[Pathophysiology of chemotherapy-associated thrombosis].

abstract：:Recurrent venous thromboembolism is associated with increased mortality in 5-9% of the patients. On the other hand prolonged anticoagulation can increase the bleeding risk which can also be responsible for an increased mortality. Therefore, it is necessary to validate the recurrence risk of venous thromboembolism on a...

journal_title：Hamostaseologie

authors： Lindhoff-Last E

更新日期：2011-02-01 00:00:00

abstract：:Platelet number or function disorders cause a range of bleeding symptoms from mild to severe. Patients with platelet dysfunction but normal platelet number are the most prevalent and typically have mild bleeding symptoms. The study of this group of patients is particularly difficult because of the lack of a gold-stand...

journal_title：Hamostaseologie

authors： Watson S,Daly M,Dawood B,Gissen P,Makris M,Mundell S,Wilde J,Mumford A

更新日期：2010-01-01 00:00:00

abstract：AIM:In children, screening for haemorrhagic disorders is further complicated by the fact that infants and young children with mild disease in many cases most likely will not have a significant history of easy bruising or bleeding making the efficacy of a questionnaire even more questionable. PATIENTS, METHODS:We compa...

journal_title：Hamostaseologie

authors： Music I,Novak M,Acham-Roschitz B,Muntean W

更新日期：2009-10-01 00:00:00

abstract：:Cardiovascular and especially thrombotic diseases remain a major cause of morbidity and mortality worldwide. In past years, significant improvements in understanding disease processes, risk assessment, and prediction of clinical outcome in the field of thrombosis and haemostasis have been made by using large-scale bio...

journal_title：Hamostaseologie

authors： Panova-Noeva M,Eggebrecht L,Prochaska JH,Wild PS

更新日期：2019-06-01 00:00:00

abstract：:By the use of conventional anticoagulants, significant improvements were achieved in all fields of medicine. Although efficacious and widely used, their use is limited in several respects. In particular, the use of vitamin K antagonists is restricted in the clinical routine setting. The main reasons are the delayed on...

journal_title：Hamostaseologie

authors： Haas S

更新日期：2002-08-01 00:00:00

abstract：:Activated by calcium and thrombin, factor XIII (FXIIIa) cross-links fibrin, thus increasing the stability of the fibrin clot. Furthermore, the hemostatic and reparative function of factor XIIIa is mediated by cross-linking other proteins like alpha(2)-plasmin-inhibitor, fibronectin, and collagen. The FXIII Val34Leu po...

journal_title：Hamostaseologie

authors： Dufner GS,Marbet GA

更新日期：2002-02-01 00:00:00

abstract：:Coronary heart disease and stroke, the deadliest forms of cardiovascular disease (CVD), are mainly caused by atherosclerosis, a chronic inflammatory disease of the artery wall driven by maladaptive immune responses in the vessel wall. Various risk factors for CVD influence this pathogenic process, including diabetes m...

journal_title：Hamostaseologie

authors： Polyzos KA,Ketelhuth DF

更新日期：2015-01-01 00:00:00

abstract：:The occurrence of cerebral or retinal ischemic symptoms ipsilateral to high-grade internal carotid artery (ICA) stenosis indicates a status of instability with a substantial risk for future major stroke. Additionally, the detection of microembolic signals downstream of ICA stenosis is predictive for future cerebral is...

journal_title：Hamostaseologie

authors： Sitzer M,Trostdorf F

更新日期：2003-05-01 00:00:00

abstract：:Recombinant interleukin-2 (rIL-2) is indicated for metastatic renal cell carcinoma and melanoma. Over recent years low-dose rIL-2 has been studied for the treatment of autoimmune diseases and acute coronary syndrome because of its ability to expand and activate T regulatory (Treg) cells. However, several medical condi...

journal_title：Hamostaseologie

authors： Mahmoudpour SH,Valerio L,Douxfils J,Mahan CE,Jankowski M,Quitzau K,Konstantinides SV,Barco S

更新日期：2020-12-01 00:00:00

abstract：:Hermansky-Pudlak syndrome (HPS) is a rare, autosomal recessive disorder affecting lysosome-related organelles (LRO), including dense platelet granules. HPS causes oculocutaneous hypopigmentation, bleeding diathesis and granulomatous colitis or pulmonary fibrosis. To date, there is no curative treatment and the clinica...

