[Platelets: biochemistry and physiology].

abstract：:The structure-activity relationship of dipetalogastin II, the strongest thrombin inhibitor isolated and cloned from the bug Dipetalogaster maximus, was examined by introducing gradual changes into the molecule by means of molecular biological methods. The effect upon its inhibition equilibrium constant was determined ...

journal_title：Hamostaseologie

authors： Lopez M,Nowak G

更新日期：2005-08-01 00:00:00

abstract：:The DHR (Deutsches Hämophilieregister, German Haemophilia Register) records patient data on haemophilia A, haemophilia B, von Willebrand disease, and other coagulation factor deficiency disorders. The DHR has been online since 2009. The participation in the DHR leads to additional administrative workload for the hospi...

journal_title：Hamostaseologie

authors： Haschberger B,Hesse J,Heiden M,Seitz R,Schramm W

更新日期：2010-11-01 00:00:00

abstract：:An understanding of reversal strategies alone is important to safely and effectively care for patients in cases of bleeding or invasive procedures. The recent diversification in the number of licensed anticoagulants makes an understanding of drug-specific reversal strategies essential. Intravenous or oral vitamin K ca...

journal_title：Hamostaseologie

authors： Koscielny J,Rutkauskaite E,Sucker C,von Heymann C

更新日期：2020-06-01 00:00:00

abstract：:Replacement therapy of coagulation factor preparations (AT, FFP, PPSB, FXIII, rFVIIa) are frequently used on the Intensive Care Units. Indications, dosage, specific effects and side effects have to be considered. ...

journal_title：Hamostaseologie

authors： Scharrer I

更新日期：2005-05-01 00:00:00

abstract：:The antiphospholipid syndrome (APS) is defined by the association of arterial and/or venous thrombosis and/or pregnancy complications with the presence of at least one among the main antiphospholipid antibodies (aPL) (i. e., Lupus anticoagulants, LA, IgG and/or IgM anticardiolipin antibodies, aCL, IgG and/or IgM antiβ...

journal_title：Hamostaseologie

authors： Galli M

更新日期：2011-11-01 00:00:00

abstract：:Epidemiological studies revealed that most antineoplastic agents and regimes enhance the risk of venous and arterial thromboembolic events in cancer patients. The purpose of this article is to review clinical and pathophysiological data related to chemotherapy-associated thromboembolism under special consideration of ...

journal_title：Hamostaseologie

authors： Lechner D,Weltermann A

更新日期：2009-01-01 00:00:00

abstract：:Recombinant activated factor VII (rFVIIa) is a pro-haemostatic agent that can be used for patients with haemophilia and inhibiting antibodies towards a coagulation factor. Recombinant factor VIIa is, however, increasingly used for several other indications, including patients who experience serious and life-threatenin...

journal_title：Hamostaseologie

authors： Levi M

更新日期：2009-01-01 00:00:00

abstract：:The antiphospholipid syndrome is defined as the occurrence of one or more episodes of vascular thrombosis and/or miscarriage together with antiphospholipid antibodies. Some of these antibodies can be detected via coagulation assays by prolonging phospholipids-dependent assays. These unspecific inhibitors are termed lu...

journal_title：Hamostaseologie

authors： Quehenberger P,Wagner O

更新日期：2005-02-01 00:00:00

abstract：:Von Willebrand factor (VWF) structure-function relationship has been studied only through in vitro approaches. The VWF-deficient mouse model has been extremely useful to examine the in vivo function of VWF but does not allow a more subtle analysis of the relative importance of its different domains. However, consideri...

journal_title：Hamostaseologie

authors： Denis CV,Marx I,Badirou I,Pendu R,Christophe O

更新日期：2009-01-01 00:00:00

abstract：:Acquired haemophilia A (AHA) is caused by autoantibody inhibitors of coagulation factor VIII (FVIII : C). Recent onset of bleeds and isolated prolongation of the activated partial thromboplastin time (aPTT) are characteristic features of the disorder. Reduced FVIII : C activity and a detectable FVIII : C inhibitor in ...

