Inactivation of SNF5 cooperates with p53 loss to accelerate tumor formation in Snf5(+/-);p53(+/-) mice.

abstract：:The role of estrogen and the estrogen receptor (ER) in the induction and promotion of tumors was investigated by using transgenic MT-mER mice, which overexpress the ER. It was hypothesized that because of this abnormal expression of the ER, the reproductive-tract tissues of the MT-mER mice may be more susceptible to t...

journal_title：Molecular carcinogenesis

authors： Couse JF,Davis VL,Hanson RB,Jefferson WN,McLachlan JA,Bullock BC,Newbold RR,Korach KS

更新日期：1997-08-01 00:00:00

abstract：:Oxidative stress is known to play a key role in estrogen-induced breast cancer. This study assessed the chemopreventive activity of the naturally occurring γ-tocopherol-rich mixture of tocopherols (γ-TmT) in early stages of estrogen-induced mammary hyperplasia in ACI rats. ACI rats provide an established model of rode...

journal_title：Molecular carcinogenesis

authors： Das Gupta S,So JY,Wall B,Wahler J,Smolarek AK,Sae-Tan S,Soewono KY,Yu H,Lee MJ,Thomas PE,Yang CS,Suh N

更新日期：2015-09-01 00:00:00

abstract：:Extracellular signal-regulated kinase 1/2 (ERK1/2) constitute a point of convergence for complex signaling events that regulate essential cellular processes, including proliferation and survival. As such, dysregulation of the ERK signaling pathway is prevalent in many cancers. In the case of BRAF-V600E mutant melanoma...

journal_title：Molecular carcinogenesis

authors： Sammons RM,Ghose R,Tsai KY,Dalby KN

更新日期：2019-09-01 00:00:00

abstract：:Loss of heterozygosity (LOH) on the long arm of chromosome 13 is common in human breast tumors, pointing to the existence of several suppressor genes in this region. LOH at 13q14 has been implicated in alterations of retinoblastoma gene (RB1) expression. However, attempts to identify a link between the absence of reti...

journal_title：Molecular carcinogenesis

authors： Bièche I,Lidereau R

更新日期：2000-11-01 00:00:00

abstract：:The expression profile of adenoma induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice was compared with that of normal lung tissue by suppression subtractive hybridization (SSH). The mRNAs of surfactant-associated protein A (SP-A) and lysozyme showed characteristically higher transcription in t...

journal_title：Molecular carcinogenesis

authors： Okubo C,Morishita Y,Minami Y,Ishiyama T,Kano J,Iijima T,Noguchi M

更新日期：2005-02-01 00:00:00

abstract：:ZD1839 ("Iressa") is an orally active, selective epidermal growth factor (EGF) receptor-tyrosine kinase inhibitor. We evaluated the antitumor activity of ZD1839 in combination with HSP90 antagonist, 17-AAG in malignant human glioma cell lines. ZD1839 independently produced a dose-dependent inhibition of cellular proli...

journal_title：Molecular carcinogenesis

authors： Premkumar DR,Arnold B,Pollack IF

更新日期：2006-05-01 00:00:00

abstract：:Polyamine metabolism is a highly coordinated process that is essential for normal development and neoplastic growth in mammals. Although polyamine metabolism is a validated pathway for prevention of carcinogenesis, the mechanisms by which polyamines elicit their tumorigenic effects are poorly understood. In this study...

journal_title：Molecular carcinogenesis

authors： Paz EA,LaFleur B,Gerner EW

更新日期：2014-02-01 00:00:00

abstract：:Polymorphisms of the base excision repair gene APE1 may be associated with an increased risk for developing prostate cancer. In other cancer types, altered APE1 protein expression is a candidate prognostic marker. Using immunohistochemistry, we thus analyzed APE1 expression in 9763 prostate cancers in a tissue microar...

journal_title：Molecular carcinogenesis

authors： Juhnke M,Heumann A,Chirico V,Höflmayer D,Menz A,Hinsch A,Hube-Magg C,Kluth M,Lang DS,Möller-Koop C,Sauter G,Simon R,Beyer B,Pompe R,Thederan I,Schlomm T,Luebke AM

更新日期：2017-09-01 00:00:00

abstract：:Flavonoids are the most investigated phytochemicals due to their pharmacological and therapeutic activities. Their ability to chelate with metal ions has resulted in the emergence of a new category of molecules with a broader spectrum of pharmacological activities. In this study, the ruthenium quercetin complex has be...

journal_title：Molecular carcinogenesis

authors： Roy S,Das R,Ghosh B,Chakraborty T

更新日期：2018-06-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are elevated in patients with squamous cell carcinoma (SCC) over either the head and neck (HNSCC) or the esophagus (ESCC). Synchronous SCC with both HNSCC and ESCC predispose to worse survival. This study tested if serum MMP levels correlate with clinical features and predict survival ...

