Diallyl trisulfides, a natural histone deacetylase inhibitor, attenuate HIF-1α synthesis, and decreases breast cancer metastasis.

abstract：:The effects of the flavonoid compound, kaempferol, which is an inhibitor of cancer cell proliferation and an inducer of cell apoptosis have been shown in various cancers, including lung, pancreatic, and ovarian, but its effect has never been studied in bladder cancer. Here, we investigated the effects of kaempferol on...

journal_title：Molecular carcinogenesis

authors： Dang Q,Song W,Xu D,Ma Y,Li F,Zeng J,Zhu G,Wang X,Chang LS,He D,Li L

更新日期：2015-09-01 00:00:00

abstract：:Lasp2, as well as Lasp1, is a member of the LIM-protein subfamily of the nebulin group characterized by the combined presence of LIM and SH3 domains. Lasp1 and Lasp2 are highly conserved in their LIM, nebulin-like, and SH3 domains but differ significantly at their linker regions. Lasp1 had been described as an oncogen...

journal_title：Molecular carcinogenesis

authors： Zhang X,Cai L,Zhou H,Liu Y,Fan C,Wang L,Li A,Miao Y,Li Q,Qiu X,Wang E

更新日期：2017-12-01 00:00:00

abstract：:Most human colorectal cancers arise through the accumulation of a series of genetic alterations such as point mutations within the Ki-ras and p53 genes, but the chemical carcinogens that may be implicated in these events are still unidentified. In a previous study, we showed that DNA from human colorectal tissue conta...

journal_title：Molecular carcinogenesis

authors： Jackson PE,Hall CN,Badawi AF,O'Connor PJ,Cooper DP,Povey AC

更新日期：1996-05-01 00:00:00

abstract：:Increased epidermal growth factor receptor (EGFR) expression in triple-negative breast cancer (TNBC) is recognized as a promising therapeutic target, specifically through the use of selective EGFR inhibitors combined with chemotherapies. TNBC is characterized by genetic instability that leads to increased sensitivity ...

journal_title：Molecular carcinogenesis

authors： El Guerrab A,Bamdad M,Bignon YJ,Penault-Llorca F,Aubel C

更新日期：2017-05-01 00:00:00

abstract：:Triptolide is an active component from a Chinese herb, Tripterygium wilfordii which has been applied for treating immune-related diseases over centuries. Recently, it was reported that a variety of cancer cell lines could be sensitized to DNA-damage based chemotherapy drugs in combination with Triptolide treatment. In...

journal_title：Molecular carcinogenesis

authors： Deng Y,Li F,He P,Yang Y,Yang J,Zhang Y,Liu J,Tong Y,Li Q,Mei X,Shu Z,Zhao Q

更新日期：2018-06-01 00:00:00

abstract：:Identification of long noncoding RNA (lncRNA) expression quantitative trait loci (lncR-eQTL) that associated with lung cancer can provide insights into regulatory mechanisms of lncRNA, and help reveal the role of lncRNA in lung cancer. A two-stage case-control design was implemented in this study. We first selected th...

journal_title：Molecular carcinogenesis

authors： Sun Q,Wang Y,Fan J,Li Z,Zhang J,Wang L,Fan X,Ji M,Zhu M,Dai J,Ma H,Jin G,Hu Z,Shen H

更新日期：2019-07-01 00:00:00

abstract：:Serially transplantable rat mammary tumor (RMT) cells are not dependent on exogenous epidermal growth factor (EGF) and insulin-like growth factor-I for continuous growth in serum-free medium. Previously, we found that conditioned medium obtained from these cells contained EGF-like mitogenic activity and stimulated tyr...

journal_title：Molecular carcinogenesis

authors： Ethier SP,Langton BC,Dilts CA

更新日期：1996-02-01 00:00:00

abstract：:We previously reported that the Wnt pathway is preferentially activated in basal-like breast cancer. However, the mechanisms by which the Wnt pathway regulates down-stream targets in basal-like breast cancer, and the biological significance of this regulation, are poorly understood. In this study, we found that c-Myc ...

