Involvement of protein kinase C α and δ activities on the induction of the retinoic acid system in mammary cancer cells.

abstract：:Diet-derived butyrate, a histone deacetylase inhibitor (HDI), decreases proliferation and increases apoptosis in colorectal cancer (CRC) cells via epigenetic changes in gene expression. Other HDIs such as suberoylanilide hydroxamic acid (SAHA) and trichostatin A (TSA) have similar effects. This study examined the role...

journal_title：Molecular carcinogenesis

authors： Humphreys KJ,Cobiac L,Le Leu RK,Van der Hoek MB,Michael MZ

更新日期：2013-06-01 00:00:00

abstract：:To analyze the mechanism of neoplastic transformation of rodent diploid cells by ras and myc oncogenes, human EJ c-Ha-ras and mouse c-myc second and third exons promoted by SV40 promoter were connected to pSV2neo and pSV2gpt, respectively. Mouse and rat primary fetal cells cotransfected with both genes formed transfor...

journal_title：Molecular carcinogenesis

authors： Yagi T,Sasayama S,Sasai H,Kakunaga T

更新日期：1989-01-01 00:00:00

abstract：:In human lung cancers, alterations of both a dominant oncogene (ras) and a tumor suppressor gene (p53) have been identified. Polymerase chain reaction (PCR) analysis of mRNA was used to amplify the c-Ki-ras-2 and p53 genes from Syrian golden hamsters. The PCR products were confirmed by predicted-size analysis, probing...

journal_title：Molecular carcinogenesis

authors： Oreffo VI,Lin HW,Gumerlock PH,Kraegel SA,Witschi H

更新日期：1992-01-01 00:00:00

abstract：:We examined whether betulin, a naturally abundant compound, has anticancer functions in human cancer cells. The results showed that betulin significantly inhibited cell viability in cervix carcinoma HeLa cells, hepatoma HepG2 cells, lung adenocarcinoma A549 cells, and breast cancer MCF-7 cells with IC(50) values rangi...

journal_title：Molecular carcinogenesis

authors： Li Y,He K,Huang Y,Zheng D,Gao C,Cui L,Jin YH

更新日期：2010-07-01 00:00:00

abstract：:The expression of members of the family of matrix-degrading metalloproteinases (MMPs) is believed to contribute to the complex process of invasion and metastasis. In this study, specific cDNA probes for three members of the stromelysin subfamily of MMPs--stromelysin (MMP-3), stromelysin-2 (MMP-10), and pump-1 (MMP-7)-...

journal_title：Molecular carcinogenesis

authors： McDonnell S,Navre M,Coffey RJ Jr,Matrisian LM

更新日期：1991-01-01 00:00:00

abstract：:The MN/CA9 (G250) gene expressed in the normal alimentary tract in a tissue-specific manner is often activated in renal cell carcinomas. To cast light on the activation mechanism, we examined the methylation status of this gene in seven human renal cell carcinoma cell lines (SKRC-01, -06, -10, -12, -14, -44, and -59) ...

journal_title：Molecular carcinogenesis

authors： Cho M,Grabmaier K,Kitahori Y,Hiasa Y,Nakagawa Y,Uemura H,Hirao Y,Ohnishi T,Yoshikawa K,Ooesterwijk E

更新日期：2000-03-01 00:00:00

abstract：:Glioblastoma (GBM) is the most aggressive and highly invasive type of astrocytic tumors. Despite advances in diagnosis and therapy, the prognosis and survival time remain poor. Identifying key mediators of tumor cell proliferation, migration, and invasion is crucial to the development of new and more effective therapi...

journal_title：Molecular carcinogenesis

authors： Liu X,Gao Q,Zhao N,Zhang X,Cui W,Sun J,Fu J,Hao J

更新日期：2018-04-01 00:00:00

abstract：:Polyamine metabolism is a highly coordinated process that is essential for normal development and neoplastic growth in mammals. Although polyamine metabolism is a validated pathway for prevention of carcinogenesis, the mechanisms by which polyamines elicit their tumorigenic effects are poorly understood. In this study...

journal_title：Molecular carcinogenesis

authors： Paz EA,LaFleur B,Gerner EW

更新日期：2014-02-01 00:00:00

abstract：:In this report, we describe in detail the evolving procedures to optimize humanized mouse cohort generation, including optimal conditioning, choice of lineage for engraftment, threshold for successful engraftment, HNSCC tumor implantation, and immune and stroma cell analyses. We developed a dual infusion protocol of h...

journal_title：Molecular carcinogenesis

authors： Morton JJ,Keysar SB,Perrenoud L,Chimed TS,Reisinger J,Jackson B,Le PN,Nieto C,Gomez K,Miller B,Gao D,Somerset H,Wang XJ,Jimeno A

更新日期：2018-11-01 00:00:00

abstract：:The aims of the present study are to investigate sub-cellular location, differential expression in different cancer stages and functional role of FAM134B in colon cancer development. FAM134B expression was studied and quantified at protein and mRNA levels in cell lines using immunocytochemistry, Western blot and real-...

