Betulin induces mitochondrial cytochrome c release associated apoptosis in human cancer cells.

abstract：:Although fibroblast growth factor (FGF) signals are strongly associated with malignancy, limited information is available regarding the role of the FGF9 signal in colorectal cancer (CRC). In this study, we investigated the frequency of FGF9 amplification in CRC clinical specimens and the association between the FGF9 g...

journal_title：Molecular carcinogenesis

authors： Mizukami T,Togashi Y,Naruki S,Banno E,Terashima M,de Velasco MA,Sakai K,Yoneshige A,Hayashi H,Fujita Y,Tomida S,Nakajima TE,Fujino T,Boku N,Ito A,Nakagawa K,Nishio K

更新日期：2017-01-01 00:00:00

abstract：:Canonical Wnt signaling is altered in most cases of colorectal cancer. Experimental evidence indicates that protein phosphatase 2A (PP2A) may play either positive or negative roles in Wnt signaling but its precise in vivo functions remain elusive. In this work, using colon cultured cell lines we showed that basal PP2A...

journal_title：Molecular carcinogenesis

authors： Carmen Figueroa-Aldariz M,Castañeda-Patlán MC,Santoyo-Ramos P,Zentella A,Robles-Flores M

更新日期：2015-11-01 00:00:00

abstract：:The tyrosinase promoter has been used to target expression of the mutated human T24 Ha-ras oncogene in pigment-producing cells of transgenic mice. Two independent founder mice carrying the transgene survived and showed the same distinct phenotype of mutated coat color, deeply pigmented skin with multiple nevi, and twi...

journal_title：Molecular carcinogenesis

authors： Powell MB,Hyman P,Bell OD,Balmain A,Brown K,Alberts D,Bowden GT

更新日期：1995-02-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is an embryonic program that is reactivated in cancer and regulates the invasion and metastasis of tumor cells. Zinc finger E-box binding homeobox 2 (ZEB2) induces EMT by upregulating matrix metalloproteinases (MMP), yet MMP genes lack ZEB2 binding motif in their promoters. Rece...

journal_title：Molecular carcinogenesis

authors： Yalim-Camci I,Balcik-Ercin P,Cetin M,Odabas G,Tokay N,Sayan AE,Yagci T

更新日期：2019-06-01 00:00:00

abstract：:To investigate the importance of oncogenes and tumor suppressor genes in bladder carcinogenesis, we determined the status of the expression of the MDM-2 and p53 genes and genetic alterations in the p53 gene in five bladder carcinoma cell lines and one kidney urothelial carcinoma cell line. Overexpression of MDM-2 mRNA...

journal_title：Molecular carcinogenesis

authors： Cheng YT,Li YL,Wu JD,Long SB,Tzai TS,Tzeng CC,Lai MD

更新日期：1995-07-01 00:00:00

abstract：:Multidrug resistance (MDR) is one of the most important factors leading to chemotherapeutic failure in patients with breast cancer. The invasive/metastatic ability of MDR cells is strengthened compared with their parental cells. However, the mechanisms underlying MDR have not been fully elucidated. We found that CD44 ...

journal_title：Molecular carcinogenesis

authors： Cheng Y,Tao L,Xu J,Li Q,Yu J,Jin Y,Chen Q,Xu Z,Zou Q,Liu X

更新日期：2014-09-01 00:00:00

abstract：:N-nitrosomethylbenzylamine (NMBA)-induced rat esophageal tumorigenesis is an important model for squamous cell carcinoma of the human esophagus. In this model, previous studies have shown that the GGA-->GAA Ha-ras codon 12 mutation is present in the majority of papillomas. No other Ha-ras mutation has been identified....

journal_title：Molecular carcinogenesis

authors： Liston BW,Gupta A,Nines R,Carlton PS,Kresty LA,Harris GK,Stoner GD

更新日期：2001-09-01 00:00:00

abstract：:Peptidylarginine deiminase type 4 (PAD4/PADI4) posttranslationally converts peptidylarginine to citrulline, in a process known as citrullination. Evidence suggests that PAD4 plays an essential role in pathogenesis of rheumatoid arthritis (RA). RA synovium has many features in common with tumor tissues, including abnor...

journal_title：Molecular carcinogenesis

authors： Chang X,Han J

更新日期：2006-03-01 00:00:00

abstract：:We previously reported that two dietary regimens, calorie restriction (CR) and a high olive oil-containing diet supplemented with a freeze-dried fruit and vegetable extract (OFV), reduced the development of intestinal adenomas in Apc(Min) mice by 57% and 33%, respectively, compared to control mice fed a defined diet a...

journal_title：Molecular carcinogenesis

authors： Mai V,Colbert LH,Perkins SN,Schatzkin A,Hursting SD

更新日期：2007-01-01 00:00:00

abstract：:Plakoglobin (Pg) and beta-catenin are homologous proteins that function in cell-cell adhesion and signaling. The cadherin-associated form of these proteins mediates adhesion, whereas the cytosolic/nuclear form has a signaling role. Despite their interactions with common cellular partners, beta-catenin has a well-docum...

