[Antithrombotic therapy of acute coronary syndromes].

Abstract:

:Recent advances in the diagnosis and the treatment of acute coronary syndromes (ACS) have led to a substantial reduction of major coronary events, to an improvement in patient outcome and the definition of new guidelines. Current strategies for the treatment of patients with non-ST-elevation ACS recommend a combined antithrombotic therapy (including aspirin, clopidogrel, anticoagulation with low-molecular weight or unfractionated heparins or FXa-inhibitors or direct antithrombins and, eventually glycoprotein IIb/IIIa receptor antagonists). This combined antithrombotic therapy allows to increase the benefit of an early invasive strategy including coronary angiogram with stent percutaneous coronary angioplasty. The purpose of this review is to discuss and highlight the recommendations for the appropriate use of antithrombotic strategies in the setting of angioplasty in ACS patients.

journal_name

Hamostaseologie

journal_title

Hamostaseologie

authors

Hölschermann H

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

319-25; quiz 326-7

issue

5

eissn

0720-9355

issn

2567-5761

pii

07050319

journal_volume

27

pub_type

杂志文章
  • Subchondral haematoma.

    abstract::Haemophilic arthropathy is a complex multifactorial disorder that poses significant challenges to both the treating haematologist and arthroplasty surgeon. Its pathogenesis is incompletely understood. Recent literature has concentrated on the toxic effects of iron and the characteristic inflammatory synovitis. Discuss...

    journal_title:Hamostaseologie

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    doi:10.5482/HAMO-15-12-0033

    authors: Wharton R,Austin S,Back D

    更新日期:2017-01-01 00:00:00

  • [Platelets: biochemistry and physiology].

    abstract::This article reviews the roles of blood platelets in haemostasis as well as in the pathogenesis of thromboembolic diseases. Besides the basic processes in primary haemostasis, platelet adhesion, platelet secretion, platelet aggregation, clot retraction, the new model of thrombin formation on the platelet surface is pr...

    journal_title:Hamostaseologie

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    doi:

    authors: Kehrel BE

    更新日期:2008-12-01 00:00:00

  • The Impact of Bleeding Disorders on the Socioeconomic Status of Adult Patients.

    abstract::The impact of inherited bleeding disorders on the socioeconomic status (SES) of affected individuals is not clear. The SES of adult patients with congenital bleeding disorders (PWBD) from a centre in Germany (age 42.3 ± 15.0 years) was compared to that of a gender- and age-matched control group of patients with thromb...

    journal_title:Hamostaseologie

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    doi:10.5482/HAMO-16-12-0047

    authors: Holstein K,von Mackensen S,Bokemeyer C,Langer F

    更新日期:2018-08-01 00:00:00

  • [Factor XIII in man: a review].

    abstract::Activated by calcium and thrombin, factor XIII (FXIIIa) cross-links fibrin, thus increasing the stability of the fibrin clot. Furthermore, the hemostatic and reparative function of factor XIIIa is mediated by cross-linking other proteins like alpha(2)-plasmin-inhibitor, fibronectin, and collagen. The FXIII Val34Leu po...

    journal_title:Hamostaseologie

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    doi:

    authors: Dufner GS,Marbet GA

    更新日期:2002-02-01 00:00:00

  • Hermansky-Pudlak syndrome. Overview of clinical and molecular features and case report of a new HPS-1 variant.

    abstract::Hermansky-Pudlak syndrome (HPS) is a rare, autosomal recessive disorder affecting lysosome-related organelles (LRO), including dense platelet granules. HPS causes oculocutaneous hypopigmentation, bleeding diathesis and granulomatous colitis or pulmonary fibrosis. To date, there is no curative treatment and the clinica...

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    doi:10.5482/HAMO-14-06-0024

    authors: Sánchez-Guiu I,Torregrosa JM,Velasco F,Antón AI,Lozano ML,Vicente V,Rivera J

    更新日期:2014-01-01 00:00:00

  • Health Care Transition of Adolescents and Young Adults with Haemophilia: the Situation in Germany and the Munich experience.

