No involvement of Ki-ras or p53 gene mutations in colitis-associated rat colon tumors induced by 1-hydroxyanthraquinone and methylazoxymethanol acetate.

abstract：:Parafibromin, encoded by the gene HRPT2, is a tumor suppressor protein associated with the RNA polymerase II-associated complex, Paf1 complex. HRPT2 mutations were first identified in patients with the multiple endocrine neoplasia syndrome, hyperparathyroidism-jaw tumor (HPT-JT) syndrome, and have also been found in s...

journal_title：Molecular carcinogenesis

authors： Farber LJ,Kort EJ,Wang P,Chen J,Teh BT

更新日期：2010-03-01 00:00:00

abstract：:N-nitrosomethylbenzylamine (NMBA)-induced rat esophageal tumorigenesis is an important model for squamous cell carcinoma of the human esophagus. In this model, previous studies have shown that the GGA-->GAA Ha-ras codon 12 mutation is present in the majority of papillomas. No other Ha-ras mutation has been identified....

journal_title：Molecular carcinogenesis

authors： Liston BW,Gupta A,Nines R,Carlton PS,Kresty LA,Harris GK,Stoner GD

更新日期：2001-09-01 00:00:00

abstract：:Thymidylate synthase (TYMS) is involved in the folate metabolism and provision of nucleotides needed for DNA synthesis and repair. Thus, functional genetic variants in TYMS may alter cancer risk. In the study, we evaluated associations of three germline variants (rs2790 A > G, rs16430 6 bp > 0 bp, and rs1059394 C > T)...

journal_title：Molecular carcinogenesis

authors： Guan X,Liu H,Ju J,Li Y,Li P,Wang LE,Brewster AM,Buchholz TA,Arun BK,Wei Q,Liu Z

更新日期：2015-04-01 00:00:00

abstract：:The role of telomerase as an essential requirement for the neoplastic conversion of human cells has been controversial. In the model of conversion of normal human cells to cancer cells by the combination of simian virus 40 (SV40) early region genes and oncogenic Ras (H-Ras(G12V)), telomerase (hTERT) was originally des...

journal_title：Molecular carcinogenesis

authors： Liang S,Kahlenberg MS,Rousseau DL Jr,Hornsby PJ

更新日期：2008-06-01 00:00:00

abstract：:Tumor progression is a multistep process, which enables cells to evolve from benign to malignant tumors. This progression has been suggested to depend on six essential characteristics identified as the "hallmarks of cancer," which include: self-sufficiency in growth signals, insensitivity to growth-inhibitory signals,...

journal_title：Molecular carcinogenesis

authors： Cook AC,Tuck AB,McCarthy S,Turner JG,Irby RB,Bloom GC,Yeatman TJ,Chambers AF

更新日期：2005-08-01 00:00:00

abstract：:Atypical adenomatous hyperplasia (AAH) of the prostate is characterized by lobular proliferation of closely packed small acini. It is hypothesized that AAH is a precursor lesion for low-grade prostate cancer arising from the transition zone. Telomere dysfunction is common during malignant transformation of epithelia. ...

journal_title：Molecular carcinogenesis

authors： Cheng L,Montironi R,Davidson DD,Wang M,Lopez-Beltran A,Zhang S

更新日期：2019-07-01 00:00:00

abstract：:Human colorectal cancer (CRC) cells are resistant to the anti-proliferative effect of transforming growth factor-β (TGF-β), suggesting that disruption of TGF-β signaling plays an important role in colorectal carcinogenesis. Ecotropic virus integration site-1 (Evi-1) oncoprotein represses TGF-β signaling by interacting...

journal_title：Molecular carcinogenesis

authors： Deng X,Cao Y,Liu Y,Li F,Sambandam K,Rajaraman S,Perkins AS,Fields AP,Hellmich MR,Townsend CM Jr,Thompson EA,Ko TC

