Overexpression of MDM-2 mRNA and mutation of the p53 tumor suppressor gene in bladder carcinoma cell lines.

abstract：:Human DEAD-box RNA helicase gene DDX6 was cloned from B-cell lymphoma cell line RC-K8. Previously, we reported that DDX6 acts as oncogene in several cancers such as colorectal cancer and hepatocellular carcinoma. However, the detailed mechanism of DDX6 action in carcinogenesis is largely unknown. In this study, we exa...

journal_title：Molecular carcinogenesis

authors： Taniguchi K,Iwatsuki A,Sugito N,Shinohara H,Kuranaga Y,Oshikawa Y,Tajirika T,Futamura M,Yoshida K,Uchiyama K,Akao Y

更新日期：2018-05-01 00:00:00

abstract：:Hexavalent chromium [Cr(VI)] is a well-known environment carcinogen. The exposure of Cr(VI) through contaminated soil, air particles, and drinking water is a strong concern for the public health worldwide. While many studies have been done, it remains unclear which intracellular molecules transduce Cr(VI)-mediated car...

journal_title：Molecular carcinogenesis

authors： Ganapathy S,Li P,Lafontant J,Xiong R,Yu T,Zhang G,Chen C

更新日期：2017-07-01 00:00:00

abstract：:Angiogenesis is a prerequisite for progression of cancers. The number of genes linked to angiogenesis suggests the existence of complex gene-networks, which remain to be elucidated. To identify angiogenesis genes deregulated in carcinomas, we performed a meta-profiling analysis of published gene expression microarray ...

journal_title：Molecular carcinogenesis

authors： Anders M,Fehlker M,Wang Q,Wissmann C,Pilarsky C,Kemmner W,Höcker M

更新日期：2013-01-01 00:00:00

abstract：:FAM134B is an autophagy regulator of endoplasmic reticulum and acts as a cancer suppressor in colon cancer. However, the molecular signaling pathways by which FAM134B interacts within colon carcinogenesis is still unknown. Herein, this study aims to determine the interacting partners of FAM134B for the first time in c...

journal_title：Molecular carcinogenesis

authors： Islam F,Chaousis S,Wahab R,Gopalan V,Lam AK

更新日期：2018-11-01 00:00:00

abstract：:Prostate cancer (PCA) is the second most malignancy in American men. Advanced stage PCA cells possess unlimited replication potential as well as resistance to apoptosis. Therefore, targeting survival mechanisms and activating apoptotic machinery in PCA cells using nontoxic phytochemicals is suggested as an attractive ...

journal_title：Molecular carcinogenesis

authors： Deep G,Gangar SC,Oberlies NH,Kroll DJ,Agarwal R

更新日期：2010-10-01 00:00:00

abstract：:Rat neoplasms induced by methylating carcinogens frequently contain ras genes activated by a single point mutation. Rat prostatic tumors induced by a combination of a single injection of N-methyl-N-nitrosourea (MNU) and long-term treatment with testosterone were examined for the presence of such activating point mutat...

journal_title：Molecular carcinogenesis

authors： Sukumar S,Armstrong B,Bruyntjes JP,Leav I,Bosland MC

更新日期：1991-01-01 00:00:00

abstract：:Non-alcoholic steatohepatitis (NASH) is becoming one of the major causes of hepatocellular carcinoma (HCC) in the United States and Western countries; however, the molecular mechanisms associated with NASH-related liver carcinogenesis are not well understood. In the present study, we investigated cancer-associated chr...

journal_title：Molecular carcinogenesis

authors： Dechassa ML,Tryndyak V,de Conti A,Xiao W,Beland FA,Pogribny IP

更新日期：2018-08-01 00:00:00

abstract：:Dietary prevention is a cost-efficient strategy to reduce the risk of human cancers. More than 85% breast cancers are sporadic and attributable to long-term exposure to environmental carcinogens through a multistep and multiyear disease process. We used our chronically induced cellular carcinogenesis model as a target...

journal_title：Molecular carcinogenesis

authors： Choudhary S,Sood S,Wang HC

更新日期：2014-03-01 00:00:00

abstract：:Microsatellite instability (MI) and loss of heterozygosity (LOH) were examined in mammary tumors induced in Sprague-Dawley x F344 F1 female rats by 2-amino-l-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Examination of 62 microsatellite loci revealed MI in nine of 15 (60%) PhIP-induced mammary tumors, and five of thes...

journal_title：Molecular carcinogenesis

authors： Toyota M,Ushijima T,Weisburger JH,Hosoya Y,Canzian F,Rivenson A,Imai K,Sugimura T,Nagao M

更新日期：1996-03-01 00:00:00

abstract：:Prostate cancer (PCa) patients' mortality is mainly attributed to complications caused by metastasis of the tumor cells to organs critical for survival, such as bone. We hypothesized that PCa cell-bone interactions would promote paracrine signaling. A panel of PCa cell lines were cocultured with hydroxyapatite ([HA]; ...