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    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.1055/s-0039-3402804

    authors: Bidlingmaier C,Olivieri M,Schilling FH,Kurnik K,Pekrul I

    更新日期:2020-02-01 00:00:00

  • Extracellular nucleic acids as novel alarm signals in the vascular system. Mediators of defence and disease.

    abstract::Upon vascular injury or tissue damage, the exposed intracellular material such as nucleic acids, histones and other macromolecules may come into contact with vessel wall cells and circulating blood cells and may thus, have an enduring influence on wound healing and body defence processes. This short review summarizes ...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.5482/HAMO-13-01-0001

    authors: Fischer S,Preissner KT

    更新日期:2013-01-01 00:00:00

  • Follow-up of a 6-month Programmed Sports Therapy (PST) in patients with haemophilia.

    abstract::Studies describe benefits of exercise in Patients with haemophilia (PwH), but research on training sustainability is rare. Aim of this study was to observe the follow-up of a guided 6-month training intervention in PwH. This study included 28 PwH after a training intervention (RCT) over 6 months. N=17 continued traini...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,随机对照试验

    doi:10.5482/HAMO-17-04-0016

    authors: Runkel B,Hilberg T

    更新日期:2017-01-01 00:00:00

  • [Classification of von Willebrand disease].

    abstract::Von Willebrand disease (VWD) is known for its marked heterogeneity which was already recognized by von Willebrand in 1926. The basis of phenotypic differentiation are quantitative and qualitative or functional differences between the different types and subtypes of VWD. One of the most important tools in the classific...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.1267/hamo04010027

    authors: Schneppenheim R,Budde U

    更新日期:2004-02-01 00:00:00

  • The role of the kynurenine pathway of tryptophan metabolism in cardiovascular disease. An emerging field.

    abstract::Coronary heart disease and stroke, the deadliest forms of cardiovascular disease (CVD), are mainly caused by atherosclerosis, a chronic inflammatory disease of the artery wall driven by maladaptive immune responses in the vessel wall. Various risk factors for CVD influence this pathogenic process, including diabetes m...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.5482/HAMO-14-10-0052

    authors: Polyzos KA,Ketelhuth DF

    更新日期:2015-01-01 00:00:00

  • [Fibrin monomer and factor XIII: a new concept for unexplained intraoperative coagulopathy].

    abstract::Unexplained intraoperative coagulopathies continue to be a diagnostic and therapeutic dilemma. The pathophysiology behind unexplained intraoperative coagulopathies is of great variety and complexity (preexisting coagulopathies, dilutional coagulopathy, interactions of medications etc.). We have shown in prospective st...

    journal_title:Hamostaseologie

    pub_type: 杂志文章

    doi:

    authors: Korte W

    更新日期:2006-08-01 00:00:00

  • [Documentation of haemophilia treatment supported by the German Hemophilia Registry].

    abstract::The DHR (Deutsches Hämophilieregister, German Haemophilia Register) records patient data on haemophilia A, haemophilia B, von Willebrand disease, and other coagulation factor deficiency disorders. The DHR has been online since 2009. The participation in the DHR leads to additional administrative workload for the hospi...

    journal_title:Hamostaseologie

    pub_type: 杂志文章

    doi:

    authors: Haschberger B,Hesse J,Heiden M,Seitz R,Schramm W

    更新日期:2010-11-01 00:00:00

  • Methylation analysis of the promoter region and intron 1 of the factor VIII gene in haemophilia A patients.

    abstract::Methylation, CpG island, promoter, intron 1 Haemophilia A is the most common X-linked inherited coagulation disorder caused by a deficiency of the factor VIII protein (FVIII). A plethora of different mutations in the factor VIII gene (F8) have been identified as causative for this bleeding disease including a few prom...

    journal_title:Hamostaseologie

    pub_type: 杂志文章

    doi:

    authors: Zimmermann MA,Hansmann T,Haaf T,Oldenburg J,Müller CR,Rost S

    更新日期:2013-01-01 00:00:00

  • Coagulation Signalling and Metabolic Disorders: Lessons Learned from Animal Models.

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    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.1055/s-0039-1688800

    authors: Madhusudhan T,Ruf W

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  • Venous thrombosis and multiple prothrombotic gene defects. Case 5.

