Regulation of CDX2 expression in esophageal adenocarcinoma.

abstract：:A decrease in the intracellular concentrations of the transcripts for some tumor suppressor genes has been found during murine lung tumorigenesis; for p15INK4b and p16INK4a, this was due to homozygous deletions. We report here a decrease in the mRNA levels of the mutated in colorectal cancer (Mcc) and adenomatous poly...

journal_title：Molecular carcinogenesis

authors： Oreffo VI,Robinson S,You M,Wu MC,Malkinson AM

更新日期：1998-01-01 00:00:00

abstract：:In the present study, we evaluated the effect of deleting Twist1 on keratinocyte proliferation and on skin tumor development using the two-stage chemical carcinogenesis model. BK5.Cre × Twist1(flox/flox) mice, which have a keratinocyte-specific Twist1 knockout (Twist1 KO), developed significantly reduced numbers of pa...

journal_title：Molecular carcinogenesis

authors： Srivastava J,Rho O,Youssef RM,DiGiovanni J

更新日期：2016-05-01 00:00:00

abstract：:The aim of this study was to test whether long-term ethanol consumption confers therapeutic resistance to human liver cancer patients infected with hepatitis B virus (HBV). Chronic ethanol-treated cells were established by consecutively culturing a human hepatocellular carcinoma cell line, Hep 3B, which contains integ...

journal_title：Molecular carcinogenesis

authors： Huang CS,Lee YR,Chen CS,Tu SH,Wang YJ,Lee CH,Chen LC,Chang HW,Chang CH,Chih-Ming S,Wu CH,Ho YS

更新日期：2010-08-01 00:00:00

abstract：:Quercetin, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), and okadaic acid are found in various foods and have been shown to have mutagenic or promoter-like activity. The effects of these three compounds on the transmission of the inactive X chromosome were examined in MST-C6 murine tumor cells, which were de...

journal_title：Molecular carcinogenesis

authors： Kuwabara K,Odani S,Takahashi Y,Arakawa M,Takagi N,Nagao M,Kominami R

更新日期：1995-12-01 00:00:00

abstract：:Tumor progression is a multistep process, which enables cells to evolve from benign to malignant tumors. This progression has been suggested to depend on six essential characteristics identified as the "hallmarks of cancer," which include: self-sufficiency in growth signals, insensitivity to growth-inhibitory signals,...

journal_title：Molecular carcinogenesis

authors： Cook AC,Tuck AB,McCarthy S,Turner JG,Irby RB,Bloom GC,Yeatman TJ,Chambers AF

更新日期：2005-08-01 00:00:00

abstract：:Resistance to cisplatin-based chemotherapy is responsible for the majority of deaths from head and neck squamous cell carcinoma (HNSCC). In this study, using genome-wide gene expression analysis to investigate potential molecular mediators of HNSCC chemoresistance, we identified SERPINB2, a known inhibitor of extracel...

journal_title：Molecular carcinogenesis

authors： Huang Z,Li H,Huang Q,Chen D,Han J,Wang L,Pan C,Chen W,House MG,Nephew KP,Guo Z

更新日期：2014-10-01 00:00:00

abstract：:Human colorectal cancer (CRC) cells are resistant to the anti-proliferative effect of transforming growth factor-β (TGF-β), suggesting that disruption of TGF-β signaling plays an important role in colorectal carcinogenesis. Ecotropic virus integration site-1 (Evi-1) oncoprotein represses TGF-β signaling by interacting...

journal_title：Molecular carcinogenesis

authors： Deng X,Cao Y,Liu Y,Li F,Sambandam K,Rajaraman S,Perkins AS,Fields AP,Hellmich MR,Townsend CM Jr,Thompson EA,Ko TC

更新日期：2013-04-01 00:00:00

abstract：:Triptolide is an active component from a Chinese herb, Tripterygium wilfordii which has been applied for treating immune-related diseases over centuries. Recently, it was reported that a variety of cancer cell lines could be sensitized to DNA-damage based chemotherapy drugs in combination with Triptolide treatment. In...