journal_title：Molecular carcinogenesis

authors： Xu J,Chen Y,Huo D,Khramtsov A,Khramtsova G,Zhang C,Goss KH,Olopade OI

更新日期：2016-05-01 00:00:00

abstract：:Liver tumors of certain strains of mice frequently contain mutations at codon 61 of the c-Ha-ras gene. In our study, we investigated the significance of these mutations in the carcinogenic process. Male C3H/He mice received a single injection of diethylnitrosamine (DEN) on day 15 after birth, and groups of animals wer...

journal_title：Molecular carcinogenesis

authors： Bauer-Hofmann R,Klimek F,Buchmann A,Müller O,Bannasch P,Schwarz M

更新日期：1992-01-01 00:00:00

abstract：:Despite considerable knowledge of viral pathogenesis, the pathophysiological changes related to the multifactorial, multistep process of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) development remains unclear. Longitudinal metabolomics study can reveal biological process for disease progression. We ...

journal_title：Molecular carcinogenesis

authors： Huang BY,Tsai MR,Hsu JK,Lin CY,Lin CL,Hu JT,Huang YW,Liu CJ,Wu WJ,Wu CF,Sung FY,Chen PJ,Liang HJ,Lin SM,Yu MW

更新日期：2020-11-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF alpha) can function as both an autocrine and a paracrine growth factor and may therefore play a role in ovarian tumor progression. TNF alpha initiates multiple cellular responses, many of which are mediated through the mitogen-activated protein kinase pathways, which transduce signals ...

journal_title：Molecular carcinogenesis

authors： Yazlovitskaya EM,Pelling JC,Persons DL

更新日期：1999-05-01 00:00:00

abstract：:In this paper, patterns of allelic imbalances (Als) in chemically induced rat mammary, colon, and bladder tumors from (Wistar Furth x Fischer 344)F1 rats are described and compared. Male F1 rats were administered azoxymethane (AOM), and colon tumors were collected at 58 wk after treatment. Female F1 rats were given ei...

journal_title：Molecular carcinogenesis

authors： Haag JD,Brasic GM,Shepel LA,Newton MA,Grubbs CJ,Lubet RA,Kelloff GJ,Gould MN

更新日期：1999-01-01 00:00:00

abstract：:Recently, tumor initiating cells are considered as the central role of tumorigenicity in hepatocellular carcinoma. Enediyne anticancer antibiotic lidamycin with great potential antitumor activity is currently evaluated in Phase II clinical trials. In this study, we evaluated the effect of lidamycin on tumor initiating...

journal_title：Molecular carcinogenesis

authors： Chen Y,Yu D,Zhang C,Shang B,He H,Chen J,Zhang H,Zhao W,Wang Z,Xu X,Zhen Y,Shao RG

更新日期：2015-01-01 00:00:00

abstract：:The extracellular signal-regulated kinase (ERK), mitogen-activated protein kinase (MAPK) pathway is an important cell proliferation pathway. We previously reported that the transport protein particle complex 4 (TRAPPC4), ERK2 interaction may activate ERK1/2, modulate pERK2 nuclear localization and regulate proliferati...

journal_title：Molecular carcinogenesis

authors： Weng YR,Kong X,Yu YN,Wang YC,Hong J,Zhao SL,Fang JY

更新日期：2014-02-01 00:00:00

abstract：:Dishevelled-3 (Dvl-3) and p120-catenin (p120ctn) have abnormal expression in non-small cell lung cancer (NSCLC), which is associated with poor prognosis. Dvl-3 upregulates p120ctn transcription in NSCLC cells, but the mechanism is unknown. Here we transiently transfected Dvl-3 cDNA to NSCLC cells. Dvl-3 transfection i...