journal_title：Molecular carcinogenesis

authors： Li L,Chapman K,Hu X,Wong A,Pasdar M

更新日期：2007-10-01 00:00:00

abstract：:The relationship between thyroid hormone (triiodothyronine, T(3)) and breast cancer is unclear. We studied the effect of the c-erbA/TR alpha proto-oncogene encoding a functional T(3) receptor (TR alpha 1), of its ligand T(3), and of its retroviral, mutated counterpart, the v-erbA oncogene, on the proliferation capacit...

journal_title：Molecular carcinogenesis

authors： González-Sancho JM,Figueroa A,López-Barahona M,López E,Beug H,Muñoz A

更新日期：2002-05-01 00:00:00

abstract：:Transgenic mice were developed to study the role of c-src in epithelial tumorigenesis through targeted expression of a constitutively active form of murine c-src (src(529)). Src(529) was targeted to the interfollicular epidermis with the human keratin 1 (HK1) promoter. The skin phenotype of these mice was characterize...

journal_title：Molecular carcinogenesis

authors： Matsumoto T,Jiang J,Kiguchi K,Carbajal S,Rho O,Gimenez-Conti I,Beltrán L,DiGiovanni J

更新日期：2002-03-01 00:00:00

abstract：:Ezrin is known to regulate cellular survival, adhesion, migration, and invasion and has been identified as one of the key components of tumor progression and metastasis. The authors investigated ezrin expression in human hepatocellular carcinoma (HCC) and sought to determine its relation with clinicopathologic paramet...

journal_title：Molecular carcinogenesis

authors： Kang YK,Hong SW,Lee H,Kim WH

更新日期：2010-09-01 00:00:00

abstract：:Bone metastases are common complications of breast cancer. Integrins are the major adhesive molecules in mammalian cells. Here we found that osteoblast conditioned medium (OBCM) increased the migration and cell surface expression of beta1 or beta3 integrin in human breast cancer cells (MDA-MB-231 cells). beta1 or beta...

journal_title：Molecular carcinogenesis

authors： Wei YY,Chen YJ,Hsiao YC,Huang YC,Lai TH,Tang CH

更新日期：2008-07-01 00:00:00

abstract：:Human colorectal cancer (CRC) cells are resistant to the anti-proliferative effect of transforming growth factor-β (TGF-β), suggesting that disruption of TGF-β signaling plays an important role in colorectal carcinogenesis. Ecotropic virus integration site-1 (Evi-1) oncoprotein represses TGF-β signaling by interacting...

journal_title：Molecular carcinogenesis

authors： Deng X,Cao Y,Liu Y,Li F,Sambandam K,Rajaraman S,Perkins AS,Fields AP,Hellmich MR,Townsend CM Jr,Thompson EA,Ko TC

更新日期：2013-04-01 00:00:00

abstract：:microRNAs (miRNAs) are commonly altered in glioblastoma. Publicly available algorithms suggest the Wnt pathway is a potential target of miR-577 and the Wnt pathway is commonly altered in glioblastoma. Glioblastoma has not been previously evaluated for miR-577 expression. Glioblastoma tumors and cell lines were evaluat...

journal_title：Molecular carcinogenesis

authors： Zhang W,Shen C,Li C,Yang G,Liu H,Chen X,Zhu D,Zou H,Zhen Y,Zhang D,Zhao S

更新日期：2016-05-01 00:00:00

abstract：:Cytokines are considered to play an important role in tumor pathogenesis and progression, and recent studies have demonstrated that a variety of forms, including interleukins (ILs) and transforming growth factor-beta(s) (TGF-beta(s)), may regulate tumors. In the present study, the expression of TGF-beta isoforms and I...

journal_title：Molecular carcinogenesis

authors： Honoki K,Tsujiuchi T,Sasaki Y,Tsutsumi M,Morishita T,Kido A,Miyauchi Y,Mii Y,Takakura Y,Konishi Y

更新日期：2002-02-01 00:00:00

abstract：:Gap junctions are cellular structures which permit direct exchanges of small molecules from cytoplasm to cytoplasm in most of the cells of metazoan organisms. For four decades, it has been observed that the inhibition of this type of intercellular communication is often associated with tumorigenesis. The assumption th...

journal_title：Molecular carcinogenesis

authors： Mennecier G,Derangeon M,Coronas V,Hervé JC,Mesnil M

更新日期：2008-05-01 00:00:00

abstract：:We have reported that connexin (Cx) 32 gene, a member of gap junction protein family, acts as a tumor suppressor gene in human renal cell carcinoma (RCC). Of solid tumors, RCC is one of the most chemoresistant cancers, and there is no effective cancer chemotherapy against RCC at present. In this study, we examined if ...

journal_title：Molecular carcinogenesis

authors： Sato H,Senba H,Virgona N,Fukumoto K,Ishida T,Hagiwara H,Negishi E,Ueno K,Yamasaki H,Yano T

更新日期：2007-03-01 00:00:00

abstract：:Formation of G4 DNA may occur in the course of replication and transcription, and contribute to genomic instability. We have quantitated abundance of G4 motifs and potential for G4 DNA formation of the nontemplate strand of 5' exons and introns of transcripts of human genes. We find that, for all human genes, G4 motif...

