbes and foreign antigens. Calcium and vitamin D may be involved in maintaining the integrity of the intestinal mucosal barrier, the dysfunction of which may lead to endotoxemia and inflammatio...

journal_title：Molecular carcinogenesis

authors： Mandle HB,Jahan FA,Bostick RM,Baron JA,Barry EL,Yacoub R,Merrill J,Rutherford RE,Seabrook ME,Fedirko V

更新日期：2019-07-01 00:00:00

abstract：:Barrett's metaplasia consists of columnar epithelium that replaces the normal esophageal mucosa in patients with chronic gastroesophageal reflux. Because intestinal-type Barrett's metaplasia is the major risk factor for adenocarcinoma development, understanding the mechanisms that predispose the esophageal mucosa to m...

journal_title：Molecular carcinogenesis

authors： Compton KR,Orringer MB,Beer DG

更新日期：1999-02-01 00:00:00

abstract：:The mutational specificity of the cyclic nitrosamine N-nitrosopyrrolidine (NPYR) was determined through the DNA sequence characterization of 33 lacl-d mutations of Escherichia coli. Base substitution was the predominant class of mutation induced (91%). The majority of these (64%) occurred at GC base pairs, in accordan...

journal_title：Molecular carcinogenesis

authors： Zielenska M,Ahmed A,Glickman BW

更新日期：1990-01-01 00:00:00

abstract：:In tumor cells that have lost responsiveness to the growth inhibitory effects of transforming growth factor beta (TGFbeta), increased TGFbeta production by the tumor cells often contributes to cancer progression, primarily through paracrine mechanisms. Here we investigated the major components of the activator protein...

journal_title：Molecular carcinogenesis

authors： Liu G,Ding W,Liu X,Mulder KM

更新日期：2006-08-01 00:00:00

abstract：:It is well known that the TP53 gene considerably influences on DNA repair processes. Polymorphisms in the TP53 gene, particularly the well-known Arg72Pro in codon 72 of exon 4 (Ex4+119 G>C; rs1042522), can modify the functionality of the p53 protein and activation of DNA repair. Actually, polymorphic variants Arg and ...

journal_title：Molecular carcinogenesis

authors： Litviakov NV,Denisov EV,Takhauov RM,Karpov AB,Skobel'skaja EV,Vasil'eva EO,Goncharik OO,Ageeva AM,Mamonova NV,Mezheritskiy SA,Sevost'janova NV,Koshel AP

更新日期：2010-06-01 00:00:00

abstract：:In our previous study, we showed that miR-125a directly targeted a WT1 oncogene, which was overexpressed in leukemia and various kinds of solid tumors including lung, breast, gastric, and colon cancers, and brain tumors and was deeply involved in leukemogenesis and tumorigenesis and that miR-125a knockout mice overexp...

journal_title：Molecular carcinogenesis

authors： Hojo N,Tatsumi N,Moriguchi N,Matsumura A,Morimoto S,Nakata J,Fujiki F,Nishida S,Nakajima H,Tsuboi A,Oka Y,Hosen N,Hayashi S,Sugiyama H,Oji Y

更新日期：2016-12-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is an embryonic program that is reactivated in cancer and regulates the invasion and metastasis of tumor cells. Zinc finger E-box binding homeobox 2 (ZEB2) induces EMT by upregulating matrix metalloproteinases (MMP), yet MMP genes lack ZEB2 binding motif in their promoters. Rece...

journal_title：Molecular carcinogenesis

authors： Yalim-Camci I,Balcik-Ercin P,Cetin M,Odabas G,Tokay N,Sayan AE,Yagci T

更新日期：2019-06-01 00:00:00

abstract：:Liver tumor initiating cells (TICs), a small subset cells in tumor bulk, are responsible for liver tumor initiation, metastasis, and relapse. However, the regulatory mechanism of liver TICs remains largely unknown. Here we found a long noncoding RNA lncAPC, locating near from APC locus, was highly expressed in liver c...

