Tocopherols inhibit oxidative and nitrosative stress in estrogen-induced early mammary hyperplasia in ACI rats.

abstract：:Genotoxicity tests indicate methanol (MeOH) is not mutagenic, but a rodent study has suggested carcinogenic potential, which could result from free radical-initiated oxidative DNA damage. To investigate this possibility we treated male CD-1 mice, New Zealand white rabbits, and cynomolgus monkeys with MeOH (2.0 g/kg ip...

journal_title：Molecular carcinogenesis

authors： McCallum GP,Siu M,Ondovcik SL,Sweeting JN,Wells PG

更新日期：2011-03-01 00:00:00

abstract：:Plakoglobin (Pg) and beta-catenin are homologous proteins that function in cell-cell adhesion and signaling. The cadherin-associated form of these proteins mediates adhesion, whereas the cytosolic/nuclear form has a signaling role. Despite their interactions with common cellular partners, beta-catenin has a well-docum...

journal_title：Molecular carcinogenesis

authors： Li L,Chapman K,Hu X,Wong A,Pasdar M

更新日期：2007-10-01 00:00:00

abstract：:To explore the mechanisms underlying the chemopreventive effects of the synthetic retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) in prostate cancer, we evaluated the anti-proliferative and apoptosis-inducing effects of 4-HPR in the androgen-sensitive human prostate cancer cell line LNCaP. 4-HPR decreased the number of...

journal_title：Molecular carcinogenesis

authors： Shen JC,Wang TT,Chang S,Hursting SD

更新日期：1999-03-01 00:00:00

abstract：:2-Methoxyestradiol (2-ME), an endogenous metabolite of 17beta-estradiol, is present in human blood and urine. Here we show for the first time that 2-ME significantly inhibited the growth of normal prostate epithelial cells and androgen-dependent LNCaP and androgen-independent DU145 prostate cancer cells. This growth i...

journal_title：Molecular carcinogenesis

authors： Kumar AP,Garcia GE,Slaga TJ

更新日期：2001-07-01 00:00:00

abstract：:Bone cells are a prime target for the biological function of the fos/jun (activating protein-1 (AP-1)) transcription factor complex. Deregulated expression of c-fos or v-fos in bone cells induces tumorigenicity and the formation of non-metastatic osteosarcomas. In contrast, fos oncogenes transform fibroblasts to an in...

journal_title：Molecular carcinogenesis

authors： Rupp B,Lorenz U,Schmidt J,Werenskiold AK

更新日期：1998-10-01 00:00:00

abstract：:Apigenin (4',5,7-trihydroxyflavone), a flavone subclass of flavonoid widely distributed in many herbs, fruits, and vegetables is a substantial component of the human diet and has been shown to possess a variety of biological activities including tumor growth inhibition and chemoprevention. Recent studies in several bi...

journal_title：Molecular carcinogenesis

authors： Jeyabal PV,Syed MB,Venkataraman M,Sambandham JK,Sakthisekaran D

更新日期：2005-09-01 00:00:00

abstract：:Aberrant epigenetic silencing of the tissue inhibitor of matrix metalloproteinase-3 (TIMP-3) gene that negatively regulates matrix metalloproteinases (MMPs) activity has been implicated in the pathogenesis and metastasis of breast cancer. In the present study, we demonstrate that green tea polyphenols (GTP) and its ma...

journal_title：Molecular carcinogenesis

authors： Deb G,Thakur VS,Limaye AM,Gupta S

更新日期：2015-06-01 00:00:00

abstract：:Estrogen is thought to be an important etiologic agent in endometrial and breast cancers. However, the mechanism or mechanisms by which estrogen acts as a hormonal carcinogen are not well understood. We hypothesize that in response to chronic exposure to estrogens, human endometrial stromal fibroblasts (ESF) produce f...

journal_title：Molecular carcinogenesis

authors： Li Y,Rinehart CA

更新日期：1998-12-01 00:00:00

abstract：:To determine if hemizygous transgenic mice carrying the human c-Ha-ras gene (CB6F1-Tg Hras2 mice (Hras2 mice)) are susceptible to the carcinogenic potential of known murine carcinogens, male and female Hras2 mice and their non-transgenic CB6F1 littermates (non-Tg mice) were each given a single intraperitoneal injectio...

journal_title：Molecular carcinogenesis

authors： Mitsumori K,Wakana S,Yamamoto S,Kodama Y,Yasuhara K,Nomura T,Hayashi Y,Maronpot RR

更新日期：1997-11-01 00:00:00

abstract：:The interplay between cancer cells and the normal surrounding tissue is believed to influence the biological behavior of the tumor. However, the presence of multiple cell types within the prelevated tumor specimen may attenuate changes that occur specifically in the malignant cells within their microenvironment. To st...

journal_title：Molecular carcinogenesis

authors： Verlinden I,Janssens J,Raus J,Michiels L

更新日期：2004-12-01 00:00:00

abstract：:Loss of heterozygosity (LOH) on the long arm of chromosome 13 is common in human breast tumors, pointing to the existence of several suppressor genes in this region. LOH at 13q14 has been implicated in alterations of retinoblastoma gene (RB1) expression. However, attempts to identify a link between the absence of reti...