journal_title：Molecular carcinogenesis

authors： Deng Y,Li F,He P,Yang Y,Yang J,Zhang Y,Liu J,Tong Y,Li Q,Mei X,Shu Z,Zhao Q

更新日期：2018-06-01 00:00:00

abstract：:We found that caffeine significantly inhibited epidermal growth factor (EGF)- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cell transformation in the JB6 mouse epidermal cell line. The tumor promoter-induced cell transformation was also blocked by treatment with an adenosine A1 receptor antagonist, 8-phenylt...

journal_title：Molecular carcinogenesis

authors： Nomura M,Ichimatsu D,Moritani S,Koyama I,Dong Z,Yokogawa K,Miyamoto K

更新日期：2005-09-01 00:00:00

abstract：:Both EGFR and HER2 are important mediators of tumorigenesis and tumor progression. Despite their best-characterized roles as plasma membrane-bound receptors, both receptors undergo nuclear translocation though the impact of this process remains unclear. In this study, we provide evidence showing that EGFR upregulates ...

journal_title：Molecular carcinogenesis

authors： Han W,Carpenter RL,Cao X,Lo HW

更新日期：2013-12-01 00:00:00

abstract：:The expression of members of the family of matrix-degrading metalloproteinases (MMPs) is believed to contribute to the complex process of invasion and metastasis. In this study, specific cDNA probes for three members of the stromelysin subfamily of MMPs--stromelysin (MMP-3), stromelysin-2 (MMP-10), and pump-1 (MMP-7)-...

journal_title：Molecular carcinogenesis

authors： McDonnell S,Navre M,Coffey RJ Jr,Matrisian LM

更新日期：1991-01-01 00:00:00

abstract：:Carcinogenesis is a multistep sequential process of clonal expansion of initiated cells associated with the accumulation of multiple cancer-specific heritable phenotypes. The acquisition of these heritable cancer-specific alterations may be triggered by mutational and/or non-mutational changes in the genome that affec...

journal_title：Molecular carcinogenesis

authors： Koturbash I,Melnyk S,James SJ,Beland FA,Pogribny IP

更新日期：2013-04-01 00:00:00

abstract：:LEC (Long-Evans with a cinnamon-like coat color) rats develop hepatocellular carcinomas (HCCs) spontaneously. We examined mutations of codons 12, 13, and 61 of the Ha-ras, Ki-ras, and N-ras genes in four HCCs by the polymerase chain reaction (PCR)-single-stranded DNA direct sequencing method. No ras gene mutations wer...

journal_title：Molecular carcinogenesis

authors： Fujimoto Y,Ishizaka Y,Tahira T,Sone H,Takahashi H,Enomoto K,Mori M,Sugimura T,Nagao M

更新日期：1991-01-01 00:00:00

abstract：:In rats, gamma-glutamyl transpeptidase (gamma GT) exists as a single-copy gene, and three distinct species of RNA (types I, II, and III) that differ in their 5' untranslated regions have been identified. To compare steady-state levels of these gamma GT RNAs in rat tissues, hepatic carcinomas, and cultured cells, we us...

journal_title：Molecular carcinogenesis

authors： Habib GM,Rajagopalan S,Godwin AK,Lebovitz RM,Lieberman MW

更新日期：1992-01-01 00:00:00

abstract：:Dietary heterocyclic aromatic amines (HCA) and polyunsaturated fatty acids (PUFA) are both believed to play a role in colon carcinogenesis, and are both substrate for the enzyme cyclooxygenase (COX). In HCA-7 cells, highly expressing isoform COX-2, we investigated the effects of PUFA on prostaglandin synthesis and DNA...

journal_title：Molecular carcinogenesis

authors： Moonen HJ,Dommels YE,van Zwam M,van Herwijnen MH,Kleinjans JC,Alink GM,de Kok TM