journal_title：Molecular carcinogenesis

authors： Fu X,Lin J,Qin F,Yang Z,Ding Y,Zhang Y,Han L,Zhu X,Zhang Q

更新日期：2018-03-01 00:00:00

abstract：:Aberrant epigenetic silencing of the tissue inhibitor of matrix metalloproteinase-3 (TIMP-3) gene that negatively regulates matrix metalloproteinases (MMPs) activity has been implicated in the pathogenesis and metastasis of breast cancer. In the present study, we demonstrate that green tea polyphenols (GTP) and its ma...

journal_title：Molecular carcinogenesis

authors： Deb G,Thakur VS,Limaye AM,Gupta S

更新日期：2015-06-01 00:00:00

abstract：:Regions of genomic DNA containing repetitive nucleotide sequences can adopt a number of different structures in addition to the canonical B-DNA form: many of these non-B DNA structures are causative factors in genetic instability and human disease. Although chromosomal DNA replication through such repetitive sequences...

journal_title：Molecular carcinogenesis

authors： Wang G,Vasquez KM

更新日期：2009-04-01 00:00:00

abstract：:Prostate cancer (PCA) is the second most malignancy in American men. Advanced stage PCA cells possess unlimited replication potential as well as resistance to apoptosis. Therefore, targeting survival mechanisms and activating apoptotic machinery in PCA cells using nontoxic phytochemicals is suggested as an attractive ...

journal_title：Molecular carcinogenesis

authors： Deep G,Gangar SC,Oberlies NH,Kroll DJ,Agarwal R

更新日期：2010-10-01 00:00:00

abstract：:Development of chemoresistance in androgen-refractory prostate cancer cells is partly due to constitutive activation of Rel/NF-kappaB transcription factors that regulate several cell survival and anti-apoptotic genes. In this study we examined whether betulinic acid (BetA), a pentacyclic triterpene from the bark of wh...

journal_title：Molecular carcinogenesis

authors： Rabi T,Shukla S,Gupta S

更新日期：2008-12-01 00:00:00

abstract：:Mutations in the Ki-ras oncogene and the p53 tumor suppressor gene are known to occur at high frequencies in human colon cancers. We measured the frequency of mutations in these two genes in colon adenocarcinomas obtained from a widely used experimental model of human colon carcinogenesis: F344 rats treated with the c...

journal_title：Molecular carcinogenesis

authors： Erdman SH,Wu HD,Hixson LJ,Ahnen DJ,Gerner EW

更新日期：1997-06-01 00:00:00

abstract：:Because oxidative processes can participate in tumor promotion, it is likely that the cellular antioxidant defense also plays a role. We have compared the levels of the three major antioxidant enzymes, Cu,Zn-superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx), in promotable mouse epidermal JB6 cells ...

journal_title：Molecular carcinogenesis

authors： Crawford DR,Amstad PA,Foo DD,Cerutti PA

更新日期：1989-01-01 00:00:00

abstract：:1-Hydroxyanthraquinone (1-HA), which is present in some herbs, and methylazoxymethanol (MAM) acetate, a metabolite of azoxymethane, show synergistic carcinogenicity in rat colon, and 1-HA induces ulcerative changes with simultaneous severe inflammation of the entire colon. In this study, mutations in Ki-ras (exons 1 a...

journal_title：Molecular carcinogenesis

authors： Suzui M,Yoshimi N,Ushijima T,Hirose Y,Makita H,Wang A,Kawamori T,Tanaka T,Mori H,Nagao M

更新日期：1995-04-01 00:00:00

abstract：:Transforming growth factor beta (TGFbeta) signaling has both tumor suppression and promotion roles. Smads are transcription factors that primarily mediate intracellular signaling for the TGFbeta superfamily. Loss of Smad2 and Smad4, but not Smad3 is common in human cancers. Given the complex nature of TGFbeta signalin...

journal_title：Molecular carcinogenesis

authors： Bornstein S,Hoot K,Han GW,Lu SL,Wang XJ

更新日期：2007-08-01 00:00:00

abstract：:Many cytotoxic agents kill cells by invoking a specific death pathway termed physiological cell death, or apoptosis. Treatment of a murine hemopoietic stem cell line, FDCP-mix, with methylmethanesulfonate (MMS) or N'-methyl-N'-nitrosourea (MNU) leads to death by apoptosis. Retroviral gene transfer was used to overexpr...