journal_title：Hamostaseologie

authors： Tiede A,Scharf RE,Dobbelstein C,Werwitzke S

更新日期：2015-01-01 00:00:00

abstract：:A survey is given on the clinical important haemostatic facts and diseases in gynaecology and obstetrics from the viewpoint of the gynecologist and obstetrician. ...

journal_title：Hamostaseologie

authors： Heilmann L

更新日期：2004-11-01 00:00:00

abstract：:By the use of conventional anticoagulants, significant improvements were achieved in all fields of medicine. Although efficacious and widely used, their use is limited in several respects. In particular, the use of vitamin K antagonists is restricted in the clinical routine setting. The main reasons are the delayed on...

journal_title：Hamostaseologie

authors： Haas S

更新日期：2002-08-01 00:00:00

abstract：:Platelets react immediately in response to traumatic vascular injury by adhesion, activation, aggregation and subsequent haemostatic plug formation. While this reaction pattern is essential for haemostasis, platelet responses can also cause occlusive thrombi in diseased arteries, leading to myocardial infarction or st...

journal_title：Hamostaseologie

authors： Scharf RE

更新日期：2018-11-01 00:00:00

abstract：AIM:In children, screening for haemorrhagic disorders is further complicated by the fact that infants and young children with mild disease in many cases most likely will not have a significant history of easy bruising or bleeding making the efficacy of a questionnaire even more questionable. PATIENTS, METHODS:We compa...

journal_title：Hamostaseologie

authors： Music I,Novak M,Acham-Roschitz B,Muntean W

更新日期：2009-10-01 00:00:00

abstract：UNLABELLED:Molecular genetic testing for factor VIII (FVIII) mutations is indicated in haemophilia A since determination of FVIII activity cannot reliably identify female carriers. Given the large number of FVIII mutations the identification of novel mutations is not uncommon. Since amino acid polymorphisms of FVIII ar...

journal_title：Hamostaseologie

authors： Schneppenheim R,Schröder J,Obser T,Oyen F,Schneppenheim S,Oldenburg J

更新日期：2009-05-01 00:00:00

abstract：UNLABELLED:Atherosclerosis is a chronic inflammatory disease of the vascular wall that results from disturbed lipoprotein metabolism and increased oxidative stress. A major consequence of this is lipid peroxidation, which generates a number of breakdown products of membrane lipids that form so called oxidation-specific...

journal_title：Hamostaseologie

authors： Bartolini Gritti B,Binder CJ

更新日期：2016-05-10 00:00:00

abstract：:Clinically overt, preoperative, disseminated intravascular coagulation (DIC) is not common in patient with aortic aneurysm. However, cases with large and expanding aneurysm are especially prone for this coagulopathy. Contrary to the clinically overt form compensated DIC in patients with aortic aneurysm seems frequent ...

journal_title：Hamostaseologie

authors： Jeleńska MM

更新日期：2004-08-01 00:00:00

abstract：:Acquired haemophilia A (AHA) is a rare autoimmune disease caused by antibodies directed against clotting factor VIII. About half of cases are idiopathic, but AHA may also be secondary to autoimmune, dermatologic, or oncologic diseases. In approximately 10% of non-idiopathic cases, the disease occurs after or with the ...

journal_title：Hamostaseologie

authors： Pacholczak R,Bazan-Socha S,Zdziarska J,Iwaniec T,Walocha JA,Musiał J,Dropiński J

更新日期：2019-02-01 00:00:00

abstract：:Cardiovascular disease is the major cause of morbidity and mortality in subjects suffering from diabetes mellitus. While coronary artery disease is the leading cause of cardiac complications in diabetics, it is widely recognized that diabetes increases the risk for the development of heart failure independently of cor...

journal_title：Hamostaseologie

authors： Bugger H,Bode C

更新日期：2015-01-01 00:00:00

abstract：:Unexplained intraoperative coagulopathies continue to be a diagnostic and therapeutic dilemma. The pathophysiology behind unexplained intraoperative coagulopathies is of great variety and complexity (preexisting coagulopathies, dilutional coagulopathy, interactions of medications etc.). We have shown in prospective st...