更新日期：2004-07-01 00:00:00

abstract：:Recent evidence suggests that the A allele of the ornithine decarboxylase (ODC) gene is a genetic risk factor for prostate cancer. ODC is a target gene of the highly polymorphic androgen receptor (AR) gene, short alleles of which have been associated in some studies with increased prostate cancer risk. We determined O...

journal_title：Molecular carcinogenesis

authors： O'Brien TG,Guo Y,Visvanathan K,Sciulli J,McLaine M,Helzlsouer KJ,Watkins-Bruner D

更新日期：2004-10-01 00:00:00

abstract：:The levels of the antioxidant enzyme manganese superoxide dismutase (Mn-SOD) are frequently decreased in tumor cells and increased in normal cells upon treatment with ionizing radiation. We studied Mn-SOD at different stages during the neoplastic conversion of radiation-initiated Syrian hamster embryo HDR-3 cells. Mn-...

journal_title：Molecular carcinogenesis

authors： Otero G,Avila MA,Emfietzoglou D,Clerch LB,Massaro D,Notario V

更新日期：1996-12-01 00:00:00

abstract：:Heat shock protein 60 (HSP60) overexpresses in various types of cancer, but its expression levels and functions in hepatocellular carcinoma (HCC) are still in dispute. We aim to clarify this issue and examine whether HSP60 could be a therapeutic target for HCC. We found drastically enhanced cell apoptosis and suppress...

journal_title：Molecular carcinogenesis

authors： Huang YH,Lin KH,Yu JS,Wu TJ,Lee WC,Chao CC,Pan TL,Yeh CT

更新日期：2018-09-01 00:00:00

abstract：:Despite considerable knowledge of viral pathogenesis, the pathophysiological changes related to the multifactorial, multistep process of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) development remains unclear. Longitudinal metabolomics study can reveal biological process for disease progression. We ...

journal_title：Molecular carcinogenesis

authors： Huang BY,Tsai MR,Hsu JK,Lin CY,Lin CL,Hu JT,Huang YW,Liu CJ,Wu WJ,Wu CF,Sung FY,Chen PJ,Liang HJ,Lin SM,Yu MW

更新日期：2020-11-01 00:00:00

abstract：:The physical gut barrier, comprised of a thick mucus layer and the epithelium, plays an important role in defense against microbes and foreign antigens. Calcium and vitamin D may be involved in maintaining the integrity of the intestinal mucosal barrier, the dysfunction of which may lead to endotoxemia and inflammatio...

journal_title：Molecular carcinogenesis

authors： Mandle HB,Jahan FA,Bostick RM,Baron JA,Barry EL,Yacoub R,Merrill J,Rutherford RE,Seabrook ME,Fedirko V

更新日期：2019-07-01 00:00:00

abstract：:LW-213 is a derivative of Wogonin and the anticancer activities of Wogonin have been reported. To study whether LW-213 inhibits cancer cells and explore a possible mechanism, we investigate the compound in several cancer cell lines. We found LW-213 arrests G2/M cycle in breast cancer cells by suppression of Akt/Gsk3β/...

journal_title：Molecular carcinogenesis

authors： Zhao L,Miao HC,Li WJ,Sun Y,Huang SL,Li ZY,Guo QL

更新日期：2016-05-01 00:00:00

abstract：:Bcl-x(L) is one of several antiapoptotic proteins regulated by signal transducer and activator of transcription 3 (Stat3). We have recently shown that Stat3 is required for chemically induced and ultraviolet B (UVB)-induced skin carcinogenesis. In this study, the functional role of Bcl-x(L) in skin carcinogenesis was ...

journal_title：Molecular carcinogenesis

authors： Kim DJ,Kataoka K,Sano S,Connolly K,Kiguchi K,DiGiovanni J

更新日期：2009-10-01 00:00:00

abstract：:Ultraviolet (UV) light-induced activation of activator protein-1 (AP-1), resulting at least in part from oxidative stress, promotes skin carcinogenesis. It has not yet been determined whether elevating cellular phase II enzymes and glutathione (GSH) levels inhibits the AP-1 activation. We have, therefore, examined the...

