Infrequent loss of heterozygosity and mutation of the p53 gene in immortal and transformed mouse embryo fibroblasts.

abstract：:2-Amino-3-methylimidazo[4,5-f]quinoline (IQ), a food carcinogen formed in cooked meats, can induce gene mutation at the hprt locus of CHO-K1 cells in the presence of hepatic S9 mix. To elucidate the molecular nature of IQ-induced mutation, we characterized the entire coding region of the hypoxanthine phosphoribosyl-tr...

journal_title：Molecular carcinogenesis

authors： Lee H,Shih MK

更新日期：1995-06-01 00:00:00

abstract：:Apc mutations cause intestinal tumorigenesis through Tcf4 activation. However, direct techniques for studying Tcf4 activation in vivo are limited. Here, we describe the development of a Tcf4-GFP reporter mouse model for directly studying Tcf4 activation. We first developed a GFP reporter construct (Tcf4-GFP) and trans...

journal_title：Molecular carcinogenesis

authors： Boman B,Kopelovich L,Siracusa LD,Zhang T,Henderson K,Cofer Z,Buchberg AM,Fields JZ,Otevrel T

更新日期：2009-09-01 00:00:00

abstract：:Hypoxia is a critical event in solid tumor development, invasion, and metastasis. Cellular adaptation to hypoxic microenvironment is essential for tumor progression and is largely mediated by hypoxia-inducible factor-1α (HIF-1α) through coordinated regulation of hypoxia-responsive genes. In this study, we found that m...

journal_title：Molecular carcinogenesis

authors： Zhu S,Zhou Y,Wang L,Zhang J,Wu H,Xiong J,Zhang J,Tian Y,Wang C,Wu H

更新日期：2011-10-01 00:00:00

abstract：:Xiphophorus fish have been the subject of intensive genetic research for more than 60 yr, primarily because of the availability of a number of interspecific hybrids that are malignant melanoma models with apparently simple oncogene and tumor suppressor gene determinants. The gene map of Xiphophorus is one of the most ...

journal_title：Molecular carcinogenesis

authors： Morizot DC,McEntire BB,Della Coletta L,Kazianis S,Schartl M,Nairn RS

更新日期：1998-07-01 00:00:00

abstract：:The human p53 gene, a putative tumor suppressor gene, has a polymorphism in amino acid residue 72. We recently developed a method of detecting codon 72 polymorphism in this gene by digestion of polymerase chain reaction-amplified DNA using an allele-specific restriction endonuclease. This polymorphism allows the ident...

journal_title：Molecular carcinogenesis

authors： Oka K,Ishikawa J,Bruner JM,Takahashi R,Saya H

更新日期：1991-01-01 00:00:00

abstract：:Chromosomal double-strand breaks (DSBs) occurring in mammalian cells can initiate genomic instability, and their misrepairs result in chromosomal deletion, amplification, and translocation, common findings in human tumors. The tumor-suppressor protein p53 is involved in maintaining genomic stability. In this study, we...

journal_title：Molecular carcinogenesis

authors： Honma M,Momose M,Tanabe H,Sakamoto H,Yu Y,Little JB,Sofuni T,Hayashi M

更新日期：2000-08-01 00:00:00

abstract：:The endocannabinoid arachidonoyl ethanolamide (AEA) is a potent inducer of tumor cell apoptosis however its mechanism of cytotoxicity is unclear. A previous report from our laboratory showed that AEA induced cell death in a cyclooxygenase-2 (COX-2)-dependent manner and in this report our data indicate that AEA-induced...

journal_title：Molecular carcinogenesis

authors： Kuc C,Jenkins A,Van Dross RT

更新日期：2012-02-01 00:00:00

abstract：:Obesity increases colorectal cancer (CRC) risk and progression. However, the impact of obesity on CRC in women is dependent on ovarian hormone status. The purpose of this study was to determine the interactive roles of obesity and ovarian hormones on serum markers of inflammation, cell signaling, and transplanted colo...

journal_title：Molecular carcinogenesis

authors： Rondini EA,Harvey AE,Steibel JP,Hursting SD,Fenton JI

更新日期：2011-05-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest cancers in the world. All-trans retinoic acid (ATRA) is the major physiologically active form of vitamin A, regulating expression of many genes. Disturbances of vitamin A metabolism are prevalent in some cancer cells. The main aim of this work was...

journal_title：Molecular carcinogenesis

authors： Bleul T,Rühl R,Bulashevska S,Karakhanova S,Werner J,Bazhin AV

更新日期：2015-09-01 00:00:00

abstract：:Withaferin A (WA), a natural product derived from Withania somnifera, has been used in traditional oriental medicines to treat neurological disorders. Recent studies have demonstrated that this compound may have a potential for cancer treatment and a clinical trial has been launched to test WA in treating melanoma. He...

journal_title：Molecular carcinogenesis

authors： Li W,Zhang C,Du H,Huang V,Sun B,Harris JP,Richardson Q,Shen X,Jin R,Li G,Kevil CG,Gu X,Shi R,Zhao Y

