Arachidonoyl ethanolamide (AEA)-induced apoptosis is mediated by J-series prostaglandins and is enhanced by fatty acid amide hydrolase (FAAH) blockade.

abstract：:The normal function of excision repair cross complementing group 1 (ERCC1) is essential for maintaining genomic integrity and preventing cellular neoplastic transformation, and multiple studies have reported an association between ERCC1 polymorphisms and increased risk of cancers. To test whether the genetic variants ...

journal_title：Molecular carcinogenesis

authors： Yang ZH,Dai Q,Kong XL,Yang WL,Zhang L

更新日期：2009-03-01 00:00:00

abstract：:Sel-1-like (SEL1L) is a putative tumor suppressor gene that is significantly downregulated in human pancreatic ductal adenocarcinoma (PDA). The mechanism of the downregulation is unclear. Here, we investigated whether aberrantly upregulated microRNAs (miRNAs) repressed the expression of SEL1L. From reported miRNA micr...

journal_title：Molecular carcinogenesis

authors： Liu Q,Chen J,Wang J,Amos C,Killary AM,Sen S,Wei C,Frazier ML

更新日期：2014-09-01 00:00:00

abstract：:Cytogenetic and molecular studies of human renal cell carcinoma (RCC) have suggested that the genetic and functional losses of one or more putative tumor suppressor genes on the short arm of chromosome 3 play a crucial role in the development of this disease. To examine whether the introduction of chromosome 3 has any...

journal_title：Molecular carcinogenesis

authors： Yoshida MA,Shimizu M,Ikeuchi T,Tonomura A,Yokota J,Oshimura M

更新日期：1994-03-01 00:00:00

abstract：:N-nitrosomethylbenzylamine (NMBA)-induced rat esophageal tumorigenesis is an important model for squamous cell carcinoma of the human esophagus. In this model, previous studies have shown that the GGA-->GAA Ha-ras codon 12 mutation is present in the majority of papillomas. No other Ha-ras mutation has been identified....

journal_title：Molecular carcinogenesis

authors： Liston BW,Gupta A,Nines R,Carlton PS,Kresty LA,Harris GK,Stoner GD

更新日期：2001-09-01 00:00:00

abstract：:The ubiquitin-proteasome pathway is fundamental to synchronized continuation of many cellular processes, for example, cell-cycle progression, stress response, and cell differentiation. Recent studies have shown that the ubiquitin-proteasome pathway functions in the regulation of nucleotide excision repair (NER) in yea...

journal_title：Molecular carcinogenesis

authors： Wang QE,Wani MA,Chen J,Zhu Q,Wani G,El-Mahdy MA,Wani AA

更新日期：2005-01-01 00:00:00

abstract：:Two genetic instability pathways viz. chromosomal instability, driven primarily by APC mutation induced deregulated Wnt signaling, and microsatellite instability (MSI) caused by mismatch repair (MMR) inactivation, together account for >90% of late-onset colorectal cancer (CRC). Our understanding of early-onset sporadi...

journal_title：Molecular carcinogenesis

authors： Raman R,Kotapalli V,Adduri R,Gowrishankar S,Bashyam L,Chaudhary A,Vamsy M,Patnaik S,Srinivasulu M,Sastry R,Rao S,Vasala A,Kalidindi N,Pollack J,Murthy S,Bashyam M

更新日期：2014-02-01 00:00:00

abstract：:Xiphophorus fish have been the subject of intensive genetic research for more than 60 yr, primarily because of the availability of a number of interspecific hybrids that are malignant melanoma models with apparently simple oncogene and tumor suppressor gene determinants. The gene map of Xiphophorus is one of the most ...

journal_title：Molecular carcinogenesis

authors： Morizot DC,McEntire BB,Della Coletta L,Kazianis S,Schartl M,Nairn RS

更新日期：1998-07-01 00:00:00

abstract：:Obesity and its associated metabolic syndrome (MetS) are recognized risk factors for breast cancer. The molecular basis for this association remains largely unknown. Adipokines, in particular leptin and adiponectin, are thought to form part of the mechanism linking obesity with cancer through their altered expression/...

