Endocrine disrupting chemicals promote the growth of ovarian cancer cells via the ER-CXCL12-CXCR4 signaling axis.

abstract：:2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), a compound found in cooked meat, is a mammary gland carcinogen in female Sprague-Dawley rats. PhIP-induced rat mammary gland carcinomas were examined for mutations in several genes (exons) known to regulate cell growth and apoptosis, including p53 (4-8), p21(Waf1...

journal_title：Molecular carcinogenesis

authors： Yu M,Ryu DY,Snyderwine EG

更新日期：2000-02-01 00:00:00

abstract：:Male F(1) hybrids between MSM mice carrying a deficient p53 allele and BALB/c mice were irradiated with gamma-rays, and 80 thymic lymphomas were obtained, 46 of which developed in mice carrying the deficient p53 allele. Because the Y chromosome contributes little to cellular function, the stability of the Y chromosome...

journal_title：Molecular carcinogenesis

authors： Chou D,Matsuki J,Saitou Y,Kosugi SI,Shinbo T,Gejyo F,Niwa O,Kominami R

更新日期：1999-11-01 00:00:00

abstract：:Increasing evidence from recent research suggests a connection between cancer and a deranged equilibrium of histone acetylation, which is maintained by two competing enzymatic activities, histone acetyltransferases (HATs) and histone deacetylases (HDACs). It is our hypothesis that a significant proportion of leukemias...

journal_title：Molecular carcinogenesis

authors： Mahlknecht U,Ottmann OG,Hoelzer D

更新日期：2000-04-01 00:00:00

abstract：:Apigenin (4',5,7-trihydroxyflavone), a flavone subclass of flavonoid widely distributed in many herbs, fruits, and vegetables is a substantial component of the human diet and has been shown to possess a variety of biological activities including tumor growth inhibition and chemoprevention. Recent studies in several bi...

journal_title：Molecular carcinogenesis

authors： Jeyabal PV,Syed MB,Venkataraman M,Sambandham JK,Sakthisekaran D

更新日期：2005-09-01 00:00:00

abstract：:Centchroman (CC), a female oral contraceptive, has been shown to possess breast anti-cancer activities. Recently, we have shown CC-mediated antimetastatic effect through reversal of epithelial-to-mesenchymal transition (EMT) in breast cancer. The loss of tumor suppressor genes (TSGs) has been shown to promote EMT in b...

journal_title：Molecular carcinogenesis

authors： Khan S,Shukla S,Sinha S,Meeran SM

更新日期：2016-11-01 00:00:00

abstract：:We confirmed the expression of cathepsin K, the most abundant and specific cysteine protease found in osteoclasts, at the mRNA level in most of our cases of breast cancer, and even at the protein level in bone metastatic lesions. Therefore, we investigated the functions of cathepsin K in osteoclasts with special atten...

journal_title：Molecular carcinogenesis

authors： Ishikawa T,Kamiyama M,Tani-Ishii N,Suzuki H,Ichikawa Y,Hamaguchi Y,Momiyama N,Shimada H

更新日期：2001-10-01 00:00:00

abstract：:Preventive measures against oral carcinogenesis are urgently warranted to lower the high morbidity and mortality associated with this malignancy worldwide. Here, we investigated the chemopreventive efficacy of grape seed extract (GSE) and resveratrol (Res) in 4-nitroquinoline-1-oxide (4NQO)-induced tongue tumorigenesi...

journal_title：Molecular carcinogenesis

authors： Shrotriya S,Tyagi A,Deep G,Orlicky DJ,Wisell J,Wang XJ,Sclafani RA,Agarwal R,Agarwal C

更新日期：2015-04-01 00:00:00

abstract：:Loss of heterozygosity (LOH) on the long arm of chromosome 13 is common in human breast tumors, pointing to the existence of several suppressor genes in this region. LOH at 13q14 has been implicated in alterations of retinoblastoma gene (RB1) expression. However, attempts to identify a link between the absence of reti...

journal_title：Molecular carcinogenesis

authors： Bièche I,Lidereau R

更新日期：2000-11-01 00:00:00

abstract：:Chloride intracellular channel 4 (CLIC4) is a putative chloride channel for intracellular organelles. CLIC4 has biological activities in addition to or because of its channel activity. In keratinocytes, CLIC4 resides in the mitochondria and cytoplasm, and CLIC4 gene expression is regulated by p53, TNF-alpha, and c-Myc...

journal_title：Molecular carcinogenesis

authors： Suh KS,Malik M,Shukla A,Yuspa SH

更新日期：2007-08-01 00:00:00

abstract：:Dishevelled-3 (Dvl-3) and p120-catenin (p120ctn) have abnormal expression in non-small cell lung cancer (NSCLC), which is associated with poor prognosis. Dvl-3 upregulates p120ctn transcription in NSCLC cells, but the mechanism is unknown. Here we transiently transfected Dvl-3 cDNA to NSCLC cells. Dvl-3 transfection i...

journal_title：Molecular carcinogenesis

authors： Zhao H,Zhao Y,Jiang G,Zhang X,Zhang Y,Dong Q,Luan L,Papavassiliou P,Wang E,Wang E

