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AD biomarker discovery in CSF and in alternative matrices.

Abstract：

:Core Alzheimer's Disease (AD) biomarkers are the cerebrospinal fluid (CSF) proteins amyloid β42 and β40, and the tau proteins, total and phosphorylated. Their use is recommended by research guidelines for diagnostic purpose and for stratification of patients for clinical trials. However, novel potential biomarkers are needed, which can mirror risk factors and other different mechanisms of the disease, hopefully in less invasive biological fluids or matrices. Studies on blood, urine, saliva, tears gave promising results, and several novel molecules have been identified, as potential brain derived biomarkers, thanks to the development of novel ultrasensitive technologies. In this review, we discuss about advantages and limits of the classical CSF biomarkers of AD, as well as of novel CSF candidate biomarkers and recent promises from alternative matrices.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Sancesario G,Bernardini S

doi

10.1016/j.clinbiochem.2019.08.008

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

52-57

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(19)30417-5

journal_volume

72

pub_type

杂志文章,评审

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