journal_title：Molecular carcinogenesis

authors： Eddy J,Maizels N

更新日期：2009-04-01 00:00:00

abstract：:The expression profile of adenoma induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice was compared with that of normal lung tissue by suppression subtractive hybridization (SSH). The mRNAs of surfactant-associated protein A (SP-A) and lysozyme showed characteristically higher transcription in t...

journal_title：Molecular carcinogenesis

authors： Okubo C,Morishita Y,Minami Y,Ishiyama T,Kano J,Iijima T,Noguchi M

更新日期：2005-02-01 00:00:00

abstract：:The P53 gene is a tumor suppressor gene and can prevent mutation and tumor induction though apoptosis and DNA repair when it is activated by genotoxic stress. miR-34a expression is regulated by the P53 gene and might be required for cell response to DNA damage. TK6 cells are human lymphoblast cells with normal P53 fun...

journal_title：Molecular carcinogenesis

authors： Chen X,Yan J,Chen T

更新日期：2012-08-01 00:00:00

abstract：:Resistance to cisplatin-based chemotherapy is responsible for the majority of deaths from head and neck squamous cell carcinoma (HNSCC). In this study, using genome-wide gene expression analysis to investigate potential molecular mediators of HNSCC chemoresistance, we identified SERPINB2, a known inhibitor of extracel...

journal_title：Molecular carcinogenesis

authors： Huang Z,Li H,Huang Q,Chen D,Han J,Wang L,Pan C,Chen W,House MG,Nephew KP,Guo Z

更新日期：2014-10-01 00:00:00

abstract：:Several studies have shown that E-cadherin expression is lost during malignant transformation. We hypothesized that CpG methylation in the promoter region may inactivate the expression of the E-cadherin gene in human bladder cancer. Normal and bladder cancer samples from 51 patients were compared in terms of E-cadheri...

journal_title：Molecular carcinogenesis

authors： Ribeiro-Filho LA,Franks J,Sasaki M,Shiina H,Li LC,Nojima D,Arap S,Carroll P,Enokida H,Nakagawa M,Yonezawa S,Dahiya R

更新日期：2002-08-01 00:00:00

abstract：:Growth factor receptors of the tyrosine kinase family regulate proliferation of a variety of cell types. In some human cancers, the epidermal growth factor receptor (EGFR) and its ligands often are overexpressed, leading to both constitutive and autocrine activation. Intracellular signaling via this receptor takes pla...

journal_title：Molecular carcinogenesis

authors： Crowe DL,Tsang KJ

更新日期：2001-12-01 00:00:00

abstract：:Despite a decline in the incidence of squamous cell carcinomas (SCCs) over the past 20 years, their survival rate has remained nearly the same, indicating that treatment options have not improved relative to other cancer types. Immunotherapies have a high potential for a sustained effect in SCC patients, but their res...

journal_title：Molecular carcinogenesis

authors： Strait AA,Wang XJ

更新日期：2020-07-01 00:00:00

abstract：:Indole-3-carbinol (I3C), an anti-cancer phytochemical derived from cruciferous vegetables, strongly inhibited proliferation and down-regulated protein levels of the melanocyte master regulator micropthalmia-associated transcription factor (MITF-M) in oncogenic BRAF-V600E expressing melanoma cells in culture as well as...

journal_title：Molecular carcinogenesis

authors： Kundu A,Quirit JG,Khouri MG,Firestone GL

更新日期：2017-01-01 00:00:00

abstract：:Breast cancer is a major health problem worldwide. Current standard practices for treatment of breast cancer are less than satisfactory because of high rates of metastasis. Arsenic trioxide (As(2)O(3)), which induces demethylation of DNA and causes apoptosis, has been used as an anti-tumor agent. Little is known, howe...

journal_title：Molecular carcinogenesis

authors： Si L,Jiang F,Li Y,Ye X,Mu J,Wang X,Ning S,Hu C,Li Z

更新日期：2015-09-01 00:00:00

abstract：:The cyclin-dependent kinase inhibitor 2a (Cdkn2a) locus encodes two distinct tumor suppressors, p16INK4a and p19ARF, whose functions interrelate in the regulation of cell proliferation as key components of the retinoblastoma and p53 pathways, respectively. In many types of cancer, alterations of Cdkn2a abrogate the fu...

journal_title：Molecular carcinogenesis

authors： Herzog CR,Noh S,Lantry LE,Guan KL,You M

更新日期：1999-06-01 00:00:00

abstract：:Patulin (PAT), a present day major contaminant of commercial apple and apple products is reported to be carcinogenic, embryotoxic, and immunotoxic. While oral and inhalation are considered to be the most prevalent routes of exposure to this toxin, exposure through skin is now being extensively investigated. Our previo...

journal_title：Molecular carcinogenesis

authors： Alam S,Pal A,Kumar R,Dwivedi PD,Das M,Ansari KM

更新日期：2014-12-01 00:00:00