journal_title：Molecular carcinogenesis

authors： Zhao H,Zhao Y,Jiang G,Zhang X,Zhang Y,Dong Q,Luan L,Papavassiliou P,Wang E,Wang E

更新日期：2015-06-01 00:00:00

abstract：:The vaccinia virus cDNA expression system was used to produce human cytochrome P450 IA2 in a hepatoma cell line that is devoid of significant basal levels of P450. The expressed enzyme yielded a reduced carbon monoxide-bound difference spectrum with a lambda max of 449 nm. Catalytic activities and mutagen activation a...

journal_title：Molecular carcinogenesis

authors： Aoyama T,Gonzalez FJ,Gelboin HV

更新日期：1989-01-01 00:00:00

abstract：:The metalloproteinase matrilysin is widely expressed in the epithelial tumor cells of malignant colorectal adenocarcinomas. Approximately 50% of benign adenomas also express low levels of matrilysin that is focally localized. The expression of stromelysin-1, stromelysin-3, and gelatinase A was observed in the stromal ...

journal_title：Molecular carcinogenesis

authors： Newell KJ,Witty JP,Rodgers WH,Matrisian LM

更新日期：1994-08-01 00:00:00

abstract：:The WW domain-containing oxidoreductase (WWOX) gene is an identified tumor suppressor gene, of which several single nucleotide polymorphisms have been reported to contribute to cancer susceptibility. We hypothesized that genetic variations in WWOX are associated with lung cancer risk. In two independent case-control s...

journal_title：Molecular carcinogenesis

authors： Huang D,Qiu F,Yang L,Li Y,Cheng M,Wang H,Ma G,Wang Y,Hu M,Ji W,Zhou Y,Lu J

更新日期：2013-11-01 00:00:00

abstract：:Patients with advanced hepatocellular carcinoma (HCC) continue to have a dismal prognosis. Potential biomarkers to determine prognosis and select targeted therapies are urgently needed for patients with HCC. This study aimed to elucidate the role of UCK2 in HCC prognosis and tumor progression. We performed a screen of...

journal_title：Molecular carcinogenesis

authors： Huang S,Li J,Tam NL,Sun C,Hou Y,Hughes B,Wang Z,Zhou Q,He X,Wu L

更新日期：2019-04-01 00:00:00

abstract：:To investigate the importance of oncogenes and tumor suppressor genes in bladder carcinogenesis, we determined the status of the expression of the MDM-2 and p53 genes and genetic alterations in the p53 gene in five bladder carcinoma cell lines and one kidney urothelial carcinoma cell line. Overexpression of MDM-2 mRNA...

journal_title：Molecular carcinogenesis

authors： Cheng YT,Li YL,Wu JD,Long SB,Tzai TS,Tzeng CC,Lai MD

更新日期：1995-07-01 00:00:00

abstract：:2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MelQx) are carcinogens found in cooked meats that form DNA adducts upon metabolic activation. Purified DNA from Chinese hamster ovary (CHO) cells was reacted in vitro with the active metabolites N-acetoxy-IQ or N-acetoxy-Me...

journal_title：Molecular carcinogenesis

authors： Nouso K,Bohr VA,Schut HA,Snyderwine EG

更新日期：1993-01-01 00:00:00

abstract：:Signaling networks play important roles in cancer progression. For example, overexpression of the epidermal growth factor receptor (EGFR) is a poor prognostic indicator in multiple tumor types. Recent studies have postulated that the EGFR functions as a central conduit for signaling by different classes of cell surfac...

journal_title：Molecular carcinogenesis

authors： Boerner JL,Biscardi JS,Silva CM,Parsons SJ

更新日期：2005-12-01 00:00:00

abstract：:Although many reports suggest that aberrant regulation of cytokine signaling pathways via the interleukin-2 receptor (IL-2R) induces tumorigenic transformation, constitutively active IL-2R in tumors has not been reported. We searched for genomic alteration of the IL-2/15R beta-subunit gene (IL-2/15R beta) in cytokine-...