更新日期：2015-06-01 00:00:00

abstract：:In this report we characterized the transcriptional regulation of the rat mdr1b gene by xenobiotics. The expression of this gene was increased in primary rat hepatocytes and in the H4-II-E hepatoma cell line by exposure to carcinogens such as aflatoxin B1, N-acetoxy-2-acetylaminofluorene, and methyl methanesulfonate. ...

journal_title：Molecular carcinogenesis

authors： Silverman JA,Hill BA

更新日期：1995-05-01 00:00:00

abstract：:Tamoxifen (TAM) is widely used in the treatment and prevention of breast cancer. There is clear evidence that cytochrome P450 (CYP) 3A enzymes play an important role in TAM metabolism, resulting in metabolites that lead to formation of TAM-DNA adducts. We have investigated the effect of CYP3A2 antisense (AVI-4472) exp...

journal_title：Molecular carcinogenesis

authors： Mahadevan B,Arora V,Schild LJ,Keshava C,Cate ML,Iversen PL,Poirier MC,Weston A,Pereira C,Baird WM

更新日期：2006-02-01 00:00:00

abstract：:Prostate cancer (PCa) patients' mortality is mainly attributed to complications caused by metastasis of the tumor cells to organs critical for survival, such as bone. We hypothesized that PCa cell-bone interactions would promote paracrine signaling. A panel of PCa cell lines were cocultured with hydroxyapatite ([HA]; ...

journal_title：Molecular carcinogenesis

authors： Henderson VM,Hawsawi O,Burton LJ,Campbell T,Trice K,Dougan J,Howard SM,Odero-Marah VA

更新日期：2019-08-01 00:00:00

abstract：:Here, we have demonstrated that xenobiotic activation of the nuclear receptor (CAR, NR1I3) can result in arresting DNA-damaged human hepatocellular carcinoma Huh7 cells at the G2/M phase. Huh7 cells over-expressing CAR were either treated with dimethyl sulfoxide, the CAR activator TCPOBOP (1,4-bis[2-(3,5-dichloropyrid...

journal_title：Molecular carcinogenesis

authors： Kamino H,Negishi M

更新日期：2012-02-01 00:00:00

abstract：:The tumor suppressor p27, which is a member of the Cip/Kip family of Cyclin-dependent kinase inhibitory proteins (CKIs), controls anti-proliferative events. The post-translational addition of O-GlcNAc to p27 occurs in HEK293T and HCC (hepatocellular carcinoma) cell lines, and we identified Ser2, Ser106, Ser110, Thr157...

journal_title：Molecular carcinogenesis

authors： Qiu H,Liu F,Tao T,Zhang D,Liu X,Zhu G,Xu Z,Ni R,Shen A

更新日期：2017-01-01 00:00:00

abstract：:Expression analysis of 7129 transcripts was carried out in five human prostate cancer cell lines derived from orthotopic xenografts after one to five passages in nude mice and primary cultures of human normal prostate epithelial (NPE) cells. These experiments identified a consensus class of 214 genes (43 up- and 171 d...

journal_title：Molecular carcinogenesis

authors： Glinsky GV,Krones-Herzig A,Glinskii AB,Gebauer G

更新日期：2003-08-01 00:00:00

abstract：:The relationship between thyroid hormone (triiodothyronine, T(3)) and breast cancer is unclear. We studied the effect of the c-erbA/TR alpha proto-oncogene encoding a functional T(3) receptor (TR alpha 1), of its ligand T(3), and of its retroviral, mutated counterpart, the v-erbA oncogene, on the proliferation capacit...

journal_title：Molecular carcinogenesis

authors： González-Sancho JM,Figueroa A,López-Barahona M,López E,Beug H,Muñoz A

更新日期：2002-05-01 00:00:00

abstract：:Two genetic instability pathways viz. chromosomal instability, driven primarily by APC mutation induced deregulated Wnt signaling, and microsatellite instability (MSI) caused by mismatch repair (MMR) inactivation, together account for >90% of late-onset colorectal cancer (CRC). Our understanding of early-onset sporadi...

journal_title：Molecular carcinogenesis

authors： Raman R,Kotapalli V,Adduri R,Gowrishankar S,Bashyam L,Chaudhary A,Vamsy M,Patnaik S,Srinivasulu M,Sastry R,Rao S,Vasala A,Kalidindi N,Pollack J,Murthy S,Bashyam M

更新日期：2014-02-01 00:00:00

abstract：:Ultraviolet (UV) light-induced activation of activator protein-1 (AP-1), resulting at least in part from oxidative stress, promotes skin carcinogenesis. It has not yet been determined whether elevating cellular phase II enzymes and glutathione (GSH) levels inhibits the AP-1 activation. We have, therefore, examined the...

journal_title：Molecular carcinogenesis

authors： Zhu M,Zhang Y,Cooper S,Sikorski E,Rohwer J,Bowden GT

更新日期：2004-11-01 00:00:00

abstract：:Environmental health science research, with its focus on fundamental science and disease prevention, is important for the development of rational and cost-effective public health and regulatory policies related to environmental protection. Environmentally related diseases are preventable, yet they impose a major burde...

