Abstract：
:Atherosclerosis and its sequelae have a major impact on morbidity and mortality. The rupture of an inflamed atherosclerotic plaque is a crucial event, since it can result in acute thrombotic closure of an arterial vessel, resulting e. g. in myocardial infarction or stroke. Not only detection of early plaque rupture with imminent closure is therefore of clinical interest, but also timely detection of vascular inflammation and atherosclerotic plaque progression. However, plaque inflammation or even plaque rupture without vessel occlusion is not reliably detectable by current imaging techniques. Coronary angiography is the gold standard for evaluation of the coronary vessels, but only allows visualization of the vessel lumen without characterizing the important pathophysiology of the vessel wall. Therefore, highly inflamed and rupture prone plaques can be missed, or appear as a minor vessel narrowing. Although currently available techniques such as intravascular ultrasound or optical coherence tomography allow a further characterization of atherosclerotic plaques, it would be desirable to detect plaque inflammation, early plaque rupture or vascular thrombosis by non-invasive techniques such as magnetic resonance imaging (MRI), since they could allow early identification of patients at risk or triage of symptomatic patients. In this manuscript, different strategies for detection of vascular inflammation, plaque-rupture and thrombosis by MRI will be discussed, with a special focus on molecular imaging contrast agents.
journal_name
Hamostaseologiejournal_title
Hamostaseologieauthors
von Zur Muhlen C,Bode Cdoi
10.5482/HAMO-14-11-0061subject
Has Abstractpub_date
2015-01-01 00:00:00pages
252-62issue
3eissn
0720-9355issn
2567-5761pii
14-11-0061journal_volume
35pub_type
杂志文章,评审相关文献
Hamostaseologie文献大全abstract：UNLABELLED:The retrospective cohort study surveys the influence of age, co-morbidity and laboratory values on FVIII-activity (FVIII:C) in patients with haemophilia A with (mild n = 48, moderate n = 10, severe n = 7 and carriers n = 23). Median observation was 19 years for patients with haemophilia A and 9,5 years for c...
journal_title：Hamostaseologie
pub_type： 杂志文章
doi：
更新日期：2011-11-01 00:00:00
abstract：:Recurrent venous thromboembolism is associated with increased mortality in 5-9% of the patients. On the other hand prolonged anticoagulation can increase the bleeding risk which can also be responsible for an increased mortality. Therefore, it is necessary to validate the recurrence risk of venous thromboembolism on a...
journal_title：Hamostaseologie
pub_type： 杂志文章,评审
doi：10.5482/ha-1144
更新日期：2011-02-01 00:00:00
abstract：:Replacement therapy of coagulation factor preparations (AT, FFP, PPSB, FXIII, rFVIIa) are frequently used on the Intensive Care Units. Indications, dosage, specific effects and side effects have to be considered. ...
journal_title：Hamostaseologie
pub_type： 杂志文章,评审
doi：10.1267/hämo05020209
更新日期：2005-05-01 00:00:00
abstract：UNLABELLED:The doses of these drugs are barely tested and the potential clinical thromboembolic risk must be taken into account. Despite the widespread use of NOAC (non vitamin-K dependent oral anticoagulants) and recommendations of regulatory agencies and first consensus meeting on handling the bleeding situation unde...
journal_title：Hamostaseologie
pub_type： 杂志文章
doi：
更新日期：2015-01-01 00:00:00
abstract：:Vitamin-K-antagonists (VKA) and heparins have been complementary anticoagulants for prevention and treatment of thrombosis for almost 70 years. In contrast to heparins, VKA have not been modified pharmacologically, however treatment surveillance has improved by introducing INR and self-monitoring/management. Disclosur...
journal_title：Hamostaseologie
pub_type： 杂志文章,评审
doi：10.5482/ha-1149
更新日期：2011-02-01 00:00:00
abstract：:Platelets react immediately in response to traumatic vascular injury by adhesion, activation, aggregation and subsequent haemostatic plug formation. While this reaction pattern is essential for haemostasis, platelet responses can also cause occlusive thrombi in diseased arteries, leading to myocardial infarction or st...
journal_title：Hamostaseologie
pub_type： 杂志文章,评审
doi：10.1055/s-0038-1675144
更新日期：2018-11-01 00:00:00
abstract：:Patients with myeloproliferative neoplasms (MPNs), such as polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are at increased risk for arterial and venous thrombosis/thromboembolism. In particular, the risk of splanchnic venous thrombosis, such as portal vein thrombosis or Budd-Chiari syndrome, ...
