Abstract：
:Recombinant activated factor VII (rFVIIa) is a pro-haemostatic agent that can be used for patients with haemophilia and inhibiting antibodies towards a coagulation factor. Recombinant factor VIIa is, however, increasingly used for several other indications, including patients who experience serious and life-threatening bleeding. In addition, rFVIIa has been evaluated for the prevention of major blood loss in patients undergoing surgical procedures that are known to be associated with major blood loss. In this manuscript we review the data on efficacy and safety of rFVIIa in the prevention of excessive blood loss and transfusion requirements in the perioperative period. We conclude that recombinant factor VIIa is a promising agent for perioperative prevention of major blood loss but that its efficacy will probably vary between specific clinical settings. Its exact place in surgery warrants further clinical trials in various situations that will also more precisely determine the safety of this intervention.
journal_name
Hamostaseologiejournal_title
Hamostaseologieauthors
Levi Msubject
Has Abstractpub_date
2009-01-01 00:00:00pages
68-70issue
1eissn
0720-9355issn
2567-5761pii
09010068journal_volume
29pub_type
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