journal_title：Molecular carcinogenesis

authors： Ukai H,Ishii-Oba H,Ukai-Tadenuma M,Ogiu T,Tsuji H

更新日期：2003-06-01 00:00:00

abstract：:Expression of the tumor suppressor deleted in liver cancer-1 (DLC-1) is lost in non-small cell lung (NSCLC) and other human carcinomas, and ectopic DLC-1 expression dramatically reduces proliferation and tumorigenicity. DLC-1 is a multi-domain protein that includes a Rho GTPase activating protein (RhoGAP) domain which...

journal_title：Molecular carcinogenesis

authors： Healy KD,Hodgson L,Kim TY,Shutes A,Maddileti S,Juliano RL,Hahn KM,Harden TK,Bang YJ,Der CJ

更新日期：2008-05-01 00:00:00

abstract：:Expression analysis of 7129 transcripts was carried out in five human prostate cancer cell lines derived from orthotopic xenografts after one to five passages in nude mice and primary cultures of human normal prostate epithelial (NPE) cells. These experiments identified a consensus class of 214 genes (43 up- and 171 d...

journal_title：Molecular carcinogenesis

authors： Glinsky GV,Krones-Herzig A,Glinskii AB,Gebauer G

更新日期：2003-08-01 00:00:00

abstract：:Carcinogenesis is a multistep sequential process of clonal expansion of initiated cells associated with the accumulation of multiple cancer-specific heritable phenotypes. The acquisition of these heritable cancer-specific alterations may be triggered by mutational and/or non-mutational changes in the genome that affec...

journal_title：Molecular carcinogenesis

authors： Koturbash I,Melnyk S,James SJ,Beland FA,Pogribny IP

更新日期：2013-04-01 00:00:00

abstract：:Mutations in the Ki-ras oncogene and the p53 tumor suppressor gene are known to occur at high frequencies in human colon cancers. We measured the frequency of mutations in these two genes in colon adenocarcinomas obtained from a widely used experimental model of human colon carcinogenesis: F344 rats treated with the c...

journal_title：Molecular carcinogenesis

authors： Erdman SH,Wu HD,Hixson LJ,Ahnen DJ,Gerner EW

更新日期：1997-06-01 00:00:00

abstract：:Cytokines are considered to play an important role in tumor pathogenesis and progression, and recent studies have demonstrated that a variety of forms, including interleukins (ILs) and transforming growth factor-beta(s) (TGF-beta(s)), may regulate tumors. In the present study, the expression of TGF-beta isoforms and I...

journal_title：Molecular carcinogenesis

authors： Honoki K,Tsujiuchi T,Sasaki Y,Tsutsumi M,Morishita T,Kido A,Miyauchi Y,Mii Y,Takakura Y,Konishi Y

更新日期：2002-02-01 00:00:00

abstract：:Composition of extracellular matrix (ECM) is crucial to the establishment and maintenance of epithelial apical-basolateral polarity. Increased ECM rigidity caused by deposition of fibrillar collagen, for example, collagen type I (Col-1), promotes loss of epithelial polarity and tumor progression. microRNAs are small n...

journal_title：Molecular carcinogenesis

authors： Li C,Nguyen HT,Zhuang Y,Lin Y,Flemington EK,Guo W,Guenther J,Burow ME,Morris GF,Sullivan D,Shan B

更新日期：2011-07-01 00:00:00

abstract：:Transgenic mice were developed to study the role of c-src in epithelial tumorigenesis through targeted expression of a constitutively active form of murine c-src (src(529)). Src(529) was targeted to the interfollicular epidermis with the human keratin 1 (HK1) promoter. The skin phenotype of these mice was characterize...

journal_title：Molecular carcinogenesis

authors： Matsumoto T,Jiang J,Kiguchi K,Carbajal S,Rho O,Gimenez-Conti I,Beltrán L,DiGiovanni J

更新日期：2002-03-01 00:00:00