Notch3-specific inhibition using siRNA knockdown or GSI sensitizes paclitaxel-resistant ovarian cancer cells.

abstract：:The metalloproteinase matrilysin is widely expressed in the epithelial tumor cells of malignant colorectal adenocarcinomas. Approximately 50% of benign adenomas also express low levels of matrilysin that is focally localized. The expression of stromelysin-1, stromelysin-3, and gelatinase A was observed in the stromal ...

journal_title：Molecular carcinogenesis

authors： Newell KJ,Witty JP,Rodgers WH,Matrisian LM

更新日期：1994-08-01 00:00:00

abstract：:In tumor cells that have lost responsiveness to the growth inhibitory effects of transforming growth factor beta (TGFbeta), increased TGFbeta production by the tumor cells often contributes to cancer progression, primarily through paracrine mechanisms. Here we investigated the major components of the activator protein...

journal_title：Molecular carcinogenesis

authors： Liu G,Ding W,Liu X,Mulder KM

更新日期：2006-08-01 00:00:00

abstract：:In this study, we found that rat nasal coumarin-7-hydroxylase (COH) activity was two orders of magnitude higher than rat hepatic COH activity and could be induced by adding coumarin to the rats' drinking water. In western blot analysis, an anti-cytochrome P450 (Cyp) 2a-5 (mouse liver COH) antibody recognized a sharp b...

journal_title：Molecular carcinogenesis

authors： Béréziat JC,Raffalli F,Schmezer P,Frei E,Geneste O,Lang MA

更新日期：1995-10-01 00:00:00

abstract：:Osteosarcoma is the primary human malignant tumor affecting bone. This cancer most frequently arises in children and adolescents, with a second peak in those over the age of 50. Currently, surgery followed by radiotherapy and chemotherapy are the main treatments, but long-term positive effects are very poor. Aurora B ...

journal_title：Molecular carcinogenesis

authors： Zhao Z,Jin G,Yao K,Liu K,Liu F,Chen H,Wang K,Gorja DR,Reddy K,Bode AM,Guo Z,Dong Z

更新日期：2019-06-01 00:00:00

abstract：:Phloretin (Ph), which can be obtained from apples, apple juice, and cider, is a known inhibitor of the type II glucose transporter (GLUT2). In this study, real-time PCR analysis of laser-capture microdissected (LCM) human hepatoma cells showed elevated expression (>5-fold) of GLUT2 mRNA in comparison with nonmalignant...

journal_title：Molecular carcinogenesis

authors： Yang KC,Tsai CY,Wang YJ,Wei PL,Lee CH,Chen JH,Wu CH,Ho YS

更新日期：2009-05-01 00:00:00

abstract：:To study the possible involvement of DNA damage in cell transformation induced by estrogens, we examined whether DNA adduct formation is elicited in cultured Syrian hamster embryo (SHE) cells treated with estrogens and their derivatives by means of the 32P-postlabeling assay. Morphological transformation of the cells ...

journal_title：Molecular carcinogenesis

authors： Hayashi N,Hasegawa K,Komine A,Tanaka Y,McLachian JA,Barrett JC,Tsutsui T

更新日期：1996-07-01 00:00:00

abstract：:Atypical adenomatous hyperplasia (AAH) of the prostate is characterized by lobular proliferation of closely packed small acini. It is hypothesized that AAH is a precursor lesion for low-grade prostate cancer arising from the transition zone. Telomere dysfunction is common during malignant transformation of epithelia. ...

journal_title：Molecular carcinogenesis

authors： Cheng L,Montironi R,Davidson DD,Wang M,Lopez-Beltran A,Zhang S

更新日期：2019-07-01 00:00:00

abstract：:As the prognostic significance of the three most frequently amplified oncogenes in breast cancer (c-myc, int-2/FGF3, and c-erbB-2/neu) is still unclear, and as the amplification of these genes appears to be mutually exclusive, we investigated the prognostic significance of oncogene amplification per se by multivariate...

journal_title：Molecular carcinogenesis

authors： Champème MH,Bièche I,Hacène K,Lidereau R

更新日期：1994-12-01 00:00:00

abstract：:microRNAs (miRNA) silence target genes through Watson-Crick based binding to the 3'untranslated regions (3'UTR). Thus, polymorphisms in the miRNA-binding sites may disrupt this process and play a potential role in cancer pathogenesis. Integrins have been implicated in the genesis and development of many tumors. This s...

journal_title：Molecular carcinogenesis

authors： Liu J,Huang J,He Y,Liu J,Liao B,Liao G

更新日期：2014-04-01 00:00:00

abstract：:To analyze the mechanism of neoplastic transformation of rodent diploid cells by ras and myc oncogenes, human EJ c-Ha-ras and mouse c-myc second and third exons promoted by SV40 promoter were connected to pSV2neo and pSV2gpt, respectively. Mouse and rat primary fetal cells cotransfected with both genes formed transfor...

