Regulation of the transcription factor AP-1 in benign and malignant mouse keratinocyte cells.

abstract：:Dietary heterocyclic aromatic amines (HCA) and polyunsaturated fatty acids (PUFA) are both believed to play a role in colon carcinogenesis, and are both substrate for the enzyme cyclooxygenase (COX). In HCA-7 cells, highly expressing isoform COX-2, we investigated the effects of PUFA on prostaglandin synthesis and DNA...

journal_title：Molecular carcinogenesis

authors： Moonen HJ,Dommels YE,van Zwam M,van Herwijnen MH,Kleinjans JC,Alink GM,de Kok TM

更新日期：2004-07-01 00:00:00

abstract：:Recent studies have implicated a role for midkine (MK) in cancer progression. This is based upon its structural homology with pleiotrophin, an angiogenic growth factor, and its ability to enhance fibrinolytic activity of bovine endothelial cells. To investigate whether MK plays a role in breast cancer, we examined MK ...

journal_title：Molecular carcinogenesis

authors： Chen Y,McKenzie KE,Aldaz CM,Sukumar S

更新日期：1996-11-01 00:00:00

abstract：:The atomic bombing of Hiroshima and Nagasaki and the nuclear accident at Chernobyl raised the question of prenatal sensitivity to ionizing radiation-induced cancer. In this study, mice were exposed to single doses of gamma-radiation (0.2-2.0 Gy) at different embryonic stages. The tumor incidence increased with dose fr...

journal_title：Molecular carcinogenesis

authors： Lumniczky K,Antal S,Unger E,Wunderlich L,Hidvégi EJ,Sáfrány G

更新日期：1998-02-01 00:00:00

abstract：:Liver cirrhosis is a critical state in the natural course of hepatocellular carcinoma (HCC). We sought to investigate the potential of in-depth proteomics to reveal plasma protein signatures that reflect common networks/pathways of liver cirrhosis, and to determine whether the cirrhosis-related signature in plasma is ...

journal_title：Molecular carcinogenesis

authors： Liu CC,Wang YH,Chuang EY,Tsai MH,Chuang YH,Lin CL,Liu CJ,Hsiao BY,Lin SM,Liu LY,Yu MW

更新日期：2014-01-01 00:00:00

abstract：:Indole-3-carbinol (I3C), an anti-cancer phytochemical derived from cruciferous vegetables, strongly inhibited proliferation and down-regulated protein levels of the melanocyte master regulator micropthalmia-associated transcription factor (MITF-M) in oncogenic BRAF-V600E expressing melanoma cells in culture as well as...

journal_title：Molecular carcinogenesis

authors： Kundu A,Quirit JG,Khouri MG,Firestone GL

更新日期：2017-01-01 00:00:00

abstract：:microRNAs (miRNAs) are commonly altered in glioblastoma. Publicly available algorithms suggest the Wnt pathway is a potential target of miR-577 and the Wnt pathway is commonly altered in glioblastoma. Glioblastoma has not been previously evaluated for miR-577 expression. Glioblastoma tumors and cell lines were evaluat...

journal_title：Molecular carcinogenesis

authors： Zhang W,Shen C,Li C,Yang G,Liu H,Chen X,Zhu D,Zou H,Zhen Y,Zhang D,Zhao S

更新日期：2016-05-01 00:00:00

abstract：:Metformin, an oral biguanide for the treatment of type II diabetes, has been shown to have anticancer effects in ovarian cancer. Energy starvation induced by metformin causes endoplasmic reticulum stress-mediated unfolded protein response (UPR) and autophagy. UPR and autophagy act as a survival or death mechanism in c...

journal_title：Molecular carcinogenesis

authors： Moon HS,Kim B,Gwak H,Suh DH,Song YS

更新日期：2016-04-01 00:00:00

abstract：:Transforming growth factor beta (TGFbeta) signaling has both tumor suppression and promotion roles. Smads are transcription factors that primarily mediate intracellular signaling for the TGFbeta superfamily. Loss of Smad2 and Smad4, but not Smad3 is common in human cancers. Given the complex nature of TGFbeta signalin...

journal_title：Molecular carcinogenesis

authors： Bornstein S,Hoot K,Han GW,Lu SL,Wang XJ

更新日期：2007-08-01 00:00:00

abstract：:Krüppel-like factor 4 (KLF4) is a zinc-finger-containing transcription factor with tumor suppressor activity in various cancer types. Cells that sustain double strand breaks (DSBs) in their DNA due to high levels of reactive oxygen species (ROS) can develop genomic instability, which can result in cancer formation. On...

journal_title：Molecular carcinogenesis

authors： Liu C,La Rosa S,Hagos EG

更新日期：2015-09-01 00:00:00

abstract：:The majority of ovarian cancers over-express the estrogen receptor (ERα) and grow in response to estrogens. We previously demonstrated that ER induction of the chemokine CXCL12 (stromal cell-derived factor-1) is required for estradiol (E2)-stimulated proliferation of human ovarian carcinoma cells. In the current study...

