Abstract:
UNLABELLED:The retrospective cohort study surveys the influence of age, co-morbidity and laboratory values on FVIII-activity (FVIII:C) in patients with haemophilia A with (mild n = 48, moderate n = 10, severe n = 7 and carriers n = 23). Median observation was 19 years for patients with haemophilia A and 9,5 years for carriers. RESULTS:FVIII:C levels collected from patients with mild haemophilia A displayed a significant median increase of 6.5% with proceeding age (p = 0.0013). Patients with moderate haemophilia A (and carriers of haemophilia A) showed a non significant median increase of 1.05% (carriers 8%). Eight patients showed FVIII:C levels at last blood withdrawal that indicated a change of severity from moderate to mild haemophilia A. A significant correlation was found between FVIII:C and VWF:RCo (p = 0.0203) and AFP (p < 0.0005). The correlation between FVIII:C and triglycerides and LDH was significant negative (p < 0.0005). No significant correlation could be found for FVIII:C and co-morbidity, fibrinogen, cholesterol and VWF:Ag.
journal_name
Hamostaseologiejournal_title
Hamostaseologieauthors
Delbrück C,Haferland I,Scholz K,Asmelash G,Makki V,Müller S,Krekeler S,Alesci S,Miesbach Wsubject
Has Abstractpub_date
2011-11-01 00:00:00pages
S24-8eissn
0720-9355issn
2567-5761pii
11410S24journal_volume
31 Suppl 1pub_type
杂志文章相关文献
Hamostaseologie文献大全abstract:INTRODUCTION: Regular visits at haemophilia treatment centres (HTCs) in rural regions are often dependent on the access to a private car due to lack of or limited availability of public means. Therefore, a mobile haemophilia outpatient care (MHOC) concept providing home visits to haemophilia patients has been developed...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:10.1055/s-0038-1654721
更新日期:2018-08-01 00:00:00
abstract::Clinically overt, preoperative, disseminated intravascular coagulation (DIC) is not common in patient with aortic aneurysm. However, cases with large and expanding aneurysm are especially prone for this coagulopathy. Contrary to the clinically overt form compensated DIC in patients with aortic aneurysm seems frequent ...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.1267/hamo04030162
更新日期:2004-08-01 00:00:00
abstract::The endothelium lining the vascular lumen is continuously exposed to complement from the circulation. When erroneously activated on host cells, complement may generate a deleterious effect on the vascular wall leading to endothelial injury, exposure of the subendothelial matrix and platelet activation. In this review ...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.5482/HAMO-12-12-0025
更新日期:2013-05-29 00:00:00
abstract::Platelet number or function disorders cause a range of bleeding symptoms from mild to severe. Patients with platelet dysfunction but normal platelet number are the most prevalent and typically have mild bleeding symptoms. The study of this group of patients is particularly difficult because of the lack of a gold-stand...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:
更新日期:2010-01-01 00:00:00
abstract::Recurrent venous thromboembolism is associated with increased mortality in 5-9% of the patients. On the other hand prolonged anticoagulation can increase the bleeding risk which can also be responsible for an increased mortality. Therefore, it is necessary to validate the recurrence risk of venous thromboembolism on a...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.5482/ha-1144
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE: This article aims to analyze the phenotype and genotype of an inherited dysfibrinogenemia pedigree associated with a heterozygous mutation in the FGA gene, and to investigate the pathogenesis of this disease. CLINICAL PRESENTATION: The proband of interest is a 29-year-old woman. She was in her 37 weeks of g...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:10.1055/a-1261-3884
更新日期:2020-12-01 00:00:00
abstract:UNLABELLED:An adequate number of qualified haemophilia centres is an essential requirement for effective and cost-efficient haemophilia care. During a reassessment of the delivery of haemophilia care in Germany a broad range of criteria relating to structure and quality of the centres were defined and a questionnaire w...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract:UNLABELLED:A protein Z deficiency is presumably related with a threefold risk of venous and arterial thrombosis. Mucosal bleedings and post-operative haematomas can occur more frequently. This is seen in an increased in vivo bleeding time without other plasmatic coagulation disorders or thrombopathies. Pregnancy compli...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract::Unexplained intraoperative coagulopathies continue to be a diagnostic and therapeutic dilemma. The pathophysiology behind unexplained intraoperative coagulopathies is of great variety and complexity (preexisting coagulopathies, dilutional coagulopathy, interactions of medications etc.). We have shown in prospective st...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:
更新日期:2006-08-01 00:00:00
abstract:UNLABELLED:The retrospective observational study surveys the relationship between development of inhibitors in the treatment of haemophilia patients and risk factors such as changing FVIII products. A total of 119 patients were included in this study, 198 changes of FVIII products were evaluated. RESULTS:During the ob...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract::Haemophilic arthropathy is a complex multifactorial disorder that poses significant challenges to both the treating haematologist and arthroplasty surgeon. Its pathogenesis is incompletely understood. Recent literature has concentrated on the toxic effects of iron and the characteristic inflammatory synovitis. Discuss...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:10.5482/HAMO-15-12-0033
更新日期:2017-01-01 00:00:00
abstract::Obesity is a major cause for a spectrum of metabolic syndrome-related diseases that include insulin resistance, type 2 diabetes, and steatosis of the liver. Inflammation elicited by macrophages and other immune cells contributes to the metabolic abnormalities in obesity. In addition, coagulation activation following t...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.5482/HAMO-14-11-0068
更新日期:2015-01-01 00:00:00
abstract::Characteristic features of disseminated intravascular coagulation (DIC) are the opposing risks of bleeding (due to consumptive coagulopathy and hyperfibrinolysis) and organ failure (due to widespread microvascular thromboses). The purpose of anticoagulation in DIC is to attenuate excessive thrombin generation and fibr...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:10.1055/s-0038-1675386
更新日期:2019-08-01 00:00:00
abstract::Current antithrombotic therapy in patients with acute coronary syndrome (ACS) comprises antiplatelet and anticoagulant therapy. Dual antiplatelet therapy composed of aspirin plus a third generation P2Y12 inhibitor (prasugrel or ticagrelor) represents the gold standard, while aspirin plus second generation P2Y12 inhibi...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.5482/HAMO-13-09-0048
更新日期:2014-01-01 00:00:00
abstract::In Germany one-third of the women in fertile age use combined oral contraceptives (COCs), which consist mostly of ethinylestradiol (EE) and a synthetic progestin. Older COCs with norethisterone or levonorgestrel have a lower risk for venous thromboembolism (VTE) than newer COCs with desogestrel, drospirenone, or gesto...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.1055/s-0039-1677806
更新日期:2019-02-01 00:00:00
abstract::Percutaneous coronary intervention (PCI) has significantly improved clinical outcomes in coronary artery disease patients. Since PCI is associated with platelet activation, antiplatelet therapy with aspirin, clopidogrel and GPIIb/IIIa inhibitors comprise the cornerstone strategy during and following PCI. The latter ag...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:
更新日期:2009-11-01 00:00:00
abstract::Patients with diabetes are at increased risk of cardiovascular morbidity and mortality. While arteriosclerotic lesions have long been recognized as the underlying cause more recent studies suggest that alterations of the blood are also critically involved. Following plaque rupture, adherence of platelets is followed b...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:10.5482/HAMO-14-09-0039
更新日期:2015-01-01 00:00:00
abstract:UNLABELLED:Clinical expression of inadequately treated haemophilia is dominated by orthopedic complications, requiring invasive or non-invasive interventions. OBJECTIVE:In Romania, with under dosed and late introduced "on demand" substitution, we aimed at highlighting the experience of orthopedic treatment and its out...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:
更新日期:2008-10-01 00:00:00
abstract::The structure-activity relationship of dipetalogastin II, the strongest thrombin inhibitor isolated and cloned from the bug Dipetalogaster maximus, was examined by introducing gradual changes into the molecule by means of molecular biological methods. The effect upon its inhibition equilibrium constant was determined ...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:10.1267/hämo05030267