journal_title：Molecular carcinogenesis

authors： Henderson VM,Hawsawi O,Burton LJ,Campbell T,Trice K,Dougan J,Howard SM,Odero-Marah VA

更新日期：2019-08-01 00:00:00

abstract：:Breast cancer is a major health problem worldwide. Current standard practices for treatment of breast cancer are less than satisfactory because of high rates of metastasis. Arsenic trioxide (As(2)O(3)), which induces demethylation of DNA and causes apoptosis, has been used as an anti-tumor agent. Little is known, howe...

journal_title：Molecular carcinogenesis

authors： Si L,Jiang F,Li Y,Ye X,Mu J,Wang X,Ning S,Hu C,Li Z

更新日期：2015-09-01 00:00:00

abstract：:Genotoxicity tests indicate methanol (MeOH) is not mutagenic, but a rodent study has suggested carcinogenic potential, which could result from free radical-initiated oxidative DNA damage. To investigate this possibility we treated male CD-1 mice, New Zealand white rabbits, and cynomolgus monkeys with MeOH (2.0 g/kg ip...

journal_title：Molecular carcinogenesis

authors： McCallum GP,Siu M,Ondovcik SL,Sweeting JN,Wells PG

更新日期：2011-03-01 00:00:00

abstract：:Growth factor receptors of the tyrosine kinase family regulate proliferation of a variety of cell types. In some human cancers, the epidermal growth factor receptor (EGFR) and its ligands often are overexpressed, leading to both constitutive and autocrine activation. Intracellular signaling via this receptor takes pla...

journal_title：Molecular carcinogenesis

authors： Crowe DL,Tsang KJ

更新日期：2001-12-01 00:00:00

abstract：:Most human colorectal cancers arise through the accumulation of a series of genetic alterations such as point mutations within the Ki-ras and p53 genes, but the chemical carcinogens that may be implicated in these events are still unidentified. In a previous study, we showed that DNA from human colorectal tissue conta...

journal_title：Molecular carcinogenesis

authors： Jackson PE,Hall CN,Badawi AF,O'Connor PJ,Cooper DP,Povey AC

更新日期：1996-05-01 00:00:00

abstract：:Recent studies of the individual functionalities of long non-coding RNAs (lncRNAs) in the development and progression of cancer have suggested that HOX transcript antisense RNA (HOTAIR) is capable of reprogramming chromatin organization and promoting cancer cell metastasis. In order to ascertain the expression pattern...

journal_title：Molecular carcinogenesis

authors： Chen FJ,Sun M,Li SQ,Wu QQ,Ji L,Liu ZL,Zhou GZ,Cao G,Jin L,Xie HW,Wang CM,Lv J,De W,Wu M,Cao XF

更新日期：2013-11-01 00:00:00

abstract：:The atomic bombing of Hiroshima and Nagasaki and the nuclear accident at Chernobyl raised the question of prenatal sensitivity to ionizing radiation-induced cancer. In this study, mice were exposed to single doses of gamma-radiation (0.2-2.0 Gy) at different embryonic stages. The tumor incidence increased with dose fr...

journal_title：Molecular carcinogenesis

authors： Lumniczky K,Antal S,Unger E,Wunderlich L,Hidvégi EJ,Sáfrány G

更新日期：1998-02-01 00:00:00

abstract：:Exposure to aflatoxin B(1) (AFB(1)) is one of the risk factors for developing hepatoma. In rats, activation of the ras gene is a prevalent event in AFB(1)-induced hepatocarcinogenesis. It is not clear whether a similar event occurs in humans. By analysis of codon 249 of the p53 gene, six of 36 human hepatoma samples w...

journal_title：Molecular carcinogenesis

authors： Chao HK,Tsai TF,Lin CS,Su TS

更新日期：1999-10-01 00:00:00

abstract：:The incidence and pattern of mutations of the ras oncogenes and the p53 tumor suppressor gene have been shown to differ among different cancer types and even among the same cancer types with different etiological backgrounds. For example, in a previous study we showed that not only the etiology but also the incidence ...

journal_title：Molecular carcinogenesis

authors： Kiba T,Tsuda H,Pairojkul C,Inoue S,Sugimura T,Hirohashi S

更新日期：1993-01-01 00:00:00

abstract：:It becomes feasible to perform genome-wide differential gene or protein expression in the post genome era. However, little has been addressed on the effects of external stresses and microenvironment alterations on the outcomes of gene and protein expression. To identify downregulated genes during hepatoma development,...

journal_title：Molecular carcinogenesis

authors： Hsieh SY,Chen WY,Shih TC,Yeh JY,Jeng JT

更新日期：2005-06-01 00:00:00

abstract：:ZD1839 ("Iressa") is an orally active, selective epidermal growth factor (EGF) receptor-tyrosine kinase inhibitor. We evaluated the antitumor activity of ZD1839 in combination with HSP90 antagonist, 17-AAG in malignant human glioma cell lines. ZD1839 independently produced a dose-dependent inhibition of cellular proli...