journal_title：Hamostaseologie
pub_type： 杂志文章,评审
doi：10.1055/s-0040-1701474
更新日期：2020-02-01 00:00:00
abstract：:The antiphospholipid syndrome is defined as the occurrence of one or more episodes of vascular thrombosis and/or miscarriage together with antiphospholipid antibodies. Some of these antibodies can be detected via coagulation assays by prolonging phospholipids-dependent assays. These unspecific inhibitors are termed lu...
journal_title：Hamostaseologie
pub_type： 杂志文章,评审
doi：10.1267/hämo05010050
更新日期：2005-02-01 00:00:00
abstract：:Nearly every second patient, who needs an oral anticoagulation with vitamin K antagonists, is feasible to perform INR-self-management after participation in a structured teaching program. Patient self-testing or measuring the INR value by relatives or nurses would increase this method of control by the aid of telemedi...
journal_title：Hamostaseologie
pub_type： 杂志文章
doi：
更新日期：2008-10-01 00:00:00
abstract：:Superficial vein thrombosis (SVT) is a common disease, characterized by an inflammatory-thrombotic process in a superficial vein. Typical clinical findings are pain and a warm, tender, reddish cord along the vein. Until recently, no reliable epidemiological data were available. The incidence is estimated to be higher ...
journal_title：Hamostaseologie
pub_type： 杂志文章
doi：10.5482/HAMO-13-04-0027
更新日期：2013-08-01 00:00:00
abstract：:Acquired haemophilia A (AHA) is a rare autoimmune disease caused by antibodies directed against clotting factor VIII. About half of cases are idiopathic, but AHA may also be secondary to autoimmune, dermatologic, or oncologic diseases. In approximately 10% of non-idiopathic cases, the disease occurs after or with the ...
journal_title：Hamostaseologie
pub_type： 杂志文章
doi：10.1055/s-0038-1668570
更新日期：2019-02-01 00:00:00
abstract：:Studies describe benefits of exercise in Patients with haemophilia (PwH), but research on training sustainability is rare. Aim of this study was to observe the follow-up of a guided 6-month training intervention in PwH. This study included 28 PwH after a training intervention (RCT) over 6 months. N=17 continued traini...
journal_title：Hamostaseologie
pub_type： 杂志文章,随机对照试验
doi：10.5482/HAMO-17-04-0016
更新日期：2017-01-01 00:00:00
abstract：UNLABELLED:In recent years thrombophilia has gained much attention as a risk factor for pregnancy complications. Whereas there is an established correlation between antiphospholipid-antibodies and pregnancy loss, data for other risk factors of thrombosis are less well established. Data suggest associations with antithr...
journal_title：Hamostaseologie
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：:The endothelium lining the vascular lumen is continuously exposed to complement from the circulation. When erroneously activated on host cells, complement may generate a deleterious effect on the vascular wall leading to endothelial injury, exposure of the subendothelial matrix and platelet activation. In this review ...
journal_title：Hamostaseologie
pub_type： 杂志文章,评审
doi：10.5482/HAMO-12-12-0025
更新日期：2013-05-29 00:00:00
abstract：:For decades, the options for therapeutic anticoagulation were limited to unfractionated heparin (UFH) and vitamin K antagonists (VKA), and their well-known limitations had to be accepted. With the introduction of the various LMWHs, the short- and medium-term anticoagulation could be much improved, but an alternative t...
journal_title：Hamostaseologie
pub_type： 杂志文章,评审
doi：
更新日期：2008-12-01 00:00:00
abstract：:Vitamin K 2,3-epoxide reductase complex, subunit 1 (VKORC1) is an enzyme essential for the vitamin K cycle. VKORC1 catalyses the reduction of vitamin K 2,3-epoxide to the quinone form of vitamin K and further to vitamin K hydroquinone. The generated vitamin K hydroquinone serves as substrate for the enzyme γ-glutamyl-...
journal_title：Hamostaseologie
pub_type： 杂志文章,评审
doi：
更新日期：2016-11-08 00:00:00
abstract：:Recent advances in the diagnosis and the treatment of acute coronary syndromes (ACS) have led to a substantial reduction of major coronary events, to an improvement in patient outcome and the definition of new guidelines. Current strategies for the treatment of patients with non-ST-elevation ACS recommend a combined a...
journal_title：Hamostaseologie
pub_type： 杂志文章
doi：
更新日期：2007-12-01 00:00:00
abstract：:Atherosclerosis and its major complications - myocardial infarction and stroke - remain major causes of death and disability in the United States and world-wide. Indeed, with dramatic increases in obesity and diabetes mellitus, the prevalence and public health impact of cardiovascular diseases (CVD) will likely remain...
journal_title：Hamostaseologie
pub_type： 杂志文章,评审
doi：10.5482/HAMO-14-11-0076
更新日期：2016-05-10 00:00:00
abstract：:Patients with diabetes are at increased risk of cardiovascular morbidity and mortality. While arteriosclerotic lesions have long been recognized as the underlying cause more recent studies suggest that alterations of the blood are also critically involved. Following plaque rupture, adherence of platelets is followed b...