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    journal_title:Hamostaseologie

    pub_type: 杂志文章

    doi:

    authors: Mengis C,Demarmels Biasiutti F

    更新日期:2003-08-01 00:00:00

  • The Role of Low Molecular Weight Heparins for Venous Thromboembolism Prevention in Medical Patients-What Is New in 2019?

    abstract::Low molecular weight heparins and fondaparinux have been the cornerstones for prevention of venous thromboembolism (VTE) in acutely ill medical patients for almost two decades. Guidelines recommend the use of these parenteral anticoagulants for 6 to 14 days but advise against extended-duration thromboprophylaxis after...

    journal_title:Hamostaseologie

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    doi:10.1055/s-0038-1677522

    authors: Haas S

    更新日期:2019-02-01 00:00:00

  • Nucleic acid aptamers and their complimentary antidotes. Entering an era of antithrombotic pharmacobiologic therapy.

    abstract::The translation of fundamental science-based constructs to the preemptive identification and optimal management of individuals with or those at risk for thrombotic disorders of the cardiovascular system has taken a step closer to being realized with the development of molecular technologies that include nucleic acid a...

    journal_title:Hamostaseologie

    pub_type: 杂志文章

    doi:

    authors: Becker RC,Oney S,Becker KC,Rusconi CP,Sullenger B

    更新日期:2007-12-01 00:00:00

  • Recurrent cerebral ischaemia in a pregnant woman with patent foramen ovale II° and thrombophilia.

    abstract::This case report concerns a pregnant multipara (age: 27 years) in the 16th gestational week. She developed a sudden onset of paraesthesia in her left lower arm although injecting dalteparin 5000 IU once daily subcutaneously (s. c.) due to a heterozygous factor V Leiden mutation and a prior miscarriage in the first pre...

    journal_title:Hamostaseologie

    pub_type: 杂志文章

    doi:10.5482/HAMO-14-03-0022

    authors: Hecking C,Hendelmeier M,von Bardeleben R,Gröschel K,Schinzel H

    更新日期:2014-01-01 00:00:00

  • [Future potential indications for an oral thrombin inhibitor].

    abstract::By the use of conventional anticoagulants, significant improvements were achieved in all fields of medicine. Although efficacious and widely used, their use is limited in several respects. In particular, the use of vitamin K antagonists is restricted in the clinical routine setting. The main reasons are the delayed on...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:

    authors: Haas S

    更新日期:2002-08-01 00:00:00

  • Cofactor-Independent Antiphospholipid Antibodies: Implications for Pathogenesis, Diagnosis, and Treatment of Antiphospholipid Syndrome.

    abstract::The antiphospholipid syndrome (APS) has occupied haemostaseologists, rheumatologists and obstetricians since its initial description 35 years ago. Its name has been coined because of the antibodies against phospholipids which were the common property of affected patients. In particular, the pathogenesis of APS has bee...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.1055/s-0038-1675355

    authors: Lackner KJ,Müller-Calleja N

    更新日期:2019-06-01 00:00:00

  • Platelet monitoring for PCI: is it really necessary?

    abstract::Percutaneous coronary intervention (PCI) has significantly improved clinical outcomes in coronary artery disease patients. Since PCI is associated with platelet activation, antiplatelet therapy with aspirin, clopidogrel and GPIIb/IIIa inhibitors comprise the cornerstone strategy during and following PCI. The latter ag...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:

    authors: Tantry US,Gurbel PA

    更新日期:2009-11-01 00:00:00

  • [Bleedings under NOAC (non Vitamin-K dependent oral anticoagulants). Evidence and practical management].

    abstract:UNLABELLED:The doses of these drugs are barely tested and the potential clinical thromboembolic risk must be taken into account. Despite the widespread use of NOAC (non vitamin-K dependent oral anticoagulants) and recommendations of regulatory agencies and first consensus meeting on handling the bleeding situation unde...

    journal_title:Hamostaseologie

    pub_type: 杂志文章

    doi:

    authors: Koscielny J,Rutkauskaite E

    更新日期:2015-01-01 00:00:00

  • RhoGAPs and Rho GTPases in platelets.

