Abstract:
:The cellular senescence program is controlled by multiple genetic pathways, one of which involves the regulation of telomerase and telomere shortening. The introduction of a normal human chromosome 3 into the human renal cell carcinoma cell line RCC23 caused repression of telomerase activity, progressive shortening of telomeres, and restoration of the cellular senescence program. We attributed the repression of telomerase activity to the marked downregulation of the gene encoding the catalytic subunit of telomerase (hEST2/hTRT) but not another protein component (TP1/TLP1) or the RNA component of telomerase. These results suggest that a senescence-inducing gene on chromosome 3 controls hEST2/hTRT gene expression either directly or indirectly and support the notion that hEST2/hTRT is the major determinant of telomerase enzymatic activity in human cells.
journal_name
Mol Carcinogjournal_title
Molecular carcinogenesisauthors
Horikawa I,Oshimura M,Barrett JCdoi
10.1002/(sici)1098-2744(199806)22:2<65::aid-mc1>3.subject
Has Abstractpub_date
1998-06-01 00:00:00pages
65-72issue
2eissn
0899-1987issn
1098-2744pii
10.1002/(SICI)1098-2744(199806)22:2<65::AID-MC1>3.journal_volume
22pub_type
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更新日期:2005-11-01 00:00:00
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