journal_title：Molecular carcinogenesis

authors： Carroll PA,Healy L,Lysaght J,Boyle T,Reynolds JV,Kennedy MJ,Pidgeon G,Connolly EM

更新日期：2011-08-01 00:00:00

abstract：:Increasing evidence from various clinical and experimental studies has demonstrated that the inflammatory microenvironment facilitates tumor metastasis. Clinically, it will be a promising choice to suppress tumor metastasis by targeting inflammatory microenvironment. Our previous studies have demonstrated that wogonin...

journal_title：Molecular carcinogenesis

authors： Zhao Y,Yao J,Wu XP,Zhao L,Zhou YX,Zhang Y,You QD,Guo QL,Lu N

更新日期：2015-06-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) plays an important role in the development and progression of lung cancer. A previous report noted that an increased number of polymorphic CA repeats in the first intron of the EGFR gene results in decreased transcriptional activity. To estimate the association of the length of ...

journal_title：Molecular carcinogenesis

authors： Zhang W,Weissfeld JL,Romkes M,Land SR,Grandis JR,Siegfried JM

更新日期：2007-05-01 00:00:00

abstract：:Human colorectal cancer (CRC) cells are resistant to the anti-proliferative effect of transforming growth factor-β (TGF-β), suggesting that disruption of TGF-β signaling plays an important role in colorectal carcinogenesis. Ecotropic virus integration site-1 (Evi-1) oncoprotein represses TGF-β signaling by interacting...

journal_title：Molecular carcinogenesis

authors： Deng X,Cao Y,Liu Y,Li F,Sambandam K,Rajaraman S,Perkins AS,Fields AP,Hellmich MR,Townsend CM Jr,Thompson EA,Ko TC

更新日期：2013-04-01 00:00:00

abstract：:Astrocyte elevated gene-1 (AEG-1) plays a critical role in the development, progression, and metastasis of a variety of cancers, including non-small-cell lung cancer (NSCLC). The objective of the current study is to unravel the upstream signaling of AEG-1. A cohort of 28 NSCLC tissues and 30 normal tissues were collec...

journal_title：Molecular carcinogenesis

authors： Li YH,Xu CL,He CJ,Pu HH,Liu JL,Wang Y

更新日期：2020-02-01 00:00:00

abstract：:It has been established that retinoids exert some of their effects on cell differentiation and malignant phenotype reversion through the interaction with different members of the protein kinase C (PKC) family. Till nowadays the nature and extension of this interaction is not well understood. Due to the cytostatic and ...

journal_title：Molecular carcinogenesis

authors： Berardi DE,Bessone MI,Motter A,Bal de Kier Joffé ED,Urtreger AJ,Todaro LB

更新日期：2015-10-01 00:00:00

abstract：:An allelotype analysis of lung tumors in mouse hybrids was conducted to identify common regions of allelic loss. By using 50 informative genetic markers, the autosomes of 36 (A/J x C3H/HeJ) F1 adenocarcinomas were examined. Additional adenocarcinomas from as many as 72 (C3H/HeJ x A/J) F1 and 15 (BALB/cJ x DBA/2J) F1 h...

journal_title：Molecular carcinogenesis

authors： Herzog CR,Chen B,Wang Y,Schut HA,You M

更新日期：1996-06-01 00:00:00

abstract：:In rats, gamma-glutamyl transpeptidase (gamma GT) exists as a single-copy gene, and three distinct species of RNA (types I, II, and III) that differ in their 5' untranslated regions have been identified. To compare steady-state levels of these gamma GT RNAs in rat tissues, hepatic carcinomas, and cultured cells, we us...