journal_title：Molecular carcinogenesis

authors： Hall JM,Korach KS

更新日期：2013-09-01 00:00:00

abstract：:Preventive measures against oral carcinogenesis are urgently warranted to lower the high morbidity and mortality associated with this malignancy worldwide. Here, we investigated the chemopreventive efficacy of grape seed extract (GSE) and resveratrol (Res) in 4-nitroquinoline-1-oxide (4NQO)-induced tongue tumorigenesi...

journal_title：Molecular carcinogenesis

authors： Shrotriya S,Tyagi A,Deep G,Orlicky DJ,Wisell J,Wang XJ,Sclafani RA,Agarwal R,Agarwal C

更新日期：2015-04-01 00:00:00

abstract：:Xiphophorus fish have been the subject of intensive genetic research for more than 60 yr, primarily because of the availability of a number of interspecific hybrids that are malignant melanoma models with apparently simple oncogene and tumor suppressor gene determinants. The gene map of Xiphophorus is one of the most ...

journal_title：Molecular carcinogenesis

authors： Morizot DC,McEntire BB,Della Coletta L,Kazianis S,Schartl M,Nairn RS

更新日期：1998-07-01 00:00:00

abstract：:Dishevelled-3 (Dvl-3) and p120-catenin (p120ctn) have abnormal expression in non-small cell lung cancer (NSCLC), which is associated with poor prognosis. Dvl-3 upregulates p120ctn transcription in NSCLC cells, but the mechanism is unknown. Here we transiently transfected Dvl-3 cDNA to NSCLC cells. Dvl-3 transfection i...

journal_title：Molecular carcinogenesis

authors： Zhao H,Zhao Y,Jiang G,Zhang X,Zhang Y,Dong Q,Luan L,Papavassiliou P,Wang E,Wang E

更新日期：2015-06-01 00:00:00

abstract：:Arsenic is a known human carcinogen. However, the mechanism of how arsenic induces cell transformation remains unclear. In this study, we demonstrated that long-term exposure to sodium arsenite at low-dose (2 µM) increases cell proliferation and neoplastic transformation in a mouse epidermal cell model, JB6 promotion-...

journal_title：Molecular carcinogenesis

authors： Zhang Y,Wang Q,Guo X,Miller R,Guo Y,Yang HS

更新日期：2011-07-01 00:00:00

abstract：:We previously reported that two dietary regimens, calorie restriction (CR) and a high olive oil-containing diet supplemented with a freeze-dried fruit and vegetable extract (OFV), reduced the development of intestinal adenomas in Apc(Min) mice by 57% and 33%, respectively, compared to control mice fed a defined diet a...

journal_title：Molecular carcinogenesis

authors： Mai V,Colbert LH,Perkins SN,Schatzkin A,Hursting SD

更新日期：2007-01-01 00:00:00

abstract：:Prostate cancer (PCa) patients' mortality is mainly attributed to complications caused by metastasis of the tumor cells to organs critical for survival, such as bone. We hypothesized that PCa cell-bone interactions would promote paracrine signaling. A panel of PCa cell lines were cocultured with hydroxyapatite ([HA]; ...

journal_title：Molecular carcinogenesis

authors： Henderson VM,Hawsawi O,Burton LJ,Campbell T,Trice K,Dougan J,Howard SM,Odero-Marah VA

更新日期：2019-08-01 00:00:00

abstract：:Phloretin (Ph), which can be obtained from apples, apple juice, and cider, is a known inhibitor of the type II glucose transporter (GLUT2). In this study, real-time PCR analysis of laser-capture microdissected (LCM) human hepatoma cells showed elevated expression (>5-fold) of GLUT2 mRNA in comparison with nonmalignant...

journal_title：Molecular carcinogenesis

authors： Yang KC,Tsai CY,Wang YJ,Wei PL,Lee CH,Chen JH,Wu CH,Ho YS

更新日期：2009-05-01 00:00:00

abstract：:Barrett's metaplasia consists of columnar epithelium that replaces the normal esophageal mucosa in patients with chronic gastroesophageal reflux. Because intestinal-type Barrett's metaplasia is the major risk factor for adenocarcinoma development, understanding the mechanisms that predispose the esophageal mucosa to m...

journal_title：Molecular carcinogenesis

authors： Compton KR,Orringer MB,Beer DG

更新日期：1999-02-01 00:00:00

abstract：:Environmental health science research, with its focus on fundamental science and disease prevention, is important for the development of rational and cost-effective public health and regulatory policies related to environmental protection. Environmentally related diseases are preventable, yet they impose a major burde...

journal_title：Molecular carcinogenesis

authors： Olden K,Klein JL

更新日期：1995-09-01 00:00:00

abstract：:Heat shock protein 60 (HSP60) overexpresses in various types of cancer, but its expression levels and functions in hepatocellular carcinoma (HCC) are still in dispute. We aim to clarify this issue and examine whether HSP60 could be a therapeutic target for HCC. We found drastically enhanced cell apoptosis and suppress...