journal_title：Molecular carcinogenesis

authors： Fairbairn LJ,Cowling GJ,Dexter TM,Rafferty JA,Margison GP,Reipert B

更新日期：1994-09-01 00:00:00

abstract：:We evaluated whether high-fat diet (HFD), in the absence of increased calorie intake, increases colon cancer growth and metastasis. Four-week-old male BALB/c mice were fed on an HFD (60 kcal% fat) or control diet (10 kcal% fat) for 16 wk, after which CT26 colon cancer cells were subcutaneously injected into the right ...

journal_title：Molecular carcinogenesis

authors： Park H,Kim M,Kwon GT,Lim DY,Yu R,Sung MK,Lee KW,Daily JW 3rd,Park JH

更新日期：2012-11-01 00:00:00

abstract：:microRNAs (miRNAs) are commonly altered in glioblastoma. Publicly available algorithms suggest the Wnt pathway is a potential target of miR-577 and the Wnt pathway is commonly altered in glioblastoma. Glioblastoma has not been previously evaluated for miR-577 expression. Glioblastoma tumors and cell lines were evaluat...

journal_title：Molecular carcinogenesis

authors： Zhang W,Shen C,Li C,Yang G,Liu H,Chen X,Zhu D,Zou H,Zhen Y,Zhang D,Zhao S

更新日期：2016-05-01 00:00:00

abstract：:Protein kinases play important roles in tumor development and progression. A variety of members of the signal transduction enzymes serve as targets for therapeutic intervention in cancer. The dysregulation of Axl receptor and its ligand growth arrest-specific 6 (Gas6) is implicated in the pathogenesis of several cance...

journal_title：Molecular carcinogenesis

authors： He L,Zhang J,Jiang L,Jin C,Zhao Y,Yang G,Jia L

更新日期：2010-10-01 00:00:00

abstract：:Heterocyclic amines present in cooked foods are known to produce colon tumors in F344 rats at a high incidence, indicating the possibility of involvement of ras gene activation in colon carcinogenesis in rats as in humans. We examined mutations at codons 12, 13, and 61 of the Ki-ras, Ha-ras, and N-ras genes by polymer...

journal_title：Molecular carcinogenesis

authors： Kakiuchi H,Ushijima T,Ochiai M,Imai K,Ito N,Yachi A,Sugimura T,Nagao M

更新日期：1993-01-01 00:00:00

abstract：:Indole-3-carbinol (I3C), an anti-cancer phytochemical derived from cruciferous vegetables, strongly inhibited proliferation and down-regulated protein levels of the melanocyte master regulator micropthalmia-associated transcription factor (MITF-M) in oncogenic BRAF-V600E expressing melanoma cells in culture as well as...

journal_title：Molecular carcinogenesis

authors： Kundu A,Quirit JG,Khouri MG,Firestone GL

更新日期：2017-01-01 00:00:00

abstract：:The sequentiation of the human genome, together with the development of high throughput technologies, particularly gene-expression profiling, is giving us the opportunity to describe biological features in a quantitative manner. Here we review the use of global gene expression analyses in cancer research. Microarray a...

journal_title：Molecular carcinogenesis

authors： García-Escudero R,Paramio JM

更新日期：2008-08-01 00:00:00

abstract：:Exportin-T (XPOT) belongs to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Up-regulation of XPOT indicates poor prognosis in breast cancer patients. However, the correlation between XPOT and hepatocellular carcinoma (HCC) remains unclear. Here, we found that high expres...

journal_title：Molecular carcinogenesis

authors： Lin J,Hou Y,Huang S,Wang Z,Sun C,Wang Z,He X,Tam NL,Wu C,Wu L

更新日期：2019-02-01 00:00:00

abstract：:The majority of human neoplasms have aberrations in the retinoblastoma pathway due to hyperactivation of cyclin-dependent kinases (CDK). Based on this observation, novel small molecules, such as flavopiridol and UCN-01, are being developed and are currently being tested in the clinic. Efforts to develop CDK modulators...

journal_title：Molecular carcinogenesis

authors： Lahusen T,De Siervi A,Kunick C,Senderowicz AM

更新日期：2003-04-01 00:00:00