更新日期：2016-11-01 00:00:00

abstract：:High-level expression of the c-sis oncogene, which encodes the beta chain of platelet-derived growth factor, transforms immortalized rodent fibroblasts in vitro to a malignant phenotype. c-sis gene expression has been demonstrated in a variety of human tumors, although generally at levels much lower than those shown t...

journal_title：Molecular carcinogenesis

authors： MacArthur LH,Clarke MF,Westin EH

更新日期：1992-01-01 00:00:00

abstract：:Despite effective surgical methods for non-melanoma skin cancer (NMSC), patients suffer from tissue damage, scarring, or even disfigurement; thus, there is a need for chemopreventive approaches. Because of the complex interplay between glucocorticoids (GCs), inflammation, and cancer, we sought to determine the role of...

journal_title：Molecular carcinogenesis

authors： Mancha-Ramirez AM,Yang X,Liang H,Junco J,Lee KP,Bovio SF,Espinoza M,Wool J,Slaga A,Glade DC,Hanes M,Malik G,Kim DJ,DiGiovanni J,Slaga TJ

更新日期：2019-01-01 00:00:00

abstract：:The WW domain-containing oxidoreductase (WWOX) gene is an identified tumor suppressor gene, of which several single nucleotide polymorphisms have been reported to contribute to cancer susceptibility. We hypothesized that genetic variations in WWOX are associated with lung cancer risk. In two independent case-control s...

journal_title：Molecular carcinogenesis

authors： Huang D,Qiu F,Yang L,Li Y,Cheng M,Wang H,Ma G,Wang Y,Hu M,Ji W,Zhou Y,Lu J

更新日期：2013-11-01 00:00:00

abstract：:Nonmelanoma skin cancers (NMSCs) consist of a variety of tumor types including basal cell carcinoma, squamous cell carcinoma, a variety of hair follicle tumors, and sebaceous gland tumors. Genetic alterations that alter the fate of multipotent stem cells are believed to influence NMSC phenotype. We previously generate...

journal_title：Molecular carcinogenesis

authors： Honeycutt KA,Waikel RL,Koster MI,Wang XJ,Roop DR

更新日期：2010-04-01 00:00:00

abstract：:The expression profile of adenoma induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice was compared with that of normal lung tissue by suppression subtractive hybridization (SSH). The mRNAs of surfactant-associated protein A (SP-A) and lysozyme showed characteristically higher transcription in t...

journal_title：Molecular carcinogenesis

authors： Okubo C,Morishita Y,Minami Y,Ishiyama T,Kano J,Iijima T,Noguchi M

更新日期：2005-02-01 00:00:00

abstract：:Ezrin is known to regulate cellular survival, adhesion, migration, and invasion and has been identified as one of the key components of tumor progression and metastasis. The authors investigated ezrin expression in human hepatocellular carcinoma (HCC) and sought to determine its relation with clinicopathologic paramet...

journal_title：Molecular carcinogenesis

authors： Kang YK,Hong SW,Lee H,Kim WH

更新日期：2010-09-01 00:00:00

abstract：:Tobacco smoking represents an important known cause of ductal pancreatic adenocarcinoma. Recent data from pooled analyses in consortia involving multiple case-control and cohort studies suggest that heavy (but not moderate or light) alcohol consumption also may increase pancreatic cancer risk. Animal and human evidenc...

journal_title：Molecular carcinogenesis

authors： Duell EJ

更新日期：2012-01-01 00:00:00

abstract：:An in vitro model system for xenogenization has been developed in which an immunogenic, nonmalignant phenotype was selected from a highly malignant T-cell line (S49). We showed by single-strand conformation polymorphism and DNA sequence analysis that specific point mutations in the p53 tumor suppressor gene correlated...

journal_title：Molecular carcinogenesis

authors： Bergel M,Bhatia K,Siwarski D,Gutierrez M,Hochman J,Huppi K

更新日期：1993-01-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) is a cellular energy sensor that is conserved in eukaryotes. Although AMPK is traditionally thought to play a major role in the regulation of cellular lipid and protein metabolism, recent discoveries reveal that AMPK inhibits mammalian target of rapamycin (mTOR) signaling and connec...

journal_title：Molecular carcinogenesis

authors： Tong X,Smith KA,Pelling JC

更新日期：2012-03-01 00:00:00

abstract：:2-Deoxyglucose (2-DG), which has been shown to inhibit mammary carcinogenesis, was used as a metabolic probe to investigate effects of limiting energy availability (reduced cellular ATP) on patterns of proteins' phosphorylation that play a role in the development of cancer. Experiments were conducted using a human bre...

journal_title：Molecular carcinogenesis

authors： Jiang W,Zhu Z,Thompson HJ

更新日期：2008-08-01 00:00:00

abstract：:The molecular pathogenesis of papillary thyroid carcinoma (PTC) is largely attributed to chromosomal rearrangements and point mutations in genes within the MAPK pathway (i.e., BRAF and RAS). Despite KRAS being the 6th most frequently mutated gene for all cancers, the reported frequency in thyroid cancer is only 2%. Th...