journal_title：Molecular carcinogenesis

authors： Huang YH,Lin KH,Yu JS,Wu TJ,Lee WC,Chao CC,Pan TL,Yeh CT

更新日期：2018-09-01 00:00:00

abstract：:Alterations in the p16(INK4a) gene have been implicated in the pathogenesis of different human cancers and animal tumors. We postulated that alterations in the p16(INK4a) gene may also be involved in mouse colon tumorigenesis induced by the chemical carcinogen azoxymethane (AOM). In the present study, p16(INK4a) delet...

journal_title：Molecular carcinogenesis

authors： Wang QS,Papanikolaou A,Nambiar PR,Rosenberg DW

更新日期：2000-07-01 00:00:00

abstract：:Oncoprotein p28(GANK), overexpressed in hepatocellular carcinomas (HCC), binds to RelA and retains NF-κB in the cytoplasm to suppress NF-κB transactivation. However, the mechanism has not yet been elucidated. In this study, we clarified the mechanism of NF-κB regulated by p28(GANK). p28(GANK) reduced TNF-α-induced nuc...

journal_title：Molecular carcinogenesis

authors： Ren YB,Luo T,Li J,Fu J,Wang Q,Cao GW,Chen Y,Wang HY

更新日期：2015-12-01 00:00:00

abstract：:N(6)-isopentenyladenosine (i6A) inhibits the tumor cell growth by inducing cell apoptosis in various cancer cell lines. However, little is known regarding the mechanisms by which the drug induces cell apoptosis. In this study, we further explored the molecular mechanisms of i6A as an anticancer agent on a human breast...

journal_title：Molecular carcinogenesis

authors： Laezza C,Malfitano AM,Di Matola T,Ricchi P,Bifulco M

更新日期：2010-10-01 00:00:00

abstract：:Potassium chromate induced the formation of DNA-protein complexes in cultured Chinese hamster ovary cells. The DNA-protein complexes were isolated by ultracentrifugal sedimentation in the presence of 2% sodium dodecyl sulfate (SDS) and 5 M urea. Two-dimensional SDS-polyacrylamide gel electrophoresis analysis of the ch...

journal_title：Molecular carcinogenesis

authors： Miller CA 3rd,Costa M

更新日期：1988-01-01 00:00:00

abstract：:Triptolide is an active component from a Chinese herb, Tripterygium wilfordii which has been applied for treating immune-related diseases over centuries. Recently, it was reported that a variety of cancer cell lines could be sensitized to DNA-damage based chemotherapy drugs in combination with Triptolide treatment. In...

journal_title：Molecular carcinogenesis

authors： Deng Y,Li F,He P,Yang Y,Yang J,Zhang Y,Liu J,Tong Y,Li Q,Mei X,Shu Z,Zhao Q

更新日期：2018-06-01 00:00:00

abstract：:Multidrug resistance (MDR) is one of the most important factors leading to chemotherapeutic failure in patients with breast cancer. The invasive/metastatic ability of MDR cells is strengthened compared with their parental cells. However, the mechanisms underlying MDR have not been fully elucidated. We found that CD44 ...

journal_title：Molecular carcinogenesis

authors： Cheng Y,Tao L,Xu J,Li Q,Yu J,Jin Y,Chen Q,Xu Z,Zou Q,Liu X

更新日期：2014-09-01 00:00:00

abstract：:Development of chemoresistance in androgen-refractory prostate cancer cells is partly due to constitutive activation of Rel/NF-kappaB transcription factors that regulate several cell survival and anti-apoptotic genes. In this study we examined whether betulinic acid (BetA), a pentacyclic triterpene from the bark of wh...

journal_title：Molecular carcinogenesis

authors： Rabi T,Shukla S,Gupta S

更新日期：2008-12-01 00:00:00

abstract：:KITLG/KIT pathway plays a vital role in multiple types of human cancer including head and neck squamous cell carcinoma (HNSCC). Genetic variations in KITLG and KIT may affect the expression or function of these genes, thereby modifying cancer risk. In this study, we evaluated the association of KITLG and KIT polymorph...

journal_title：Molecular carcinogenesis

authors： Hang D,Yuan H,Liu L,Wang L,Miao L,Zhu M,Du J,Dai J,Hu Z,Chen N,Shen H,Ma H

更新日期：2017-01-01 00:00:00

abstract：:Base excision repair (BER) is critical for the maintenance of genome stability because it repairs at least 20,000 endogenously generated DNA lesions/cell/d. Several enzymes within the BER pathway exhibit sequence context dependency during the excision and DNA synthesis steps of repair. New evidence is emerging that ge...

journal_title：Molecular carcinogenesis

authors： Donigan KA,Sweasy JB

更新日期：2009-04-01 00:00:00

abstract：:The aims of the present study are to investigate sub-cellular location, differential expression in different cancer stages and functional role of FAM134B in colon cancer development. FAM134B expression was studied and quantified at protein and mRNA levels in cell lines using immunocytochemistry, Western blot and real-...

journal_title：Molecular carcinogenesis

authors： Islam F,Gopalan V,Wahab R,Smith RA,Qiao B,Lam AK

更新日期：2017-01-01 00:00:00