Screening for haemorrhagic disorders in paediatric patients by means of a questionnaire.

abstract：:Low molecular weight heparins and fondaparinux have been the cornerstones for prevention of venous thromboembolism (VTE) in acutely ill medical patients for almost two decades. Guidelines recommend the use of these parenteral anticoagulants for 6 to 14 days but advise against extended-duration thromboprophylaxis after...

journal_title：Hamostaseologie

authors： Haas S

更新日期：2019-02-01 00:00:00

abstract：:Von Willebrand disease (VWD) is known for its marked heterogeneity which was already recognized by von Willebrand in 1926. The basis of phenotypic differentiation are quantitative and qualitative or functional differences between the different types and subtypes of VWD. One of the most important tools in the classific...

journal_title：Hamostaseologie

authors： Schneppenheim R,Budde U

更新日期：2004-02-01 00:00:00

abstract：:Placenta-mediated pregnancy complications are clinically important conditions and include preeclampsia, placental abruption, intrauterine growth restriction, and late fetal loss. Pathophysiology is complex, and may be linked to prothrombotic disorders such as antiphospholipid syndrome, whose understanding is still evo...

journal_title：Hamostaseologie

authors： Skeith L,Blondon M,Ní Áinle F

更新日期：2020-08-01 00:00:00

abstract：UNLABELLED:The retrospective cohort study surveys the influence of age, co-morbidity and laboratory values on FVIII-activity (FVIII:C) in patients with haemophilia A with (mild n = 48, moderate n = 10, severe n = 7 and carriers n = 23). Median observation was 19 years for patients with haemophilia A and 9,5 years for c...

journal_title：Hamostaseologie

authors： Delbrück C,Haferland I,Scholz K,Asmelash G,Makki V,Müller S,Krekeler S,Alesci S,Miesbach W

更新日期：2011-11-01 00:00:00

abstract：:Myocardial infarction (MI) shows a strong heritability. For a long time the identification of responsible genes has been rather unsuccessful. However, with the advent of genome wide association studies (GWAS) using DNA-array technology a number of significant loci for MI have been identified which were widely replicat...

journal_title：Hamostaseologie

authors： Linsel-Nitschke P,Erdmann J,Schunkert H

更新日期：2010-11-01 00:00:00

abstract：:Cardiovascular disease is the major cause of morbidity and mortality in subjects suffering from diabetes mellitus. While coronary artery disease is the leading cause of cardiac complications in diabetics, it is widely recognized that diabetes increases the risk for the development of heart failure independently of cor...

journal_title：Hamostaseologie

authors： Bugger H,Bode C

更新日期：2015-01-01 00:00:00

abstract：:Platelets react immediately in response to traumatic vascular injury by adhesion, activation, aggregation and subsequent haemostatic plug formation. While this reaction pattern is essential for haemostasis, platelet responses can also cause occlusive thrombi in diseased arteries, leading to myocardial infarction or st...

journal_title：Hamostaseologie

authors： Scharf RE

更新日期：2018-11-01 00:00:00

abstract：UNLABELLED:A protein Z deficiency is presumably related with a threefold risk of venous and arterial thrombosis. Mucosal bleedings and post-operative haematomas can occur more frequently. This is seen in an increased in vivo bleeding time without other plasmatic coagulation disorders or thrombopathies. Pregnancy compli...

journal_title：Hamostaseologie

authors： Kiesewetter H,Radtke H,Jainz A,Schmidt FP

更新日期：2012-01-01 00:00:00

abstract：:Recombinant activated factor VII (rFVIIa) is a pro-haemostatic agent that can be used for patients with haemophilia and inhibiting antibodies towards a coagulation factor. Recombinant factor VIIa is, however, increasingly used for several other indications, including patients who experience serious and life-threatenin...

journal_title：Hamostaseologie

authors： Levi M

更新日期：2009-01-01 00:00:00

abstract：:Nutrient excess in obesity drives metabolic reprogramming in multiple tissues involving extensive interorgan and intercellular crosstalk. Experimental and clinical studies show that prolonged nutrient excess often compromises metabolic adaptation propagating proobesogenic and proinflammatory responses. Chronic inflamm...