journal_title：Hamostaseologie

authors： Sánchez-Guiu I,Torregrosa JM,Velasco F,Antón AI,Lozano ML,Vicente V,Rivera J

更新日期：2014-01-01 00:00:00

abstract：:The DHR (Deutsches Hämophilieregister, German Haemophilia Register) records patient data on haemophilia A, haemophilia B, von Willebrand disease, and other coagulation factor deficiency disorders. The DHR has been online since 2009. The participation in the DHR leads to additional administrative workload for the hospi...

journal_title：Hamostaseologie

authors： Haschberger B,Hesse J,Heiden M,Seitz R,Schramm W

更新日期：2010-11-01 00:00:00

abstract：:In Germany one-third of the women in fertile age use combined oral contraceptives (COCs), which consist mostly of ethinylestradiol (EE) and a synthetic progestin. Older COCs with norethisterone or levonorgestrel have a lower risk for venous thromboembolism (VTE) than newer COCs with desogestrel, drospirenone, or gesto...

journal_title：Hamostaseologie

authors： Rott H

更新日期：2019-02-01 00:00:00

abstract：UNLABELLED:Atherosclerosis is a chronic inflammatory disease of the vascular wall that results from disturbed lipoprotein metabolism and increased oxidative stress. A major consequence of this is lipid peroxidation, which generates a number of breakdown products of membrane lipids that form so called oxidation-specific...

journal_title：Hamostaseologie

authors： Bartolini Gritti B,Binder CJ

更新日期：2016-05-10 00:00:00

abstract：:The antiphospholipid syndrome (APS) has occupied haemostaseologists, rheumatologists and obstetricians since its initial description 35 years ago. Its name has been coined because of the antibodies against phospholipids which were the common property of affected patients. In particular, the pathogenesis of APS has bee...

journal_title：Hamostaseologie

authors： Lackner KJ,Müller-Calleja N

更新日期：2019-06-01 00:00:00

abstract：UNLABELLED:The retrospective observational study surveys the relationship between development of inhibitors in the treatment of haemophilia patients and risk factors such as changing FVIII products. A total of 119 patients were included in this study, 198 changes of FVIII products were evaluated. RESULTS:During the ob...

journal_title：Hamostaseologie

authors： Kocher S,Asmelash G,Makki V,Müller S,Krekeler S,Alesci S,Miesbach W

更新日期：2012-01-01 00:00:00

abstract：:We describe the case of a 30-year-old woman with homozygous prothrombin G20210A transition and heterozygous FV Leiden mutation and a history of postpartum venous thrombosis. Despite the high thrombotic risk to be assumed in the presence of this combined thrombophilia our patient suffered her first venous thrombotic ev...

journal_title：Hamostaseologie

authors： Mengis C,Demarmels Biasiutti F

更新日期：2003-08-01 00:00:00

abstract：:The antiphospholipid syndrome is defined as the occurrence of one or more episodes of vascular thrombosis and/or miscarriage together with antiphospholipid antibodies. Some of these antibodies can be detected via coagulation assays by prolonging phospholipids-dependent assays. These unspecific inhibitors are termed lu...

journal_title：Hamostaseologie

authors： Quehenberger P,Wagner O

更新日期：2005-02-01 00:00:00

abstract：:Von Willebrand disease (VWD) is known for its marked heterogeneity which was already recognized by von Willebrand in 1926. The basis of phenotypic differentiation are quantitative and qualitative or functional differences between the different types and subtypes of VWD. One of the most important tools in the classific...

journal_title：Hamostaseologie

authors： Schneppenheim R,Budde U

更新日期：2004-02-01 00:00:00

abstract：:The structure-activity relationship of dipetalogastin II, the strongest thrombin inhibitor isolated and cloned from the bug Dipetalogaster maximus, was examined by introducing gradual changes into the molecule by means of molecular biological methods. The effect upon its inhibition equilibrium constant was determined ...

journal_title：Hamostaseologie

authors： Lopez M,Nowak G

更新日期：2005-08-01 00:00:00

abstract：:Characteristic features of disseminated intravascular coagulation (DIC) are the opposing risks of bleeding (due to consumptive coagulopathy and hyperfibrinolysis) and organ failure (due to widespread microvascular thromboses). The purpose of anticoagulation in DIC is to attenuate excessive thrombin generation and fibr...