更新日期：2013-04-01 00:00:00

abstract：:Loss of heterozygosity (LOH) on the long arm of chromosome 13 is common in human breast tumors, pointing to the existence of several suppressor genes in this region. LOH at 13q14 has been implicated in alterations of retinoblastoma gene (RB1) expression. However, attempts to identify a link between the absence of reti...

journal_title：Molecular carcinogenesis

authors： Bièche I,Lidereau R

更新日期：2000-11-01 00:00:00

abstract：:Merkel cell carcinoma (MCC) is a rare neuroendocrine carcinoma of the skin, for which the exact mechanisms of carcinogenesis remain unknown. Therapeutic options for this highly aggressive malignancy have historically been limited in both their initial response and response durability. Recent improvements in our unders...

journal_title：Molecular carcinogenesis

authors： Cohen L,Tsai KY

更新日期：2019-09-01 00:00:00

abstract：:The extracellular signal-regulated kinase (ERK), mitogen-activated protein kinase (MAPK) pathway is an important cell proliferation pathway. We previously reported that the transport protein particle complex 4 (TRAPPC4), ERK2 interaction may activate ERK1/2, modulate pERK2 nuclear localization and regulate proliferati...

journal_title：Molecular carcinogenesis

authors： Weng YR,Kong X,Yu YN,Wang YC,Hong J,Zhao SL,Fang JY

更新日期：2014-02-01 00:00:00

abstract：:DIXDC1 (Dishevelled-Axin domain containing 1) is a DIX (Dishevelled-Axin) domain-possessing protein that promotes colon cancer cell proliferation and increases the invasion and migration ability of non-small-cell lung cancer via the PI3K pathway. As a positive regulator of the Wnt/β-catenin pathway, the biological rol...

journal_title：Molecular carcinogenesis

authors： Tan C,Qiao F,Wei P,Chi Y,Wang W,Ni S,Wang Q,Chen T,Sheng W,Du X,Wang L

更新日期：2016-04-01 00:00:00

abstract：:Inflammation plays a major role in colon carcinogenesis. Endogenously produced specialized proresolving lipid mediators (SPMs) play a central role in inflammation and tissue homeostasis, and have been implicated in carcinogenesis. We studied the associations of plasma levels of two SPMs [lipoxin A4 (LXA4 ) and resolvi...

journal_title：Molecular carcinogenesis

authors： Fedirko V,McKeown-Eyssen G,Serhan CN,Barry EL,Sandler RS,Figueiredo JC,Ahnen DJ,Bresalier RS,Robertson DJ,Anderson CW,Baron JA

更新日期：2017-08-01 00:00:00

abstract：:In human lung cancers, alterations of both a dominant oncogene (ras) and a tumor suppressor gene (p53) have been identified. Polymerase chain reaction (PCR) analysis of mRNA was used to amplify the c-Ki-ras-2 and p53 genes from Syrian golden hamsters. The PCR products were confirmed by predicted-size analysis, probing...

journal_title：Molecular carcinogenesis

authors： Oreffo VI,Lin HW,Gumerlock PH,Kraegel SA,Witschi H

更新日期：1992-01-01 00:00:00

abstract：:Krüppel-like factor 4 (KLF4) is a zinc-finger-containing transcription factor with tumor suppressor activity in various cancer types. Cells that sustain double strand breaks (DSBs) in their DNA due to high levels of reactive oxygen species (ROS) can develop genomic instability, which can result in cancer formation. On...

journal_title：Molecular carcinogenesis

authors： Liu C,La Rosa S,Hagos EG

更新日期：2015-09-01 00:00:00

abstract：:Regions of genomic DNA containing repetitive nucleotide sequences can adopt a number of different structures in addition to the canonical B-DNA form: many of these non-B DNA structures are causative factors in genetic instability and human disease. Although chromosomal DNA replication through such repetitive sequences...

