Use of recombinant factor VIIa in the perioperative period.

abstract：:Epidemiological studies revealed that most antineoplastic agents and regimes enhance the risk of venous and arterial thromboembolic events in cancer patients. The purpose of this article is to review clinical and pathophysiological data related to chemotherapy-associated thromboembolism under special consideration of ...

journal_title：Hamostaseologie

authors： Lechner D,Weltermann A

更新日期：2009-01-01 00:00:00

abstract：:The occurrence of cerebral or retinal ischemic symptoms ipsilateral to high-grade internal carotid artery (ICA) stenosis indicates a status of instability with a substantial risk for future major stroke. Additionally, the detection of microembolic signals downstream of ICA stenosis is predictive for future cerebral is...

journal_title：Hamostaseologie

authors： Sitzer M,Trostdorf F

更新日期：2003-05-01 00:00:00

abstract：:The structure-activity relationship of dipetalogastin II, the strongest thrombin inhibitor isolated and cloned from the bug Dipetalogaster maximus, was examined by introducing gradual changes into the molecule by means of molecular biological methods. The effect upon its inhibition equilibrium constant was determined ...

journal_title：Hamostaseologie

authors： Lopez M,Nowak G

更新日期：2005-08-01 00:00:00

abstract：UNLABELLED:Molecular genetic testing for factor VIII (FVIII) mutations is indicated in haemophilia A since determination of FVIII activity cannot reliably identify female carriers. Given the large number of FVIII mutations the identification of novel mutations is not uncommon. Since amino acid polymorphisms of FVIII ar...

journal_title：Hamostaseologie

authors： Schneppenheim R,Schröder J,Obser T,Oyen F,Schneppenheim S,Oldenburg J

更新日期：2009-05-01 00:00:00

abstract：UNLABELLED:The retrospective cohort study surveys the influence of age, co-morbidity and laboratory values on FVIII-activity (FVIII:C) in patients with haemophilia A with (mild n = 48, moderate n = 10, severe n = 7 and carriers n = 23). Median observation was 19 years for patients with haemophilia A and 9,5 years for c...

journal_title：Hamostaseologie

authors： Delbrück C,Haferland I,Scholz K,Asmelash G,Makki V,Müller S,Krekeler S,Alesci S,Miesbach W

更新日期：2011-11-01 00:00:00

abstract：:This article reviews the roles of blood platelets in haemostasis as well as in the pathogenesis of thromboembolic diseases. Besides the basic processes in primary haemostasis, platelet adhesion, platelet secretion, platelet aggregation, clot retraction, the new model of thrombin formation on the platelet surface is pr...

journal_title：Hamostaseologie

authors： Kehrel BE

更新日期：2008-12-01 00:00:00

abstract：UNLABELLED:An adequate number of qualified haemophilia centres is an essential requirement for effective and cost-efficient haemophilia care. During a reassessment of the delivery of haemophilia care in Germany a broad range of criteria relating to structure and quality of the centres were defined and a questionnaire w...

journal_title：Hamostaseologie

authors： Zimmermann R,Eifrig B,Lenk H,Pollmann H,Scharrer I,Huth-Kühne A

更新日期：2012-01-01 00:00:00

abstract：:Several challenges arise from the wide application of molecular genetic analyses, among them the need to introduce rules to evaluate molecular genetic test systems as well as test laboratories. This article specifically addresses laboratories performing molecular genetic tests for diagnosis, prevention and therapy of ...

journal_title：Hamostaseologie

authors： Mannhalter C

更新日期：2010-05-01 00:00:00

abstract：:Recent advances in the diagnosis and the treatment of acute coronary syndromes (ACS) have led to a substantial reduction of major coronary events, to an improvement in patient outcome and the definition of new guidelines. Current strategies for the treatment of patients with non-ST-elevation ACS recommend a combined a...

journal_title：Hamostaseologie

authors： Hölschermann H

更新日期：2007-12-01 00:00:00

abstract：:The antiphospholipid syndrome (APS) is defined by the association of arterial and/or venous thrombosis and/or pregnancy complications with the presence of at least one among the main antiphospholipid antibodies (aPL) (i. e., Lupus anticoagulants, LA, IgG and/or IgM anticardiolipin antibodies, aCL, IgG and/or IgM antiβ...