journal_title：Hamostaseologie

authors： Korte W

更新日期：2006-08-01 00:00:00

abstract：:Von Willebrand disease (VWD) is known for its marked heterogeneity which was already recognized by von Willebrand in 1926. The basis of phenotypic differentiation are quantitative and qualitative or functional differences between the different types and subtypes of VWD. One of the most important tools in the classific...

journal_title：Hamostaseologie

authors： Schneppenheim R,Budde U

更新日期：2004-02-01 00:00:00

abstract：:Percutaneous coronary intervention (PCI) has significantly improved clinical outcomes in coronary artery disease patients. Since PCI is associated with platelet activation, antiplatelet therapy with aspirin, clopidogrel and GPIIb/IIIa inhibitors comprise the cornerstone strategy during and following PCI. The latter ag...

journal_title：Hamostaseologie

authors： Tantry US,Gurbel PA

更新日期：2009-11-01 00:00:00

abstract：:Low molecular weight heparins and fondaparinux have been the cornerstones for prevention of venous thromboembolism (VTE) in acutely ill medical patients for almost two decades. Guidelines recommend the use of these parenteral anticoagulants for 6 to 14 days but advise against extended-duration thromboprophylaxis after...

journal_title：Hamostaseologie

authors： Haas S

更新日期：2019-02-01 00:00:00

abstract：:This article reviews the current understanding of the pathophysiology of acute coronary syndrome and how these concepts have altered our clinical approach to the acute phase of coronary heart disease. Thrombosis due to erosion or, in most cases, rupture of a vulnerable atherosclerotic plaque underlies most acute coron...

journal_title：Hamostaseologie

authors： Hölschermann H,Tillmanns H,Bode C

更新日期：2006-05-01 00:00:00

abstract：:Studies describe benefits of exercise in Patients with haemophilia (PwH), but research on training sustainability is rare. Aim of this study was to observe the follow-up of a guided 6-month training intervention in PwH. This study included 28 PwH after a training intervention (RCT) over 6 months. N=17 continued traini...

journal_title：Hamostaseologie

authors： Runkel B,Hilberg T

更新日期：2017-01-01 00:00:00

abstract：:An overview is given on congenital and acquired thrombocytopenias, their pathophysiology, symptoms, diagnosis and therapy with emphasizing heparin-induced thrombocytopenia (HIT) and the thrombotic thrombocytopenic purpura (TTP). ...

journal_title：Hamostaseologie

authors： Scharf RE

更新日期：2003-11-01 00:00:00

abstract：:Dabigatran is a novel direct thrombin inhibitor that has recently been approved for primary and secondary stroke prevention and prevention of systemic embolism in patients with atrial fibrillation. In the pivotal RE-LY study, dabigatran 110 mg BID was demonstrated to be associated with a stroke rate similar to that ob...

journal_title：Hamostaseologie

authors： Hohnloser SH,Diener HC

更新日期：2012-01-01 00:00:00

abstract：:Nutrient excess in obesity drives metabolic reprogramming in multiple tissues involving extensive interorgan and intercellular crosstalk. Experimental and clinical studies show that prolonged nutrient excess often compromises metabolic adaptation propagating proobesogenic and proinflammatory responses. Chronic inflamm...

journal_title：Hamostaseologie

authors： Madhusudhan T,Ruf W

更新日期：2019-06-01 00:00:00

abstract：UNLABELLED:The retrospective cohort study surveys the influence of age, co-morbidity and laboratory values on FVIII-activity (FVIII:C) in patients with haemophilia A with (mild n = 48, moderate n = 10, severe n = 7 and carriers n = 23). Median observation was 19 years for patients with haemophilia A and 9,5 years for c...

journal_title：Hamostaseologie

authors： Delbrück C,Haferland I,Scholz K,Asmelash G,Makki V,Müller S,Krekeler S,Alesci S,Miesbach W

更新日期：2011-11-01 00:00:00

abstract：:Coronary heart disease and the acute coronary syndrome are the leading causes of death in Germany. In prospective observational studies conventional risk factors such as smoking, arterial hypertension, hypercholesterolaemia, and diabetes can explain over 80% of cardiovascular diseases. Therefore, cardiovascular diseas...

journal_title：Hamostaseologie

authors： Weingärtner O,Laufs U

更新日期：2006-05-01 00:00:00