journal_title：Molecular carcinogenesis

authors： Myers MB,McKim KL,Parsons BL

更新日期：2014-02-01 00:00:00

abstract：:It has been established that retinoids exert some of their effects on cell differentiation and malignant phenotype reversion through the interaction with different members of the protein kinase C (PKC) family. Till nowadays the nature and extension of this interaction is not well understood. Due to the cytostatic and ...

journal_title：Molecular carcinogenesis

authors： Berardi DE,Bessone MI,Motter A,Bal de Kier Joffé ED,Urtreger AJ,Todaro LB

更新日期：2015-10-01 00:00:00

abstract：:Transgenic mice were developed to study the role of c-src in epithelial tumorigenesis through targeted expression of a constitutively active form of murine c-src (src(529)). Src(529) was targeted to the interfollicular epidermis with the human keratin 1 (HK1) promoter. The skin phenotype of these mice was characterize...

journal_title：Molecular carcinogenesis

authors： Matsumoto T,Jiang J,Kiguchi K,Carbajal S,Rho O,Gimenez-Conti I,Beltrán L,DiGiovanni J

更新日期：2002-03-01 00:00:00

abstract：:The pi-class glutathione S-transferase (GSTP1) actively protect cells from carcinogens and electrophilic compounds. Loss of GSTP1 expression via promoter hypermethylation is the most common epigenetic alteration observed in human prostate cancer. Silencing of GSTP1 can increase generation of reactive oxygen species (R...

journal_title：Molecular carcinogenesis

authors： Kanwal R,Pandey M,Bhaskaran N,Maclennan GT,Fu P,Ponsky LE,Gupta S

更新日期：2014-01-01 00:00:00

abstract：:Despite a decline in the incidence of squamous cell carcinomas (SCCs) over the past 20 years, their survival rate has remained nearly the same, indicating that treatment options have not improved relative to other cancer types. Immunotherapies have a high potential for a sustained effect in SCC patients, but their res...

journal_title：Molecular carcinogenesis

authors： Strait AA,Wang XJ

更新日期：2020-07-01 00:00:00

abstract：:Diet-derived butyrate, a histone deacetylase inhibitor (HDI), decreases proliferation and increases apoptosis in colorectal cancer (CRC) cells via epigenetic changes in gene expression. Other HDIs such as suberoylanilide hydroxamic acid (SAHA) and trichostatin A (TSA) have similar effects. This study examined the role...

journal_title：Molecular carcinogenesis

authors： Humphreys KJ,Cobiac L,Le Leu RK,Van der Hoek MB,Michael MZ

更新日期：2013-06-01 00:00:00

abstract：:In the present study, we evaluated the effect of deleting Twist1 on keratinocyte proliferation and on skin tumor development using the two-stage chemical carcinogenesis model. BK5.Cre × Twist1(flox/flox) mice, which have a keratinocyte-specific Twist1 knockout (Twist1 KO), developed significantly reduced numbers of pa...

journal_title：Molecular carcinogenesis

authors： Srivastava J,Rho O,Youssef RM,DiGiovanni J

更新日期：2016-05-01 00:00:00

abstract：:Expression of the tumor suppressor deleted in liver cancer-1 (DLC-1) is lost in non-small cell lung (NSCLC) and other human carcinomas, and ectopic DLC-1 expression dramatically reduces proliferation and tumorigenicity. DLC-1 is a multi-domain protein that includes a Rho GTPase activating protein (RhoGAP) domain which...

journal_title：Molecular carcinogenesis

authors： Healy KD,Hodgson L,Kim TY,Shutes A,Maddileti S,Juliano RL,Hahn KM,Harden TK,Bang YJ,Der CJ

更新日期：2008-05-01 00:00:00

abstract：:microRNAs (miRNAs) are commonly altered in glioblastoma. Publicly available algorithms suggest the Wnt pathway is a potential target of miR-577 and the Wnt pathway is commonly altered in glioblastoma. Glioblastoma has not been previously evaluated for miR-577 expression. Glioblastoma tumors and cell lines were evaluat...

journal_title：Molecular carcinogenesis

authors： Zhang W,Shen C,Li C,Yang G,Liu H,Chen X,Zhu D,Zou H,Zhen Y,Zhang D,Zhao S

更新日期：2016-05-01 00:00:00

abstract：:KITLG/KIT pathway plays a vital role in multiple types of human cancer including head and neck squamous cell carcinoma (HNSCC). Genetic variations in KITLG and KIT may affect the expression or function of these genes, thereby modifying cancer risk. In this study, we evaluated the association of KITLG and KIT polymorph...

journal_title：Molecular carcinogenesis

authors： Hang D,Yuan H,Liu L,Wang L,Miao L,Zhu M,Du J,Dai J,Hu Z,Chen N,Shen H,Ma H

更新日期：2017-01-01 00:00:00