journal_title：Hamostaseologie
pub_type： 杂志文章
doi：10.5482/HAMO-14-09-0039
更新日期：2015-01-01 00:00:00
abstract：:Methylation, CpG island, promoter, intron 1 Haemophilia A is the most common X-linked inherited coagulation disorder caused by a deficiency of the factor VIII protein (FVIII). A plethora of different mutations in the factor VIII gene (F8) have been identified as causative for this bleeding disease including a few prom...
journal_title：Hamostaseologie
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
abstract：UNLABELLED:Clinical expression of inadequately treated haemophilia is dominated by orthopedic complications, requiring invasive or non-invasive interventions. OBJECTIVE:In Romania, with under dosed and late introduced "on demand" substitution, we aimed at highlighting the experience of orthopedic treatment and its out...
journal_title：Hamostaseologie
pub_type： 杂志文章
doi：
更新日期：2008-10-01 00:00:00
abstract：:Children with an unexplained bleeding tendency are frequently referred to a haemostaseologist for further evaluation. Careful standardized history taking and clinical evaluation should allow for distinguishing bleeds after minor injury and trauma which are very common in all children. However, in two groups of childre...
journal_title：Hamostaseologie
pub_type： 杂志文章,评审
doi：10.1055/s-0039-1677714
更新日期：2019-02-01 00:00:00
abstract：:The translation of fundamental science-based constructs to the preemptive identification and optimal management of individuals with or those at risk for thrombotic disorders of the cardiovascular system has taken a step closer to being realized with the development of molecular technologies that include nucleic acid a...
journal_title：Hamostaseologie
pub_type： 杂志文章
doi：
更新日期：2007-12-01 00:00:00
abstract：:Von Willebrand factor (VWF) structure-function relationship has been studied only through in vitro approaches. The VWF-deficient mouse model has been extremely useful to examine the in vivo function of VWF but does not allow a more subtle analysis of the relative importance of its different domains. However, consideri...
journal_title：Hamostaseologie
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
abstract：:Obesity is a major cause for a spectrum of metabolic syndrome-related diseases that include insulin resistance, type 2 diabetes, and steatosis of the liver. Inflammation elicited by macrophages and other immune cells contributes to the metabolic abnormalities in obesity. In addition, coagulation activation following t...
journal_title：Hamostaseologie
pub_type： 杂志文章,评审
doi：10.5482/HAMO-14-11-0068
更新日期：2015-01-01 00:00:00
abstract：:The antiphospholipid syndrome (APS) is defined by the association of arterial and/or venous thrombosis and/or pregnancy complications with the presence of at least one among the main antiphospholipid antibodies (aPL) (i. e., Lupus anticoagulants, LA, IgG and/or IgM anticardiolipin antibodies, aCL, IgG and/or IgM antiβ...
journal_title：Hamostaseologie
pub_type： 杂志文章,评审
doi：10.5482/ha-1165
更新日期：2011-11-01 00:00:00
abstract：:Trauma-induced coagulopathy (TIC) is a heterogeneous entity that contributes to a significant morbidity and mortality following trauma. The activated protein C system, endotheliopathy and platelet dysfunction have been implicated in the pathogenesis of TIC, although there are still controversies on the exact pathogene...
journal_title：Hamostaseologie
pub_type： 杂志文章,评审
doi：10.1055/s-0039-1677853
更新日期：2019-02-01 00:00:00
abstract：:The DHR (Deutsches Hämophilieregister, German Haemophilia Register) records patient data on haemophilia A, haemophilia B, von Willebrand disease, and other coagulation factor deficiency disorders. The DHR has been online since 2009. The participation in the DHR leads to additional administrative workload for the hospi...
journal_title：Hamostaseologie
pub_type： 杂志文章
doi：
更新日期：2010-11-01 00:00:00
abstract：UNLABELLED:With the development of clotting-factors in the seventies the haemophilia patients were released from being handicapped and began to live a quite normal life. Thus, psychosocial counselling did not seem to be necessary. But the impact of HIV-infection to the world of haemophilia was so intense that professio...
journal_title：Hamostaseologie
pub_type： 杂志文章
doi：
更新日期：2010-11-01 00:00:00
abstract：:Coronary heart disease and the acute coronary syndrome are the leading causes of death in Germany. In prospective observational studies conventional risk factors such as smoking, arterial hypertension, hypercholesterolaemia, and diabetes can explain over 80% of cardiovascular diseases. Therefore, cardiovascular diseas...
journal_title：Hamostaseologie
pub_type： 杂志文章,评审
doi：
更新日期：2006-05-01 00:00:00