journal_title：Molecular carcinogenesis

authors： Olden K,Klein JL

更新日期：1995-09-01 00:00:00

abstract：:Although many reports suggest that aberrant regulation of cytokine signaling pathways via the interleukin-2 receptor (IL-2R) induces tumorigenic transformation, constitutively active IL-2R in tumors has not been reported. We searched for genomic alteration of the IL-2/15R beta-subunit gene (IL-2/15R beta) in cytokine-...

journal_title：Molecular carcinogenesis

authors： Ukai H,Ishii-Oba H,Ukai-Tadenuma M,Ogiu T,Tsuji H

更新日期：2003-06-01 00:00:00

abstract：:ZD1839 ("Iressa") is an orally active, selective epidermal growth factor (EGF) receptor-tyrosine kinase inhibitor. We evaluated the antitumor activity of ZD1839 in combination with HSP90 antagonist, 17-AAG in malignant human glioma cell lines. ZD1839 independently produced a dose-dependent inhibition of cellular proli...

journal_title：Molecular carcinogenesis

authors： Premkumar DR,Arnold B,Pollack IF

更新日期：2006-05-01 00:00:00

abstract：:Exposure to aflatoxin B(1) (AFB(1)) is one of the risk factors for developing hepatoma. In rats, activation of the ras gene is a prevalent event in AFB(1)-induced hepatocarcinogenesis. It is not clear whether a similar event occurs in humans. By analysis of codon 249 of the p53 gene, six of 36 human hepatoma samples w...

journal_title：Molecular carcinogenesis

authors： Chao HK,Tsai TF,Lin CS,Su TS

更新日期：1999-10-01 00:00:00

abstract：:To perform a comprehensive genomic analysis of colorectal cancer (CRC) tumor to detect genetic variants and identify novel resistant mutations associated with cetuximab-resistance in CRC patients. A retrospective study was performed using whole exome sequencing (WES) to identify common genetic factors from 22 cetuxima...

journal_title：Molecular carcinogenesis

authors： Jing C,Wang T,Ma R,Cao H,Wang Z,Liu S,Chen D,Zhang J,Wu Y,Zhang Y,Wu J,Feng J

更新日期：2020-05-01 00:00:00

abstract：:Betanin, also called beetroot red, has been extensively used as a food colorant. In this study, the chemopreventive activity of betanin by oral consumption was investigated in two mouse lung tumor models. Vinyl carbamate (VC) and benzo(a)pyrene (B(a)P) were used to induce lung tumors, and female A/J mice were treated ...

journal_title：Molecular carcinogenesis

authors： Zhang Q,Pan J,Wang Y,Lubet R,You M

更新日期：2013-09-01 00:00:00

abstract：:Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide. The colonic mucosa constitutes a critical barrier and a major site of immune regulation. The immune system plays important roles in cancer development and treatment, and immune activation caused by chronic infection or inflammation is well-k...

journal_title：Molecular carcinogenesis

authors： Ruan H,Leibowitz BJ,Zhang L,Yu J

更新日期：2020-07-01 00:00:00

abstract：:Lasp2, as well as Lasp1, is a member of the LIM-protein subfamily of the nebulin group characterized by the combined presence of LIM and SH3 domains. Lasp1 and Lasp2 are highly conserved in their LIM, nebulin-like, and SH3 domains but differ significantly at their linker regions. Lasp1 had been described as an oncogen...

journal_title：Molecular carcinogenesis

authors： Zhang X,Cai L,Zhou H,Liu Y,Fan C,Wang L,Li A,Miao Y,Li Q,Qiu X,Wang E

更新日期：2017-12-01 00:00:00

abstract：:To explore the mechanisms underlying the chemopreventive effects of the synthetic retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) in prostate cancer, we evaluated the anti-proliferative and apoptosis-inducing effects of 4-HPR in the androgen-sensitive human prostate cancer cell line LNCaP. 4-HPR decreased the number of...

journal_title：Molecular carcinogenesis

authors： Shen JC,Wang TT,Chang S,Hursting SD

更新日期：1999-03-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is one of the isoforms of cyclooxygenase, a rate-limiting enzyme in the arachidonic acid cascade. COX-2 protein expression is highly induced by numerous factors and it has been reportedly overexpressed in various human malignancies. Although anti-tumorigenic effects of COX-2 inhibitors have be...

journal_title：Molecular carcinogenesis

authors： Kim J,Shim M

更新日期：2016-12-01 00:00:00

abstract：:The levels of the antioxidant enzyme manganese superoxide dismutase (Mn-SOD) are frequently decreased in tumor cells and increased in normal cells upon treatment with ionizing radiation. We studied Mn-SOD at different stages during the neoplastic conversion of radiation-initiated Syrian hamster embryo HDR-3 cells. Mn-...

journal_title：Molecular carcinogenesis

authors： Otero G,Avila MA,Emfietzoglou D,Clerch LB,Massaro D,Notario V

更新日期：1996-12-01 00:00:00