journal_title：Molecular carcinogenesis

authors： Wang G,Vasquez KM

更新日期：2009-04-01 00:00:00

abstract：:Preventive measures against oral carcinogenesis are urgently warranted to lower the high morbidity and mortality associated with this malignancy worldwide. Here, we investigated the chemopreventive efficacy of grape seed extract (GSE) and resveratrol (Res) in 4-nitroquinoline-1-oxide (4NQO)-induced tongue tumorigenesi...

journal_title：Molecular carcinogenesis

authors： Shrotriya S,Tyagi A,Deep G,Orlicky DJ,Wisell J,Wang XJ,Sclafani RA,Agarwal R,Agarwal C

更新日期：2015-04-01 00:00:00

abstract：:High-level expression of the c-sis oncogene, which encodes the beta chain of platelet-derived growth factor, transforms immortalized rodent fibroblasts in vitro to a malignant phenotype. c-sis gene expression has been demonstrated in a variety of human tumors, although generally at levels much lower than those shown t...

journal_title：Molecular carcinogenesis

authors： MacArthur LH,Clarke MF,Westin EH

更新日期：1992-01-01 00:00:00

abstract：:Angelica gigas Nakai (AGN) root ethanol extract exerts anti-cancer activity in several allograft and xenograft models. Here we examined its chemopreventive efficacy through gavage administration against primary carcinogenesis in the transgenic adenocarcinoma of mouse prostate (TRAMP) model. Male C57BL/6 TRAMP mice and...

journal_title：Molecular carcinogenesis

authors： Zhang J,Wang L,Zhang Y,Li L,Tang S,Xing C,Kim SH,Jiang C,Lü J

更新日期：2015-12-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is recognized as one of the malignant tumors with poor prognosis. UAP1L1 (UDP-N-acetylglucosamine-1-like-1) affects numerous biological processes, which is a key regulator of the development of malignant tumors. The biological function and molecular mechanism of UAP1L1 in ESCC...

journal_title：Molecular carcinogenesis

authors： Xiao X,Jiang L,Hu H,Huang Y,Yang L,Jiao Y,Wei G

更新日期：2021-01-12 00:00:00

abstract：:Breast cancer-associated mutations affecting the highly-conserved C-terminal BRCT domains of the tumor suppressor gene breast cancer susceptibility gene 1 (BRCA1) fully disrupt the ability of BRCA1 to interact with acetyl coenzyme A carboxylase alpha (ACCA), the rate-limiting enzyme catalyzing de novo fatty acid bioge...

journal_title：Molecular carcinogenesis

authors： Brunet J,Vazquez-Martin A,Colomer R,Graña-Suarez B,Martin-Castillo B,Menendez JA

更新日期：2008-02-01 00:00:00

abstract：:Ultraviolet (UV) light-induced activation of activator protein-1 (AP-1), resulting at least in part from oxidative stress, promotes skin carcinogenesis. It has not yet been determined whether elevating cellular phase II enzymes and glutathione (GSH) levels inhibits the AP-1 activation. We have, therefore, examined the...

journal_title：Molecular carcinogenesis

authors： Zhu M,Zhang Y,Cooper S,Sikorski E,Rohwer J,Bowden GT

更新日期：2004-11-01 00:00:00

abstract：:Although many reports suggest that aberrant regulation of cytokine signaling pathways via the interleukin-2 receptor (IL-2R) induces tumorigenic transformation, constitutively active IL-2R in tumors has not been reported. We searched for genomic alteration of the IL-2/15R beta-subunit gene (IL-2/15R beta) in cytokine-...

journal_title：Molecular carcinogenesis

authors： Ukai H,Ishii-Oba H,Ukai-Tadenuma M,Ogiu T,Tsuji H

更新日期：2003-06-01 00:00:00

abstract：:Although many anti-VEGF agents are available for cancer treatment, side effects of these agents limit their application for cancer treatment and prevention. Here we studied the potential use of a diet-based agent as an inhibitor for VEGF production. Using a VEGF reporter assay, our data showed that an extract from cin...