journal_title：Molecular carcinogenesis

authors： Yagi T,Sasayama S,Sasai H,Kakunaga T

更新日期：1989-01-01 00:00:00

abstract：:Alterations of the Rassf1a gene were investigated in pancreatic duct adenocarcinomas (PDAs) induced by N-nitrosobis(2-oxopropyl)amine (BOP) in hamsters. Female Syrian golden hamsters received 70 mg/kg BOP, followed by repeated exposures to an augmentation pressure regimen consisting of a choline-deficient diet combine...

journal_title：Molecular carcinogenesis

authors： Shimizu K,Itsuzaki Y,Fujii H,Honoki K,Tsujiuchi T

更新日期：2008-02-01 00:00:00

abstract：:Gastrointestinal stromal tumor (GIST) is a common mesenchymal tumor in the gastrointestinal tract. Prostate cancer associated transcript 6 (PCAT6) is a long noncoding RNA (lncRNA) and plays a pivotal role in tumor formation. Present study was designed to explore the function of PCAT6 in GIST. Ki67 staining, colony for...

journal_title：Molecular carcinogenesis

authors： Bai F,Zhang N,Fang W,He X,Zheng Y,Gu D

更新日期：2020-06-01 00:00:00

abstract：:Reflux of acidic gastric contents and bile acids into the lower esophagus has been identified to have a central role in esophageal malignancy and is reported to upregulate caudal-related homologue 2 (CDX2), a regulatory gene involved in embryonic development and axial patterning of the alimentary tract. The aim of thi...

journal_title：Molecular carcinogenesis

authors： Vaninetti N,Williams L,Geldenhuys L,Porter GA,Guernsey DL,Casson AG

更新日期：2009-10-01 00:00:00

abstract：:Oxidative stress is known to play a key role in estrogen-induced breast cancer. This study assessed the chemopreventive activity of the naturally occurring γ-tocopherol-rich mixture of tocopherols (γ-TmT) in early stages of estrogen-induced mammary hyperplasia in ACI rats. ACI rats provide an established model of rode...

journal_title：Molecular carcinogenesis

authors： Das Gupta S,So JY,Wall B,Wahler J,Smolarek AK,Sae-Tan S,Soewono KY,Yu H,Lee MJ,Thomas PE,Yang CS,Suh N

更新日期：2015-09-01 00:00:00

abstract：:Rapid advances in multimodality therapy have not significantly improved the overall 5-yr survival of oral cancer patients in the past two decades, thereby underscoring the need for molecular therapeutics. The development of new treatment strategies for more effective management of oral cancer requires identification o...

journal_title：Molecular carcinogenesis

authors： Arora S,Matta A,Shukla NK,Deo SV,Ralhan R

更新日期：2005-02-01 00:00:00

abstract：:Gallbladder carcinoma (GBC) is a highly malignant neoplasm and represents the leading cause of cancer death in Chilean women. In order to determine the potential role of promoter methylation in gallbladder carcinogenesis, we investigated the frequency of this epigenetic mechanism by methylation-specific polymerase cha...

journal_title：Molecular carcinogenesis

authors： García P,Manterola C,Araya JC,Villaseca M,Guzmán P,Sanhueza A,Thomas M,Alvarez H,Roa JC

更新日期：2009-01-01 00:00:00

abstract：:Dietary heterocyclic aromatic amines (HCA) and polyunsaturated fatty acids (PUFA) are both believed to play a role in colon carcinogenesis, and are both substrate for the enzyme cyclooxygenase (COX). In HCA-7 cells, highly expressing isoform COX-2, we investigated the effects of PUFA on prostaglandin synthesis and DNA...

journal_title：Molecular carcinogenesis

authors： Moonen HJ,Dommels YE,van Zwam M,van Herwijnen MH,Kleinjans JC,Alink GM,de Kok TM

更新日期：2004-07-01 00:00:00

abstract：:Differentiation antagonizing non-protein coding RNA (DANCR) is a newly identified oncogenic long noncoding RNA found in various cancers. However, the functional role of DANCR in tumor angiogenesis and the underlying mechanisms are still unclear. The expression of DANCR was determined in ovarian malignant tissues and c...

journal_title：Molecular carcinogenesis

authors： Lin X,Yang F,Qi X,Li Q,Wang D,Yi T,Yin R,Zhao X,Zhong X,Bian C

更新日期：2019-12-01 00:00:00

abstract：:Bone cells are a prime target for the biological function of the fos/jun (activating protein-1 (AP-1)) transcription factor complex. Deregulated expression of c-fos or v-fos in bone cells induces tumorigenicity and the formation of non-metastatic osteosarcomas. In contrast, fos oncogenes transform fibroblasts to an in...

journal_title：Molecular carcinogenesis

authors： Rupp B,Lorenz U,Schmidt J,Werenskiold AK

更新日期：1998-10-01 00:00:00

abstract：:Single nucleotide polymorphisms (SNPs) of matrix metalloproteinase3 (MMP3) promoter in the development and progression of gastric cancer of whole stomach has never been investigated in any population. We conducted a hospital-based case-control study to explore the MMP3 SNPs and their haplotypes with the risk of gastri...