journal_title：Hamostaseologie

authors： Madhusudhan T,Ruf W

更新日期：2019-06-01 00:00:00

abstract：:Recurrent venous thromboembolism is associated with increased mortality in 5-9% of the patients. On the other hand prolonged anticoagulation can increase the bleeding risk which can also be responsible for an increased mortality. Therefore, it is necessary to validate the recurrence risk of venous thromboembolism on a...

journal_title：Hamostaseologie

authors： Lindhoff-Last E

更新日期：2011-02-01 00:00:00

abstract：:Patients with myeloproliferative neoplasms (MPNs), such as polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are at increased risk for arterial and venous thrombosis/thromboembolism. In particular, the risk of splanchnic venous thrombosis, such as portal vein thrombosis or Budd-Chiari syndrome, ...

journal_title：Hamostaseologie

authors： Koschmieder S

更新日期：2020-02-01 00:00:00

abstract：:Thrombocytosis (defined as platelets >450 x 109/l) has several aetiologies. After having excluded spurious thrombocytosis (e. g., due to microspherocytes, schistocytes, cryoglobulins, or bacteria), the differential diagnosis of true thrombocytosis encompasses secondary causes (as diverse as inflammation, infection, ma...

journal_title：Hamostaseologie

authors： Alberio L

更新日期：2016-11-07 00:00:00

abstract：INTRODUCTION: Regular visits at haemophilia treatment centres (HTCs) in rural regions are often dependent on the access to a private car due to lack of or limited availability of public means. Therefore, a mobile haemophilia outpatient care (MHOC) concept providing home visits to haemophilia patients has been developed...

journal_title：Hamostaseologie

authors： Eichler H,Schleicher C,Heine S,Graf N,von Mackensen S

更新日期：2018-08-01 00:00:00

abstract：:Dabigatran is a novel direct thrombin inhibitor that has recently been approved for primary and secondary stroke prevention and prevention of systemic embolism in patients with atrial fibrillation. In the pivotal RE-LY study, dabigatran 110 mg BID was demonstrated to be associated with a stroke rate similar to that ob...

journal_title：Hamostaseologie

authors： Hohnloser SH,Diener HC

更新日期：2012-01-01 00:00:00

abstract：:The endothelium lining the vascular lumen is continuously exposed to complement from the circulation. When erroneously activated on host cells, complement may generate a deleterious effect on the vascular wall leading to endothelial injury, exposure of the subendothelial matrix and platelet activation. In this review ...

journal_title：Hamostaseologie

authors： Karpman D,Tati R

更新日期：2013-05-29 00:00:00

abstract：:Recombinant interleukin-2 (rIL-2) is indicated for metastatic renal cell carcinoma and melanoma. Over recent years low-dose rIL-2 has been studied for the treatment of autoimmune diseases and acute coronary syndrome because of its ability to expand and activate T regulatory (Treg) cells. However, several medical condi...

journal_title：Hamostaseologie

authors： Mahmoudpour SH,Valerio L,Douxfils J,Mahan CE,Jankowski M,Quitzau K,Konstantinides SV,Barco S

更新日期：2020-12-01 00:00:00

abstract：:In Germany one-third of the women in fertile age use combined oral contraceptives (COCs), which consist mostly of ethinylestradiol (EE) and a synthetic progestin. Older COCs with norethisterone or levonorgestrel have a lower risk for venous thromboembolism (VTE) than newer COCs with desogestrel, drospirenone, or gesto...

journal_title：Hamostaseologie

authors： Rott H

更新日期：2019-02-01 00:00:00

abstract：:A survey is given on the clinical important haemostatic facts and diseases in gynaecology and obstetrics from the viewpoint of the gynecologist and obstetrician. ...

journal_title：Hamostaseologie

authors： Heilmann L

更新日期：2004-11-01 00:00:00

abstract：:For decades, the options for therapeutic anticoagulation were limited to unfractionated heparin (UFH) and vitamin K antagonists (VKA), and their well-known limitations had to be accepted. With the introduction of the various LMWHs, the short- and medium-term anticoagulation could be much improved, but an alternative t...

