Abstract:
:Cardiovascular and especially thrombotic diseases remain a major cause of morbidity and mortality worldwide. In past years, significant improvements in understanding disease processes, risk assessment, and prediction of clinical outcome in the field of thrombosis and haemostasis have been made by using large-scale biodatabases. These important research resources enable a comprehensive research approach by integrating clinical, environmental, genomic, and molecular information. Cutting edge, high throughput technologies open new data dimensions for clinical large-scale investigations. Joining multiple information levels from several pathophysiological pathways in contrast to a single marker approach might better model the complexity of disease pathogenesis. This review focuses on the possibilities that ultimately allow conducting wide-scale analyses for unravelling the multifaceted interplay between coagulation and cellular (e.g., platelets) elements in the development of thrombotic disease. It further provides examples for the use of biodatabases in the field of venous thromboembolism, explores the links between venous and arterial thrombotic diseases, and finally informs on the current use of platelet biomarkers in the thrombosis and haemostasis field. :Kardiovaskuläre und insbesondere thrombotische Erkrankungen sind nach wie vor eine der Hauptursachen für Morbidität und Mortalität weltweit. In den vergangenen Jahren wurden signifikante Verbesserungen hinsichtlich des Verständnisses von Krankheitsprozessen, der Risikobewertung und der Vorhersage des klinischen Ergebnisses auf dem Gebiet der Thrombose und Hämostase unter Verwendung von Biodatenbanken im großen Maßstab erzielt. Diese wichtigen Forschungsressourcen ermöglichen einen umfassenden Forschungsansatz, indem klinische, Umwelt-, Genom- und molekulare Informationen integriert werden. Spitzentechnologien mit hohem Durchsatz eröffnen neue Datendimensionen für klinische Großuntersuchungen. Das Zusammenfügen mehrerer Informationsebenen aus mehreren pathophysiologischen Wegen im Gegensatz zu einem einzelnen Marker kann die Komplexität der Pathogenese von Krankheiten besser modellieren. Diese Übersichtsarbeit konzentriert sich auf die Möglichkeiten, welche die Durchführung breit angelegter Analysen ermöglichen, um das vielfältige Wechselspiel zwischen Koagulation und zellulären (z. B. Blutplättchen) Elementen bei der Entwicklung einer thrombotischen Erkrankung aufzuklären. Sie bietet außerdem Beispiele für die Verwendung von Biodatenbanken im Bereich der Venenthromboembolie, untersucht die Verbindungen zwischen venösen und arteriellen thrombotischen Erkrankungen und informiert schließlich über die derzeitige Verwendung von Blutplättchen-Biomarkern im Bereich von Thrombose und Hämostase.
journal_name
Hamostaseologiejournal_title
Hamostaseologieauthors
Panova-Noeva M,Eggebrecht L,Prochaska JH,Wild PSdoi
10.1055/s-0038-1677520subject
Has Abstractpub_date
2019-06-01 00:00:00pages
152-163issue
2eissn
0720-9355issn
2567-5761journal_volume
39pub_type
杂志文章,评审相关文献
Hamostaseologie文献大全abstract::The occurrence of cerebral or retinal ischemic symptoms ipsilateral to high-grade internal carotid artery (ICA) stenosis indicates a status of instability with a substantial risk for future major stroke. Additionally, the detection of microembolic signals downstream of ICA stenosis is predictive for future cerebral is...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:
更新日期:2003-05-01 00:00:00
abstract:UNLABELLED:Clinical expression of inadequately treated haemophilia is dominated by orthopedic complications, requiring invasive or non-invasive interventions. OBJECTIVE:In Romania, with under dosed and late introduced "on demand" substitution, we aimed at highlighting the experience of orthopedic treatment and its out...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:
更新日期:2008-10-01 00:00:00
abstract::The translation of fundamental science-based constructs to the preemptive identification and optimal management of individuals with or those at risk for thrombotic disorders of the cardiovascular system has taken a step closer to being realized with the development of molecular technologies that include nucleic acid a...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:
更新日期:2007-12-01 00:00:00
abstract::Recombinant activated factor VII (rFVIIa) is a pro-haemostatic agent that can be used for patients with haemophilia and inhibiting antibodies towards a coagulation factor. Recombinant factor VIIa is, however, increasingly used for several other indications, including patients who experience serious and life-threatenin...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract::Placenta-mediated pregnancy complications are clinically important conditions and include preeclampsia, placental abruption, intrauterine growth restriction, and late fetal loss. Pathophysiology is complex, and may be linked to prothrombotic disorders such as antiphospholipid syndrome, whose understanding is still evo...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:10.1055/a-1184-8388
更新日期:2020-08-01 00:00:00