journal_title：Molecular carcinogenesis

authors： Bièche I,Lidereau R

更新日期：2000-11-01 00:00:00

abstract：:Deregulation of insulin-like growth factor-1 receptor (IGF-1R) and focal adhesion kinase (FAK) signaling pathways plays an important role in cancer cell proliferation and metastasis. In pancreatic cancer cells, the crosstalk and compensatory mechanisms between these two pathways reduce the efficacy of the treatments t...

journal_title：Molecular carcinogenesis

authors： Zheng D,Golubovskaya V,Kurenova E,Wood C,Massoll NA,Ostrov D,Cance WG,Hochwald SN

更新日期：2010-02-01 00:00:00

abstract：:Apc mutations cause intestinal tumorigenesis through Tcf4 activation. However, direct techniques for studying Tcf4 activation in vivo are limited. Here, we describe the development of a Tcf4-GFP reporter mouse model for directly studying Tcf4 activation. We first developed a GFP reporter construct (Tcf4-GFP) and trans...

journal_title：Molecular carcinogenesis

authors： Boman B,Kopelovich L,Siracusa LD,Zhang T,Henderson K,Cofer Z,Buchberg AM,Fields JZ,Otevrel T

更新日期：2009-09-01 00:00:00

abstract：:The sequentiation of the human genome, together with the development of high throughput technologies, particularly gene-expression profiling, is giving us the opportunity to describe biological features in a quantitative manner. Here we review the use of global gene expression analyses in cancer research. Microarray a...

journal_title：Molecular carcinogenesis

authors： García-Escudero R,Paramio JM

更新日期：2008-08-01 00:00:00

abstract：:Hepatitis B virus (HBV) X protein (HBx) and cyclooxygenase-2 (COX-2) are all playing roles in hepatocellular carcinoma (HCC), but the reversing effects of COX-2 inhibitors on the neoplastic features caused by HBx protein is still unclear. To further evaluate the therapeutic potential of celecoxib on HBx mediated trans...

journal_title：Molecular carcinogenesis

authors： Xie H,Gao L,Chai N,Song J,Wang J,Song Z,Chen C,Pan Y,Zhao L,Sun S,Wu K,Feitelson MA,Liu J,Fan D

更新日期：2009-01-01 00:00:00

abstract：:DPC4/SMAD4 is a candidate tumor suppressor gene with a strikingly high frequency of gene alterations in pancreatic cancer that suggests a discrete role for DPC4 in these tumors. DPC4 tumor-suppressive function has been implicated to mediate the transforming growth factor-beta (TGFbeta)-suppressive pathway; however, in...

journal_title：Molecular carcinogenesis

authors： Dai JL,Schutte M,Bansal RK,Wilentz RE,Sugar AY,Kern SE

更新日期：1999-09-01 00:00:00

abstract：:High levels of the cell growth inhibitor transforming growth factor-beta1 (TGF-beta1) are often found in a variety of human cancers. However, the physiological significance of this overexpression depends on the availability of the biologically active form of TGF-beta1 within the extracellular matrix of the tumor micro...

journal_title：Molecular carcinogenesis

authors： Guda K,Claffey KP,Dong M,Nambiar PR,Rosenberg DW

更新日期：2003-05-01 00:00:00

abstract：:Betanin, also called beetroot red, has been extensively used as a food colorant. In this study, the chemopreventive activity of betanin by oral consumption was investigated in two mouse lung tumor models. Vinyl carbamate (VC) and benzo(a)pyrene (B(a)P) were used to induce lung tumors, and female A/J mice were treated ...

journal_title：Molecular carcinogenesis

authors： Zhang Q,Pan J,Wang Y,Lubet R,You M

更新日期：2013-09-01 00:00:00

abstract：:The E5 open reading frame (ORF) from bovine papillomavirus type 1 (BPV 1) as well as the E5 ORFs from human papillomaviruses (HPV) type 6 and type 16 have been reported to transform immortalized rodent cells. In an analysis of murine and human tumors for the presence of putative papillomavirus-related sequences, we cl...

journal_title：Molecular carcinogenesis

authors： Kahn T,Friesl H,Copeland NG,Gilbert DJ,Jenkins NA,Gissmann L,Kramer J,zur Hausen H

更新日期：1992-01-01 00:00:00

abstract：:Studies show that elevated insulin-like growth factor-1 (IGF-1) levels are associated with an increased risk of breast cancer; however, mechanisms through which IGF-1 promotes mammary tumorigenesis in vivo have not been fully elucidated. To assess the possible involvement of COX-2 signaling in the pro-tumorigenic effe...

journal_title：Molecular carcinogenesis

authors： Tian J,Lambertz I,Berton TR,Rundhaug JE,Kiguchi K,Shirley SH,Digiovanni J,Conti CJ,Fischer SM,Fuchs-Young R