更新日期:2005-08-01 00:00:00
abstract:UNLABELLED:The doses of these drugs are barely tested and the potential clinical thromboembolic risk must be taken into account. Despite the widespread use of NOAC (non vitamin-K dependent oral anticoagulants) and recommendations of regulatory agencies and first consensus meeting on handling the bleeding situation unde...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:
更新日期:2015-01-01 00:00:00
abstract::Von Willebrand factor (VWF) structure-function relationship has been studied only through in vitro approaches. The VWF-deficient mouse model has been extremely useful to examine the in vivo function of VWF but does not allow a more subtle analysis of the relative importance of its different domains. However, consideri...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract::Myocardial infarction (MI) shows a strong heritability. For a long time the identification of responsible genes has been rather unsuccessful. However, with the advent of genome wide association studies (GWAS) using DNA-array technology a number of significant loci for MI have been identified which were widely replicat...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:
更新日期:2010-11-01 00:00:00
abstract::Dabigatran is a novel direct thrombin inhibitor that has recently been approved for primary and secondary stroke prevention and prevention of systemic embolism in patients with atrial fibrillation. In the pivotal RE-LY study, dabigatran 110 mg BID was demonstrated to be associated with a stroke rate similar to that ob...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:10.5482/ha-1196
更新日期:2012-01-01 00:00:00
abstract::Upon vascular injury or tissue damage, the exposed intracellular material such as nucleic acids, histones and other macromolecules may come into contact with vessel wall cells and circulating blood cells and may thus, have an enduring influence on wound healing and body defence processes. This short review summarizes ...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.5482/HAMO-13-01-0001
更新日期:2013-01-01 00:00:00
abstract::Patients suffering from haemophilia encounter various phases in life, in which individual needs, life situations, and self- and disease perception change rapidly. One of these phases spans from the beginning of puberty until early adulthood, in which individuals gain self-responsibility and reach independence and auto...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.1055/s-0039-3402804
更新日期:2020-02-01 00:00:00
abstract::Acquired haemophilia A (AHA) is caused by autoantibody inhibitors of coagulation factor VIII (FVIII : C). Recent onset of bleeds and isolated prolongation of the activated partial thromboplastin time (aPTT) are characteristic features of the disorder. Reduced FVIII : C activity and a detectable FVIII : C inhibitor in ...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.5482/HAMO-14-11-0064
更新日期:2015-01-01 00:00:00
abstract::This article reviews the roles of blood platelets in haemostasis as well as in the pathogenesis of thromboembolic diseases. Besides the basic processes in primary haemostasis, platelet adhesion, platelet secretion, platelet aggregation, clot retraction, the new model of thrombin formation on the platelet surface is pr...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:
更新日期:2008-12-01 00:00:00
abstract::Hermansky-Pudlak syndrome (HPS) is a rare, autosomal recessive disorder affecting lysosome-related organelles (LRO), including dense platelet granules. HPS causes oculocutaneous hypopigmentation, bleeding diathesis and granulomatous colitis or pulmonary fibrosis. To date, there is no curative treatment and the clinica...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.5482/HAMO-14-06-0024
更新日期:2014-01-01 00:00:00
abstract::Superficial vein thrombosis (SVT) is a common disease, characterized by an inflammatory-thrombotic process in a superficial vein. Typical clinical findings are pain and a warm, tender, reddish cord along the vein. Until recently, no reliable epidemiological data were available. The incidence is estimated to be higher ...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:10.5482/HAMO-13-04-0027
更新日期:2013-08-01 00:00:00
abstract::The translation of fundamental science-based constructs to the preemptive identification and optimal management of individuals with or those at risk for thrombotic disorders of the cardiovascular system has taken a step closer to being realized with the development of molecular technologies that include nucleic acid a...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:
更新日期:2007-12-01 00:00:00