journal_title：Molecular carcinogenesis

authors： Islam F,Gopalan V,Wahab R,Smith RA,Qiao B,Lam AK

更新日期：2017-01-01 00:00:00

abstract：:The protein EPHB4 plays a vital role in various tumor types. However, few studies into the function of circ-EPHB4 (hsa_circ_0001730) in tumors have been conducted. This study aimed to investigate the functions of circ-EPHB4 and the underlying mechanism of circ-EPHB4 in regulating hepatocellular carcinoma (HCC). The ex...

journal_title：Molecular carcinogenesis

authors： Tan Y,Du B,Zhan Y,Wang K,Wang X,Chen B,Wei X,Xiao J

更新日期：2019-06-01 00:00:00

abstract：:2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MelQx) are carcinogens found in cooked meats that form DNA adducts upon metabolic activation. Purified DNA from Chinese hamster ovary (CHO) cells was reacted in vitro with the active metabolites N-acetoxy-IQ or N-acetoxy-Me...

journal_title：Molecular carcinogenesis

authors： Nouso K,Bohr VA,Schut HA,Snyderwine EG

更新日期：1993-01-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest cancers in the world. All-trans retinoic acid (ATRA) is the major physiologically active form of vitamin A, regulating expression of many genes. Disturbances of vitamin A metabolism are prevalent in some cancer cells. The main aim of this work was...

journal_title：Molecular carcinogenesis

authors： Bleul T,Rühl R,Bulashevska S,Karakhanova S,Werner J,Bazhin AV

更新日期：2015-09-01 00:00:00

abstract：:Astrocyte elevated gene-1 (AEG-1) plays a critical role in the development, progression, and metastasis of a variety of cancers, including non-small-cell lung cancer (NSCLC). The objective of the current study is to unravel the upstream signaling of AEG-1. A cohort of 28 NSCLC tissues and 30 normal tissues were collec...

journal_title：Molecular carcinogenesis

authors： Li YH,Xu CL,He CJ,Pu HH,Liu JL,Wang Y

更新日期：2020-02-01 00:00:00

abstract：:To explore the mechanisms underlying the chemopreventive effects of the synthetic retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) in prostate cancer, we evaluated the anti-proliferative and apoptosis-inducing effects of 4-HPR in the androgen-sensitive human prostate cancer cell line LNCaP. 4-HPR decreased the number of...

journal_title：Molecular carcinogenesis

authors： Shen JC,Wang TT,Chang S,Hursting SD

更新日期：1999-03-01 00:00:00

abstract：:Phloretin (Ph), which can be obtained from apples, apple juice, and cider, is a known inhibitor of the type II glucose transporter (GLUT2). In this study, real-time PCR analysis of laser-capture microdissected (LCM) human hepatoma cells showed elevated expression (>5-fold) of GLUT2 mRNA in comparison with nonmalignant...

journal_title：Molecular carcinogenesis

authors： Yang KC,Tsai CY,Wang YJ,Wei PL,Lee CH,Chen JH,Wu CH,Ho YS

更新日期：2009-05-01 00:00:00

abstract：:Extracellular signal-regulated kinase 1/2 (ERK1/2) constitute a point of convergence for complex signaling events that regulate essential cellular processes, including proliferation and survival. As such, dysregulation of the ERK signaling pathway is prevalent in many cancers. In the case of BRAF-V600E mutant melanoma...

journal_title：Molecular carcinogenesis

authors： Sammons RM,Ghose R,Tsai KY,Dalby KN

更新日期：2019-09-01 00:00:00

abstract：:Development of chemoresistance in androgen-refractory prostate cancer cells is partly due to constitutive activation of Rel/NF-kappaB transcription factors that regulate several cell survival and anti-apoptotic genes. In this study we examined whether betulinic acid (BetA), a pentacyclic triterpene from the bark of wh...

journal_title：Molecular carcinogenesis

authors： Rabi T,Shukla S,Gupta S

更新日期：2008-12-01 00:00:00

abstract：:N(6)-isopentenyladenosine (i6A) inhibits the tumor cell growth by inducing cell apoptosis in various cancer cell lines. However, little is known regarding the mechanisms by which the drug induces cell apoptosis. In this study, we further explored the molecular mechanisms of i6A as an anticancer agent on a human breast...

journal_title：Molecular carcinogenesis

authors： Laezza C,Malfitano AM,Di Matola T,Ricchi P,Bifulco M

更新日期：2010-10-01 00:00:00

abstract：:Canonical Wnt signaling is altered in most cases of colorectal cancer. Experimental evidence indicates that protein phosphatase 2A (PP2A) may play either positive or negative roles in Wnt signaling but its precise in vivo functions remain elusive. In this work, using colon cultured cell lines we showed that basal PP2A...

journal_title：Molecular carcinogenesis

authors： Carmen Figueroa-Aldariz M,Castañeda-Patlán MC,Santoyo-Ramos P,Zentella A,Robles-Flores M