更新日期：2012-12-01 00:00:00

abstract：:The abnormal expression of adipocyte enhancer binding protein 1 (AEBP1) has been implicated in the carcinogenesis and progression of various types of human tumors. However, the role of AEBP1 in colon adenocarcinoma (COAD) remains largely unelucidated. In this study, we explored the clinical significance and biological...

journal_title：Molecular carcinogenesis

authors： Xing Y,Zhang Z,Chi F,Zhou Y,Ren S,Zhao Z,Zhu Y,Piao D

更新日期：2019-10-01 00:00:00

abstract：:Cytokines are considered to play an important role in tumor pathogenesis and progression, and recent studies have demonstrated that a variety of forms, including interleukins (ILs) and transforming growth factor-beta(s) (TGF-beta(s)), may regulate tumors. In the present study, the expression of TGF-beta isoforms and I...

journal_title：Molecular carcinogenesis

authors： Honoki K,Tsujiuchi T,Sasaki Y,Tsutsumi M,Morishita T,Kido A,Miyauchi Y,Mii Y,Takakura Y,Konishi Y

更新日期：2002-02-01 00:00:00

abstract：:We evaluated whether high-fat diet (HFD), in the absence of increased calorie intake, increases colon cancer growth and metastasis. Four-week-old male BALB/c mice were fed on an HFD (60 kcal% fat) or control diet (10 kcal% fat) for 16 wk, after which CT26 colon cancer cells were subcutaneously injected into the right ...

journal_title：Molecular carcinogenesis

authors： Park H,Kim M,Kwon GT,Lim DY,Yu R,Sung MK,Lee KW,Daily JW 3rd,Park JH

更新日期：2012-11-01 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the most abundant mutagenic heterocyclic amine in cooked foods. Two mouse tumor cell lines, BMT11 and FM3A, were exposed to its proximate form, 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP). Fifty-six subclones of BMT11 and 39 subclones of ...

journal_title：Molecular carcinogenesis

authors： Kitazawa T,Kominami R,Tanaka R,Wakabayashi K,Nagao M

更新日期：1994-02-01 00:00:00

abstract：:The physical gut barrier, comprised of a thick mucus layer and the epithelium, plays an important role in defense against microbes and foreign antigens. Calcium and vitamin D may be involved in maintaining the integrity of the intestinal mucosal barrier, the dysfunction of which may lead to endotoxemia and inflammatio...

journal_title：Molecular carcinogenesis

authors： Mandle HB,Jahan FA,Bostick RM,Baron JA,Barry EL,Yacoub R,Merrill J,Rutherford RE,Seabrook ME,Fedirko V

更新日期：2019-07-01 00:00:00

abstract：:We found that caffeine significantly inhibited epidermal growth factor (EGF)- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cell transformation in the JB6 mouse epidermal cell line. The tumor promoter-induced cell transformation was also blocked by treatment with an adenosine A1 receptor antagonist, 8-phenylt...

journal_title：Molecular carcinogenesis

authors： Nomura M,Ichimatsu D,Moritani S,Koyama I,Dong Z,Yokogawa K,Miyamoto K

更新日期：2005-09-01 00:00:00

abstract：:In the present study, we evaluated the effect of deleting Twist1 on keratinocyte proliferation and on skin tumor development using the two-stage chemical carcinogenesis model. BK5.Cre × Twist1(flox/flox) mice, which have a keratinocyte-specific Twist1 knockout (Twist1 KO), developed significantly reduced numbers of pa...

journal_title：Molecular carcinogenesis

authors： Srivastava J,Rho O,Youssef RM,DiGiovanni J

更新日期：2016-05-01 00:00:00

abstract：:Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide. The colonic mucosa constitutes a critical barrier and a major site of immune regulation. The immune system plays important roles in cancer development and treatment, and immune activation caused by chronic infection or inflammation is well-k...

journal_title：Molecular carcinogenesis

authors： Ruan H,Leibowitz BJ,Zhang L,Yu J

更新日期：2020-07-01 00:00:00

abstract：:Gliomas are common, aggressive central nervous system tumors with poor overall survival rates. Despite improvements in neurosurgery, chemotherapy, and radiotherapy, the outcomes of patients with malignant gliomas remain poor. Therefore, increased knowledge of the molecular mechanisms that regulate glioma progression i...

journal_title：Molecular carcinogenesis

authors： Zhou Y,Tan Z,Chen K,Wu W,Zhu J,Wu G,Cao L,Zhang X,Zeng X,Li J,Zhang W

更新日期：2018-09-01 00:00:00

abstract：:Recent evidence suggests that the A allele of the ornithine decarboxylase (ODC) gene is a genetic risk factor for prostate cancer. ODC is a target gene of the highly polymorphic androgen receptor (AR) gene, short alleles of which have been associated in some studies with increased prostate cancer risk. We determined O...

journal_title：Molecular carcinogenesis

authors： O'Brien TG,Guo Y,Visvanathan K,Sciulli J,McLaine M,Helzlsouer KJ,Watkins-Bruner D

更新日期：2004-10-01 00:00:00