journal_title：Molecular carcinogenesis

authors： Zhu M,Zhang Y,Cooper S,Sikorski E,Rohwer J,Bowden GT

更新日期：2004-11-01 00:00:00

abstract：:To study the possible involvement of DNA damage in cell transformation induced by estrogens, we examined whether DNA adduct formation is elicited in cultured Syrian hamster embryo (SHE) cells treated with estrogens and their derivatives by means of the 32P-postlabeling assay. Morphological transformation of the cells ...

journal_title：Molecular carcinogenesis

authors： Hayashi N,Hasegawa K,Komine A,Tanaka Y,McLachian JA,Barrett JC,Tsutsui T

更新日期：1996-07-01 00:00:00

abstract：:We transformed JB6P+ cells with prolonged intermittent low-dose UVB radiation or prolonged exposure to low-dose H(2)O(2) or CdCl(2). Stable transformation was confirmed by an anchorage-independence assay. The JB6P+ transformants formed more colonies (approximately six folds) in soft agar as compared to their JB6P+ par...

journal_title：Molecular carcinogenesis

authors： Yang S,Misner B,Chiu R,Meyskens FL Jr

更新日期：2008-07-01 00:00:00

abstract：:Palliative treatment options for human cholangiocarcinoma (CCC) are quite limited and new therapeutic strategies are of utmost need. c-MET has been shown to be deregulated in many cancers, but the role of c-MET in the carcinogenesis of CCC remains unclear. The main purpose of this study is to evaluate the expression a...

journal_title：Molecular carcinogenesis

authors： Barat S,Bozko P,Chen X,Scholta T,Hanert F,Götze J,Malek NP,Wilkens L,Plentz RR

更新日期：2016-12-01 00:00:00

abstract：:To investigate the effect of tumor-associated macrophages on the in vivo growth properties of cervical carcinoma cells, tumorigenic human papilloma virus (HPV) 18-positive HeLa cells were transfected with an expression vector harboring the cDNA for the macrophage chemoattractant protein-1 JE (MCP-1). Although the endo...

journal_title：Molecular carcinogenesis

authors： Kleine K,König G,Kreuzer J,Komitowski D,Zur Hausen H,Rösl F

更新日期：1995-11-01 00:00:00

abstract：:Preventive measures against oral carcinogenesis are urgently warranted to lower the high morbidity and mortality associated with this malignancy worldwide. Here, we investigated the chemopreventive efficacy of grape seed extract (GSE) and resveratrol (Res) in 4-nitroquinoline-1-oxide (4NQO)-induced tongue tumorigenesi...

journal_title：Molecular carcinogenesis

authors： Shrotriya S,Tyagi A,Deep G,Orlicky DJ,Wisell J,Wang XJ,Sclafani RA,Agarwal R,Agarwal C

更新日期：2015-04-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a member of the tumor necrosis factor family, induces apoptosis in a variety of cancer cells. However, gastric cancer (GC) cells are insensitive to TRAIL usually. In the previous study, we showed that Periplocin could induce apoptosis in GC cells via the...

journal_title：Molecular carcinogenesis

authors： Zhao LM,Li L,Huang Y,Han LJ,Li D,Huo BJ,Dai SL,Xu LY,Zhan Q,Shan BE

更新日期：2019-06-01 00:00:00

abstract：:Ezrin is known to regulate cellular survival, adhesion, migration, and invasion and has been identified as one of the key components of tumor progression and metastasis. The authors investigated ezrin expression in human hepatocellular carcinoma (HCC) and sought to determine its relation with clinicopathologic paramet...

journal_title：Molecular carcinogenesis

authors： Kang YK,Hong SW,Lee H,Kim WH

更新日期：2010-09-01 00:00:00