更新日期：2015-11-01 00:00:00

abstract：:In this study, we found that rat nasal coumarin-7-hydroxylase (COH) activity was two orders of magnitude higher than rat hepatic COH activity and could be induced by adding coumarin to the rats' drinking water. In western blot analysis, an anti-cytochrome P450 (Cyp) 2a-5 (mouse liver COH) antibody recognized a sharp b...

journal_title：Molecular carcinogenesis

authors： Béréziat JC,Raffalli F,Schmezer P,Frei E,Geneste O,Lang MA

更新日期：1995-10-01 00:00:00

abstract：:The atomic bombing of Hiroshima and Nagasaki and the nuclear accident at Chernobyl raised the question of prenatal sensitivity to ionizing radiation-induced cancer. In this study, mice were exposed to single doses of gamma-radiation (0.2-2.0 Gy) at different embryonic stages. The tumor incidence increased with dose fr...

journal_title：Molecular carcinogenesis

authors： Lumniczky K,Antal S,Unger E,Wunderlich L,Hidvégi EJ,Sáfrány G

更新日期：1998-02-01 00:00:00

abstract：:Identification of long noncoding RNA (lncRNA) expression quantitative trait loci (lncR-eQTL) that associated with lung cancer can provide insights into regulatory mechanisms of lncRNA, and help reveal the role of lncRNA in lung cancer. A two-stage case-control design was implemented in this study. We first selected th...

journal_title：Molecular carcinogenesis

authors： Sun Q,Wang Y,Fan J,Li Z,Zhang J,Wang L,Fan X,Ji M,Zhu M,Dai J,Ma H,Jin G,Hu Z,Shen H

更新日期：2019-07-01 00:00:00

abstract：:Composition of extracellular matrix (ECM) is crucial to the establishment and maintenance of epithelial apical-basolateral polarity. Increased ECM rigidity caused by deposition of fibrillar collagen, for example, collagen type I (Col-1), promotes loss of epithelial polarity and tumor progression. microRNAs are small n...

journal_title：Molecular carcinogenesis

authors： Li C,Nguyen HT,Zhuang Y,Lin Y,Flemington EK,Guo W,Guenther J,Burow ME,Morris GF,Sullivan D,Shan B

更新日期：2011-07-01 00:00:00

abstract：:2-Methoxyestradiol (2-ME), an endogenous metabolite of 17beta-estradiol, is present in human blood and urine. Here we show for the first time that 2-ME significantly inhibited the growth of normal prostate epithelial cells and androgen-dependent LNCaP and androgen-independent DU145 prostate cancer cells. This growth i...

journal_title：Molecular carcinogenesis

authors： Kumar AP,Garcia GE,Slaga TJ

更新日期：2001-07-01 00:00:00

abstract：:Mutational activation of RAS proteins occurs in nearly 30% of all human tumors. To date direct pharmacological inhibition of RAS oncoproteins has not been possible. As a consequence, current strategies are focusing on the development of inhibitors that target those kinases acting downstream of RAS proteins, including ...

journal_title：Molecular carcinogenesis

authors： Urosevic J,Sum EY,Moneo V,Drosten M,Dhawahir A,Becerra M,Carnero A,Barbacid M

更新日期：2009-11-01 00:00:00

abstract：:The role of telomerase as an essential requirement for the neoplastic conversion of human cells has been controversial. In the model of conversion of normal human cells to cancer cells by the combination of simian virus 40 (SV40) early region genes and oncogenic Ras (H-Ras(G12V)), telomerase (hTERT) was originally des...

journal_title：Molecular carcinogenesis

authors： Liang S,Kahlenberg MS,Rousseau DL Jr,Hornsby PJ

更新日期：2008-06-01 00:00:00

abstract：:The aim of this study was to test whether long-term ethanol consumption confers therapeutic resistance to human liver cancer patients infected with hepatitis B virus (HBV). Chronic ethanol-treated cells were established by consecutively culturing a human hepatocellular carcinoma cell line, Hep 3B, which contains integ...

journal_title：Molecular carcinogenesis

authors： Huang CS,Lee YR,Chen CS,Tu SH,Wang YJ,Lee CH,Chen LC,Chang HW,Chang CH,Chih-Ming S,Wu CH,Ho YS

更新日期：2010-08-01 00:00:00

abstract：:FAM134B is an autophagy regulator of endoplasmic reticulum and acts as a cancer suppressor in colon cancer. However, the molecular signaling pathways by which FAM134B interacts within colon carcinogenesis is still unknown. Herein, this study aims to determine the interacting partners of FAM134B for the first time in c...

journal_title：Molecular carcinogenesis

authors： Islam F,Chaousis S,Wahab R,Gopalan V,Lam AK

更新日期：2018-11-01 00:00:00

abstract：:Cell senescence and programmed cell death (apoptosis) are two fundamental biological mechanisms that regulate proliferative capacity, survival potential, aging, and death of cells. Here we report several independent lines of experimental evidence that support the hypothesis that telomerase function and telomere length...

journal_title：Molecular carcinogenesis

authors： Holt SE,Glinsky VV,Ivanova AB,Glinsky GV

更新日期：1999-08-01 00:00:00