journal_title：Molecular carcinogenesis

authors： Habib GM,Rajagopalan S,Godwin AK,Lebovitz RM,Lieberman MW

更新日期：1992-01-01 00:00:00

abstract：:Human DEAD-box RNA helicase gene DDX6 was cloned from B-cell lymphoma cell line RC-K8. Previously, we reported that DDX6 acts as oncogene in several cancers such as colorectal cancer and hepatocellular carcinoma. However, the detailed mechanism of DDX6 action in carcinogenesis is largely unknown. In this study, we exa...

journal_title：Molecular carcinogenesis

authors： Taniguchi K,Iwatsuki A,Sugito N,Shinohara H,Kuranaga Y,Oshikawa Y,Tajirika T,Futamura M,Yoshida K,Uchiyama K,Akao Y

更新日期：2018-05-01 00:00:00

abstract：:MAP1S (originally named C19ORF5) is a widely distributed homolog of neuronal-specific MAP1A and MAP1B, and bridges autophagic components with microtubules and mitochondria to affect autophagosomal biogenesis and degradation. Mitochondrion-associated protein LRPPRC functions as an inhibitor for autophagy initiation to ...

journal_title：Molecular carcinogenesis

authors： Jiang X,Zhong W,Huang H,He H,Jiang F,Chen Y,Yue F,Zou J,Li X,He Y,You P,Yang W,Lai Y,Wang F,Liu L

更新日期：2015-10-01 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) exerts an important role in the late steps of carcinogenesis by cooperating with Ras to induce cell motility and tumor invasion. The transcription complex AP-1 has been implicated in the regulation of genes involved in motility and invasion, by mechanisms not yet delineated. ...

journal_title：Molecular carcinogenesis

authors： Güller MC,André J,Legrand A,Setterblad N,Mauviel A,Verrecchia F,Daniel F,Bernuau D

更新日期：2009-06-01 00:00:00

abstract：:Recently, tumor initiating cells are considered as the central role of tumorigenicity in hepatocellular carcinoma. Enediyne anticancer antibiotic lidamycin with great potential antitumor activity is currently evaluated in Phase II clinical trials. In this study, we evaluated the effect of lidamycin on tumor initiating...

journal_title：Molecular carcinogenesis

authors： Chen Y,Yu D,Zhang C,Shang B,He H,Chen J,Zhang H,Zhao W,Wang Z,Xu X,Zhen Y,Shao RG

更新日期：2015-01-01 00:00:00

abstract：:Composition of extracellular matrix (ECM) is crucial to the establishment and maintenance of epithelial apical-basolateral polarity. Increased ECM rigidity caused by deposition of fibrillar collagen, for example, collagen type I (Col-1), promotes loss of epithelial polarity and tumor progression. microRNAs are small n...

journal_title：Molecular carcinogenesis

authors： Li C,Nguyen HT,Zhuang Y,Lin Y,Flemington EK,Guo W,Guenther J,Burow ME,Morris GF,Sullivan D,Shan B

更新日期：2011-07-01 00:00:00

abstract：:Non-alcoholic steatohepatitis (NASH) is becoming one of the major causes of hepatocellular carcinoma (HCC) in the United States and Western countries; however, the molecular mechanisms associated with NASH-related liver carcinogenesis are not well understood. In the present study, we investigated cancer-associated chr...

journal_title：Molecular carcinogenesis

authors： Dechassa ML,Tryndyak V,de Conti A,Xiao W,Beland FA,Pogribny IP

更新日期：2018-08-01 00:00:00

abstract：:Regions of genomic DNA containing repetitive nucleotide sequences can adopt a number of different structures in addition to the canonical B-DNA form: many of these non-B DNA structures are causative factors in genetic instability and human disease. Although chromosomal DNA replication through such repetitive sequences...

journal_title：Molecular carcinogenesis

authors： Wang G,Vasquez KM

更新日期：2009-04-01 00:00:00

abstract：:Arsenic is a known human carcinogen. However, the mechanism of how arsenic induces cell transformation remains unclear. In this study, we demonstrated that long-term exposure to sodium arsenite at low-dose (2 µM) increases cell proliferation and neoplastic transformation in a mouse epidermal cell model, JB6 promotion-...