    abstract::Platelet cytoskeletal reorganization is essential for platelet adhesion and thrombus formation in hemostasis and thrombosis. The Rho GTPases RhoA, Rac1 and Cdc42 are the main players in cytoskeletal dynamics of platelets responsible for the formation of filopodia and lamellipodia to strongly increase the platelet surf...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.5482/HAMO-14-09-0046

    authors: Elvers M

    更新日期:2016-08-03 00:00:00

  • Do we need antiplatelet therapy in thrombocytosis? Pro. Diagnostic and pathophysiologic considerations for a treatment choice.

    abstract::Thrombocytosis (defined as platelets >450 x 109/l) has several aetiologies. After having excluded spurious thrombocytosis (e. g., due to microspherocytes, schistocytes, cryoglobulins, or bacteria), the differential diagnosis of true thrombocytosis encompasses secondary causes (as diverse as inflammation, infection, ma...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.5482/HAMO-14-11-0074

    authors: Alberio L

    更新日期:2016-11-07 00:00:00

  • The problem of novel FVIII missense mutations for haemophilia A genetic counseling.

    abstract:UNLABELLED:Molecular genetic testing for factor VIII (FVIII) mutations is indicated in haemophilia A since determination of FVIII activity cannot reliably identify female carriers. Given the large number of FVIII mutations the identification of novel mutations is not uncommon. Since amino acid polymorphisms of FVIII ar...

    journal_title:Hamostaseologie

    pub_type: 杂志文章

    doi:

    authors: Schneppenheim R,Schröder J,Obser T,Oyen F,Schneppenheim S,Oldenburg J

    更新日期:2009-05-01 00:00:00

  • Potential Drug Interactions between Recombinant Interleukin-2 and Direct Oral Anticoagulants: Indirect Evidence from In Vivo Animal Studies.

    abstract::Recombinant interleukin-2 (rIL-2) is indicated for metastatic renal cell carcinoma and melanoma. Over recent years low-dose rIL-2 has been studied for the treatment of autoimmune diseases and acute coronary syndrome because of its ability to expand and activate T regulatory (Treg) cells. However, several medical condi...

    journal_title:Hamostaseologie

    pub_type: 杂志文章

    doi:10.1055/a-1120-4064

    authors: Mahmoudpour SH,Valerio L,Douxfils J,Mahan CE,Jankowski M,Quitzau K,Konstantinides SV,Barco S

    更新日期:2020-12-01 00:00:00

  • [Pathophysiology of acute coronary syndrome].

    abstract::This article reviews the current understanding of the pathophysiology of acute coronary syndrome and how these concepts have altered our clinical approach to the acute phase of coronary heart disease. Thrombosis due to erosion or, in most cases, rupture of a vulnerable atherosclerotic plaque underlies most acute coron...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:

    authors: Hölschermann H,Tillmanns H,Bode C

    更新日期:2006-05-01 00:00:00

  • Child Abuse or Bleeding Disorder-An Interdisciplinary Approach.

    abstract::Children with an unexplained bleeding tendency are frequently referred to a haemostaseologist for further evaluation. Careful standardized history taking and clinical evaluation should allow for distinguishing bleeds after minor injury and trauma which are very common in all children. However, in two groups of childre...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.1055/s-0039-1677714

    authors: Knöfler R,Streif W,Watzer-Herberth I,Hahn G,Schmidt U

    更新日期:2019-02-01 00:00:00

  • VKCFD2 - from clinical phenotype to molecular mechanism.

    abstract::Vitamin K 2,3-epoxide reductase complex, subunit 1 (VKORC1) is an enzyme essential for the vitamin K cycle. VKORC1 catalyses the reduction of vitamin K 2,3-epoxide to the quinone form of vitamin K and further to vitamin K hydroquinone. The generated vitamin K hydroquinone serves as substrate for the enzyme γ-glutamyl-...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:

    authors: Czogalla KJ,Watzka M,Oldenburg J

    更新日期:2016-11-08 00:00:00

  • [Protein Z deficiency in unexplained affinity to thromboses, bleedings or abortions].

    abstract:UNLABELLED:A protein Z deficiency is presumably related with a threefold risk of venous and arterial thrombosis. Mucosal bleedings and post-operative haematomas can occur more frequently. This is seen in an increased in vivo bleeding time without other plasmatic coagulation disorders or thrombopathies. Pregnancy compli...

    journal_title:Hamostaseologie

    pub_type: 杂志文章

    doi:

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    更新日期:2012-01-01 00:00:00