A functional polymorphism C-1310G in the promoter region of Ku70/XRCC6 is associated with risk of renal cell carcinoma.

abstract：:The role of estrogen and the estrogen receptor (ER) in the induction and promotion of tumors was investigated by using transgenic MT-mER mice, which overexpress the ER. It was hypothesized that because of this abnormal expression of the ER, the reproductive-tract tissues of the MT-mER mice may be more susceptible to t...

journal_title：Molecular carcinogenesis

authors： Couse JF,Davis VL,Hanson RB,Jefferson WN,McLachlan JA,Bullock BC,Newbold RR,Korach KS

更新日期：1997-08-01 00:00:00

abstract：:The aim of this study was to test whether long-term ethanol consumption confers therapeutic resistance to human liver cancer patients infected with hepatitis B virus (HBV). Chronic ethanol-treated cells were established by consecutively culturing a human hepatocellular carcinoma cell line, Hep 3B, which contains integ...

journal_title：Molecular carcinogenesis

authors： Huang CS,Lee YR,Chen CS,Tu SH,Wang YJ,Lee CH,Chen LC,Chang HW,Chang CH,Chih-Ming S,Wu CH,Ho YS

更新日期：2010-08-01 00:00:00

abstract：:Astrocyte elevated gene-1 (AEG-1) plays a critical role in the development, progression, and metastasis of a variety of cancers, including non-small-cell lung cancer (NSCLC). The objective of the current study is to unravel the upstream signaling of AEG-1. A cohort of 28 NSCLC tissues and 30 normal tissues were collec...

journal_title：Molecular carcinogenesis

authors： Li YH,Xu CL,He CJ,Pu HH,Liu JL,Wang Y

更新日期：2020-02-01 00:00:00

abstract：:The P53 gene is a tumor suppressor gene and can prevent mutation and tumor induction though apoptosis and DNA repair when it is activated by genotoxic stress. miR-34a expression is regulated by the P53 gene and might be required for cell response to DNA damage. TK6 cells are human lymphoblast cells with normal P53 fun...

journal_title：Molecular carcinogenesis

authors： Chen X,Yan J,Chen T

更新日期：2012-08-01 00:00:00

abstract：:We examined the expression of two groups of matrix metalloproteinases (MMPs), stromelysin and interstitial collagenase, in human skin cancer by northern blot analysis and in situ hybridization. Stromelysin-3 (ST-3) mRNA was overexpressed more than tenfold in 17 of 19 (89%) specimens of basal cell carcinoma (BCC) but i...

journal_title：Molecular carcinogenesis

authors： Majmudar G,Nelson BR,Jensen TC,Voorhees JJ,Johnson TM

更新日期：1994-01-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is recognized as one of the malignant tumors with poor prognosis. UAP1L1 (UDP-N-acetylglucosamine-1-like-1) affects numerous biological processes, which is a key regulator of the development of malignant tumors. The biological function and molecular mechanism of UAP1L1 in ESCC...

journal_title：Molecular carcinogenesis

authors： Xiao X,Jiang L,Hu H,Huang Y,Yang L,Jiao Y,Wei G

更新日期：2021-01-12 00:00:00

abstract：:Transforming growth factor beta (TGFbeta) signaling has both tumor suppression and promotion roles. Smads are transcription factors that primarily mediate intracellular signaling for the TGFbeta superfamily. Loss of Smad2 and Smad4, but not Smad3 is common in human cancers. Given the complex nature of TGFbeta signalin...

journal_title：Molecular carcinogenesis

authors： Bornstein S,Hoot K,Han GW,Lu SL,Wang XJ

更新日期：2007-08-01 00:00:00

abstract：:Integrin alpha6beta4 is altered in many neoplastic cells, but no data exist to show this happens in esophageal neoplasms. To examine the expression of this integrin in rat esophageal tumorigenesis induced by N-nitrosomethylbenzylamine (NMBA), (alpha6 and beta4 expression was evaluated in normal esophageal epithelium, ...

journal_title：Molecular carcinogenesis

authors： Khare L,Sabourin CL,DeYoung BR,Wagner BA,Stoner GD

更新日期：1998-03-01 00:00:00

abstract：:Mutational activation of RAS proteins occurs in nearly 30% of all human tumors. To date direct pharmacological inhibition of RAS oncoproteins has not been possible. As a consequence, current strategies are focusing on the development of inhibitors that target those kinases acting downstream of RAS proteins, including ...

journal_title：Molecular carcinogenesis

authors： Urosevic J,Sum EY,Moneo V,Drosten M,Dhawahir A,Becerra M,Carnero A,Barbacid M

更新日期：2009-11-01 00:00:00

abstract：:Triptolide is an active component from a Chinese herb, Tripterygium wilfordii which has been applied for treating immune-related diseases over centuries. Recently, it was reported that a variety of cancer cell lines could be sensitized to DNA-damage based chemotherapy drugs in combination with Triptolide treatment. In...