journal_title：Molecular carcinogenesis

authors： Wang WL,Chang WL,Yeh YC,Lee CT,Chang CY,Lin JT,Sheu BS

更新日期：2013-06-01 00:00:00

abstract：:Betanin, also called beetroot red, has been extensively used as a food colorant. In this study, the chemopreventive activity of betanin by oral consumption was investigated in two mouse lung tumor models. Vinyl carbamate (VC) and benzo(a)pyrene (B(a)P) were used to induce lung tumors, and female A/J mice were treated ...

journal_title：Molecular carcinogenesis

authors： Zhang Q,Pan J,Wang Y,Lubet R,You M

更新日期：2013-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a neoplasia representing the fifth most common malignancy worldwide and the third cause of death from cancer. Diets with high content in fruits and vegetables are widely recommended for their health-promoting properties, among them, the protection against diabetes, cancer, and cardiov...

journal_title：Molecular carcinogenesis

authors： Fernández-Bedmar Z,Anter J,Alonso-Moraga A,Martín de Las Mulas J,Millán-Ruiz Y,Guil-Luna S

更新日期：2017-06-01 00:00:00

abstract：:Apc mutations cause intestinal tumorigenesis through Tcf4 activation. However, direct techniques for studying Tcf4 activation in vivo are limited. Here, we describe the development of a Tcf4-GFP reporter mouse model for directly studying Tcf4 activation. We first developed a GFP reporter construct (Tcf4-GFP) and trans...

journal_title：Molecular carcinogenesis

authors： Boman B,Kopelovich L,Siracusa LD,Zhang T,Henderson K,Cofer Z,Buchberg AM,Fields JZ,Otevrel T

更新日期：2009-09-01 00:00:00

abstract：:Triptolide is an active component from a Chinese herb, Tripterygium wilfordii which has been applied for treating immune-related diseases over centuries. Recently, it was reported that a variety of cancer cell lines could be sensitized to DNA-damage based chemotherapy drugs in combination with Triptolide treatment. In...

journal_title：Molecular carcinogenesis

authors： Deng Y,Li F,He P,Yang Y,Yang J,Zhang Y,Liu J,Tong Y,Li Q,Mei X,Shu Z,Zhao Q

更新日期：2018-06-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest cancers in the world. All-trans retinoic acid (ATRA) is the major physiologically active form of vitamin A, regulating expression of many genes. Disturbances of vitamin A metabolism are prevalent in some cancer cells. The main aim of this work was...

journal_title：Molecular carcinogenesis

authors： Bleul T,Rühl R,Bulashevska S,Karakhanova S,Werner J,Bazhin AV

更新日期：2015-09-01 00:00:00

abstract：:2-Methoxyestradiol (2-ME), an endogenous metabolite of 17beta-estradiol, is present in human blood and urine. Here we show for the first time that 2-ME significantly inhibited the growth of normal prostate epithelial cells and androgen-dependent LNCaP and androgen-independent DU145 prostate cancer cells. This growth i...

journal_title：Molecular carcinogenesis

authors： Kumar AP,Garcia GE,Slaga TJ

更新日期：2001-07-01 00:00:00

abstract：:The influence of the tumor promoter 2-acetylaminofluorene (2-AAF) on cell proliferation and on the epidermal growth factor receptor (EGFR) system was assessed in normal and nodular rat livers. DNA replication in vivo was inhibited below the detection level after 8d of dietary 2-AAF treatment of previously unexposed ra...

journal_title：Molecular carcinogenesis

authors： Strömblad S,Eriksson LC,Andersson G

更新日期：1994-06-01 00:00:00

abstract：:Plakoglobin (Pg) and beta-catenin are homologous proteins that function in cell-cell adhesion and signaling. The cadherin-associated form of these proteins mediates adhesion, whereas the cytosolic/nuclear form has a signaling role. Despite their interactions with common cellular partners, beta-catenin has a well-docum...

journal_title：Molecular carcinogenesis

authors： Li L,Chapman K,Hu X,Wong A,Pasdar M

更新日期：2007-10-01 00:00:00

abstract：:Male F(1) hybrids between MSM mice carrying a deficient p53 allele and BALB/c mice were irradiated with gamma-rays, and 80 thymic lymphomas were obtained, 46 of which developed in mice carrying the deficient p53 allele. Because the Y chromosome contributes little to cellular function, the stability of the Y chromosome...

journal_title：Molecular carcinogenesis

authors： Chou D,Matsuki J,Saitou Y,Kosugi SI,Shinbo T,Gejyo F,Niwa O,Kominami R

更新日期：1999-11-01 00:00:00

abstract：:Adenocarcinoma accounts for ∼40% of lung cancer, equating to ∼88 500 new patients in 2015, most of who will succumb to this disease, thus, the public health burden is evident. Unfortunately, few early biomarkers as well as effective therapies exist, hence the need for novel targets in lung cancer treatment. We previou...

journal_title：Molecular carcinogenesis

authors： Bauer AK,Velmurugan K,Xiong KN,Alexander CM,Xiong J,Brooks R

更新日期：2017-01-01 00:00:00

abstract：:To perform a comprehensive genomic analysis of colorectal cancer (CRC) tumor to detect genetic variants and identify novel resistant mutations associated with cetuximab-resistance in CRC patients. A retrospective study was performed using whole exome sequencing (WES) to identify common genetic factors from 22 cetuxima...