journal_title：Molecular carcinogenesis

authors： Zhang K,Han ES,Dellinger TH,Lu J,Nam S,Anderson RA,Yim JH,Wen W

更新日期：2017-02-01 00:00:00

abstract：:Obesity and its associated metabolic syndrome (MetS) are recognized risk factors for breast cancer. The molecular basis for this association remains largely unknown. Adipokines, in particular leptin and adiponectin, are thought to form part of the mechanism linking obesity with cancer through their altered expression/...

journal_title：Molecular carcinogenesis

authors： Carroll PA,Healy L,Lysaght J,Boyle T,Reynolds JV,Kennedy MJ,Pidgeon G,Connolly EM

更新日期：2011-08-01 00:00:00

abstract：:Despite considerable knowledge of viral pathogenesis, the pathophysiological changes related to the multifactorial, multistep process of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) development remains unclear. Longitudinal metabolomics study can reveal biological process for disease progression. We ...

journal_title：Molecular carcinogenesis

authors： Huang BY,Tsai MR,Hsu JK,Lin CY,Lin CL,Hu JT,Huang YW,Liu CJ,Wu WJ,Wu CF,Sung FY,Chen PJ,Liang HJ,Lin SM,Yu MW

更新日期：2020-11-01 00:00:00

abstract：:Telomerase activity is suppressed in normal human somatic tissues but is activated in cancer cells and immortal cell lines. The reverse transcriptase (RT) subunit human telomerase reverse transcriptase (hTERT) is the key regulator of telomerase activity. The hTERT promoter contains E-box elements and may allow upstrea...

journal_title：Molecular carcinogenesis

authors： Chang JT,Yang HT,Wang TC,Cheng AJ

更新日期：2005-11-01 00:00:00

abstract：:Oxidative stress is known to play a key role in estrogen-induced breast cancer. This study assessed the chemopreventive activity of the naturally occurring γ-tocopherol-rich mixture of tocopherols (γ-TmT) in early stages of estrogen-induced mammary hyperplasia in ACI rats. ACI rats provide an established model of rode...

journal_title：Molecular carcinogenesis

authors： Das Gupta S,So JY,Wall B,Wahler J,Smolarek AK,Sae-Tan S,Soewono KY,Yu H,Lee MJ,Thomas PE,Yang CS,Suh N

更新日期：2015-09-01 00:00:00

abstract：:The cellular senescence program is controlled by multiple genetic pathways, one of which involves the regulation of telomerase and telomere shortening. The introduction of a normal human chromosome 3 into the human renal cell carcinoma cell line RCC23 caused repression of telomerase activity, progressive shortening of...

journal_title：Molecular carcinogenesis

authors： Horikawa I,Oshimura M,Barrett JC

更新日期：1998-06-01 00:00:00

abstract：:A model of neoplastic transformation by the combination of SV40 large T antigen (LT), SV40 small T antigen (ST), oncogenic Ras, and human telomerase reverse trasncriptase subunit (hTERT) has become established and replicated in primary human fibroblasts, however, there is no report on human hepatocytes. Here we use ce...

journal_title：Molecular carcinogenesis

authors： Sun B,Chen M,Hawks C,Hornsby PJ,Wang X

更新日期：2006-04-01 00:00:00

abstract：:Many cytotoxic agents kill cells by invoking a specific death pathway termed physiological cell death, or apoptosis. Treatment of a murine hemopoietic stem cell line, FDCP-mix, with methylmethanesulfonate (MMS) or N'-methyl-N'-nitrosourea (MNU) leads to death by apoptosis. Retroviral gene transfer was used to overexpr...

journal_title：Molecular carcinogenesis

authors： Fairbairn LJ,Cowling GJ,Dexter TM,Rafferty JA,Margison GP,Reipert B

更新日期：1994-09-01 00:00:00