journal_title：Molecular carcinogenesis

authors： Premkumar DR,Arnold B,Pollack IF

更新日期：2006-05-01 00:00:00

abstract：:As the prognostic significance of the three most frequently amplified oncogenes in breast cancer (c-myc, int-2/FGF3, and c-erbB-2/neu) is still unclear, and as the amplification of these genes appears to be mutually exclusive, we investigated the prognostic significance of oncogene amplification per se by multivariate...

journal_title：Molecular carcinogenesis

authors： Champème MH,Bièche I,Hacène K,Lidereau R

更新日期：1994-12-01 00:00:00

abstract：:The effects of the flavonoid compound, kaempferol, which is an inhibitor of cancer cell proliferation and an inducer of cell apoptosis have been shown in various cancers, including lung, pancreatic, and ovarian, but its effect has never been studied in bladder cancer. Here, we investigated the effects of kaempferol on...

journal_title：Molecular carcinogenesis

authors： Dang Q,Song W,Xu D,Ma Y,Li F,Zeng J,Zhu G,Wang X,Chang LS,He D,Li L

更新日期：2015-09-01 00:00:00

abstract：:LW-213 is a derivative of Wogonin and the anticancer activities of Wogonin have been reported. To study whether LW-213 inhibits cancer cells and explore a possible mechanism, we investigate the compound in several cancer cell lines. We found LW-213 arrests G2/M cycle in breast cancer cells by suppression of Akt/Gsk3β/...

journal_title：Molecular carcinogenesis

authors： Zhao L,Miao HC,Li WJ,Sun Y,Huang SL,Li ZY,Guo QL

更新日期：2016-05-01 00:00:00

abstract：:Withaferin A (WA) exhibits cancer chemopreventive efficacy in preclinical models representative of two different subtypes of breast cancer. However, the mechanism(s) underlying breast cancer chemoprevention by WA is not fully elucidated. We performed RNA-seq analyses using a non-tumorigenic mammary epithelial cell lin...

journal_title：Molecular carcinogenesis

authors： Hahm ER,Kim SH,Singh KB,Singh SV

更新日期：2021-01-01 00:00:00

abstract：:Dishevelled-3 (Dvl-3) and p120-catenin (p120ctn) have abnormal expression in non-small cell lung cancer (NSCLC), which is associated with poor prognosis. Dvl-3 upregulates p120ctn transcription in NSCLC cells, but the mechanism is unknown. Here we transiently transfected Dvl-3 cDNA to NSCLC cells. Dvl-3 transfection i...

journal_title：Molecular carcinogenesis

authors： Zhao H,Zhao Y,Jiang G,Zhang X,Zhang Y,Dong Q,Luan L,Papavassiliou P,Wang E,Wang E

更新日期：2015-06-01 00:00:00

abstract：:Cytogenetic and molecular studies of human renal cell carcinoma (RCC) have suggested that the genetic and functional losses of one or more putative tumor suppressor genes on the short arm of chromosome 3 play a crucial role in the development of this disease. To examine whether the introduction of chromosome 3 has any...

journal_title：Molecular carcinogenesis

authors： Yoshida MA,Shimizu M,Ikeuchi T,Tonomura A,Yokota J,Oshimura M

更新日期：1994-03-01 00:00:00

abstract：:Nonmelanoma skin cancers (NMSCs) consist of a variety of tumor types including basal cell carcinoma, squamous cell carcinoma, a variety of hair follicle tumors, and sebaceous gland tumors. Genetic alterations that alter the fate of multipotent stem cells are believed to influence NMSC phenotype. We previously generate...

journal_title：Molecular carcinogenesis

authors： Honeycutt KA,Waikel RL,Koster MI,Wang XJ,Roop DR

更新日期：2010-04-01 00:00:00

abstract：:Numerous studies have shown that aberrant microRNA (miRNA) expression is associated with the development and progression of various types of human cancer and serum miRNAs are potential biomarkers. This study examined whether some commonly deregulated miRNAs in hepatocellular carcinoma (HCC) are presented in serum of p...

journal_title：Molecular carcinogenesis

authors： Xu J,Wu C,Che X,Wang L,Yu D,Zhang T,Huang L,Li H,Tan W,Wang C,Lin D

更新日期：2011-02-01 00:00:00

abstract：:In tumor cells that have lost responsiveness to the growth inhibitory effects of transforming growth factor beta (TGFbeta), increased TGFbeta production by the tumor cells often contributes to cancer progression, primarily through paracrine mechanisms. Here we investigated the major components of the activator protein...

journal_title：Molecular carcinogenesis

authors： Liu G,Ding W,Liu X,Mulder KM

更新日期：2006-08-01 00:00:00

abstract：:A rapid and sensitive assay was developed to detect CAA-->AAA mutations at codon 61 of Ha-ras. The region surrounding codon 61 was amplified by the polymerase chain reaction (PCR) using one primer containing a mismatch at the second position of codon 60. Using this primer creates an Msel restriction enzyme site if cod...

journal_title：Molecular carcinogenesis

authors： Shinder GA,Manam S,Nichols WW

更新日期：1993-01-01 00:00:00