journal_title：Molecular carcinogenesis

authors： Jing C,Wang T,Ma R,Cao H,Wang Z,Liu S,Chen D,Zhang J,Wu Y,Zhang Y,Wu J,Feng J

更新日期：2020-05-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) is a growth modulator that inhibits the proliferation of many epithelial cells through interaction with its receptors, the type I and type II receptors (TGF-beta RI and RII) by activating their serine/threonine kinase activities. Loss of growth inhibition by TGF-beta is thoug...

journal_title：Molecular carcinogenesis

authors： Jakowlew SB,Moody TW,You L,Mariano JM

更新日期：1998-05-01 00:00:00

abstract：:The temporal order of replication of several genes was studied in 10T1/2 cells synchronized by release from confluence-induced arrest of proliferation followed by treatment with 2 micrograms/mL aphidicolin for 24 h. DNA subjected to bromodeoxyuridine substitution for 1- or 2-h intervals spanning the S phase was separa...

journal_title：Molecular carcinogenesis

authors： Doggett NA,Cordeiro-Stone M,Chae CB,Kaufman DG

更新日期：1988-01-01 00:00:00

abstract：:In epithelial ovarian cancer, tumor grade is an independent prognosticator whose molecular determinants remain unknown. We investigated patterns of gene expression in well- and poorly differentiated serous papillary ovarian and peritoneal carcinomas with cDNA microarrays. A 6500-feature cDNA microarray was used for co...

journal_title：Molecular carcinogenesis

authors： Jazaeri AA,Lu K,Schmandt R,Harris CP,Rao PH,Sotiriou C,Chandramouli GV,Gershenson DM,Liu ET

更新日期：2003-02-01 00:00:00

abstract：:Phloretin (Ph), which can be obtained from apples, apple juice, and cider, is a known inhibitor of the type II glucose transporter (GLUT2). In this study, real-time PCR analysis of laser-capture microdissected (LCM) human hepatoma cells showed elevated expression (>5-fold) of GLUT2 mRNA in comparison with nonmalignant...

journal_title：Molecular carcinogenesis

authors： Yang KC,Tsai CY,Wang YJ,Wei PL,Lee CH,Chen JH,Wu CH,Ho YS

更新日期：2009-05-01 00:00:00

abstract：:LEC (Long-Evans with a cinnamon-like coat color) rats develop hepatocellular carcinomas (HCCs) spontaneously. We examined mutations of codons 12, 13, and 61 of the Ha-ras, Ki-ras, and N-ras genes in four HCCs by the polymerase chain reaction (PCR)-single-stranded DNA direct sequencing method. No ras gene mutations wer...

journal_title：Molecular carcinogenesis

authors： Fujimoto Y,Ishizaka Y,Tahira T,Sone H,Takahashi H,Enomoto K,Mori M,Sugimura T,Nagao M

更新日期：1991-01-01 00:00:00

abstract：:Inflammation plays a major role in colon carcinogenesis. Endogenously produced specialized proresolving lipid mediators (SPMs) play a central role in inflammation and tissue homeostasis, and have been implicated in carcinogenesis. We studied the associations of plasma levels of two SPMs [lipoxin A4 (LXA4 ) and resolvi...

journal_title：Molecular carcinogenesis

authors： Fedirko V,McKeown-Eyssen G,Serhan CN,Barry EL,Sandler RS,Figueiredo JC,Ahnen DJ,Bresalier RS,Robertson DJ,Anderson CW,Baron JA

更新日期：2017-08-01 00:00:00

abstract：:Aberrant epigenetic silencing of the tissue inhibitor of matrix metalloproteinase-3 (TIMP-3) gene that negatively regulates matrix metalloproteinases (MMPs) activity has been implicated in the pathogenesis and metastasis of breast cancer. In the present study, we demonstrate that green tea polyphenols (GTP) and its ma...

journal_title：Molecular carcinogenesis

authors： Deb G,Thakur VS,Limaye AM,Gupta S

更新日期：2015-06-01 00:00:00

abstract：:The DNA repair gene Ku70 plays a key role in the DNA double strand break (DSB) repair system. Defects in DSB repair capacity can lead to genomic instability. We hypothesized that the Ku70 C-1310G polymorphism (rs2267437) was associated with risk of renal cell carcinoma (RCC). We genotyped the Ku70 C-1310G polymorphism...

journal_title：Molecular carcinogenesis

authors： Wang W,Pan X,Huo X,Yan F,Wang M,Wang D,Gao Y,Cao Q,Luo D,Qin C,Yin C,Zhang Z

更新日期：2012-10-01 00:00:00

abstract：:The incidence and pattern of mutations of the ras oncogenes and the p53 tumor suppressor gene have been shown to differ among different cancer types and even among the same cancer types with different etiological backgrounds. For example, in a previous study we showed that not only the etiology but also the incidence ...

journal_title：Molecular carcinogenesis

authors： Kiba T,Tsuda H,Pairojkul C,Inoue S,Sugimura T,Hirohashi S

更新日期：1993-01-01 00:00:00