journal_title：Hamostaseologie

authors： Janjetovic S,Holstein K,Dicke C,Bokemeyer C,Langer F

更新日期：2019-08-01 00:00:00

abstract：:The antiphospholipid syndrome (APS) is defined by the association of arterial and/or venous thrombosis and/or pregnancy complications with the presence of at least one among the main antiphospholipid antibodies (aPL) (i. e., Lupus anticoagulants, LA, IgG and/or IgM anticardiolipin antibodies, aCL, IgG and/or IgM antiβ...

journal_title：Hamostaseologie

authors： Galli M

更新日期：2011-11-01 00:00:00

abstract：:Patients suffering from haemophilia encounter various phases in life, in which individual needs, life situations, and self- and disease perception change rapidly. One of these phases spans from the beginning of puberty until early adulthood, in which individuals gain self-responsibility and reach independence and auto...

journal_title：Hamostaseologie

authors： Bidlingmaier C,Olivieri M,Schilling FH,Kurnik K,Pekrul I

更新日期：2020-02-01 00:00:00

abstract：:For the last decades, anticoagulation for stroke prevention in atrial fibrillation (AF) as well as for the prophylaxis and long-term treatment of venous thromboembolism has been entirely based on vitamin K antagonists (VKA). Although very effective under optimal conditions, long-term treatment with these drugs is flaw...

journal_title：Hamostaseologie

authors： Steffel J,Luscher TF

更新日期：2012-01-01 00:00:00

abstract：:Placenta-mediated pregnancy complications are clinically important conditions and include preeclampsia, placental abruption, intrauterine growth restriction, and late fetal loss. Pathophysiology is complex, and may be linked to prothrombotic disorders such as antiphospholipid syndrome, whose understanding is still evo...

journal_title：Hamostaseologie

authors： Skeith L,Blondon M,Ní Áinle F

更新日期：2020-08-01 00:00:00

abstract：:When assessing the quality of clinical trials in intermittent claudication, on principle the same strict biometric and medical standards need to be applied for studies on the effect of walking exercise as for conservative drug treatment studies. However, as demonstrated by a recent review of the Cochrane Collaboration...

journal_title：Hamostaseologie

authors： Amendt K

更新日期：2006-08-01 00:00:00

abstract：:Coronary heart disease and the acute coronary syndrome are the leading causes of death in Germany. In prospective observational studies conventional risk factors such as smoking, arterial hypertension, hypercholesterolaemia, and diabetes can explain over 80% of cardiovascular diseases. Therefore, cardiovascular diseas...

journal_title：Hamostaseologie

authors： Weingärtner O,Laufs U

更新日期：2006-05-01 00:00:00

abstract：:This article reviews the roles of blood platelets in haemostasis as well as in the pathogenesis of thromboembolic diseases. Besides the basic processes in primary haemostasis, platelet adhesion, platelet secretion, platelet aggregation, clot retraction, the new model of thrombin formation on the platelet surface is pr...

journal_title：Hamostaseologie

authors： Kehrel BE

更新日期：2008-12-01 00:00:00

abstract：:Haemophilic arthropathy is a complex multifactorial disorder that poses significant challenges to both the treating haematologist and arthroplasty surgeon. Its pathogenesis is incompletely understood. Recent literature has concentrated on the toxic effects of iron and the characteristic inflammatory synovitis. Discuss...

journal_title：Hamostaseologie

authors： Wharton R,Austin S,Back D

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE: This article aims to analyze the phenotype and genotype of an inherited dysfibrinogenemia pedigree associated with a heterozygous mutation in the FGA gene, and to investigate the pathogenesis of this disease. CLINICAL PRESENTATION: The proband of interest is a 29-year-old woman. She was in her 37 weeks of g...

journal_title：Hamostaseologie

authors： Li S,Wang M,Li X,Xu Q,Liu S,Luo S,Chen Y

更新日期：2020-12-01 00:00:00

abstract：UNLABELLED:The retrospective cohort study surveys the influence of age, co-morbidity and laboratory values on FVIII-activity (FVIII:C) in patients with haemophilia A with (mild n = 48, moderate n = 10, severe n = 7 and carriers n = 23). Median observation was 19 years for patients with haemophilia A and 9,5 years for c...

journal_title：Hamostaseologie

authors： Delbrück C,Haferland I,Scholz K,Asmelash G,Makki V,Müller S,Krekeler S,Alesci S,Miesbach W

更新日期：2011-11-01 00:00:00