journal_title：Molecular carcinogenesis

authors： Deng Y,Li F,He P,Yang Y,Yang J,Zhang Y,Liu J,Tong Y,Li Q,Mei X,Shu Z,Zhao Q

更新日期：2018-06-01 00:00:00

abstract：:Merkel cell carcinoma (MCC) is a rare neuroendocrine carcinoma of the skin, for which the exact mechanisms of carcinogenesis remain unknown. Therapeutic options for this highly aggressive malignancy have historically been limited in both their initial response and response durability. Recent improvements in our unders...

journal_title：Molecular carcinogenesis

authors： Cohen L,Tsai KY

更新日期：2019-09-01 00:00:00

abstract：:Promoter hypermethylation is gaining strength as one of the main mechanisms through which tumor suppressor genes are silenced during tumor progression. Three tumor suppressor genes are frequently found methylated in their promoter, in concordance with absence of expression, RASSF1A, SLIT2, and WIF1. In addition, a pre...

journal_title：Molecular carcinogenesis

authors： Alvarez C,Tapia T,Cornejo V,Fernandez W,Muñoz A,Camus M,Alvarez M,Devoto L,Carvallo P

更新日期：2013-06-01 00:00:00

abstract：:This study examines the relationship between p53 immunostaining and direct sequencing of polymerase chain reaction (PCR) products in 61 gliomas. Glioma tissues obtained from patients at surgery were analyzed immunohistochemically with the monoclonal antibody PAb1801 to detect p53 protein abnormalities. Amplified p53 c...

journal_title：Molecular carcinogenesis

authors： Kyritsis AP,Xu R,Bondy ML,Levin VA,Bruner JM

更新日期：1996-01-01 00:00:00

abstract：:Loss or decrease of wild type BRCA1 function, by either mutation or reduced expression, has a role in hereditary and sporadic human breast and ovarian cancers. We report here that the PI3K/AKT pathway is constitutively active in BRCA1-defective human breast cancer cells. Levels of phospho-AKT are sustained even after ...

journal_title：Molecular carcinogenesis

authors： Yi YW,Kang HJ,Kim HJ,Hwang JS,Wang A,Bae I

更新日期：2013-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a neoplasia representing the fifth most common malignancy worldwide and the third cause of death from cancer. Diets with high content in fruits and vegetables are widely recommended for their health-promoting properties, among them, the protection against diabetes, cancer, and cardiov...

journal_title：Molecular carcinogenesis

authors： Fernández-Bedmar Z,Anter J,Alonso-Moraga A,Martín de Las Mulas J,Millán-Ruiz Y,Guil-Luna S

更新日期：2017-06-01 00:00:00

abstract：:Although fibroblast growth factor (FGF) signals are strongly associated with malignancy, limited information is available regarding the role of the FGF9 signal in colorectal cancer (CRC). In this study, we investigated the frequency of FGF9 amplification in CRC clinical specimens and the association between the FGF9 g...

journal_title：Molecular carcinogenesis

authors： Mizukami T,Togashi Y,Naruki S,Banno E,Terashima M,de Velasco MA,Sakai K,Yoneshige A,Hayashi H,Fujita Y,Tomida S,Nakajima TE,Fujino T,Boku N,Ito A,Nakagawa K,Nishio K

更新日期：2017-01-01 00:00:00

abstract：:Parafibromin, encoded by the gene HRPT2, is a tumor suppressor protein associated with the RNA polymerase II-associated complex, Paf1 complex. HRPT2 mutations were first identified in patients with the multiple endocrine neoplasia syndrome, hyperparathyroidism-jaw tumor (HPT-JT) syndrome, and have also been found in s...

journal_title：Molecular carcinogenesis

authors： Farber LJ,Kort EJ,Wang P,Chen J,Teh BT

更新日期：2010-03-01 00:00:00

abstract：:Most human colorectal cancers arise through the accumulation of a series of genetic alterations such as point mutations within the Ki-ras and p53 genes, but the chemical carcinogens that may be implicated in these events are still unidentified. In a previous study, we showed that DNA from human colorectal tissue conta...

journal_title：Molecular carcinogenesis

authors： Jackson PE,Hall CN,Badawi AF,O'Connor PJ,Cooper DP,Povey AC

更新日期：1996-05-01 00:00:00

abstract：:Rapid advances in multimodality therapy have not significantly improved the overall 5-yr survival of oral cancer patients in the past two decades, thereby underscoring the need for molecular therapeutics. The development of new treatment strategies for more effective management of oral cancer requires identification o...

journal_title：Molecular carcinogenesis

authors： Arora S,Matta A,Shukla NK,Deo SV,Ralhan R

更新日期：2005-02-01 00:00:00

abstract：:Genomic DNA sequences with the ability to assume non-B form secondary structures have been recently shown to be particularly susceptible to genetic instability, an early contributing factor in human disease and cancer development. Transcription appears to play a central role in formation of these structures and in pro...