journal_title：Hamostaseologie

authors： Galli M

更新日期：2011-11-01 00:00:00

abstract：:Vitamin K-antagonists and heparin belong to the established indirect acting anticoagulants. For many years these drugs were the only possibility for prophylaxis and treatment of venous and arterial thrombosis. The challenges for the routine laboratory related to the treatment with vitamin K-antagonists and heparin can...

journal_title：Hamostaseologie

authors： Schuster B

更新日期：2009-08-01 00:00:00

abstract：:The endothelium lining the vascular lumen is continuously exposed to complement from the circulation. When erroneously activated on host cells, complement may generate a deleterious effect on the vascular wall leading to endothelial injury, exposure of the subendothelial matrix and platelet activation. In this review ...

journal_title：Hamostaseologie

authors： Karpman D,Tati R

更新日期：2013-05-29 00:00:00

abstract：:Nearly every second patient, who needs an oral anticoagulation with vitamin K antagonists, is feasible to perform INR-self-management after participation in a structured teaching program. Patient self-testing or measuring the INR value by relatives or nurses would increase this method of control by the aid of telemedi...

journal_title：Hamostaseologie

authors： Völler H,Braun S

更新日期：2008-10-01 00:00:00

abstract：:Vitamin-K-antagonists (VKA) and heparins have been complementary anticoagulants for prevention and treatment of thrombosis for almost 70 years. In contrast to heparins, VKA have not been modified pharmacologically, however treatment surveillance has improved by introducing INR and self-monitoring/management. Disclosur...

journal_title：Hamostaseologie

authors： Harbrecht U

更新日期：2011-02-01 00:00:00

abstract：:When assessing the quality of clinical trials in intermittent claudication, on principle the same strict biometric and medical standards need to be applied for studies on the effect of walking exercise as for conservative drug treatment studies. However, as demonstrated by a recent review of the Cochrane Collaboration...

journal_title：Hamostaseologie

authors： Amendt K

更新日期：2006-08-01 00:00:00

abstract：:Replacement therapy of coagulation factor preparations (AT, FFP, PPSB, FXIII, rFVIIa) are frequently used on the Intensive Care Units. Indications, dosage, specific effects and side effects have to be considered. ...

journal_title：Hamostaseologie

authors： Scharrer I

更新日期：2005-05-01 00:00:00

abstract：:Placenta-mediated pregnancy complications are clinically important conditions and include preeclampsia, placental abruption, intrauterine growth restriction, and late fetal loss. Pathophysiology is complex, and may be linked to prothrombotic disorders such as antiphospholipid syndrome, whose understanding is still evo...

journal_title：Hamostaseologie

authors： Skeith L,Blondon M,Ní Áinle F

更新日期：2020-08-01 00:00:00

abstract：:Nutrient excess in obesity drives metabolic reprogramming in multiple tissues involving extensive interorgan and intercellular crosstalk. Experimental and clinical studies show that prolonged nutrient excess often compromises metabolic adaptation propagating proobesogenic and proinflammatory responses. Chronic inflamm...

journal_title：Hamostaseologie

authors： Madhusudhan T,Ruf W

更新日期：2019-06-01 00:00:00

abstract：UNLABELLED:A protein Z deficiency is presumably related with a threefold risk of venous and arterial thrombosis. Mucosal bleedings and post-operative haematomas can occur more frequently. This is seen in an increased in vivo bleeding time without other plasmatic coagulation disorders or thrombopathies. Pregnancy compli...

journal_title：Hamostaseologie

authors： Kiesewetter H,Radtke H,Jainz A,Schmidt FP

更新日期：2012-01-01 00:00:00

abstract：:Platelet number or function disorders cause a range of bleeding symptoms from mild to severe. Patients with platelet dysfunction but normal platelet number are the most prevalent and typically have mild bleeding symptoms. The study of this group of patients is particularly difficult because of the lack of a gold-stand...