journal_title：Hamostaseologie

authors： Alban S

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE: This article aims to analyze the phenotype and genotype of an inherited dysfibrinogenemia pedigree associated with a heterozygous mutation in the FGA gene, and to investigate the pathogenesis of this disease. CLINICAL PRESENTATION: The proband of interest is a 29-year-old woman. She was in her 37 weeks of g...

journal_title：Hamostaseologie

authors： Li S,Wang M,Li X,Xu Q,Liu S,Luo S,Chen Y

更新日期：2020-12-01 00:00:00

abstract：:Atherosclerosis and its major complications - myocardial infarction and stroke - remain major causes of death and disability in the United States and world-wide. Indeed, with dramatic increases in obesity and diabetes mellitus, the prevalence and public health impact of cardiovascular diseases (CVD) will likely remain...

journal_title：Hamostaseologie

authors： Sun QA,Runge MS,Madamanchi NR

更新日期：2016-05-10 00:00:00

abstract：:Current antithrombotic therapy in patients with acute coronary syndrome (ACS) comprises antiplatelet and anticoagulant therapy. Dual antiplatelet therapy composed of aspirin plus a third generation P2Y12 inhibitor (prasugrel or ticagrelor) represents the gold standard, while aspirin plus second generation P2Y12 inhibi...

journal_title：Hamostaseologie

authors： Ahrens I,Bode C,Zirlik A

更新日期：2014-01-01 00:00:00

abstract：:Platelet cytoskeletal reorganization is essential for platelet adhesion and thrombus formation in hemostasis and thrombosis. The Rho GTPases RhoA, Rac1 and Cdc42 are the main players in cytoskeletal dynamics of platelets responsible for the formation of filopodia and lamellipodia to strongly increase the platelet surf...

journal_title：Hamostaseologie

authors： Elvers M

更新日期：2016-08-03 00:00:00

abstract：:We describe the case of a 30-year-old woman with homozygous prothrombin G20210A transition and heterozygous FV Leiden mutation and a history of postpartum venous thrombosis. Despite the high thrombotic risk to be assumed in the presence of this combined thrombophilia our patient suffered her first venous thrombotic ev...

journal_title：Hamostaseologie

authors： Mengis C,Demarmels Biasiutti F

更新日期：2003-08-01 00:00:00

abstract：:Superficial vein thrombosis (SVT) is a common disease, characterized by an inflammatory-thrombotic process in a superficial vein. Typical clinical findings are pain and a warm, tender, reddish cord along the vein. Until recently, no reliable epidemiological data were available. The incidence is estimated to be higher ...

journal_title：Hamostaseologie

authors： Bauersachs RM

更新日期：2013-08-01 00:00:00

abstract：:Direct oral anticoagulants (DOACs) are increasingly prescribed substances in patients with indication for effective anticoagulation. Patients with chronic kidney disease (CKD) have a high burden of cardiovascular risk and are more likely to develop atrial fibrillation (AF) than patients without CKD. Patients with mild...

journal_title：Hamostaseologie

authors： Kcükköylü S,Rump LC

更新日期：2017-01-01 00:00:00

abstract：:This is a very short review on quantitative coagulation factor assays for the beginner. For systematic training several excellent textbooks in German language are available. Quantitative functional assays of coagulation factors and of physiological inhibitor proteins are based on the principle of parallel-line or slop...

journal_title：Hamostaseologie

authors： Marbet GA

更新日期：2006-01-01 00:00:00

abstract：:Activated by calcium and thrombin, factor XIII (FXIIIa) cross-links fibrin, thus increasing the stability of the fibrin clot. Furthermore, the hemostatic and reparative function of factor XIIIa is mediated by cross-linking other proteins like alpha(2)-plasmin-inhibitor, fibronectin, and collagen. The FXIII Val34Leu po...

journal_title：Hamostaseologie

authors： Dufner GS,Marbet GA

更新日期：2002-02-01 00:00:00

abstract：:Coronary heart disease and stroke, the deadliest forms of cardiovascular disease (CVD), are mainly caused by atherosclerosis, a chronic inflammatory disease of the artery wall driven by maladaptive immune responses in the vessel wall. Various risk factors for CVD influence this pathogenic process, including diabetes m...

journal_title：Hamostaseologie

authors： Polyzos KA,Ketelhuth DF

更新日期：2015-01-01 00:00:00