journal_title：Molecular carcinogenesis

authors： Dey S,Stalin S,Gupta A,Saha D,Kesh K,Swarnakar S

更新日期：2012-10-01 00:00:00

abstract：:Withaferin A (WA), a natural product derived from Withania somnifera, has been used in traditional oriental medicines to treat neurological disorders. Recent studies have demonstrated that this compound may have a potential for cancer treatment and a clinical trial has been launched to test WA in treating melanoma. He...

journal_title：Molecular carcinogenesis

authors： Li W,Zhang C,Du H,Huang V,Sun B,Harris JP,Richardson Q,Shen X,Jin R,Li G,Kevil CG,Gu X,Shi R,Zhao Y

更新日期：2016-11-01 00:00:00

abstract：:Cytokines are considered to play an important role in tumor pathogenesis and progression, and recent studies have demonstrated that a variety of forms, including interleukins (ILs) and transforming growth factor-beta(s) (TGF-beta(s)), may regulate tumors. In the present study, the expression of TGF-beta isoforms and I...

journal_title：Molecular carcinogenesis

authors： Honoki K,Tsujiuchi T,Sasaki Y,Tsutsumi M,Morishita T,Kido A,Miyauchi Y,Mii Y,Takakura Y,Konishi Y

更新日期：2002-02-01 00:00:00

abstract：:Recent evidence suggests that the A allele of the ornithine decarboxylase (ODC) gene is a genetic risk factor for prostate cancer. ODC is a target gene of the highly polymorphic androgen receptor (AR) gene, short alleles of which have been associated in some studies with increased prostate cancer risk. We determined O...

journal_title：Molecular carcinogenesis

authors： O'Brien TG,Guo Y,Visvanathan K,Sciulli J,McLaine M,Helzlsouer KJ,Watkins-Bruner D

更新日期：2004-10-01 00:00:00

abstract：:Gene amplification contributes to carcinogenesis by enhancing proto-oncogene activity and causing chromosomal instability. The ease of detecting amplified tumor-virus sequences has encouraged use of this system as a surrogate for studying the molecular events involved in endogenous gene amplification. We report here a...

journal_title：Molecular carcinogenesis

authors： Rossman TG,Wolosin D

更新日期：1992-01-01 00:00:00

abstract：:The physical gut barrier, comprised of a thick mucus layer and the epithelium, plays an important role in defense against microbes and foreign antigens. Calcium and vitamin D may be involved in maintaining the integrity of the intestinal mucosal barrier, the dysfunction of which may lead to endotoxemia and inflammatio...

journal_title：Molecular carcinogenesis

authors： Mandle HB,Jahan FA,Bostick RM,Baron JA,Barry EL,Yacoub R,Merrill J,Rutherford RE,Seabrook ME,Fedirko V

更新日期：2019-07-01 00:00:00

abstract：:Increasing evidence from recent research suggests a connection between cancer and a deranged equilibrium of histone acetylation, which is maintained by two competing enzymatic activities, histone acetyltransferases (HATs) and histone deacetylases (HDACs). It is our hypothesis that a significant proportion of leukemias...

journal_title：Molecular carcinogenesis

authors： Mahlknecht U,Ottmann OG,Hoelzer D

更新日期：2000-04-01 00:00:00

abstract：:Expression of the tumor suppressor deleted in liver cancer-1 (DLC-1) is lost in non-small cell lung (NSCLC) and other human carcinomas, and ectopic DLC-1 expression dramatically reduces proliferation and tumorigenicity. DLC-1 is a multi-domain protein that includes a Rho GTPase activating protein (RhoGAP) domain which...

journal_title：Molecular carcinogenesis

authors： Healy KD,Hodgson L,Kim TY,Shutes A,Maddileti S,Juliano RL,Hahn KM,Harden TK,Bang YJ,Der CJ

更新日期：2008-05-01 00:00:00

abstract：:Chloride intracellular channel 4 (CLIC4) is a putative chloride channel for intracellular organelles. CLIC4 has biological activities in addition to or because of its channel activity. In keratinocytes, CLIC4 resides in the mitochondria and cytoplasm, and CLIC4 gene expression is regulated by p53, TNF-alpha, and c-Myc...

journal_title：Molecular carcinogenesis

authors： Suh KS,Malik M,Shukla A,Yuspa SH

更新日期：2007-08-01 00:00:00

abstract：:Obesity increases colorectal cancer (CRC) risk and progression. However, the impact of obesity on CRC in women is dependent on ovarian hormone status. The purpose of this study was to determine the interactive roles of obesity and ovarian hormones on serum markers of inflammation, cell signaling, and transplanted colo...

journal_title：Molecular carcinogenesis

authors： Rondini EA,Harvey AE,Steibel JP,Hursting SD,Fenton JI

更新日期：2011-05-01 00:00:00

abstract：:Extracellular signal-regulated kinase 1/2 (ERK1/2) constitute a point of convergence for complex signaling events that regulate essential cellular processes, including proliferation and survival. As such, dysregulation of the ERK signaling pathway is prevalent in many cancers. In the case of BRAF-V600E mutant melanoma...

journal_title：Molecular carcinogenesis

authors： Sammons RM,Ghose R,Tsai KY,Dalby KN

更新日期：2019-09-01 00:00:00