journal_title：Hamostaseologie

authors： Watson S,Daly M,Dawood B,Gissen P,Makris M,Mundell S,Wilde J,Mumford A

更新日期：2010-01-01 00:00:00

abstract：:Platelets react immediately in response to traumatic vascular injury by adhesion, activation, aggregation and subsequent haemostatic plug formation. While this reaction pattern is essential for haemostasis, platelet responses can also cause occlusive thrombi in diseased arteries, leading to myocardial infarction or st...

journal_title：Hamostaseologie

authors： Scharf RE

更新日期：2018-11-01 00:00:00

abstract：:An overview is given on congenital and acquired thrombocytopenias, their pathophysiology, symptoms, diagnosis and therapy with emphasizing heparin-induced thrombocytopenia (HIT) and the thrombotic thrombocytopenic purpura (TTP). ...

journal_title：Hamostaseologie

authors： Scharf RE

更新日期：2003-11-01 00:00:00

abstract：:Methylation, CpG island, promoter, intron 1 Haemophilia A is the most common X-linked inherited coagulation disorder caused by a deficiency of the factor VIII protein (FVIII). A plethora of different mutations in the factor VIII gene (F8) have been identified as causative for this bleeding disease including a few prom...

journal_title：Hamostaseologie

authors： Zimmermann MA,Hansmann T,Haaf T,Oldenburg J,Müller CR,Rost S

更新日期：2013-01-01 00:00:00

abstract：:The antiphospholipid syndrome is defined as the occurrence of one or more episodes of vascular thrombosis and/or miscarriage together with antiphospholipid antibodies. Some of these antibodies can be detected via coagulation assays by prolonging phospholipids-dependent assays. These unspecific inhibitors are termed lu...

journal_title：Hamostaseologie

authors： Quehenberger P,Wagner O

更新日期：2005-02-01 00:00:00

abstract：UNLABELLED:The doses of these drugs are barely tested and the potential clinical thromboembolic risk must be taken into account. Despite the widespread use of NOAC (non vitamin-K dependent oral anticoagulants) and recommendations of regulatory agencies and first consensus meeting on handling the bleeding situation unde...

journal_title：Hamostaseologie

authors： Koscielny J,Rutkauskaite E

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION: Regular visits at haemophilia treatment centres (HTCs) in rural regions are often dependent on the access to a private car due to lack of or limited availability of public means. Therefore, a mobile haemophilia outpatient care (MHOC) concept providing home visits to haemophilia patients has been developed...

journal_title：Hamostaseologie

authors： Eichler H,Schleicher C,Heine S,Graf N,von Mackensen S

更新日期：2018-08-01 00:00:00

abstract：:Superficial vein thrombosis (SVT) is a common disease, characterized by an inflammatory-thrombotic process in a superficial vein. Typical clinical findings are pain and a warm, tender, reddish cord along the vein. Until recently, no reliable epidemiological data were available. The incidence is estimated to be higher ...

journal_title：Hamostaseologie

authors： Bauersachs RM

更新日期：2013-08-01 00:00:00

abstract：:Vitamin K 2,3-epoxide reductase complex, subunit 1 (VKORC1) is an enzyme essential for the vitamin K cycle. VKORC1 catalyses the reduction of vitamin K 2,3-epoxide to the quinone form of vitamin K and further to vitamin K hydroquinone. The generated vitamin K hydroquinone serves as substrate for the enzyme γ-glutamyl-...

journal_title：Hamostaseologie

authors： Czogalla KJ,Watzka M,Oldenburg J

更新日期：2016-11-08 00:00:00

abstract：:Patients with myeloproliferative neoplasms (MPNs), such as polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are at increased risk for arterial and venous thrombosis/thromboembolism. In particular, the risk of splanchnic venous thrombosis, such as portal vein thrombosis or Budd-Chiari syndrome, ...

journal_title：Hamostaseologie

authors： Koschmieder S

更新日期：2020-02-01 00:00:00

abstract：:Cardiovascular disease is the major cause of morbidity and mortality in subjects suffering from diabetes mellitus. While coronary artery disease is the leading cause of cardiac complications in diabetics, it is widely recognized that diabetes increases the risk for the development of heart failure independently of cor...

journal_title：Hamostaseologie

authors： Bugger H,Bode C

更新日期：2015-01-01 00:00:00