journal_title：Molecular carcinogenesis

authors： Zhang Y,Wang Q,Guo X,Miller R,Guo Y,Yang HS

更新日期：2011-07-01 00:00:00

abstract：:Bcl-x(L) is one of several antiapoptotic proteins regulated by signal transducer and activator of transcription 3 (Stat3). We have recently shown that Stat3 is required for chemically induced and ultraviolet B (UVB)-induced skin carcinogenesis. In this study, the functional role of Bcl-x(L) in skin carcinogenesis was ...

journal_title：Molecular carcinogenesis

authors： Kim DJ,Kataoka K,Sano S,Connolly K,Kiguchi K,DiGiovanni J

更新日期：2009-10-01 00:00:00

abstract：:The adenovirus type 5 (Ad5) 55-kDa E1B oncoprotein has been shown to form complexes with the p53 tumor suppressor protein. These complexes are thought to interfere with normal p53 activity and may be responsible for the paucity of p53 mutations in cells transformed by these viruses. This report describes an example of...

journal_title：Molecular carcinogenesis

authors： Eyler YL,Siwarski DF,Huppi KE,Lewis AM Jr

更新日期：1995-01-01 00:00:00

abstract：:The MN/CA9 (G250) gene expressed in the normal alimentary tract in a tissue-specific manner is often activated in renal cell carcinomas. To cast light on the activation mechanism, we examined the methylation status of this gene in seven human renal cell carcinoma cell lines (SKRC-01, -06, -10, -12, -14, -44, and -59) ...

journal_title：Molecular carcinogenesis

authors： Cho M,Grabmaier K,Kitahori Y,Hiasa Y,Nakagawa Y,Uemura H,Hirao Y,Ohnishi T,Yoshikawa K,Ooesterwijk E

更新日期：2000-03-01 00:00:00

abstract：:Multidrug resistance (MDR) is one of the most important factors leading to chemotherapeutic failure in patients with breast cancer. The invasive/metastatic ability of MDR cells is strengthened compared with their parental cells. However, the mechanisms underlying MDR have not been fully elucidated. We found that CD44 ...

journal_title：Molecular carcinogenesis

authors： Cheng Y,Tao L,Xu J,Li Q,Yu J,Jin Y,Chen Q,Xu Z,Zou Q,Liu X

更新日期：2014-09-01 00:00:00

abstract：:Gap junctions are cellular structures which permit direct exchanges of small molecules from cytoplasm to cytoplasm in most of the cells of metazoan organisms. For four decades, it has been observed that the inhibition of this type of intercellular communication is often associated with tumorigenesis. The assumption th...

journal_title：Molecular carcinogenesis

authors： Mennecier G,Derangeon M,Coronas V,Hervé JC,Mesnil M

更新日期：2008-05-01 00:00:00

abstract：:Single nucleotide polymorphisms (SNPs) of matrix metalloproteinase3 (MMP3) promoter in the development and progression of gastric cancer of whole stomach has never been investigated in any population. We conducted a hospital-based case-control study to explore the MMP3 SNPs and their haplotypes with the risk of gastri...

journal_title：Molecular carcinogenesis

authors： Dey S,Stalin S,Gupta A,Saha D,Kesh K,Swarnakar S

更新日期：2012-10-01 00:00:00

abstract：:In the present study, we evaluated the effect of deleting Twist1 on keratinocyte proliferation and on skin tumor development using the two-stage chemical carcinogenesis model. BK5.Cre × Twist1(flox/flox) mice, which have a keratinocyte-specific Twist1 knockout (Twist1 KO), developed significantly reduced numbers of pa...

journal_title：Molecular carcinogenesis

authors： Srivastava J,Rho O,Youssef RM,DiGiovanni J

更新日期：2016-05-01 00:00:00