journal_title：Molecular carcinogenesis

authors： Tornaletti S

更新日期：2009-04-01 00:00:00

abstract：:Krüppel-like factor 4 (KLF4) is a zinc-finger-containing transcription factor with tumor suppressor activity in various cancer types. Cells that sustain double strand breaks (DSBs) in their DNA due to high levels of reactive oxygen species (ROS) can develop genomic instability, which can result in cancer formation. On...

journal_title：Molecular carcinogenesis

authors： Liu C,La Rosa S,Hagos EG

更新日期：2015-09-01 00:00:00

abstract：:Protein kinases play important roles in tumor development and progression. A variety of members of the signal transduction enzymes serve as targets for therapeutic intervention in cancer. The dysregulation of Axl receptor and its ligand growth arrest-specific 6 (Gas6) is implicated in the pathogenesis of several cance...

journal_title：Molecular carcinogenesis

authors： He L,Zhang J,Jiang L,Jin C,Zhao Y,Yang G,Jia L

更新日期：2010-10-01 00:00:00

abstract：:The presence of RD(INK4/ARF) (RD) enhancer in the INK4-ARF locus provides a novel mechanism to simultaneously increase the transcription of p15(INK4b) (p15), p14ARF (p14), and p16(INK4a) (p16). While such upregulation can be repressed through interactions between RD and oncoproteins CDC6 and BMI1, little is known abou...

journal_title：Molecular carcinogenesis

authors： Poi MJ,Knobloch TJ,Sears MT,Warner BM,Uhrig LK,Weghorst CM,Li J

更新日期：2015-07-01 00:00:00

abstract：:We found that caffeine significantly inhibited epidermal growth factor (EGF)- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cell transformation in the JB6 mouse epidermal cell line. The tumor promoter-induced cell transformation was also blocked by treatment with an adenosine A1 receptor antagonist, 8-phenylt...

journal_title：Molecular carcinogenesis

authors： Nomura M,Ichimatsu D,Moritani S,Koyama I,Dong Z,Yokogawa K,Miyamoto K

更新日期：2005-09-01 00:00:00

abstract：:The majority of ovarian cancers over-express the estrogen receptor (ERα) and grow in response to estrogens. We previously demonstrated that ER induction of the chemokine CXCL12 (stromal cell-derived factor-1) is required for estradiol (E2)-stimulated proliferation of human ovarian carcinoma cells. In the current study...

journal_title：Molecular carcinogenesis

authors： Hall JM,Korach KS

更新日期：2013-09-01 00:00:00

abstract：:Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide. The colonic mucosa constitutes a critical barrier and a major site of immune regulation. The immune system plays important roles in cancer development and treatment, and immune activation caused by chronic infection or inflammation is well-k...

journal_title：Molecular carcinogenesis

authors： Ruan H,Leibowitz BJ,Zhang L,Yu J

更新日期：2020-07-01 00:00:00

abstract：:Development of chemoresistance in androgen-refractory prostate cancer cells is partly due to constitutive activation of Rel/NF-kappaB transcription factors that regulate several cell survival and anti-apoptotic genes. In this study we examined whether betulinic acid (BetA), a pentacyclic triterpene from the bark of wh...

journal_title：Molecular carcinogenesis

authors： Rabi T,Shukla S,Gupta S

更新日期：2008-12-01 00:00:00

abstract：:We previously reported that the Wnt pathway is preferentially activated in basal-like breast cancer. However, the mechanisms by which the Wnt pathway regulates down-stream targets in basal-like breast cancer, and the biological significance of this regulation, are poorly understood. In this study, we found that c-Myc ...

journal_title：Molecular carcinogenesis

authors： Xu J,Chen Y,Huo D,Khramtsov A,Khramtsova G,Zhang C,Goss KH,Olopade OI

更新日期：2016-05-01 00:00:00

abstract：:Cytogenetic and molecular studies of human renal cell carcinoma (RCC) have suggested that the genetic and functional losses of one or more putative tumor suppressor genes on the short arm of chromosome 3 play a crucial role in the development of this disease. To examine whether the introduction of chromosome 3 has any...

journal_title：Molecular carcinogenesis

authors： Yoshida MA,Shimizu M,Ikeuchi T,Tonomura A,Yokota J,Oshimura M

更新日期：1994-03-01 00:00:00

abstract：:The role of telomerase as an essential requirement for the neoplastic conversion of human cells has been controversial. In the model of conversion of normal human cells to cancer cells by the combination of simian virus 40 (SV40) early region genes and oncogenic Ras (H-Ras(G12V)), telomerase (hTERT) was originally des...

journal_title：Molecular carcinogenesis

authors： Liang S,Kahlenberg MS,Rousseau DL Jr,Hornsby PJ

更新日期：2008-06-01 00:00:00