abstract::Myocardial infarction (MI) shows a strong heritability. For a long time the identification of responsible genes has been rather unsuccessful. However, with the advent of genome wide association studies (GWAS) using DNA-array technology a number of significant loci for MI have been identified which were widely replicat...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:
更新日期:2010-11-01 00:00:00
abstract::Percutaneous coronary intervention (PCI) has significantly improved clinical outcomes in coronary artery disease patients. Since PCI is associated with platelet activation, antiplatelet therapy with aspirin, clopidogrel and GPIIb/IIIa inhibitors comprise the cornerstone strategy during and following PCI. The latter ag...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:
更新日期:2009-11-01 00:00:00
abstract::Venous thromboembolism is a chronic and potential fatal disease. Determination of recurrence risk is time-consuming and costly, and sometimes not feasible: many patients carry more than one risk factor, the relevance of some factors with regard to risk of recurrence is unknown, and existence of thus far unknown risk f...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:
更新日期:2008-02-01 00:00:00
abstract::Cardiovascular disease is the major cause of morbidity and mortality in subjects suffering from diabetes mellitus. While coronary artery disease is the leading cause of cardiac complications in diabetics, it is widely recognized that diabetes increases the risk for the development of heart failure independently of cor...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.5482/HAMO-14-09-0038
更新日期:2015-01-01 00:00:00
abstract::Patients suffering from haemophilia encounter various phases in life, in which individual needs, life situations, and self- and disease perception change rapidly. One of these phases spans from the beginning of puberty until early adulthood, in which individuals gain self-responsibility and reach independence and auto...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.1055/s-0039-3402804
更新日期:2020-02-01 00:00:00
abstract::The antiphospholipid syndrome is defined as the occurrence of one or more episodes of vascular thrombosis and/or miscarriage together with antiphospholipid antibodies. Some of these antibodies can be detected via coagulation assays by prolonging phospholipids-dependent assays. These unspecific inhibitors are termed lu...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.1267/hämo05010050
更新日期:2005-02-01 00:00:00
abstract:UNLABELLED:Secondary arthrosis of the upper ankle joint (talocalcanean joint) is one of the most frequent forms of haemophilic arthropathy. It is a secondary form of arthrosis not only because of chronic synovitis and cartilage injury resulting from chronic recurrent intraarticular bleeds, but also due to the misalignm...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:
更新日期:2009-10-01 00:00:00
abstract::Platelet and coagulation factor-dependent thrombus formation is critical to limit posttraumatic blood loss at sites of vascular injury. However, under pathological conditions like rupture of an atherosclerotic plaque, it may also lead to vessel occlusion causing myocardial infarction or stroke. Therefore, antithrombot...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:
更新日期:2010-08-01 00:00:00
abstract::When assessing the quality of clinical trials in intermittent claudication, on principle the same strict biometric and medical standards need to be applied for studies on the effect of walking exercise as for conservative drug treatment studies. However, as demonstrated by a recent review of the Cochrane Collaboration...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:
更新日期:2006-08-01 00:00:00
abstract::Hermansky-Pudlak syndrome (HPS) is a rare, autosomal recessive disorder affecting lysosome-related organelles (LRO), including dense platelet granules. HPS causes oculocutaneous hypopigmentation, bleeding diathesis and granulomatous colitis or pulmonary fibrosis. To date, there is no curative treatment and the clinica...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.5482/HAMO-14-06-0024
更新日期:2014-01-01 00:00:00
abstract::Atherosclerosis and its major complications - myocardial infarction and stroke - remain major causes of death and disability in the United States and world-wide. Indeed, with dramatic increases in obesity and diabetes mellitus, the prevalence and public health impact of cardiovascular diseases (CVD) will likely remain...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.5482/HAMO-14-11-0076
更新日期:2016-05-10 00:00:00
abstract::Clinically overt, preoperative, disseminated intravascular coagulation (DIC) is not common in patient with aortic aneurysm. However, cases with large and expanding aneurysm are especially prone for this coagulopathy. Contrary to the clinically overt form compensated DIC in patients with aortic aneurysm seems frequent ...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.1267/hamo04030162
更新日期:2004-08-01 00:00:00
abstract::This is a very short review on quantitative coagulation factor assays for the beginner. For systematic training several excellent textbooks in German language are available. Quantitative functional assays of coagulation factors and of physiological inhibitor proteins are based on the principle of parallel-line or slop...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:
更新日期:2006-01-01 00:00:00
abstract::Vitamin-K-antagonists (VKA) and heparins have been complementary anticoagulants for prevention and treatment of thrombosis for almost 70 years. In contrast to heparins, VKA have not been modified pharmacologically, however treatment surveillance has improved by introducing INR and self-monitoring/management. Disclosur...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.5482/ha-1149
更新日期:2011-02-01 00:00:00
abstract::Trauma-induced coagulopathy (TIC) is a heterogeneous entity that contributes to a significant morbidity and mortality following trauma. The activated protein C system, endotheliopathy and platelet dysfunction have been implicated in the pathogenesis of TIC, although there are still controversies on the exact pathogene...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.1055/s-0039-1677853
更新日期:2019-02-01 00:00:00
abstract::Nearly every second patient, who needs an oral anticoagulation with vitamin K antagonists, is feasible to perform INR-self-management after participation in a structured teaching program. Patient self-testing or measuring the INR value by relatives or nurses would increase this method of control by the aid of telemedi...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:
更新日期:2008-10-01 00:00:00
abstract:UNLABELLED:The retrospective observational study surveys the relationship between development of inhibitors in the treatment of haemophilia patients and risk factors such as changing FVIII products. A total of 119 patients were included in this study, 198 changes of FVIII products were evaluated. RESULTS:During the ob...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract::Methylation, CpG island, promoter, intron 1 Haemophilia A is the most common X-linked inherited coagulation disorder caused by a deficiency of the factor VIII protein (FVIII). A plethora of different mutations in the factor VIII gene (F8) have been identified as causative for this bleeding disease including a few prom...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:
更新日期:2013-01-01 00:00:00
abstract::The antiphospholipid syndrome (APS) is defined by the association of arterial and/or venous thrombosis and/or pregnancy complications with the presence of at least one among the main antiphospholipid antibodies (aPL) (i. e., Lupus anticoagulants, LA, IgG and/or IgM anticardiolipin antibodies, aCL, IgG and/or IgM antiβ...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.5482/ha-1165
更新日期:2011-11-01 00:00:00
abstract::The endothelium lining the vascular lumen is continuously exposed to complement from the circulation. When erroneously activated on host cells, complement may generate a deleterious effect on the vascular wall leading to endothelial injury, exposure of the subendothelial matrix and platelet activation. In this review ...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.5482/HAMO-12-12-0025
更新日期:2013-05-29 00:00:00
abstract::Thrombocytosis (defined as platelets >450 x 109/l) has several aetiologies. After having excluded spurious thrombocytosis (e. g., due to microspherocytes, schistocytes, cryoglobulins, or bacteria), the differential diagnosis of true thrombocytosis encompasses secondary causes (as diverse as inflammation, infection, ma...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.5482/HAMO-14-11-0074
更新日期:2016-11-07 00:00:00
abstract::Coronary heart disease and the acute coronary syndrome are the leading causes of death in Germany. In prospective observational studies conventional risk factors such as smoking, arterial hypertension, hypercholesterolaemia, and diabetes can explain over 80% of cardiovascular diseases. Therefore, cardiovascular diseas...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:
更新日期:2006-05-01 00:00:00
abstract:AIM:In children, screening for haemorrhagic disorders is further complicated by the fact that infants and young children with mild disease in many cases most likely will not have a significant history of easy bruising or bleeding making the efficacy of a questionnaire even more questionable. PATIENTS, METHODS:We compa...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:
更新日期:2009-10-01 00:00:00
abstract:UNLABELLED:In recent years thrombophilia has gained much attention as a risk factor for pregnancy complications. Whereas there is an established correlation between antiphospholipid-antibodies and pregnancy loss, data for other risk factors of thrombosis are less well established. Data suggest associations with antithr...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::Coronary heart disease and stroke, the deadliest forms of cardiovascular disease (CVD), are mainly caused by atherosclerosis, a chronic inflammatory disease of the artery wall driven by maladaptive immune responses in the vessel wall. Various risk factors for CVD influence this pathogenic process, including diabetes m...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.5482/HAMO-14-10-0052
更新日期:2015-01-01 00:00:00